Tag: M.W=0-100

Liang, Yun-Yan; Huang, Jing; Ouyang, Xuan-Hui; Qin, Jing-Hao; Song, Ren-Jie; Li, Jin-Heng published the artcile< Radical-mediated alkoxypolyhaloalkylation of styrenes with polyhaloalkanes and alcohols via C(sp3)-H bond cleavage>, Application In Synthesis of 627-27-0, the main research area is polyhaloalkane preparation; styrene polyhaloalkane alc alkoxypolyhaloalkylation.

A new radical-mediated alkoxypolyhaloalkylation of styrenes RCH=C(R1)R2 (R = H, Me; R1 = 4-methoxyphenyl, 3-methylthiophen-2-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc.; R2 = H, Me, Ph) with polychloroalkanes HCR3R4R5 (R3 = H, Cl, Br; R4 = H, Cl, Br; R5 = Cl, Br, bromomethyl, chloromethyl, dichloromethyl) and alcs. R6OH (R6 = Me, 2,2-dimethylpropyl, 4-phenylbutyl, adamantan-2-yl, etc.) and aniline is provided for the facile synthesis of complex polyhaloalkanes R1R2C(OR6)C(R)CR3R4R5 and N-(3,3,3-trichloro-1-(4-methoxyphenyl)propyl)aniline. The 4-methoxybenzenediazonium tetrafluoroborate is a good radical initiator for this transformation. This protocol is well applied to the late-stage functionalization of complex mols., including vitamin E, estrone and cholesterol derivs e.g., I.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Wenliang; Jiang, Sangni; Li, Shengran; Yan, XinXin; Liu, Sanrong; Mao, Xiaobo; Yu, Xifei published the artcile< Functional Choline Phosphate Lipids for Enhanced Drug Delivery in Cancer Therapy>, SDS of cas: 627-27-0, the main research area is choline phosphate lipid drug delivery anticancer agent biocompatibility.

Liposome formulations by zwitterionic lipids (e.g., phosphatidyl choline (PC)) have been widely applied in the clin. translation of nanomedicines. However, poor bioorthogonality in the PC lipid backbone and limited cellular uptake potency significantly impede the development of a therapeutic strategy. Herein, we synthesized a novel bioorthogonal zwitterionic lipid named choline phosphate (CP), with reversed PC charge orientation via a phospholane derivative ring-opening reaction. CP lipids can assemble into liposomes with excellent biocompatibility and stable phys. and chem. properties similar to PC liposomes. Due to supramol. ionic pair interactions with the cell membrane, doxorubicin (Dox)-loaded CP liposomes (CP-Dox) were preferentially taken up and accumulated in cells compared to PC-Dox, which significantly enhanced the cytotoxicity in cancer cells and inhibited tumor growth. Furthermore, we determined the bioorthogonality of the CP lipids by conjugating folate in situ using a “”click”” reaction, which showed specificity in targeting treatment for breast cancer. Our studies provide a new proof of concept that functional liposomes can be designed at the mol. level. We also expect that CP lipids may have potential in other applications, including biosensors, antifouling coatings, cell membrane mimetic engineering, and artificial cells.

Chemistry of Materials published new progress about Antitumor agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ni, Hui-Qi; Li, Zi-Qi; Tran, Van T.; Engle, Keary M. published the artcile< Modular synthesis of non-conjugated N-(quinolin-8-yl) alkenyl amides via cross-metathesis>, Safety of But-3-en-1-ol, the main research area is amide terminal alkene olefin metathesis Grubbs catalyst directing group; internal alkene preparation; Alkene Functionalization; Alkenes; Directing group; Grubbs catalyst; Olefin metathesis.

We report a direct and modular method to access non-conjugated alkenyl amides containing the 8-aminoquinoline (AQ) directing auxiliary and related groups via cross-metathesis. In this way, readily available, AQ-containing, terminal β,γ-unsaturated amides can be coupled with various terminal alkenes to furnish internal alkene products that are otherwise difficult to prepare The value of this family of products stems from their ability to participate in a number of directed alkene functionalization reactions.

Tetrahedron published new progress about Alkenes Role: SPN (Synthetic Preparation), PREP (Preparation) (internal). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Jie; Yuan, Xiang-Ai; Yan, Zhongfei; Mu, Liying; Ma, Junyang; Zhu, Chengjian; Xie, Jin published the artcile< Manganese-catalysed divergent silylation of alkenes>, Formula: C4H8O, the main research area is diphosphinoamino diphosphinomethyl manganese carbonyl complex preparation catalyst silylation; crystal structure diphosphinoamino diphosphinomethyl manganese carbonyl complex; mol structure diphosphinoamino diphosphinomethyl manganese carbonyl complex; alkene silylation manganese catalyst; potential energy surface alkene silylation manganese catalyst DFT.

Transition-metal-catalyzed, redox-neutral dehydrosilylation of alkenes is a long-standing challenge in organic synthesis, with current methods suffering from low selectivity and narrow scope. The authors report a general and simple method for the Mn-catalyzed dehydrosilylation and hydrosilylation of alkenes, with Mn2(CO)10 as a catalyst precursor, by using a ligand-tuned metalloradical reactivity strategy. This enables versatility and controllable selectivity with a 1:1 ratio of alkenes and silanes, and the synthetic robustness and practicality of this method are demonstrated using complex alkenes and light olefins. The selectivity of the reaction was studied using d. functional theory calculations, showing the use of an iPrPNP ligand to favor dehydrosilylation, while a JackiePhos ligand favors hydrosilylation. The reaction is redox-neutral and atom-economical, exhibits a broad substrate scope and excellent functional group tolerance, and is suitable for various synthetic applications on a gram scale. [graphic not available: see fulltext].

Nature Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xiangtai; Chen, Dengfeng; Liu, Rui; Jiang, Ping; Huang, Shenlin published the artcile< Synthesis of 2-(Cyanomethyl)benzoic Esters via Carbon-Carbon Bond Cleavage of Indanones>, Related Products of 627-27-0, the main research area is cyanomethyl benzoic ester preparation; indanone alc bond cleavage.

A novel synthesis of 2-(cyanomethyl)benzoic esters 2-C(R)CN-3-R1-4-R2-5-R3C6HC(O)OR4 (R = H, Me; R1 = H, Br, CN, CF3; R2 = H, Br, OMe, Cl, etc.; R3 = H, Me, OMe, Br; R4 = Me, Bn, furan-2-ylmethyl, 2H-1,3-benzodioxol-5-ylmethyl, etc.) and ethyl2-(3-cyanopropyl)benzoate from indanone derivatives I (R5 = Me, Ph, 4-trifluoromethylphenyl) and [5-oxo-6,7,8,9-tetrahydro-5H-benzo[7]annulen-6-ylidene]amino acetate has been established. This reaction proceeds via a deprotonation of alcs. R4OH with a chem. base, followed by a nucleophilic addition to indanones I and Beckmann fragmentation. In addition, this reaction could also work under electrochem. conditions, and no external chem. bases were needed. This mild method offers a novel strategy for the late-stage functionalization of various natural alcs. such as citronellol, nerol, abietyl alc., etc.

Journal of Organic Chemistry published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zheqi; Wu, Dong; Ding, Chao; Yin, Guoyin published the artcile< Modular synthesis of diarylalkanes by nickel-catalyzed 1,1-diarylation of unactivated terminal alkenes>, Electric Literature of 627-27-0, the main research area is arylboronic acid terminal alkene bromoarene nickel catalyst regioselective diarylation; diaryl alkane preparation.

A nickel-catalyzed 1,1-diarylation of electronically unbiased alkenes was developed, providing straightforward access to diarylalkanes from readily available materials. Importantly, both the efficiency and the regioselectivity of this transformation were ensured by reaction conditions, rather than the coordinating group of substrates. It was also demonstrated that under balloon pressure, ethylene and propylene was also be utilized as substrates. Preliminary mechanistic experiments suggested that this transformation involves a Ni(0)/Ni(II) catalytic cycle rather than a Ni(I)/Ni(III) cycle.

CCS Chemistry published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rana, Rohit; Shreya; Upadhyay, Rahul; Maurya, Sushil K. published the artcile< Synthesis of Macrocyclic Lactones and Dilactones Using Olive Oil>, Recommanded Product: But-3-en-1-ol, the main research area is ester olive oil Grubbs second generation macrocyclization catalyst; lactone preparation; dilactone preparation.

Macrocyclic lactones have redolent characteristics of muscones that originate from the rectal musk organs of the musk deer. These lactones are the primary raw material in the flavor and fragrance industry and are also found within the cyclic frameworks of various bioactive mols. Due to great demand, many efforts have been made for their synthesis; however, strategies generating a large number of macrocyclic analogs from renewable resources have not been fully realized and are urgently required. Here, we outline a sustainable, straightforward, and eco-friendly approach to synthesize high-valued macrocyclic lactones utilizing olive oil under greener reaction conditions. The outlined method allows us to turn biomass into valuable 12- to 29-membered lactones and dilactones.

ACS Omega published new progress about Diastereoselective synthesis. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fouad, Farid; Khairuddean, Melati; Twieg, Robert published the artcile< Synthesis and liquid crystalline studies of biphenylyl-1,3,4-thiadiazoles and diphenyl-1,3,4-thiadiazoles: influence of side chain semifluorination and lateral ring fluorination>, Computed Properties of 627-27-0, the main research area is biphenylyl thiadiazole preparation liquid crystal structure property thermal stability; diphenyl thiadiazole preparation liquid crystal structure property thermal stability.

Four series of 1,3,4-thiadiazole based compounds I [R = C2H5, C6H13O; R1 = Me, Et, n-Pr, etc.] II [R2 = R3 = C9H19, F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] and III [X = Y = H, F] were synthesized, and their liquid crystalline properties were studied. Series I compounds I [R = C2H5, C6H13O; R1 = Me, Et, n-Pr, etc.] were two tailed biphenylyl-1,3,4-thiadiazoles. Series II II [R2 = R3 = C9H19, F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] was a set of new diphenyl-1,3,4-thiadiazoles with perhydrogenated and semifluorinated tails. Series III compounds II [R2 = R3 = F(CF2)4(CH2)3, F(CF2)6(CH2)3, etc.] were sym. semifluorinated diphenyl-1,3,4-thiadiazoles. Two laterally fluorinated diphenyl-1,3,4-thiadiazoles along with their parent nonfluorinated compound III [X = Y = H, F] were also synthesized. In all of the four series SmA and/or SmC phases was observed

Liquid Crystals published new progress about Carboxylic acids Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Grabka, Michal; Kula, Przemyslaw; Szala, Mateusz; Jasek, Krzysztof; Czerwinski, Michal published the artcile< Fluorophenol-Containing Hydrogen-Bond Acidic Polysiloxane for Gas Sensing-Synthesis and Characterization>, COA of Formula: C4H8O, the main research area is fluorophenol polysiloxane hydrosilylation gas sensor property; coatings for gravimetric sensors; hydrogen-bond acidic polysiloxane; on-site detection of CWAs; sensor polymer.

In this work, the synthesis of a new polysiloxane, poly {dimethylsiloxane-co-[4-(2,3-difluoro-4-hydroxyphenoxy) butyl] methylsiloxane} (dubbed PMFOS), is presented. This polymer exhibits high hydrogen bond acidity and was designed to be used as a sensor layer in gas sensors. The description of the synthetic route of the PMFOS has been divided into two main stages: the synthesis of the functional substituent 4-(but-3-en-1-yloxy)-2,3-difluorophenol, and the post-polymerization functionalization of the polysiloxane chain (methylhydrosiloxane-dimethylsiloxane copolymer) via hydrosilylation. The synthesized material was subjected to instrumental anal., which confirmed its structure. The performed thermal anal. made it possible to determine some properties important for the sensor application, such as glass transition temperature and decomposition temperature The results showed that PMFOS meets the requirements for materials intended for use in gas sensors based on acoustoelec. transducers.

Polymers (Basel, Switzerland) published new progress about Gas sensors. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hewitt, Kirsten A.; Xie, Pei-Pei; Thane, Taylor A.; Hirbawi, Nadia; Zhang, Shuo-Qing; Matus, Alissa C.; Lucas, Erika L.; Hong, Xin; Jarvo, Elizabeth R. published the artcile< Nickel-Catalyzed Domino Cross-Electrophile Coupling Dicarbofunctionalization Reaction To Afford Vinylcyclopropanes>, SDS of cas: 627-27-0, the main research area is vinylcyclopropane enantioselective diastereoselective preparation DFT; alkynyl tosylpiperidine domino cross electrophile coupling dicarbofunctionalization nickel catalyst.

A nickel-catalyzed domino reaction was established that harnesses sulfonamide, alkyl chloride, and alkyne functionalities in a multistep sequence to afford vinylcyclopropanes I [R = Me, n-hexyl, Ph, etc.] bearing tetrasubstituted olefins. The starting materials were prepared by iron-promoted aza-Prins reactions of ynals. This method provided rapid synthetic access to valuable building blocks with applications in medicinal chem. Exptl. and computational results supported the initiation of the catalytic cycle by the oxidative addition of propargylic sulfonamide, and a key ambiphilic allenylnickel intermediate leads to a bifurcated reaction pathway that generates olefin isomers.

ACS Catalysis published new progress about Alkenes, trans Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts