Tag: M.W=0-100

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 3279-95-6, name is 2-(Aminooxy)ethanol. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-(Aminooxy)ethanol

Obtained in Step 3 3,4-difluoro-2- (2-fluoro-4-iodo – phenylamino) -5-vinyl – benzoic acid (180 g, 0.429 mmol) and 3-hydroxy-4-oxo-3 , 4-dihydro-1,2,3-benzotriazine (77.0 g, 0.472 mmol) was dissolved in N, N- dimethylformamide (2 L), 1- (3- dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride salt (87.2 g, 0.455 mol) and the mixture was stirred for 2 hours at room temperature. After confirming the generation and disappearance of the starting material of the active ester in LC-MS, cooling the reaction system to 0 C. The resulting 2-aminooxy in step 5 – ethanol (39.7g, 0.515 mol) and the mixture was stirred for 2 h at 0 C. To confirm the disappearance of the generation and active ester of condensates at the LC-MS. The reaction solution 0.3N hydrochloric acid (2 L) and saturated brine (500 ml) was added and the resulting mixture was extracted with ethyl acetate (2 x 2 L). The organic layers were combined, 0.3N hydrochloric acid (2L), saturated aqueous sodium bicarbonate solution (2 x 2 L), washed with saturated brine (2L), dried over anhydrous sodium sulfate, the objective compound as a white solid concentrated under reduced pressure to 3,4-difluoro-2- (2-fluoro-4-iodo – phenylamino)-N- (2-hydroxy – ethoxy) -5-vinyl – benzamide (179 g, 87%).

With the rapid development of chemical substances, we look forward to future research findings about 3279-95-6.

Reference:
Patent; CHUGAI PHARMACEUTICAL COMPANY LIMITED; UETO, TAKAMITSU; TAKATA, NORIYUKI; (19 pag.)JP2016/34901; (2016); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 16545-68-9, name is Cyclopropanol. A new synthetic method of this compound is introduced below., Safety of Cyclopropanol

To a solution of 1.5 g (7.44 mmol, 1.0 eq.) of 4-nitrophenyl chloroformate in 25 mL ofmethylene chloride at 0C was added 0.5 g (8.61 mmol, 1.16 eq.) of cyclopropanol followedby 0.63 g (8.05 mmol, 1.08 eq) of pyridine. The resulting solution was stirred at 0 C for 1.5 h. The mixture was diluted with 5 mL of methylene chloride and 10 mL of 0.1 M aqueous sulfuric acid. The organic phase was then washed with 10 mL of sat. NaHCO3, 10 mL of water and 10 mL of brine. The organic phase was dried (Na2SO4), filtered and concentratedto a volume of approximately 5 mL, and 10 mL of cyclohexane was added. The resulting yellow solid was removed, and the filtrate was evaporated to provide 0.8 g (3.58 mmol, 48%) of cyclopropyl (4-nitrophenyl) carbonate. ?H NMR (400 MHz, CDC13): 8.26-8.19 (m, 2H), 7.34-7.25 (m, 2H), 4.25-4.19 (m, 1H), 0.85-0.69 (m, 4H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 16545-68-9, Cyclopropanol.

Reference:
Patent; ARBUTUS BIOPHARMA CORPORATION; COLE, Andrew, G.; DORSEY, Bruce, D.; KAKARLA, Ramesh; KULTGEN, Steven; QUINTERO, Jorge; (353 pag.)WO2018/172852; (2018); A1;,
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Application of 616-29-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 616-29-5, name is 1,3-Diaminopropan-2-ol, molecular formula is C3H10N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Compound 21A (7 g, 77.7 mmol), and di-tert-butyldicarbonate (35.6 g, 163 mmol) were stirred in methylene chloride (100 ml_) at25 C for 2 hr. Saturated aqueous NaCI (150 mL) was added. The aqueouslayer was extracted with CHaCfe (100 ml) twice. The organic phase waswashed with brine (100 mL), dried over Na2SO4. The solvent was removed byrotary evaporator to give compound 21B (17g, 76%) which was used withoutfurther purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 616-29-5, 1,3-Diaminopropan-2-ol.

Reference:
Patent; SCHERING CORPORATION; WO2006/19768; (2006); A1;,
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Adding a certain compound to certain chemical reactions, such as: 110-73-6, 2-(Ethylamino)ethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 110-73-6, blongs to alcohols-buliding-blocks compound. HPLC of Formula: C4H11NO

1-(tert-Butoxycarbonyl)-5-hydroxyindole (2.33 g, 10.0 mmol) and triphenylphosphine (5.25 g, 20.0 mmol) were dissolved in toluene (46.0 mL), and the solution was added with glycidol (1.32 mL, 20.0 mmol) and 40% DEAD-toluene solution (9.10 mL, 20 mmol) at room temperature, followed by stirring at 80C for 4 hours. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (hexane/ethyl acetate=4/1). A crude product (1.28 g) of 1-(tert-butoxycarbonyl)-5-hydroxyindole (1.28 g) was obtained. The obtained crude product was dissolved in N,N-dimethylacetoamide (20.0 mL), and the solution was added with 2- (ethylamino) ethanol (8.60 mL, 87.8 mmol), followed by stirring at 80C for 4 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by flash column chromatography (chloroform/methanol =9/1) to obtain 1-(tert-butoxycarbonyl)-5-{3-[N-ethyl(2-hydroxyethyl)amino]-2-hy droxypropoxy}indole (1.53 g, 40%). ESI-MS m/z: 379 [M+H]+; 1H-NMR (CDCl3)delta(ppm): 1.07 (t, J = 7.2 Hz, 3H), 1.66 (s, 9H), 2.61-2.80 (m, 6H), 3.61-3.68 (m, 2H), 3.99-4.14 (m, 3H), 6.48 (d, J = 3.9 Hz, 1H), 6.94 (dd, J = 2.6, 8.7 Hz, 1H), 7.04 (d, J = 2.6 Hz, 1H), 7.56 (d, J = 3.9 Hz, 1H), 8.01 (d, J = 8.7 Hz, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,110-73-6, its application will become more common.

Reference:
Patent; Kyowa Hakko Kirin Co., Ltd.; EP2108642; (2009); A1;,
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Adding a certain compound to certain chemical reactions, such as: 4415-82-1, Cyclobutylmethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4415-82-1, blongs to alcohols-buliding-blocks compound. name: Cyclobutylmethanol

Example 37: (E)-3-(cyclobutylmethylene)octan-2-one (Compound ID 19) Prepared as described in Example 35 in 50% yield from cyclobutanecarbaldehyde (obtained by PCC-oxidation of cyclobutanemethanol) and diethyl 2-oxooctan-3- ylphosphonate (obtained from hexyl iodide and triethyl phosphite via diethyl hexylphosphonate). Boiling point: 105C (0.07 mbar).13C-NMR (100MHz, CDCI3): £199.75 (s, C(2)), 147.99 (d, CH=C(3)), 140.66 (s, C(3)), 34.82 (Cf), 31.92 (Q, 29.33 (Q, 29.20 (t, 2 C), 25.66 (Q, 25.61 (q, C(I)), 22.50 (Q, 19.05 (Q, 13.97 t°, C(S)).MS (El): 194 (2), 179 (7), 166 (16), 151 (11), 137 (29), 123 (44), 109 (39), 95 (27), 81 (27), 79 (13), 77 (8), 67 (30), 55 (13), 43 (100).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4415-82-1, its application will become more common.

Reference:
Patent; GIVAUDAN SA; WO2008/116338; (2008); A2;,
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Related Products of 627-30-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 627-30-5, name is 3-Chloropropan-1-ol. A new synthetic method of this compound is introduced below.

Example 13a) [(3-Chloropropoxy)methyl]benzene; 250 ml of dichloromethane, 85 ml (0.71 mol) of benzylbromide and 10 g (0.03 mol) of tetrabutylammonium hydrogen sulfate are added to 50 ml (0.60 mol) of 3-chloro-l-propanol. A solution of sodium hydroxide (150 g, 3.75 mol) in 150 ml of water is added to the mixture under stirring. The mixture refluxed for 22 hours. After cooling down the mixture is diluted with water (100 ml), the layers are separated and the aqueous phase is shaken with dichloromethane (lx 200 ml). The organic fractions are washed with water (lx 200 ml) and subsequently dried with anhydrous sodium sulfate. The solvent is evaporated and the residue is distilled at a reduced pressure. 98.5 g (0.53 mol) of a colourless liquid are obtained, boiling point 75-82 C (26.64 Pa).-NMR (CDC13) Patent; ZENTIVA, K.S.; VLASAKOVA, Ruzena; HAJICEK, Josef; SLAVIKOVA, Marketa; WO2012/62229; (2012); A1;,
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Reference of 124-68-5, Adding some certain compound to certain chemical reactions, such as: 124-68-5, name is 2-Amino-2-methyl-1-propanol,molecular formula is C4H11NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 124-68-5.

To a stirred solution of 2-amino-2-methylpropan-1-ol (3.0 g, 33.65 mmol) in DCM (200 ml) was added aqueous NaHCO3 (8.4 g, 100.95 mmol in 100 ml water) at 0C and 50% wt20 CbzClintoluene (11.4 g, 33.65 mmol) was added drop wise over 15mm After the addition,the reaction mixture was warmed to RT and stirred for 16 h. The reaction mixture was diluted with DCM and organic layer was dried over Na2504, concentrated under reduced pressure. The product was purified by flash column using 20% ethyl acetate in pet ether as eluent to afford 4.2 g of colorless oil. LC-MS (ES+) [M+1]: 224.2

According to the analysis of related databases, 124-68-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORION CORPORATION; WANG, Shouming; KUMPULAINEN, Esa; PYSTYNEN, Jarmo; POHJAKALLIO, Antti; HAIKARAINEN, Anssi; (92 pag.)WO2016/193551; (2016); A1;,
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Synthetic Route of 3279-95-6 ,Some common heterocyclic compound, 3279-95-6, molecular formula is C2H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

1.10 (2) Preparation of Final Compound 1-64 and 1-65 A mixture of intermediate of example 1.10(1) (350 mg, 0.76 mmol), 2-aminooxy-ethanol (CAS No. 1025727-45-0) (292. mg, 3.801 mmol) and pyridine (10 mL) in ethanol (25 mL) was stirred at 70 C. for 5 days. The solvent was removed under reduced pressure. The crude residual fraction was purified by high-performance liquid chromatography (RP-18) (eluent: Gradient:[0.25% NH4HCO3 in H2O]/CH3CN 90/10-20/80-0/100 v/v). The desired fractions were collected and evaporated to dryness. This product was further purified by HPLC on Hyperprep C18 HS BDS 100 A 8 mu (Shandon) (eluent: 60%[0.25% NH4HCO3 in H2O]/40% CH3CN, then the column was rinsed with 100% CH3CN), yielding 168 mg (42%) of compound 1-65 (the E isomer) and 57 mg (14%) of compound 1-64 (the Z isomer).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,3279-95-6, its application will become more common.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; US2012/35171; (2012); A1;,
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The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 2516-33-8, name is Cyclopropylmethanol. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 2516-33-8

General procedure: To 259 mg (26.9 mmol) pyrimidin-5-ol (J. Chem. Soc. 1956, 2033) in 200 mL DMF are added 108 mg (26.9 mmol) sodium hydride (60% dispersion in mineral oil). The mixture is stirred for 20 mm at r.t.. After that time, 500 mg (22.4 mmol) 2-fluoro-4-iodopyridine are added and the mixture is stirred for 12 h at 80 C. Subsequently the mixture is poured into water and extracted with ethyl acetate (3x). The combined organic layers are washed with brine. After drying over sodium sulphate, the solvent is removed in vacuo and the residue is purified by column chromatography (silica gel; heptane/EtOAc, 100/0 – 40/60).C9H6IN3O (M = 299.1 g/mol)ESI-MS: 300 [M+H]+ Rt(HPLC) : 2.87 min (method C) For the example XXVIII.3 THF is used as solvent and the reaction mixture is stirred at r.t. over night.

With the rapid development of chemical substances, we look forward to future research findings about 2516-33-8.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; FLECK, Martin; ROTH, Gerald Juergen; NOSSE, Bernd; HEINE, Niklas; WO2013/92616; (2013); A1;,
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Electric Literature of 14320-38-8, Adding some certain compound to certain chemical reactions, such as: 14320-38-8, name is Cyclopent-3-enol,molecular formula is C5H8O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14320-38-8.

Reference Example 1 4-Benzyloxycyclopent-1-ene: To a solution of cyclopent-3-en-1-ol ?cf. J. Org. Chem., 32, 4138[(1967)] (7.00 g) and benzyl bromide (10.5 ml) in dimethylformamide (35 ml) is added gradually 60% sodium hydride (in oil) (3.68 g) with stirring under ice-cooling, and the mixture is stirred at room temperature for 1.5 hour. The reaction mixture is diluted with ethyl acetate and washed with water six times. The ethyl acetate solution thus obtained is dried over anhydrous magnesium sulfate, evaporated to dryness under reduced pressure, and then purified by medium pressure liquid column chromatography (eluent; n-hexane, n-hexane:ethyl acetate–50:1, v/v) to give 4-benzyloxycyclopent-1-ene (11.22 g) as an oily substance. NMR (60 MHz, CDCl3, deltappm): 2.4-2.7 (4H, m), 4.29 (1H, m), 4.46 (2H, s), 5.65 (2H, s), 7.26 (5H, s)

According to the analysis of related databases, 14320-38-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Kanebo, Ltd.; US5912247; (1999); A;,
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