Tag: M.W=0-100

Monteith, John J.; Scotchburn, Katerina; Mills, L. Reginald; Rousseaux, Sophie A. L. published the artcile< Ni-Catalyzed Synthesis of Thiocarboxylic Acid Derivatives>, Application of C4H8O, the main research area is thionoester thioamide dithioester preparation; alkyl xanthate ester thiocarbonyl imidazolide organozinc reagent cross coupling.

A Ni-catalyzed cross-coupling of readily accessible O-alkyl xanthate esters or thiocarbonyl imidazolides and organozinc reagents for the synthesis of thiocarboxylic acid derivatives has been developed. This method benefits from a fast reaction time, mild reaction conditions and ease of starting material synthesis. The use of transition metal catalysis to access a diverse range of thiocarbonyl containing compounds provides a useful complementary approach when compared to previously established methodologies.

Organic Letters published new progress about Aromatic esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (thiono-). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Zhenhua; Gorski, Bartosz; Leonori, Daniele published the artcile< Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki-Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons>, Electric Literature of 627-27-0, the main research area is alkyl iodide aryl organoboron copper catalyst Suzuki Miyaura coupling; aryl alkane preparation.

A mechanistically distinct approach to achieve Suzuki-Miyaura-type cross-couplings between alkyl iodides and aryl organoborons was reported. This process required a copper catalyst but, in contrast with previous approaches based on palladium and nickel systems, does not utilizes the metal for the activation of the alkyl electrophile. Instead, this strategy exploited the halogen-atom transfer ability of α-aminoalkyl radicals to convert secondary alkyl iodides into the corresponding alkyl radicals that then were coupled with aryl, vinyl, alkynyl, benzyl and allyl boronate species. These novel coupling reactions feature simple set up and conditions (1 h at room temperature) and facilitate access to privileged motifs targeted by the pharmaceutical sector.

Journal of the American Chemical Society published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Luo, Zhe; Lu, Changtong; Histand, Gary; Lin, Dongen published the artcile< One-Step Visible Light Photoredox-Catalyzed Purine C8 Alkoxylation with Alcohol>, Application of C4H8O, the main research area is alkoxypurine preparation green chem; purine alc alkoxylation one step visible light photoredox catalyst.

A cross-dehydrogenation coupling reaction between purines and alcs., induced by visible light, using an acridinium photocatalyst and air as the sole oxidant, to synthesize a series of C8-alkoxy purine derivatives was developed. This protocol is a green and novel method to construct the C8-O bond on a purine ring with high step and atom economy.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Su; Van der Eycken, Erik V.; Sharma, Upendra K. published the artcile< Remote Alkenylation via Carbopalladation/1,4-Palladium Migration/Heck Reaction Sequence with Unactivated Alkenyl Alcohols>, Computed Properties of 627-27-0, the main research area is isochroman preparation regioselective chemoselective; alkenyl alc alkenylation carbopalladation migration Heck reaction.

Intramol. C-H bond activation via 1,4-palladium migration has become a synthetic tool to enable remote functionalization of C-H bonds. In this work, authors report a Pd-catalyzed remote alkenylation with unactivated alkenyl alcs. involving a 1,4-palladium migration step. This method provides a regioselective access to synthesize substituted unsaturated alcs. in a single operational step.

Advanced Synthesis & Catalysis published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Computed Properties of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Hao; Jilili, Yikelamu; Zhen, Weijun; Zhao, Ling published the artcile< Preparation, performance and structure-properties relationship of poly(lactic acid)/modified saponite nanocomposites based on thiol-ene click chemistry>, Category: alcohols-buliding-blocks, the main research area is structure property relationship polylactic acid modified saponite nanocomposite.

Saponite (SA)-mercaptopropyl polyhedral oligomeric silsesquioxane (POSS-SH) grafted poly (L-lactic acid) (SA-POSS-PLLA) was synthesized by thiol-ene click chem. SA-POSS-PLLA was characterized by Fourier transform IR spectroscopy and XPS. When 0.3 wt% SA-POSS-PLLA was used as a modifier in poly(lactic acid) (PLA), the impact strength and elongation at break of PLA/SA-POSS-PLLA nanocomposites were increased by 1.73 times and 4.25 times compared with pure PLA, resp. The differential scanning calorimeter anal. showed that the crystallinity of PLA/SA-POSS-PLLA nanocomposites was increased from 7.74% to 30.32%. The addition of SA-POSS-PLLA increased the crystallization rate of PLA and significantly reduced the grain size of PLA, which also was proved by polarization optical microscopy anal. Rheonaut technol. for simultaneous rheometry and FTIR demonstrated that the reason why the addition of SA-POSS-PLLA nanoparticles accelerated the crystallization rate of PLA was that SA-POSS-PLLA nanoparticles promoted the adjustment of C-O-C structure and -CH3 group in the main mol. chain of PLA.

Polymer-Plastics Technology and Materials published new progress about Binding energy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Zhujun; Chen, Zhe; Jiang, Yuan; Li, Ning; Yang, Shicheng; Wang, Guowei; Pan, Xiangcheng published the artcile< Metal-Free Hydrosilylation Polymerization by Merging Photoredox and Hydrogen Atom Transfer Catalysis>, Category: alcohols-buliding-blocks, the main research area is metal hydrosilylation polymerization merging photoredox hydrogen atom transfer catalysis.

Organosilicon compounds and polymers have found wide applications as synthetic building blocks and functional materials. Hydrosilylation is a common strategy toward the synthesis of organosilicon compounds and polymers. Although transition-metal-catalyzed hydrosilylation has achieved great advances, the metal-free hydrosilylation polymerization of dienes and bis(silane)s, especially the one suitable for both electron-rich and electron-deficient dienes, is largely lacking. Herein, the authors report a visible-light-driven metal-free hydrosilylation polymerization of both electron-rich and electron-deficient dienes with bis(silane)s by using the organic photocatalyst and hydrogen atom transfer (HAT) catalyst. The authors achieved the well-controlled step-growth hydrosilylation polymerizations of the electron-rich diene and bis(silane) monomer due to the selective activation of Si-H bonds by the organic photocatalyst (4CzIPN) and the thiol polarity reversal reagent (HAT 1). For the electron-deficient dienes, hydrosilylation polymerization and self-polymerization occurred simultaneously in the presence of 4CzIPN and aceclidine (HAT 2), providing the opportunity to produce linear, hyperbranched, and network polymers by rationally tuning the concentration of electron-deficient dienes and the ratio of bis(silane)s and dienes to alter the proportion of the two polymerizations A wide scope of bis(silane)s and dienes furnished polycarbosilanes with high mol. weight, excellent thermal stability, and tunable architectures.

Journal of the American Chemical Society published new progress about Branched polymers Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hirbawi, Nadia; Lin, Patricia C.; Jarvo, Elizabeth R. published the artcile< Halogenation Reactions of Alkyl Alcohols Employing Methyl Grignard Reagents>, Electric Literature of 627-27-0, the main research area is alkyl halide preparation; alc alkyl Grignard reagent halogenation.

Herein, an example of Grignard reagents acting as halide nucleophiles to form alkyl iodides RI [R = 1-(4-methoxyphenyl)-5-phenylpentan-3-yl, 4-phenylbutan-2-yl, 4-(2H-1,3-benzodioxol-5-yl)butan-2-yl, etc.] and alkyl bromides R1Br [R1 = 3-[4-(3-methoxyphenyl)phenyl]propyl, 2-(6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl)ethyl, 3-(4-bromophenyl)propyl, etc.] was reported. This work establishes that Grignard reagents can convert alkyl mesylates ROMs/R1OMs into alkyl halides RI/R1Br, as well as be employed in a one-pot halogenation reaction starting from alcs. ROH/R1OH, which proceed through mesylate intermediates. The halogenation reaction is confirmed to occur by an SN2 pathway with the inversion of configuration and is demonstrated to be efficient on a gram scale.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Hui; Gao, Kai; Ma, Haichen; Yip, Tsz Chun; Dai, Wei-Min published the artcile< Synthesis of the C19-C30 bis-THF fragment of iriomoteolide-13a via stepwise SN2 cyclization and intramolecular syn-oxypalladation>, Application In Synthesis of 627-27-0, the main research area is iriomoteolide fragment preparation; alkyne cyclization asym dihydroxylation.

The C19-C30 bis-THF fragment I [stereo = R or S] of the proposed structure of iriomoteolide-13a were synthesized. The ω-mesyloxy-substituted stereotetrad possessing three continuous hydroxy groups was generated by an anti-aldol reaction and asym. dihydroxylation was the key steps. Upon heating in pyridine, the stereotetrad underwent an SN2 cyclization to form the C19-C22 THF ring chemoselectively. The propargylic alc., after cleavage of the C28-OPMB ether, was reduced to the corresponding allylic alc. with spontaneous removal of the C23-OTBS protecting group. Finally, the ene triol was subjected to the Pd(II)-catalyzed intramol. syn-oxypalladation to give the C23-C26 THF ring. It was found that the C21-OH group, which might form a chelated Pd(II) complex along with the C23-OH group, was tolerated during the syn-oxypalladation process.

Organic Chemistry Frontiers published new progress about Cyclization, stereoselective. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ziemianowicz, Daniel S.; MacCallum, Justin L.; Schriemer, David C. published the artcile< Correlation between Labeling Yield and Surface Accessibility in Covalent Labeling Mass Spectrometry>, Synthetic Route of 25055-82-7, the main research area is surface accessibility covalent labeling mass spectrometry.

The functional properties of a protein are strongly influenced by its topog., or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topog. data through the measurement of surface accessibility. However, recent efforts to correlate measures of surface accessibility with labeling yield have been met with mixed success. Most applications of CL-MS involve differential anal. of protein interactions (i.e., footprinting experiments) where such inconsistencies have limited effect. Extending CL-MS into structural anal. requires an improved evaluation of the relation between labeling and surface exposure. The authors applied recently developed diazirine reagents to obtain deep coverage of the large motor domain of Eg5 (a mitotic kinesin), and together with computational methods the authors correlated labeling yields with accessibility data in a number of ways. Correlations can indeed be seen at a local structural level, but these correlations do not extend across the structure. The lack of correlation arises from the influence of protein dynamics and chem. composition on reagent partitioning and, thus, also on labeling yield. The authors’ use of CL-MS data should be considered in light of “”chem. accessibility”” rather than “”solvent accessibility”” and suggest that CL-MS data would be a useful tool in the fundamental study of protein-solute interactions.

Journal of the American Society for Mass Spectrometry published new progress about Kinesin-like protein KIF11 Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study) (Eg5, ADP-bound). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Synthetic Route of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Jiajia; Zhang, Huihui; Wu, Xinxin; Zhu, Chen published the artcile< Intermolecular radical fluoroalkylative olefination of unactivated alkenes>, Electric Literature of 627-27-0, the main research area is vinyl preparation photochem regioselective chemoselective diastereoselective; alkene intermol radical fluoroalkylative olefination.

A novel, efficient radical-mediated intermol. fluoroalkylative olefination of inactivated alkenes RCH=CH2 [R = 2-hydroxypropan-2-yl, 1-(2-oxocyclohexyl)methyl, 3-(1-benzothiophen-2-yl)-3-oxopropyl, etc.] was disclosed. The transformation proceeded through a radical docking-migration cascade, in which a portfolio of strategically designed dual-function alkenylating reagents was harnessed to afford vinylated products RC(CH=CHR1)(C(Br)(F)(R2)) [R1 = Ph, 4-MePh, naphthalen-2-yl, etc.; R2 = CN, COOEt] with exclusive E-configuration. The reaction featured mild conditions, broad functional group compatibility, and unique chemo-, regio-, and stereoselectivities. The protocol has also provided a useful approach for late-stage olefination of complex natural products and drug derivatives containing alkenyl moieties.

CCS Chemistry published new progress about Alkenes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts