Tag: M.W=0-100

Cai, Dong; Li, Jinbin; Ma, Zhuang; Gan, Zhanhui; Shao, Yu; Xing, Qian; Tan, Rui; Dong, Xue-Hui published the artcile< Effect of Molecular Architecture and Symmetry on Self-Assembly: A Quantitative Revisit Using Discrete ABA Triblock Copolymers>, Quality Control of 627-27-0, the main research area is architecture symmetry assembly discrete diblock triblock copolymer.

The inherent statistical heterogeneities associated with chain length, composition, and architecture of synthetic block copolymers compromise the quant. interpretation of their self-assembly process. This study scrutinizes the contribution of mol. architecture on phase behaviors using discrete ABA triblock copolymers with precise chem. structure and uniform chain length. A group of discrete triblock copolymers with varying composition and symmetry were modularly synthesized through a combination of iterative growth methods and efficient coupling reactions. The sym. ABA triblock copolymers self-assemble into long-range ordered structures with expanded domain spacings and enhanced phase stability, compared with the diblock counterparts snipped at the middle point. By tuning the relative chain length of two end blocks, the mol. asymmetry reduces the packing frustration, and thus increases the order-to-disorder transition temperature and enlarges the domain sizes. This study would serve as a quant. model system to correlate the exptl. observations with the theor. assessments and to provide quant. understandings for the relationship between mol. architecture and self-assembly.

ACS Macro Letters published new progress about Catalysts, Karstedt’s. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ren, Xiaoxiao; Gao, Xing; Min, Qiao-Qiao; Zhang, Shu; Zhang, Xingang published the artcile< (Fluoro)alkylation of alkenes promoted by photolysis of alkylzirconocenes>, Electric Literature of 627-27-0, the main research area is difluoroalkyl compound preparation; alkene alkylzirconocene preparation photochem fluoroalkylation.

An unprecedented example of alkylzirconocenes Cp2ZrCl(CH2)2R (R = Bn, dimethyl(phenyl)silyl, trimethylsilyl, etc.) promoted difluoroalkylation of alkyl- and silyl-alkenes RCH=CH2 with a variety of unactivated difluoroalkyl iodides and bromides R1C(F2)X (R1 = [(ethanesulfonyl)oxy]methyl, (morpholin-4-yl)carbonyl, 3-[(4-chlorophenyl)carbonyloxy]propyl, etc.; X = I, Br) under the irradiation of visible light without a catalyst. The resulting difluoroalkylated compounds RC(F2)R1 can serve as versatile synthons in organic synthesis. The reaction can also be applied to activated difluoroalkyl, trifluoromethyl, perfluoroalkyl, monofluoroalkyl, and nonfluorinated alkyl halides, providing a general method to controllably access fluorinated compounds Preliminary mechanistic studies reveal that a single electron transfer (SET) pathway induced by a Zr(III) species is involved in the reaction, in which the Zr(III) species is generated by the photolysis of alkylzirconocene with blue light.

Chemical Science published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Sankar, Raman Vijaya; Anjalikrishna, Puthannur K.; Suresh, Cherumuttathu H.; Gunanathan, Chidambaram published the artcile< Catalytic Formal Conjugate Addition: Direct Synthesis of δ-Hydroxynitriles from Nitriles and Allylic Alcohols>, Quality Control of 627-27-0, the main research area is delta hydroxynitrile preparation green chem; nitrile allylic alc selective formal conjugate addition ruthenium catalyst.

Alcs. and nitrile functionalities have widespread applications in biochem. and chem. synthesis. Catalytic transformations involving C-C bond formation relying on unsaturated coupling partners create important pathways for processes in synthetic, material, and medicinal chem. The discovery of a simple and selective coupling of nitriles with allylic alcs. catalyzed by a ruthenium pincer complex is described, which tolerates reactive functional groups such as carbamate, sulfonate, olefin, cyano, and trifluoromethyl-substituted benzyl nitriles. Homo allylic alcs. also provided 1,4-addition products following the isomerization of double bonds. Mechanistic studies supported that the allylic alcs. initially undergo selective oxidation by the catalyst to α,β-unsaturated carbonyl compounds followed by 1,4-conjugate addition of benzyl nitriles catalyzed by a base and subsequent catalytic reduction of carbonyl functionality, leading to the formation of δ-hydroxynitrile products. The catalytic cycle of this tandem process is established by d. functional theory studies. Remarkably, anipamil drug is successfully synthesized using this catalytic protocol. The utility of the δ-hydroxynitrile products in the synthesis of biol. active mols. and their further functionalization are also demonstrated.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhongcheng; Bisoyi, Hari Krishna; Huang, Yinliang; Wang, Meng; Yang, Hong; Li, Quan published the artcile< Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers>, Recommanded Product: But-3-en-1-ol, the main research area is thermo mechanochromic camouflage selfhealing biomimetic actuator liquid crystal elastomer; Biomimetic actuator; Camouflage; Chromophore; Liquid crystal elastomer; Self-healing.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chem. introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddn. method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mech. compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Angewandte Chemie, International Edition published new progress about Actuators (photoresponsive). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cox, Lydia; Zhu, Yuxiang; Smith, Philip J.; Christensen, Kirsten E.; Sidera Portela, Mireia; Donohoe, Timothy J. published the artcile< Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles>, Synthetic Route of 627-27-0, the main research area is pyrrolidine substituted piperidine diastereoselective regioselective preparation; homoallylic amine alc endo trig cyclization titanium isopropoxide catalyst; Azacycles; Carboamination; Carbocations; Hexafluoroisopropanol; Lewis Acid Catalysis.

A Ti(Oi-Pr)4 promoted 5- or 6-endo-trig cyclization to make nitrogen heterocycles was presented. The utilization of HFIP as a key solvent enabled stereoselective preparation of di- tri-substituted pyrrolidines, e.g. I and piperidines, e.g. II while forming a new C-C bond at same time. The process was triggered by a cationic intermediate generated from an allylic or benzylic alc. and led to simultaneous generation of both a C-C and a C-N bond in a single step. Notably, either 2,3-trans- or 2,3-cis-substituted heterocycles could be obtained by using a nucleophilic amine bearing different substituents. Lastly, stereoselective synthesis of enantiopure products was achieved by using readily available enantiopure acyclic starting materials.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kennedy, Cassandra R.; Goya Grocin, Andrea; Kovacic, Tristan; Singh, Ravi; Ward, Jennifer A.; Shenoy, Avinash R.; Tate, Edward W. published the artcile< A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target>, Reference of 25055-82-7, the main research area is photoaffinity probe preparation CA2 target inflammasome inhibitor MCC950 inflammation.

Inhibition of inflammasome and pyroptotic pathways are promising strategies for clin. treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has shown encouraging results in animal models for a range of conditions; however, until now, no off-targets have been identified. Herein, we report the design, synthesis, and application of a novel photoaffinity alkyne-tagged probe for MCC950 (IMP2070) which shows direct engagement with NLRP3 and inhibition of inflammasome activation in macrophages. Affinity-based chem. proteomics in live macrophages identified several potential off-targets, including carbonic anhydrase 2 (CA2) as a specific target of IMP2070, and independent cellular thermal proteomic profiling revealed stabilization of CA2 by MCC950. MCC950 displayed noncompetitive inhibition of CA2 activity, confirming carbonic anhydrase as an off-target class for this compound These data highlight potential biol. mechanisms through which MCC950 and derivatives may exhibit off-target effects in preclin. or clin. studies.

ACS Chemical Biology published new progress about Anti-inflammatory agents (potential as). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Reference of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Thiyagarajan, Subramanian; Sankar, Raman Vijaya; Anjalikrishna, Puthannur K.; Suresh, Cherumuttathu H.; Gunanathan, Chidambaram published the artcile< Catalytic Formal Conjugate Addition: Direct Synthesis of δ-Hydroxynitriles from Nitriles and Allylic Alcohols>, Quality Control of 627-27-0, the main research area is delta hydroxynitrile preparation green chem; nitrile allylic alc selective formal conjugate addition ruthenium catalyst.

Alcs. and nitrile functionalities have widespread applications in biochem. and chem. synthesis. Catalytic transformations involving C-C bond formation relying on unsaturated coupling partners create important pathways for processes in synthetic, material, and medicinal chem. The discovery of a simple and selective coupling of nitriles with allylic alcs. catalyzed by a ruthenium pincer complex is described, which tolerates reactive functional groups such as carbamate, sulfonate, olefin, cyano, and trifluoromethyl-substituted benzyl nitriles. Homo allylic alcs. also provided 1,4-addition products following the isomerization of double bonds. Mechanistic studies supported that the allylic alcs. initially undergo selective oxidation by the catalyst to α,β-unsaturated carbonyl compounds followed by 1,4-conjugate addition of benzyl nitriles catalyzed by a base and subsequent catalytic reduction of carbonyl functionality, leading to the formation of δ-hydroxynitrile products. The catalytic cycle of this tandem process is established by d. functional theory studies. Remarkably, anipamil drug is successfully synthesized using this catalytic protocol. The utility of the δ-hydroxynitrile products in the synthesis of biol. active mols. and their further functionalization are also demonstrated.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Zhongcheng; Bisoyi, Hari Krishna; Huang, Yinliang; Wang, Meng; Yang, Hong; Li, Quan published the artcile< Thermo- and Mechanochromic Camouflage and Self-Healing in Biomimetic Soft Actuators Based on Liquid Crystal Elastomers>, Recommanded Product: But-3-en-1-ol, the main research area is thermo mechanochromic camouflage selfhealing biomimetic actuator liquid crystal elastomer; Biomimetic actuator; Camouflage; Chromophore; Liquid crystal elastomer; Self-healing.

In nature, many mysterious creatures capable of deformation camouflage, color camouflage, and self-healing have inspired scientists to develop various biomimetic soft robots. However, the systematic integration of all the above functionalities into a single soft actuator system still remains a challenge. Here we chem. introduce a multi-stimuli-responsive tetraarylsuccinonitrile (TASN) chromophore into a liquid crystal elastomer (LCE) network through a facile thiol-ene photoaddn. method. The obtained TASN-LCE soft actuators not only exhibit reversible shape-morphing and reversible color-changing behavior in response to heat and mech. compression, but also show excellent self-healing, reprogramming and recycling characteristics. We hope that such a TASN-LCE actuator system endowed with dynamic distortion, thermo- and mechano-chromic camouflage, and self-healing functionalities would pave the way for further development of multifunctional biomimetic soft robotic devices.

Angewandte Chemie, International Edition published new progress about Actuators (photoresponsive). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cox, Lydia; Zhu, Yuxiang; Smith, Philip J.; Christensen, Kirsten E.; Sidera Portela, Mireia; Donohoe, Timothy J. published the artcile< Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles>, Synthetic Route of 627-27-0, the main research area is pyrrolidine substituted piperidine diastereoselective regioselective preparation; homoallylic amine alc endo trig cyclization titanium isopropoxide catalyst; Azacycles; Carboamination; Carbocations; Hexafluoroisopropanol; Lewis Acid Catalysis.

A Ti(Oi-Pr)4 promoted 5- or 6-endo-trig cyclization to make nitrogen heterocycles was presented. The utilization of HFIP as a key solvent enabled stereoselective preparation of di- tri-substituted pyrrolidines, e.g. I and piperidines, e.g. II while forming a new C-C bond at same time. The process was triggered by a cationic intermediate generated from an allylic or benzylic alc. and led to simultaneous generation of both a C-C and a C-N bond in a single step. Notably, either 2,3-trans- or 2,3-cis-substituted heterocycles could be obtained by using a nucleophilic amine bearing different substituents. Lastly, stereoselective synthesis of enantiopure products was achieved by using readily available enantiopure acyclic starting materials.

Angewandte Chemie, International Edition published new progress about Allylic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kennedy, Cassandra R.; Goya Grocin, Andrea; Kovacic, Tristan; Singh, Ravi; Ward, Jennifer A.; Shenoy, Avinash R.; Tate, Edward W. published the artcile< A Probe for NLRP3 Inflammasome Inhibitor MCC950 Identifies Carbonic Anhydrase 2 as a Novel Target>, Reference of 25055-82-7, the main research area is photoaffinity probe preparation CA2 target inflammasome inhibitor MCC950 inflammation.

Inhibition of inflammasome and pyroptotic pathways are promising strategies for clin. treatment of autoimmune and inflammatory disorders. MCC950, a potent inhibitor of the NLR-family inflammasome pyrin domain-containing 3 (NLRP3) protein, has shown encouraging results in animal models for a range of conditions; however, until now, no off-targets have been identified. Herein, we report the design, synthesis, and application of a novel photoaffinity alkyne-tagged probe for MCC950 (IMP2070) which shows direct engagement with NLRP3 and inhibition of inflammasome activation in macrophages. Affinity-based chem. proteomics in live macrophages identified several potential off-targets, including carbonic anhydrase 2 (CA2) as a specific target of IMP2070, and independent cellular thermal proteomic profiling revealed stabilization of CA2 by MCC950. MCC950 displayed noncompetitive inhibition of CA2 activity, confirming carbonic anhydrase as an off-target class for this compound These data highlight potential biol. mechanisms through which MCC950 and derivatives may exhibit off-target effects in preclin. or clin. studies.

ACS Chemical Biology published new progress about Anti-inflammatory agents (potential as). 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Reference of 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts