Tag: M.W=0-100

Wu, Yingtao; Li, Mingrui; Sun, Jiaqiong; Zheng, Guangfan; Zhang, Qian published the artcile< Synthesis of Axially Chiral Aldehydes by N-Heterocyclic-Carbene-Catalyzed Desymmetrization Followed by Kinetic Resolution>, Quality Control of 627-27-0, the main research area is axially chiral aldehyde preparation; biaryl dialdehyde atroposelective esterification desymmetrizing kinetic resolution NHC catalyzed; Axially Chiral Aldehydes; Desymmetrization; Esterification; Kinetic Resolution; N-Heterocyclic Carbenes.

Herein an NHC-catalyzed atroposelective esterification of biaryl dialdehydes as a general and practical strategy for the construction of axially chiral aldehydes I [Ar = Ph, 1-naphthyl, 9-phenanthryl, etc.; R1 = Et, CH2CF3, cyclopropyl, etc.] was described. Mechanistic studies indicated that coupling proceeds through a novel combination of NHC-catalyzed desymmetrization of the dialdehydes and kinetic resolution This protocol featured excellent enantioselectivity, mild conditions, good functional-group tolerance and applicability to late-stage functionalization and provided a modular platform for the synthesis of axially chiral aldehydes and their derivatives

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Tan; Miao, Kai; Zhao, Zhigang; Li, Yuqing; Wang, Huiyuan; Watanabe, Atsushi; Teramae, Norio; Wang, Kaige published the artcile< Understanding cellulose pyrolysis under hydrogen atmosphere>, Electric Literature of 627-27-0, the main research area is cellulose pyrolysis hydropyrolysis mechanism.

The product distributions of cellulose pyrolysis under different pressures, temperatures, and atmospheres were investigated using a high-pressure micropyrolyzer to clarify the pyrolysis reaction mechanism of cellulose decomposition with hydrogen. EGA-MS results shows that the increase in hydrogen pressure prolonged the second stage of cellulose pyrolysis, which was dominated by decarboxylation. Pyrolysis products of cellulose under helium mainly included levoglucosan, furfural, and acids, while cellulose hydropyrolysis mainly produced C5-C7 ketones, besides small amount of alcs., aromatics and aliphatic hydrocarbons, and even small amount of phenolics. Carbon yield of ketones was as high as 27.2% from cellulose hydropyrolysis under 2.5 MPa hydrogen and 500°. The yield of liquid products and non-condensable hydrocarbons increased with elevated hydrogen pressure. The formation mechanisms of aromatics, phenolics, aliphatic hydrocarbons, aldehydes, ketones, and alcs. under hydrogen atm. were discussed. Acetaldehyde was produced by acids through a HDO reaction. C5-C7 chain ketones and cyclic ketones were generated by furfural through HDO and hydrocracking reactions. The Diels-Alder reaction to generate aromatics was enhanced by increasing pyrolysis temperature under hydrogen atm. The reaction network of cellulose hydropyrolysis was also proposed.

Energy Conversion and Management published new progress about Chars. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jia, Hao; Haering, Andreas P.; Berger, Florian; Zhang, Li; Ritter, Tobias published the artcile< Trifluoromethyl Thianthrenium Triflate: A Readily Available Trifluoromethylating Reagent with Formal CF3+, CF3• and CF3- Reactivity>, Reference of 627-27-0, the main research area is trifluoromethyl thianthrenium triflate preparation application trifluoromethylation.

Here, the synthesis and application of trifluoromethyl thianthrenium triflate (TT-CF3+OTf-) as a novel trifluoromethylating reagent, which was conveniently accessible in a single step from thianthrene and triflic anhydride was reported. The use of TT-CF3+OTf- in electrophilic, radical, and nucleophilic trifluoromethylation reactions was demonstrated.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bowser, Brandon H.; Wang, Shu; Kouznetsova, Tatiana B.; Beech, Haley K.; Olsen, Bradley D.; Rubinstein, Michael; Craig, Stephen L. published the artcile< Single-Event Spectroscopy and Unravelling Kinetics of Covalent Domains Based on Cyclobutane Mechanophores>, COA of Formula: C4H8O, the main research area is spectroscopy unravelling kinetics covalent cyclobutane mechanophore.

Mechanochem. reactions that lead to an increase in polymer contour length have the potential to serve as covalent synthetic mimics of the mech. unfolding of noncovalent “”stored length”” domains in structural proteins. Here we report the force-dependent kinetics of stored length release in a family of covalent domain polymers based on cis-1,2-substituted cyclobutane mechanophores. The stored length is determined by the size (n) of a fused ring in an [n.2.0] bicyclic architecture, and it can be made sufficiently large (>3 nm per event) that individual unravelling events are resolved in both constant-velocity and constant-force single-mol. force spectroscopy (SMFS) experiments Replacing a methylene in the pulling attachment with a Ph group drops the force necessary to achieve rate constants of 1 s-1 from ca. 1970 pN (dialkyl handles) to 630 pN (diaryl handles), and the substituent effect is attributed to a combination of electronic stabilization and mech. leverage effects. In contrast, the kinetics are negligibly perturbed by changes in the amount of stored length. The independent control of unravelling force and extension holds promise as a probe of mol. behavior in polymer networks and for optimizing the behaviors of materials made from covalent domain polymers.

Journal of the American Chemical Society published new progress about Conformers. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Qizhen; Pang, Zhengyuan; Liu, Jingwei; Zhou, Yi; Sun, Yang; Yin, Zheng; Lou, Zhiyong published the artcile< Photoaffinity palladium reagents for capture of protein-protein interactions>, HPLC of Formula: 25055-82-7, the main research area is photoaffinity palladium reagent cysteine containing protein interaction.

Protein-protein interactions (PPIs) are indispensable in almost all cellular processes. Probing of complex PPIs provides new insights into the biol. system of interest and paves the way for the development of therapeutics. Herein, the authors report a strategy for the capture of protein-protein interactions using photoaffinity palladium reagents. First, the palladium-mediated reagent site specifically transferred a photoaffinity modified aryl group to the designated cysteine residue. Next, the photoaffinity group was activated by UV radiation to trap the proximal protein residue for the formation of a crosslink. This strategy was used to capture the PYL-ABA-PP2C interaction, which is at the core of the abscisic acid (ABA) signaling pathway. The authors’ results indicated that this palladium-mediated strategy can serve as an alternative for incorporating an increasing number of diverse substrates for protein crosslinking through cysteine modifications and can be explored for use in mapping protein-peptide or protein-protein interaction surfaces and in trapping potential interacting partners.

Organic & Biomolecular Chemistry published new progress about Photocrosslinking. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, HPLC of Formula: 25055-82-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Daoqian; Lu, Long; Shen, Qilong published the artcile< [Ag(bpy)(PPhtBu2)(OCF3)]: a stable nucleophilic reagent for chemoselective and stereospecific trifluoromethoxylation of secondary alkyl nosylates>, SDS of cas: 6290-03-5, the main research area is alkyl nosylate bipyridyl phosphinyl trifluoromethoxy silver preparation trifluoromethoxylation; trifluoromethoxy alkane enantioselective chemoselective preparation.

The development of a thermally stable and light-insensitive nucleophilic trifluoromethoxylative reagent [Ag(bpy)(PPhtBu2)(OCF3)], which was synthesized in high yields via a three-step one-pot process from easily available trifluoromethyl triflate (TFMT) and AgF at room temperature, was described. The high reactivity of reagent [Ag(bpy)(PPhtBu2)(OCF3)] was demonstrated by its high yielding chemoselective and stereospecific SN2-type trifluoromethoxylation with secondary alkyl nosylates.

Organic Chemistry Frontiers published new progress about Aliphatic alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, SDS of cas: 6290-03-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zi-Qi; Cao, Yilin; Kang, Taeho; Engle, Keary M. published the artcile< Electrophilic Sulfur Reagent Design Enables Directed syn-Carbosulfenylation of Unactivated Alkenes>, Electric Literature of 627-27-0, the main research area is alkene boronic ester sulfur reagent nickel catalyst regioselective carbosulfenylation; thioalkane preparation.

A multi-component approach to structurally complex organosulfur products was described via the nickel-catalyzed 1,2-carbosulfenylation of unactivated alkenes with organoboron nucleophiles and tailored organosulfur electrophiles. The key to the development of this transformation was the identification of a modular N-alkyl-N-(arylsulfenyl)arenesulfonamide family of sulfur electrophiles. Tuning the electronic and steric properties of the leaving group in these reagents controls pathway selectivity, favoring three-component coupling and suppressing side reactions, as examined via computational studies. The unique syn-stereoselectivity differed from traditional electrophilic sulfenyl transfer processes involving a thiiranium ion intermediate and arose from the directed arylnickel(I) migratory insertion mechanism, as elucidated through reaction kinetics and control experiments Reactivity and regioselectivity are facilitated by a collection of monodentate, weakly coordinating native directing groups, including sulfonamides, alcs., amines, amides, and azaheterocycles.

Journal of the American Chemical Society published new progress about Boronic acids, esters Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Electric Literature of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Meng; Chu, Da; Liu, Li; Huang, Shuai; Chen, Xu-Man; Liu, Zhi-Yang; Yang, Hong published the artcile< Intelligent Surfaces Thermally Switchable between the Highly Rough and Entirely Smooth States>, Category: alcohols-buliding-blocks, the main research area is intelligent surface liquid crystal elastomer switchable topol structure.

Reversible switching from a highly rough surface to another entirely smooth surface under external stimuli is crucial for intelligent materials applied in the fields of anti-fogging, self-cleaning, oil-water separation and biotechnol. In this work, a thermal-responsive liquid crystal elastomer (LCE) surface covered with oriented micropillars is prepared via a facile two-step crosslinking method coupled with an extrusion molding program. The reversible change of topol. structures of the LCE surface along with temperature is investigated by metallog. microscope, at. force microscopy and optical contact angle measuring system. At room temperature, the LCE sample is filled with plenty of micropillars with an average length of 8.76 Μm, resulting in a super-hydrophobic surface with a water contact angle (WCA) of 135°. When the temperature is increased to above the clearing point, all the micropillars disappear, the LCE surface becomes entirely flat and presents a hydrophilic state with a WCA of 64°. The roughness-related wetting property of this microstructured LCE surface possesses good recyclability in several heating/cooling cycles. This work realizes a truly reversible transformation from a highly rough surface to an entirely smooth surface, and might promote the potential applications of this dynamic-responsive LCE surface in smart sensors and biomimetic control devices.

Chinese Journal of Polymer Science published new progress about Antifogging agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bellenie, Benjamin R.; Cheung, Kwai-Ming J.; Varela, Ana; Pierrat, Olivier A.; Collie, Gavin W.; Box, Gary M.; Bright, Michael D.; Gowan, Sharon; Hayes, Angela; Rodrigues, Matthew J.; Shetty, Kartika N.; Carter, Michael; Davis, Owen A.; Henley, Alan T.; Innocenti, Paolo; Johnson, Louise D.; Liu, Manjuan; de Klerk, Selby; Le Bihan, Yann-Vai; Lloyd, Matthew G.; McAndrew, P. Craig; Shehu, Erald; Talbot, Rachel; Woodward, Hannah L.; Burke, Rosemary; Kirkin, Vladimir; van Montfort, Rob L. M.; Raynaud, Florence I.; Rossanese, Olivia W.; Hoelder, Swen published the artcile< Achieving In Vivo Target Depletion through the Discovery and Optimization of Benzimidazolone BCL6 Degraders>, Safety of (R)-Butane-1,3-diol, the main research area is preparation benzimidazolone inhibitor BCL6 interaction repressor lymphoma.

Deregulation of the transcriptional repressor BCL6 enables tumorigenesis of germinal center B-cells, and hence BCL6 has been proposed as a therapeutic target for the treatment of diffuse large B-cell lymphoma (DLBCL). Herein we report the discovery of a series of benzimidazolone inhibitors of the protein-protein interaction between BCL6 and its co-repressors. A subset of these inhibitors were found to cause rapid degradation of BCL6, and optimization of pharmacokinetic properties led to the discovery of 5-((5-chloro-2-((3R,5S)-4,4-difluoro-3,5-dimethylpiperidin-1-yl)pyrimidin-4-yl)amino)-3-(3-hydroxy-3-methylbutyl)-1-methyl-1,3-dihydro-2H-benzo[d]imidazol-2-one (CCT369260), which reduces BCL6 levels in a lymphoma xenograft mouse model following oral dosing.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, Safety of (R)-Butane-1,3-diol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fathalinejad, Samin; Taarning, Esben; Christensen, Peter; Christensen, Jan H. published the artcile< Chemical composition analysis of carbohydrate fragmentation products>, Recommanded Product: But-3-en-1-ol, the main research area is carbohydrate fragmentation product chem composition analysis.

Fragmentation of simple sugars, using fluidized thermal bed cracking, results in a mixture that contains a variety of polar oxygenated compounds, some yet unknown to the industries. This lack of understanding of the product composition, hinders the downstream processes in conversion of sugars to useful chems. The aim of this study was fourfold: to develop a GC-MS identification workflow for carbohydrate fragmentation compounds, to build a library of compounds detected by five GC-MS methods including liquid injection, liquid-liquid extraction, static headspace, solid-phase microextraction and derivatization, to investigate and compare the compound coverage of the five methods, and finally investigate possible reaction pathways for some of the analytes in the mixture The anal. was done on a mixture of seven representative sugar fragmentation samples. The identification workflow was based on mass spectral match factors (>80%), retention indexes and anal. standards A total of 389 compounds were detected, out of which, 46 compounds were fully identified (through confirmatory anal. of anal. standards), 87 were tentatively identified (spectral match factors above 80%), 71 were un-identified with spectral match factors of below 80% and 185 were discarded (contaminants in blanks, etc.). The production pathway for some of the identified compounds in the sugar conversion mixtures were also discussed. In conclusion, solid-phase microextraction detected the highest number of analytes (93), mostly volatile organic compounds and the derivatization GC-MS technique detected the lowest number of analytes (19) but was the only method to detect the largest mols. (C6-C12) in size. This library of CF products can be used as a suspect-screening database for other biomass fragmentation mixtures

Journal of Analytical and Applied Pyrolysis published new progress about Biomass refining. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Recommanded Product: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts