Tag: M.W=0-100

Li, Yuanhao; Gu, Fan; Ding, Bingbing; Zou, Lei; Ma, Xiang published the artcile< Photo-controllable room-temperature phosphorescence of organic photochromic polymers based on hexaarylbiimidazole>, Synthetic Route of 627-27-0, the main research area is amorphous polymer photochromism room temperature phosphorescence.

Pure organic room-temperature phosphorescent (RTP) materials have been attracting widespread attention due to the unique properties and broad applications. However, RTP materials with the adjustable photochromic property are still a challenge. Based on this, two polymers containing hexaarylbiimidazole are strategically designed with dual emission of both fluorescence and phosphorescence. Furthermore, both polymers show sensitive photochromic responses from faint yellow to brown upon exposure to UV light This study can enrich pure organic luminescent systems and provide new ideas for functional RTP materials.

Science China: Chemistry published new progress about Phosphorescence. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Synthetic Route of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Jones, Brad H.; Staiger, Chad; Powers, Jackson; Herman, Jeremy A.; Roman-Kustas, Jessica published the artcile< Selectively Depolymerizable Polyurethanes from Unsaturated Polyols Cleavable by Olefin Metathesis>, COA of Formula: C4H8O, the main research area is selectively depolymerizable polyurethane unsaturated polyol cleavable olefin metathesis; cycloalkenes; depolymerization; olefin metathesis; polyurethanes; ring-closing metathesis.

This communication describes a novel series of linear and crosslinked polyurethanes (PUs) and their selective depolymerization under mild conditions. Two unique polyols are synthesized bearing unsaturated units in a configuration designed to favor ring-closing metathesis (RCM) to five- and six-membered cycloalkenes. These polyols are co-polymerized with toluene diisocyanate to generate linear PUs and trifunctional hexamethylene- and diphenylmethane-based isocyanates to generate crosslinked PUs. The polyol design is such that the RCM reaction cleaves the backbone of the polymer chain. Upon exposure to dilute solutions of Grubbs’ catalyst under ambient conditions, the PUs are rapidly depolymerized to low mol. weight, soluble products bearing vinyl and cycloalkene functionalities. These functionalities enable further re-polymerization by traditional strategies for polymerization of double bonds. It is anticipated that this general approach can be expanded to develop a range of chem. recyclable condensation polymers that are readily depolymerized by orthogonal metathesis chem.

Macromolecular Rapid Communications published new progress about Depolymerization. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, COA of Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Cheng; Sun, Qiaoying; Rudolph, Matthias; Rominger, Frank; Hashmi, A. Stephen K. published the artcile< Gold-Catalyzed Regiodivergent Annulations of Diazo-Alkynes Controlled by Et3N(HF)3>, Name: But-3-en-1-ol, the main research area is ethyl aryl alkyl naphthoate regioselective preparation; phenyl ethyl diazo oxopropanoate annulation catalyst gold.

Selectivity control in catalytic carbene insertions was known to be dominated by the adjustment of both the electronic and steric properties of metal complexes. Herein, a conceptually distinct strategy that enables a regioselectivity switch for the gold-catalyzed carbohydroxylation of diazo-tethered alkynes controlled by the additive Et3N(HF)3 for synthesis of Et (aryl/alkyl)-naphthoates was I [R1 = OH, Ph, 4-MeC6H4, etc.; R2 = F, OH, Ph, etc.; R3 = H, 7-F, 7-MeO, etc.] reported. Depending on the reaction conditions, either direct carbohydroxylation was observed or Michael addition/1,2-shift of the quinoid carbene intermediate in the presence of a Bronsted acid was involved. In both cases, the reaction proceeded with high regioselectivity. An intramol. cascade fluorination process for the synthesis of aryl fluorides I [R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = F; R3 = H, 7-F, 7-MeO, etc.] in high yield, which could be triggered under inert conditions and the use of Et3N(HF)3 was described.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Varghese, Swapna; Rahmani, Raphael; Drew, Damien R.; Beeson, James G.; Baum, Jake; Smith, Brian J.; Baell, Jonathan B. published the artcile< Structure-Activity Studies of Truncated Latrunculin Analogues with Antimalarial Activity>, Quality Control of 627-27-0, the main research area is Plasmodium growth antimalarial latrunculin QSAR; Actin inhibitors; P. falciparum; heterocycles; latrunculin analogues; malaria; natural products.

Malarial parasites employ actin dynamics for motility, and any disruption to these dynamics renders the parasites unable to effectively establish infection. Therefore, actin presents a potential target for malarial drug discovery, and naturally occurring actin inhibitors such as latrunculins are a promising starting point. However, the limited availability of the natural product and the laborious route for synthesis of latrunculins have hindered their potential development as drug candidates. In this regard, we recently described novel truncated latrunculins, with superior actin binding potency and selectivity towards P. falciparum actin than the canonical latrunculin B. In this paper, we further explore the truncated latrunculin core to summarize the SAR for inhibition of malaria motility. This study helps further understand the binding pattern of these analogs in order to develop them as drug candidates for malaria.

ChemMedChem published new progress about Antimalarials. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Quality Control of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lam, Albert T.; Zhang, Xiao-Nan; Courouble, Valentine V.; Strutzenberg, Timothy S.; Pei, Hua; Stiles, Bangyan L.; Louie, Stan G.; Griffin, Patrick R.; Zhang, Yong published the artcile< A Bifunctional NAD+ for Profiling Poly-ADP-Ribosylation-Dependent Interacting Proteins>, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol, the main research area is poly ADP ribosylation bifunctional fluorescent ligand protein interaction.

Protein poly-ADP-ribosylation (PARylation) is a heterogeneous and dynamic post-translational modification regulated by various writers, readers, and erasers. It participates in a variety of biol. events and is involved in many human diseases. Currently, tools and technologies have yet to be developed for unambiguously defining readers and erasers of individual PARylated proteins or cognate PARylated proteins for known readers and erasers. Here, we report the generation of a bifunctional NAD (NAD+) characterized by diazirine-modified adenine and clickable ribose. By serving as an excellent substrate for poly-ADP-ribose polymerase 1 (PARP1)-catalyzed PARylation, the generated bifunctional NAD+ enables photo-crosslinking and enrichment of PARylation-dependent interacting proteins for proteomic identification. This bifunctional NAD+ provides an important tool for mapping cellular interaction networks centered on protein PARylation, which are essential for elucidating the roles of PARylation-based signals or activities in physiol. and pathophysiol. processes.

ACS Chemical Biology published new progress about Apoptosis. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yuan, Chen; Jia, Wenyan; Yu, Ziyun; Li, Yanan; Zi, Min; Yuan, Li-Ming; Cui, Yong published the artcile< Are Highly Stable Covalent Organic Frameworks the Key to Universal Chiral Stationary Phases for Liquid and Gas Chromatographic Separations?>, SDS of cas: 6290-03-5, the main research area is covalent organic framework chiral stationary phase liquid gas chromatog.

High-performance liquid chromatog. (HPLC) and gas chromatog. (GC) over chiral stationary phases (CSPs) represent the most popular and highly applicable technol. in the field of chiral separation, but there are currently no CSPs that can be used for both liquid and gas chromatog. simultaneously. We demonstrate here that two olefin-linked covalent organic frameworks (COFs) featuring chiral crown ether groups can be general CSPs for extensive separation not only in GC but also in normal-phase and reversed-phase HPLC. Both COFs have the same 2D layered porous structure but channels of different sizes and display high stability under different chem. environments including water, organic solvents, acids, and bases. Chiral crown ethers are periodically aligned within the COF channels, allowing for enantioselective recognition of guest mols. through intermol. interactions. The COF-packed HPLC and GC columns show excellent complementarity and each affords high resolution, selectivity, and durability for the separation of a wide range of racemic compounds, including amino acids, esters, lactones, amides, alcs., aldehydes, ketones, and drugs. The resolution performances are comparable to and the versatility is superior to those of the most widely used com. chiral columns, showing promises for practical applications. This work thus advances COFs with high stability as potential universal CSPs for chromatog. that are otherwise hard or impossible to produce.

Journal of the American Chemical Society published new progress about Acids Role: ARU (Analytical Role, Unclassified), ANST (Analytical Study). 6290-03-5 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H10O2, SDS of cas: 6290-03-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Martin-Acosta, Pedro; Meng, Qianli; Klimek, John; Reddy, Ashok P.; David, Larry; Petrie, Stefanie Kaech; Li, Bingbing X.; Xiao, Xiangshu published the artcile< A clickable photoaffinity probe of betulinic acid identifies tropomyosin as a target>, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol, the main research area is clickable photoaffinity probe betulinic acid tropomyosin; Betulinic acid; Cancer; Diazirine; Natural product; Photoaffinity probe; Tropomyosin.

Target identification of bioactive compounds is important for understanding their mechanisms of action and provides critical insights into their therapeutic utility. While it remains a challenge, unbiased chemoproteomics strategy using clickable photoaffinity probes is a useful and validated approach for target identification. One major limitation of this approach is the efficient synthesis of appropriately substituted clickable photoaffinity probes. Herein, we describe an efficient and consistent method to prepare such probes. We further employed this method to prepare a highly stereo-congested probe based on naturally occurring triterpenoid betulinic acid. With this photoaffinity probe, we identified tropomyosin as a novel target for betulinic acid that can account for the unique biol. phenotype on cellular cytoskeleton induced by betulinic acid.

Acta Pharmaceutica Sinica B published new progress about Bioactive agents. 25055-82-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8N2O, Recommanded Product: 2-(3-Methyl-3H-diazirin-3-yl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Wenbo; Du, Bin; Zhuo, Haitao; Chen, Shaojun published the artcile< Recyclable and reprocessable epoxy-polyhedral oligomeric silsesquioxane (POSS)/mesogenic azobenzene/poly (ethylene-co-vinyl acetate) composites with thermal- and light-responsive programmable shape-memory performance>, SDS of cas: 627-27-0, the main research area is recyclable reprocessable epoxy polyhedral oligomeric silsesquioxane.

In this study, an Epoxy/POSS-liquid crystalline azobenzene-Poly (ethylene-co-vinyl acetate) (Epoxy/POSS-Azo-EVA) composite was prepared via the thermal curing of epoxy monomers and multi-functional thiol-containing Polyhedral oligomeric silsesquioxane (POSS) in an EVA matrix. The EVA matrix afforded the composite with shape memory performance. Epoxy/POSS polymer was uniformly dispersed in the matrix to act as a rigid skeleton, leading to the improvement of the mech. properties and shape memory performance of the composite. Liquid crystalline azobenzene as the photosensitive component provided the inner stress to render the composite film with photo-induced shape-deformation behavior under UV light. The composite film not only exhibited thermal- and light-responsive programmable shape-memory behavior stimulated by heat and light, but also was recyclable and reprocessable. Moreover, the recycled composite film was processed into different functional devices. A flexible photomech. device based on the recycled Epoxy/POSS-Azo-EVA composite film was fabricated, and the soft device deformed into a hook-shape under UV light and hooked an object whose weight is larger than that of the device. A smart wire was also prepared via assembling a stretched recycled Epoxy/POSS-Azo-EVA composite film and a copper foil by adhesive. The wire could control the status of a circuit via changing its shape under UV light and maintain the status after the removal of light. The functional devices described in this work only needed a short time of UV irradiation during a work cycle, and the devices still held the temporary shape in the absence of UV irradiation The recyclable and reprocessable Epoxy/POSS-Azo-EVA composite film in this work could provide a creative approach for the fabrication of novel photomech. devices and soft robotics with energy-saving, intelligence, recyclability, and sustainability.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Apparatus (functional). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, SDS of cas: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yong; Chen, Qi; Wang, Yuyu; Zhang, Qiang; Han, Qiuxia published the artcile< Fluorocarbon-assisted surface orientation of N-halamine groups on cellulose in supercritical CO2: An effective and eco-friendly approach for developing higher biocidability>, Safety of But-3-en-1-ol, the main research area is surface orientation halamine polysiloxane cellulose supercritical carbon dioxide; biocidal halamine polysiloxane coating cotton textile antibacterial.

Preferential segregation of N-halamine structure to top surface to better contact with bacteria is demonstrated to be an effective tactic for achievement of higher biocidability. 5-Allylbarbituric acid and its fluorinated derivative, formed by sacrificing a imide hydrogen to tether a 4-perfluorohexylbutyl segment via nucleophilic substitution, were synthesized and sep. attached to (50% methylhydrosiloxane)-dimethylsiloxane block copolymer (P(MHS-DMS)) via hydrosilylation. Chlorination of N-H bonds originating from barbituric acid produced two N-halamine polysiloxanes that were interpenetrated into cellulose to form coatings with similar morphol. and thickness. Although containing ∼50% less total content of chlorine than its nonfluorinated counterpart, polysiloxane with fluorinated pendants exerted faster inactivation against Staphylococcus aureus and Escherichia coli due to the orientation of its N-halamine groups on top surface with the assistance of the low-surface-tension 4-perfluorohexylbutyl segment as verified by depth profiling using angle-dependent XPS (ADXPS). Design biocide with proper surface segregation ability therefore paves a new way for improved antibacterial efficacy. The stability and rechargeability of the biocidability of the coatings are satisfactory under washing cycles, UV irrigation, and storage.

Applied Surface Science published new progress about Antibacterial agents. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Peng-Fei; Shu, Wei published the artcile< Orthogonal Access to α-/β-Branched/Linear Aliphatic Amines by Catalyst-Tuned Regiodivergent Hydroalkylations>, Application In Synthesis of 627-27-0, the main research area is amine preparation regioselective; chiral amine preparation regioselective enantioselective; alkenyl amine alkyl halide hydroalkylation metal catalyst; Amines; Chain Walking; Cobalt Catalysis; Hydroalkylations; Regiodivergent Reactions.

Herein, a catalyst-controlled synthesis of α-branched e.g., N-(1-phenylpentan-3-yl)benzamide, β-branched e.g., N-(2-methyl-4-phenylbutyl)benzamide and linear aliphatic amines e.g., N-(5-phenylpentyl)benzamide from Ni/Co-catalyzed regio- and site-selective hydroalkylations of alkenyl amines e.g., N-(prop-2-en-1-yl)benzamide with alkyl halides RX (R = butan-2-yl, Bn, 2-phenylethyl, 2-(1,3-dioxolan-2-yl)ethyl, etc.; X = I, Br) is developed. This catalytic protocol features the reliable prediction and control of the coupling position of alkylation to provide orthogonal access to α-branched, β-branched and linear alkyl amines from identical starting materials. This platform unlocks orthogonal reactivity and selectivity of nickel hydride and cobalt hydride chem. to catalytically repurpose three types of alkyl amines under mild conditions.

Angewandte Chemie, International Edition published new progress about Aliphatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Application In Synthesis of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts