Tag: M.W=0-100

Kang, Taeho; Kim, Nana; Cheng, Peter T.; Zhang, Hao; Foo, Klement; Engle, Keary M. published the artcile< Nickel-Catalyzed 1,2-Carboamination of Alkenyl Alcohols>, Name: But-3-en-1-ol, the main research area is tertiary amine preparation regioselective; alkenyl alc boronic ester amine carboamination nickel catalyst.

An alc.-directed, nickel-catalyzed three-component umpolung carboamination of unactivated alkenes with aryl/alkenylboronic esters and electrophilic aminating reagents was reported. This transformation was enabled by specifically tailored O-(2,6-dimethoxybenzoyl)hydroxylamine electrophiles that suppressed competitive processes, including undesired β-hydride elimination and transesterification between the alc. substrate and electrophile. The reaction delivered the desired 1,2-carboaminated products with generally high regio- and syn-diastereoselectivity and exhibited a broad scope of coupling partners and alkenes, including complex natural products. Various mechanistic experiments and anal. of the stereochem. outcome with a cyclic alkene substrate, as confirmed by X-ray crystallog. anal., support alc.-directed syn-insertion of an organonickel(I) species.

Journal of the American Chemical Society published new progress about Alkenyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Name: But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Chengliang; Zhang, Xu; Zhao, Wei; Liu, Xin; Wang, Qingfu; Sun, Jingjiang published the artcile< Synthesis of Aliphatic Hyperbranched Polycarbonates via Organo-Catalyzed ""A1+B2""-Ring-Opening Polymerization>, Category: alcohols-buliding-blocks, the main research area is aliphatic hyperbranched polycarbonate organo catalyzed ring opening polymerization.

Hyperbranched aliphatic polycarbonates (HBPCs) have attracted significant attention in the field of biomedical application owing to their abundant end groups, biocompatibility, and nontoxic degradation products. However, their practical application is hampered by tedious synthesis procedures. The present work described a novel organo-catalyzed “”A1+B2″”-ring-opening polymerization (ROP) using a monofunctional primary alc. (A1) as an initiator and a bicyclic carbonate monomer (B2) for the straightforward synthesis of HBPCs under mild conditions. No gelation was observed up to 90% conversion of the cyclic carbonate ring. HBPCs with molar masses in the range from 7 to 20 kg/mol were obtained. Based on the “”A1+B2″”-ROP, HBPCs bearing a variety of functionalities including alkene, alkyne, aldehyde, furan, azide, and mPEG groups, which are of great significance in the field of click chem., have been successfully prepared by using functional alc. initiators. This polymerization strategy allowed for precise control over the HBPC structure: (1) the hyperbranched polymer (HBP) backbone can be adjusted by design of a bicyclic carbonate monomer with various linkages; (2) the use of an appropriate initiator leads to the introduction of functional end groups. Overall, the “”A1+B2″”-ROP provides an efficient method for preparing a variety of HBPs like hyperbranched polyester, polyether, polyphosphate, and poly(amino acid) with complex architectures in a single step.

Macromolecules (Washington, DC, United States) published new progress about Biocompatible materials. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zahim, Sara; Delacroix, Kenny; Carlier, Agathe; Berranger, Thierry; Bergraser, Julie; Echeverria, Pierre-Georges; Petit, Laurent published the artcile< Tetrahydro-4H-pyran-4-one: From the Laboratory Scale to Pilot Plant Manufacture>, Related Products of 627-27-0, the main research area is tetrahydropyranone preparation.

This study describes recent efforts to find an efficient and scalable route to tetrahydro-4H-pyran-4-one using the com. available starting materials. The route scouting work and the full development of an efficient access to the target are described. This work culminated in the preparation of above 20 kg of the title compound in our pilot plant facility.

Organic Process Research & Development published new progress about Oxidation. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Related Products of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scott, David E.; Aloisio, Mark D.; Rodriguez, Jose F.; Morimoto, Masato; Hamilton, Robin J.; Brown, Orain; Tykwinski, Rik R.; Stryker, Jeffrey M. published the artcile< Optimizing the Iodide/Iodonium/O2 Oxidation Cycle Enhances the Scope, Selectivity, and Yields of Hydroiodic Acid-Catalyzed Multicomponent Cyclocondensation Reactions>, Category: alcohols-buliding-blocks, the main research area is quinoline preparation; aralkyl aldehyde aniline multicomponent cyclocondensation hydroiodic acid catalyst.

This work establishes that two independent catalytic cycles (H+ and I-/I+) drive such multicomponent cyclocondensation/ oxidation reactions, provided that the oxidant is generated in sufficient concentration to inhibit oxidation of the dihydroquinoline by the intermediate iminium cation. The complementary dual catalytic cycles, when optimized, act in concert to suppress side product formation, which simplifies isolation and purification of the self-aggregating products and increases the efficiency and scope of the Wang-Kozlov multicomponent reaction.

Advanced Synthesis & Catalysis published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent) (aryl). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yajun; Zhu, Shuaishuai; Liao, Can; Wang, Yong; Lam, Jacky W. Y.; Zhou, Xingping; Wang, Xianhong; Xie, Xiaolin; Tang, Ben Zhong published the artcile< Cobalt-Mediated Switchable Catalysis for the One-Pot Synthesis of Cyclic Polymers>, Safety of But-3-en-1-ol, the main research area is cyclic polymer cobalt mediated switchable catalysis; biodegradable polymers; cyclic polymers; photo-induced radical closure; ring-opening copolymerization; switchable catalysis.

A cobalt salen pentenoate complex [salen = (R,R)-N,N’-bis(3,5-di-tertbutylsalicylidene)-1,2-cyclohexanediamine] is rationally designed as the catalyst for the ring-opening copolymerization (ROCOP) of epoxides/anhydrides/CO2. Via migratory insertion of carbon monoxide (CO) into the Co-O bonds, the ROCOP-active species α-alkene-ω-O-CoIII(salen) can be rapidly and quant. transformed into α-alkene-ω-O2C-CoIII(salen) telechelic linear precursors. Upon dilution of reaction mixtures, the homolytic cleavage of Co-C bonds induced by visible light generates α-alkene acyl radicals that spontaneously undergo intramol. radical addition to afford organocobalt-functionalized cyclic polyesters and CO2-based polycarbonates with excellent regioselectivity. The cyclic products can either react with radical scavengers to generate metal-free cyclic polymers or serve as photo-initiators for organometallic-mediated radical polymerization (OMRP) to produce tadpole-shaped copolymers.

Angewandte Chemie, International Edition published new progress about Cyclization. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Liang; Jin, Feng; Cheng, Xionglve; Tao, Suyan; Jiang, Gangzhong; Li, Xingxing; Yang, Jinwei; Bao, Xiaoguang; Wan, Xiaobing published the artcile< [2 + 2 + 1] Cycloaddition of N-tosylhydrazones, tert-butyl nitrite and alkenes: a general and practical access to isoxazolines>, Formula: C4H8O, the main research area is isoxazoline preparation; tosylhydrazone tert butyl nitrite alkene cycloaddition.

Herein, the first demonstrations of [2 + 2 + 1] cycloaddition reactions was reported that allow the facile synthesis of isoxazolines I [R1 = cyclopropyl, Ph, 2-naphthyl, etc.; R2 = CH2OH, COOEt, Ph, etc.], employing N-tosylhydrazones, tert-Bu nitrite (TBN) and alkenes as reactants. This process represented a new type of cycloaddition reaction with a distinct mechanism that does not involve the participation of nitrile oxides. This approach was both general and practical and exhibits a wide substrate scope, nearly universal functional group compatibility, tolerance of moisture and air, the potential for functionalization of complex bioactive mols. and is readily scaled up. Both control experiments and theor. calculations indicated that this transformation proceeds via the in situ generation of a nitronate from the coupling of N-tosylhydrazone and TBN, followed by cycloaddition with an alkene and subsequent elimination of a tert-butyloxy group to give the desired isoxazoline.

Chemical Science published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Formula: C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rohan, Rupesh; Hung, Miao-Ken; Yang, Yi-Fei; Hsu, Chia-Wei; Yeh, Cheng-Kuang; Chang, Yu-Lung; Lee, Jyh-Tsung published the artcile< Enhancement of the High-Rate Performance of an Organic Radical Thin-Film Battery by Decreasing the Grafting Density of Polymer Brushes>, Reference of 627-27-0, the main research area is enhancement High Rate performance organic radical Thin Film battery.

A high-rate performance enhancement of a poly(2,2,6,6-tetramethylpiperidin-1-oxy-4-yl methacrylate) (PTMA) brush as a thin-film organic radical cathode is achieved by grafting d. reduction n-Octyltrichlorosilane as a capping agent diluted the surface initiator d. on the indium tin oxide (ITO) substrate. Surface initiator-modified ITO substrates (1% and 100%) were grafted with PTMA to yield low (LD) and high (HD) grafting d. PTMA brushes (0.11 and 0.26 chains nm-2, resp.). The cyclic voltammetry and AC impedance results showed that the LD PTMA brush has a lower impedance than the HD PTMA brush electrode. The in situ electrochem. at. force microscopy detected a larger thickness change in the LD PTMA brush during the redox reactions than in the HD PTMA brush. This difference is attributed to the loose packing of the polymer chains in the LD PTMA brush that enhances polymer chain mobility and transportation of ClO4- anions. Furthermore, the thin-film organic radical battery cell with the LD PTMA brush electrode exhibited outstanding high-rate performance (>50% retention at 1500 C) and a good cycle-life performance of 89% retention at 20 C over 400 cycles.

ACS Applied Polymer Materials published new progress about Atomic force microscopy. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Reference of 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsuda, Asami; Matsumura, Yoshitaka; Yamada, Yasuhiro; Sato, Satoshi published the artcile< Vapor-phase dehydration of 1,4-butanediol to 1,3-butadiene over Y2Zr2O7 catalyst>, Product Details of C4H8O, the main research area is vapor dehydration butanediol butadiene Y2Zr2O7 catalyst.

Vapor-phase catalytic dehydration of 1,4-butanediol (1,4-BDO) was investigated over Y2O3-ZrO2 catalysts. In the dehydration, 1,3-butadiene (BD) together with 3-buten-1-ol (3B1OL), THF, and propylene was produced depending on the reaction conditions. In the dehydration over Y2O3-ZrO2 catalysts with different Y contents at 325°C, Y2Zr2O7 with an equimolar ratio of Y/Zr showed high selectivity to 3B1OL, an intermediate to BD. In the dehydration at 360°C, a BD yield higher than 90% was achieved over the Y2Zr2O7 calcined at 700°C throughout 10 h. In the dehydration of 3B1OL over Y2Zr2O7, however, the catalytic activity affected by the calcination temperature is roughly proportional to the sp. surface area of the sample. The highest activity of Y2Zr2O7 calcined at 700°C for the BD formation from 1,4-BDO is explained by the trade-off relation in the activities for the first-step dehydration of 1,4-BDO to 3B1OL and for the second-step dehydration of 3B1OL to BD. The higher reactivity of 3B1OL than saturated alcs. such as 1-butanol and 2-butanol suggests that the C=C double bond of 3B1OL induces an attractive interaction to anchor the catalyst surface and promotes the dehydration. A probable mechanism for the one-step dehydration of 1,4-BDO to BD was discussed.

Molecular Catalysis published new progress about Adsorption. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Product Details of C4H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ma, Jiajia; Chen, Shuming; Bellotti, Peter; Guo, Renyu; Schaefer, Felix; Heusler, Arne; Zhang, Xiaolong; Daniliuc, Constantin; Brown, M. Kevin; Houk, Kendall N.; Glorius, Frank published the artcile< Photochemical intermolecular dearomative cycloaddition of bicyclic azaarenes with alkenes>, Safety of But-3-en-1-ol, the main research area is regioselective diastereoselective dearomative cycloaddition bicyclic azaarene alkene.

Dearomative cycloaddition reactions represent an ideal means of converting flat arenes into three-dimensional architectures of increasing interest in medicinal chem. Quinolines, isoquinolines, and quinazolines, despite containing latent diene and alkene subunits, are scarcely applied in cycloaddition reactions because of the inherent low reactivity of aromatic systems and selectivity challenges. Here, we disclose an energy transfer-mediated, highly regio- and diastereoselective intermol. [4 + 2] dearomative cycloaddition reaction of these bicyclic azaarenes with a plethora of electronically diverse alkenes. This approach bypasses the general reactivity and selectivity issues, thereby providing various bridged polycycles that previously have been inaccessible or required elaborate synthetic efforts. Computational studies with d. functional theory elucidate the mechanism and origins of the observed regio- and diastereoselectivities.

Science (Washington, DC, United States) published new progress about Alkenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, Safety of But-3-en-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Jianqun; Zhu, Yinuo; Li, Maosheng; Wang, Yanchao; Wang, Xianhong; Tao, Youhua published the artcile< Tug-of-War between Two Distinct Catalytic Sites Enables Fast and Selective Ring-Opening Copolymerizations>, HPLC of Formula: 627-27-0, the main research area is epoxide anhydride ring opening copolymerization thiourea boron catalyst; Differentiated Catalytic Sites; Organocatalysts; Polyester; Ring-Opening Copolymerizations; Tug-of-War.

Ring-opening copolymerizations have emerged as a powerful approach towards the creation of sustainable polymers. Typical H-bonding catalysts for ring-opening are subject to a single catalytic site. Here we describe a H-bond-donor/Lewis-acidic-boron organocatalyst featuring two distinct catalytic sites in one mol. The ring-opening copolymerization of epoxides with anhydride mediated by these modular, and tunable catalysts achieves high selectivity (>99% polyester selectivity) and markedly higher activity compared to either of the di-thiourea analogs or any combinations of them. Calculations and exptl. studies reveal that the superior catalytic performance arises from tug-of-war between two differentiated catalytic sites: thiourea pulls off the propagating chain-end from boron center, simultaneously enhancing the role of monomer activation and also nucleophilicity of the propagation intermediates.

Angewandte Chemie, International Edition published new progress about Crystal structure. 627-27-0 belongs to class alcohols-buliding-blocks, and the molecular formula is C4H8O, HPLC of Formula: 627-27-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts