Tag: 500-600

Enantioselective Palladium-Catalyzed [3C + 2C] and [4C + 3C] Intramolecular Cycloadditions of Alkylidenecyclopropanes was written by Verdugo, Felipe;Villarino, Lara;Duran, Juan;Gulias, Moises;Mascarenas, Jose L.;Lopez, Fernando. And the article was included in ACS Catalysis in 2018.Product Details of 851615-07-1 The following contents are mentioned in the article:

We report a highly enantioselective [3C + 2C] intramol. cycloaddition of alkylidenecyclopropanes (ACPs) and alkenes. The best results are obtained by using sterically demanding chiral phosphoramidite ligands derived from Vapol. Moreover, we also show that related, but less bulky, phosphoramidites can also lead to very effective [4C + 3C] cycloadditions when dienes, instead of alkenes, are used as reacting partners. The reactions provide a practical, simple, and selective access to optically active, synthetically appealing 5,5- and 5,7-bicyclic systems. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Product Details of 851615-07-1).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Product Details of 851615-07-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Counteranion-Directed Catalytic Asymmetric Methylene Migration Reaction of Ene-Aldimines was written by Momiyama, Norie;Jongwohan, Chanantida;Ohtsuka, Naoya;Chaibuth, Pawittra;Fujinami, Takeshi;Adachi, Kiyohiro;Suzuki, Toshiyasu. And the article was included in Journal of Organic Chemistry in 2022.Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol The following contents are mentioned in the article:

A catalytic asym. methylene migration reaction of ene-aldimines directed by chiral counteranions was developed, with the optimal catalyst identified as phenanthryl-substituted (R)-BINOL phosphate. Control experiments and d. functional theory computations reveal the importance of the 2-hydroxy group of the ene-aldimine and attractive (e.g., OH···O, CH···O, CH···π, and π#183;··π) interactions for high enantioselectivity (up to 74% ee). The results contribute to the design of asym. catalysis for the rearrangement of highly reactive iminium intermediates. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation of a new chiral stationary phase based on (2S,3S)-O,O’-bis-(10-undecenoyl)-N,N’-bis-(3,5-dinitrobenzoyl)-2,3-diamino-1,4-butanediol and its application for the liquid chromatographic resolution of enantiomers was written by Hyun, Myung Ho;Boo, Chang Jin;Choi, Hee Jung;Kim, Yun Kyoung;Kang, Bu Sung;Ha, Hyun Ju;Choi, Min Ki;Tan, Guanghui. And the article was included in Bulletin of the Korean Chemical Society in 2006.HPLC of Formula: 851615-07-1 The following contents are mentioned in the article:

A new liquid chromatog. chiral stationary phase based on (2S,3S)-O,O’-bis-(10-undecenoyl)-N,N’-bis-(3,5-dinitrobenzoyl)-2,3-diamino-1,4-butanediol was prepared starting from (2R,3R)-1,4-bis(benzyloxy)-2,3-butanediol. The new chiral stationary phase was applied to the resolution of racemic anilide derivatives of N-acetyl-α-amino acids, 1,1′-bi-2-naphthol and 3,3′-diaryl-1,1′-bi-2-naphthols. It was also applied to the resolution of some chiral drugs including bendroflumethiazide, naproxen and alminoprofen. In every case, the chiral recognition efficiency of the new CSP was quite excellent. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1HPLC of Formula: 851615-07-1).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.HPLC of Formula: 851615-07-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Proanthocyanidin oligomers extract from hawthorn mediates cell cycle arrest, apoptosis, and lysosome vacuolation on HCT116 cells was written by Sun, Ya-Sai;Wang, Zi-Wei;Gao, Zhe;Zhao, Wen;Thakur, Kiran;Zhong, Qian;Wei, Zhao-Jun. And the article was included in Current Research in Food Science in 2022.Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol The following contents are mentioned in the article:

In this study, Hawthorn oligomic procyanidins extracts (HPOE) were evaluated for their anticancer activity on colorectal cancer. Our results showed that HPOE arrested HCT116 cells cycle at G2/M phase through P53-Cyclin B pathway and promoted apoptosis partly via mitochondrial (Caspase 9-Caspase 3) and death receptor (Caspase 8-Caspase 3) pathways. Meanwhile, it was found that HPOE aggravated HCT116 cells death through lysosomal vacuolation, which was verified by inhibitor/activator of P53-ILC3 signaling pathway. Taken together, HPOE exerted anticancer effects which lays the foundation for the development of functional foods for clin. colon cancer patients. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral lithium salts of phosphoric acids as lewis acid-base conjugate catalysts for the enantioselective cyanosilylation of ketones was written by Hatano, Manabu;Ikeno, Takumi;Matsumura, Tokihiko;Torii, Shinobu;Ishihara, Kazuaki. And the article was included in Advanced Synthesis & Catalysis in 2008.Category: alcohols-buliding-blocks The following contents are mentioned in the article:

The catalytic enantioselective cyanosilylation of aromatic ketones was developed by using chiral lithium salts of (R)-BINOL- (BINOL = 2,2′-binaphthol) or (S)-BINAM-derived (BINAM = 2,2′-binaphthamine) phosphoric acid compounds In the presence of 10 mol% of chiral conjugate lithium salts, the corresponding tertiary cyanohydrins were obtained in high yields with moderate to high enantioselectivities. This is the 1st efficient example of asym. catalysis using lithium salts of synthetically useful chiral phosphoric acid compounds A possible catalytic mechanism and transition states are also discussed as a preliminary working hypothesis. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Category: alcohols-buliding-blocks).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The influence of the fortification of red pitaya (Hylocereus polyrhizus) powder on the in vitro digestion, physical parameters, nutritional profile, polyphenols and antioxidant activity in the oat-wheat bread was written by Huang, Yanyi;He, Mengya;Kasapis, Stefan;Brennan, Margaret;Brennan, Charles. And the article was included in International Journal of Food Science and Technology in 2022.Product Details of 29106-49-8 The following contents are mentioned in the article:

This study evaluated the phys. parameters, polyphenol profile and antioxidant activity before and after the in vitro digestion of red pitaya powder-enriched oat-wheat bread compared to plain wheat bread, oat-wheat bread and red pitaya powder. The enrichment of red pitaya powder significantly increased the polyphenol, mineral contents, insoluble dietary fiber, firmness and moisture content of oat-wheat bread compared to wheat bread, while contributed to a minor reduction in bread volume and dough extensibility due to gluten dilution The oat-wheat bread was found to have the lowest predicted glycemic response, but 5%, 10% and 15% red pitaya powder formulated oat-wheat bread showed a significantly lower glycemic response than plain wheat bread as well as red pitaya powder. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Product Details of 29106-49-8).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Product Details of 29106-49-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liquid chromatographic resolution of 1,1′-bi-2-naphthol and 3,3′-diaryl-1,1′-bi-2-naphthols on Pirkle-type chiral stationary phases based on leucine and phenylglycine was written by Hyun, Myung Ho;Kim, Kwang Soo;Cho, Yoon Jae. And the article was included in Journal of Liquid Chromatography & Related Technologies in 2005.Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol The following contents are mentioned in the article:

Pirkle-type chiral stationary phases (CSPs) based on (S)-leucine and (S)-phenylglycine were applied in the resolution of 1,1′-bi-2-naphthol and 3,3′-diaryl-1,1′-bi-2-naphthols. Among the two Pirkle-type CSPs, the one based on (S)-N-(3,5-dinitrobenzoyl)leucine N-propylamide is excellent and most widely applicable. The elution orders for the resolution of 1,1′-bi-2-naphthol on the CSPs based on (S)-N-(3,5-dinitrobenzoyl)leucine N-propylamide and (S)-N-(3,5-dinitrobenzoyl)phenylglycine N-propylamide were opposite to those for the resolution of 3,3′-diaryl-1,1′-bi-2-naphthols. To rationalize the reversed elution orders, the authors proposed two different chiral recognition mechanisms based on the chromatog. resolution behaviors, with the aid of the CPK mol. model study. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An enantioselective synthesis of 3,4-benzo-5-oxacephams was written by Koziol, Anna;Frelek, Jadwiga;Woznica, Magdalena;Furman, Bartlomiej;Chmielewski, Marek. And the article was included in European Journal of Organic Chemistry in 2009.COA of Formula: C40H26O2 The following contents are mentioned in the article:

The title compounds, e.g., I, represent an interesting group of 1-lactam antibiotics and active inhibitors of β-lactamase enzymes. All these compounds have one structural feature in common, an alkoxy fragment located at C4 of the azetidin-2-one ring. The most common strategy for the synthesis of 4-alkoxyazetidinones involves intramol. nucleophilic substitution at C4 that leads to ring closure. Such a displacement proceeds via the flat intermediate that supposedly has the structure of a mesomeric acyl ammonium cation. We herein report a novel and enantioselective chiral Lewis acid-mediated cyclization that affords the corresponding 5-oxacepham with excellent enantioselectivity and chem. yields of up to 50%. This may suggest that the high asym. induction is a result of a kinetic resolution of the initially formed racemic oxacepham. This study involved multiple reactions and reactants, such as (R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1COA of Formula: C40H26O2).

(R)-[1,3′:1′,1”:3”,1”’-Quaternaphthalene]-2′,2”-diol (cas: 851615-07-1) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C40H26O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Procyanidin B2 induces porcine skeletal slow-twitch myofiber gene expression by AMP-activated protein kinase signaling pathway was written by Xu, Meng;Chen, Xiaoling;Huang, Zhiqing;Chen, Daiwen;Yu, Bing;He, Jun;Chen, Hong;Yu, Jie;Luo, Yuheng;Zheng, Ping. And the article was included in Animal Biotechnology in 2022.Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol The following contents are mentioned in the article:

In this study, our aim is to investigate the effect of dimer procyanidin B2 [epicatechin-(4β-8)-epicatechin] (PB2) on porcine skeletal myofiber gene expression in vitro. Our data showed PB2 promoted the protein expression of slow myosin heavy chain (MyHC) in porcine myotubes, concomitant with the increases in mRNA levels of MyHC I, MyHC IIa and Tnni1. We also found PB2 activated AMPK signaling in porcine myotubes. NRF1 and CaMKKβ that are two important upstream factors of AMPK, and Sirt1 and PGC-1α that are two major downstream factors of AMPK, were also up-regulated by PB2. The mechanism study showed the effect of PB2 on slow-twitch myofiber gene expression was abolished by AMPK inhibitor compound C or by AMPKα1 siRNA. Together, we found PB2 induced porcine skeletal slow-twitch myofiber gene expression by AMPK signaling pathway. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Traditional Chinese medicine extracts as novel corrosion inhibitors for AZ91 magnesium alloy in saline environment was written by Li, Haonan;Fan, Min;Wang, Kui;Bian, Xiaolan;Jiang, Haiyan;Ding, Wenjiang. And the article was included in Scientific Reports in 2022.Electric Literature of C30H26O12 The following contents are mentioned in the article:

Zingiber officinale Roscoe extract, Raphanus sativus L. extract, Rheum palmatum extract, Coptis chinensis extract, Glycyrrhiza uralensis extract (GUE), Potentilla discolor extract (PDE) and Taraxacum officinale extract (TOE) were screened for the green corrosion inhibitors of AZ91 alloy in saline environment. The experiment results demonstrated that GUE, PDE and TOE can significantly enhance the corrosion resistance of AZ91 alloy by 73.4, 87.6 and 84.6%, resp. Surface characterization using FTIR, UV-Vis and XPS revealed that the organic compounds of GUE, PDE and TOE can interact with the alloy surface to form a protective physisorbed film, effectively mitigating the corrosion process of AZ91 alloy. The present results may be helpful to discover the new green inhibitors with high inhibition efficiency for AZ91 alloy. This study involved multiple reactions and reactants, such as (2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8Electric Literature of C30H26O12).

(2R,2’R,3R,3’R,4R)-2,2′-Bis(3,4-dihydroxyphenyl)-[4,8′-bichromane]-3,3′,5,5′,7,7′-hexaol (cas: 29106-49-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C30H26O12

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts