Tag: 400-500

Ma, Yao-Bin et al. published their research in Aquaculture in 2021 | CAS: 137-08-6

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 137-08-6

Effect of tea polyphenols on flavour, healthcare components, physicochemical properties, and mechanisms of collagen synthesis in growing grass carp (Ctenopharyngodon idella) muscle was written by Ma, Yao-Bin;Zhang, Jin-Xiu;Zhou, Xiao-Qiu;Jiang, Wei-Dan;Wu, Pei;Liu, Yang;Kuang, Sheng-Yao;Tang, Ling;Feng, Lin. And the article was included in Aquaculture in 2021.HPLC of Formula: 137-08-6 This article mentions the following:

This study aimed to investigate whether dietary TP in growing grass carp could provide high quality fish flesh. 540 fish (187.49 ± 0.66 g) were fed six diets with different concentrations of TP (0, 40, 80, 120, 160 and 200 mg / kg) for 60 days to determine the effects of TP on flesh quality. The results demonstrated that appropriate dietary TP supplementation benefits growing grass carp in the following respects: (1) promoting performance of growth and nutritional value of fish, (2) enhancing flavor of flesh by increasing the levels of umami-taste free amino acids (glutamic acid and aspartic acid) (3) increasing healthcare components of flesh particularly eicosapentaenoic acid (EPA 20:5n-3) and docosahexaenoic acid (DHA 22:6n-3), (4) improving physicochem. properties (firmness,pH, water-holding capacity) of flesh. The present research explores, for the first time, the effects of TP on enhancing the collagen content, which is partly correlated with the upregulation of type I collagen synthesis genes Col1α1 and Col1α2, mediated through transforming growth factor-β1 (TGF-β1) by Smad pathway in fish muscle. Based on growth performance (percentage weight gain) and fish flesh quality indexes (EPA, DHA, shear force, and pH), the appropriate dietary supplementation of TP in growing grass carp were assessed to be 103.01, 116.30, 106.60, 141.15 and 113.49 mg/kg, using quadratic regression anal. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6HPLC of Formula: 137-08-6).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.HPLC of Formula: 137-08-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sagada, Gladstone et al. published their research in Aquaculture Nutrition in 2022 | CAS: 137-08-6

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C18H32CaN2O10

Synergistic effect of dietary inactivated Lactobacillus plantarum and berberine supplementation on growth performance, antioxidant capacity, and immune function of juvenile black sea bream (Acanthopagrus schlegelii) was written by Sagada, Gladstone;Wang, Lei;Xu, Bingying;Tegomo, Fabrice Arnaud;Chen, Kai;Zheng, Lu;Sun, Yuxiao;Liu, Yuechong;Yang, Yifei;Ullah, Sami;Shao, Qingjun. And the article was included in Aquaculture Nutrition in 2022.Formula: C18H32CaN2O10 This article mentions the following:

The interactive effect of dietary inactivated Lactobacillus plantarum and berberine on black sea bream, Acanthopagrus schlegelii, was investigated with three diets designated as D1 (Con: basal diet), D2 (LP: basal diet + 400 mg/kg L. plantarum), and D3 (LPBB: basal diet + 400 mg/kg L. plantarum + 50 mg/kg berberine) and fed to juvenile black sea bream (5.67 ± 0.05 g) for 56 days. The growth performance and feed utilization parameters, as well as intestinal trypsin activity, were significantly improved in the LP and LPBB groups (P < 0.05). Fish fed the LPBB diet showed better serum and hepatic antioxidant capacity, while the LP group had better hepatic antioxidant capacity, than the control fish (P < 0.05). Intestinal IgM and C3 levels significantly increased in the LPBB fish than the rest of the groups (P < 0.05). NF-κB was significantly upregulated in the LP group (P < 0.05). Nrf2 and IL-10 were significantly upregulated, while Keap1b and NF-κB were significantly downregulated in the LPBB group (P < 0.05). These findings show that a combination of inactivated L. plantarum and berberine in the diet of black sea bream can improve the immune response and antioxidant capacity than a diet with only the inactivated probiotic, while both diets can equally improve growth performance. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Formula: C18H32CaN2O10).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C18H32CaN2O10

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yaling et al. published their research in Aquaculture Nutrition in 2022 | CAS: 137-08-6

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Effects of dietary arginine on growth performance, digestion, absorption ability, antioxidant capability, gene expression of intestinal protein synthesis, and inflammation-related genes of triploid juvenile Oncorhynchus mykiss fed a low-fishmeal diet was written by Wang, Yaling;Wang, Chang’an;Liu, Siyuan;Zhang, Shuze;Lu, Shaoxia;Liu, Hongbai;Han, Shicheng;Jiang, Haibo;Zhang, Yin. And the article was included in Aquaculture Nutrition in 2022.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate This article mentions the following:

In this study, the effects of arginine on growth, serum antioxidant levels, intestinal digestion physiol., intestinal protein synthesis, and expression of inflammatory-related genes of triploid juvenile rainbow trout (Oncorhynchus mykiss) were investigated. Five diets containing 0.86%, 1.65%, 2.10%, 2.85%, and 3.50% arginine were fed to satiation to triplicate groups of 30 fish per tank for 8 wk. The results showed that the weight gain rate, specific growth rate, and protein efficiency ratio significantly increased. The optimal dietary arginine requirement was 2.48% (5.97% of dietary protein) based on quadratic regression anal. between specific growth rate and dietary arginine content. There were no significant differences in crude lipid and ash content. Moisture significantly decreased, and crude protein content significantly increased (P < 0.05). Superoxide dismutase, catalase, and lysozyme levels in serum and the liver first significantly increased and then decreased with the level of arginine compared to the control group (P < 0.05), while the malondialdehyde level significantly decreased. Intestinal lipase and amylase levels significantly increased, but there was no significant difference in trypsin level (P > 0.05). The muscular layer thickness and villus width foregut in the 2.85% group were significantly increased. TOR at 2.86% and IGF-1 and S6K1 at 2.11% reached the maximum level, and IL-1β, IL-6, and IL-8 showed a decreasing trend with their lowest levels in the 3.50% and 2.85% groups. The expression of TNF-a first decreased and then increased with the arginine level. Both TGF-β and IL-10 expression first decreased and then increased with the level of arginine and reached the maximum value in the 2.85% group. NF-κB showed an opposite trend and reached the lowest value in the 3.50% group. In conclusion, dietary arginine has a significant effect on growth, serum antioxidant capability, digestion physiol., immunity, digestion, and absorption of nutrients in triploid O. mykiss, and the optimum requirement is 2.48% fed a low-fishmeal diet. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Safety of Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liang, Xuan et al. published their research in Crystal Growth & Design in 2021 | CAS: 137-08-6

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 137-08-6

Improving Stability of Vitamin B5 Through Double Salt Formation was written by Liang, Xuan;Zhang, Qi;Zhang, Zaiyong;Ding, Qiaoce;Mei, Xuefeng. And the article was included in Crystal Growth & Design in 2021.Reference of 137-08-6 This article mentions the following:

Calcium pantothenate (CP) is a chem. unstable vitamin and sensitive to moisture, heat, acid, and alkali. The poor physicochem. properties have greatly limited its biol. performance and applications. In this work, four new double salts of CP with pantoic acid calcium salt (PA), calcium isobutyrate (IBA), calcium β-hydroxy-β-Me butyrate (HMB), and calcium lactate (LA) were synthesized aiming to reduce the moisture sensitivity and to enhance the stability. The three double salts (CP-PA, CP-IBA, CP-HMB) were fully characterized by single crystal X-ray diffraction, powder X-ray diffraction, differential scanning calorimetry, thermogravimetric anal., and dynamic vapor sorption. In addition, their hygroscopicity and chem. stability under different conditions were also studied. The results show that all four double salts present improved hygroscopicity, phys. stability, and chem. stability. Notably, compared to CP pure forms, CP-PA and CP-LA present significantly lower moisture absorption and obviously improved stability. This work provides a new method to improve the hygroscopicity, phys. stability, and chem. stability of organic salts. In the experiment, the researchers used many compounds, for example, Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6Reference of 137-08-6).

Calcium (R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate (cas: 137-08-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 137-08-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Md, Shadab’s team published research in Gels in 2021 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Application of 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

《Ambroxol Hydrochloride Loaded Gastro-Retentive Nanosuspension Gels Potentiate Anticancer Activity in Lung Cancer (A549) Cells》 was published in Gels in 2021. These research results belong to Md, Shadab; Abdullah, Samaa T.; Alhakamy, Nabil A.; Bani-Jaber, Ahmad; Radhakrishnan, Ammu Kutty; Karim, Shahid; Shahzad, Naiyer; Gabr, Gamal A.; Alamoudi, Abdulmohsin J.; Rizg, Waleed Y.. Application of 23828-92-4 The article mentions the following:

This study aimed to develop gastro-retentive sustained-release ambroxol (ABX) nanosuspensions utilizing ambroxol-kappa-carrageenan (ABX-CRGK) complexation formulations. The complex was characterized by differential scanning calorimetry, powder x-ray diffractometer, and SEM. The prepared co-precipitate complex was used for the development of the sustained-release formulation to overcome the high metabolic and poor solubility problems associated with ABX. Furthermore, the co-precipitate complex was formulated as a suspension in an aqueous floating gel-forming vehicle of sodium alginate with chitosan, which might be beneficial for targeting the stomach as a good absorption site for ABX. The suspension exhibited rapid floating gel behavior for more than 8 h, thus confirming the gastro-retentive effects. Particle size anal. revealed that the optimum nanosuspension (ABX-NS) had a mean particle size of 332.3 nm. Afterward, the ABX released by the nanoparticles would be distributed to the pulmonary tissue as previously described. Based on extensive pulmonary distribution, the developed nanosuspension-released ABX nanoparticles showed significant cytotoxic enhancement compared to free ABX in A549 lung cancer cells. However, a significant loss of mitochondrial membrane potential (MMP) also occurred. The level of caspase-3 was the highest in the ABX-NS-released particle-treated samples, with a value of 416.6 ± 9.11 pg/mL. Meanwhile, the levels of nuclear factor kappa beta, interleukins 6 and 1 beta, and tumor necrosis alpha (NF-kB, IL-6, IL-1β, and TNF-α, resp.) were lower for ABX-NS compared to free ABX (p < 0.05). In caspase-3, Bax, and p53, levels significantly increased in the presence of ABX-NS compared to free ABX. Overall, ABX-NS produced an enhancement of the anticancer effects of ABX on the A549 cells, and the developed sustained-release gel was successful in providing a gastro-retentive effect. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Application of 23828-92-4) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Application of 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salat, Kinga’s team published research in Molecules in 2021 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Formula: C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

In 2021,Molecules included an article by Salat, Kinga; Furgala-Wojas, Anna; Salat, Robert. Formula: C13H19Br2ClN2O. The article was titled 《The microglial activation inhibitor minocycline, used alone and in combination with duloxetine, attenuates pain caused by oxaliplatin in mice》. The information in the text is summarized as follows:

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition. Since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. To induce neuropathic pain, a single dose (10 mg/kg) of i.p. oxaliplatin was used. The mech. and cold pain thresholds were assessed using mouse von Frey and cold plate tests, resp. On the day of oxaliplatin administration, only duloxetine (30 mg/kg) and minocycline (100 mg/kg) used alone attenuated both tactile allodynia and cold hyperalgesia 1 h and 6 h after administration. Minocycline (50 mg/kg), duloxetine (10 mg/kg) and combined minocycline + duloxetine influenced only tactile allodynia. Seven days after oxaliplatin, tactile allodynia (but not cold hyperalgesia) was attenuated by minocycline (100 mg/kg), duloxetine (30 mg/kg) and combined minocycline and duloxetine. These results indicate a potential usefulness of minocycline used alone or combination with duloxetine in the treatment of oxaliplatin-induced pain. In addition to this study using trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, there are many other studies that have used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Formula: C13H19Br2ClN2O) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Formula: C13H19Br2ClN2O Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Shengke’s team published research in ChemPlusChem in 2020 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

《Supramolecular Modulation of Antibacterial Activity of Ambroxol by Cucurbit[7]uril》 was written by Li, Shengke; Kuok, Kit Ieng; Ji, Xia; Xu, Anni; Yin, Hang; Zheng, Jun; Tan, Huaping; Wang, Ruibing. Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride And the article was included in ChemPlusChem on April 30 ,2020. The article conveys some information:

Supramol. encapsulation by cucurbit[7]uril (CB[7]) was recently demonstrated to provide a simple and efficient method for antibacterial activity regulation of antibiotics. In this work, CB[7] was shown to form binary host-guest complex with ambroxol hydrochloride (ABX), a clin. mucokinetic and expectorant drug, which was reported to exhibit certain antibacterial activity. 1H NMR titration and isothermal titration calorimetry experiment results suggested that the 4-hydroxyl cyclohexylamine group of ABX was included inside the CB[7] cavity, with a binding constant Ka of (6.69±0.11)×105 M-1 in phosphate buffered saline (PBS) solution, thermodynamically driven by both enthalpy change and entropy. More importantly, ABX’s inhibitory activity (MIC50) against bacillary strains towards Pseudomonas aeruginosa and Escherichia coli strains was decreased from (5.11±0.31)×10-6 M-1 and (2.63±0.34)×10-5 M-1 to zero upon encapsulation by CB[7], and was subsequently recovered to almost its original activity when a competitive guest, amantadine hydrochloride, for disassembling CB[7]-ABX complex, was added, suggesting that the antibacterial activity of ABX could be readily “”turned off/on”” upon its complexation and decomplexation with CB[7]. In the part of experimental materials, we found many familiar compounds, such as trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Reference of trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nagata, Kenichiro’s team published research in PLoS One in 2021 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Product Details of 23828-92-4 Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

In 2021,PLoS One included an article by Nagata, Kenichiro; Tsuji, Toshikazu; Suetsugu, Kimitaka; Muraoka, Kayoko; Watanabe, Hiroyuki; Kanaya, Akiko; Egashira, Nobuaki; Ieiri, Ichiro. Product Details of 23828-92-4. The article was titled 《Detection of overdose and underdose prescriptions-An unsupervised machine learning approachã€? The information in the text is summarized as follows:

Overdose prescription errors sometimes cause serious life-threatening adverse drug events, while underdose errors lead to diminished therapeutic effects. Therefore, it is important to detect and prevent these errors. In the present study, we used the one-class support vector machine (OCSVM), one of the most common unsupervised machine learning algorithms for anomaly detection, to identify overdose and underdose prescriptions. We extracted prescription data from electronic health records in Kyushu University Hospital between Jan. 1, 2014 and Dec. 31, 2019. We constructed an OCSVM model for each of the 21 candidate drugs using three features: age, weight, and dose. Clin. overdose and underdose prescriptions, which were identified and rectified by pharmacists before administration, were collected. Synthetic overdose and underdose prescriptions were created using the maximum and min. doses, defined by drug labels or the UpToDate database. We applied these prescription data to the OCSVM model and evaluated its detection performance. We also performed comparative anal. with other unsupervised outlier detection algorithms (local outlier factor, isolation forest, and robust covariance). Twenty-seven out of 31 clin. overdose and underdose prescriptions (87.1%) were detected as abnormal by the model. The constructed OCSVM models showed high performance for detecting synthetic overdose prescriptions (precision 0.986, recall 0.964, and F-measure 0.973) and synthetic underdose prescriptions (precision 0.980, recall 0.794, and F-measure 0.839). In comparative anal., OCSVM showed the best performance. Our models detected the majority of clin. overdose and underdose prescriptions and demonstrated high performance in synthetic data anal. OCSVM models, constructed using features such as age, weight, and dose, are useful for detecting overdose and underdose prescriptions. In the part of experimental materials, we found many familiar compounds, such as trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Product Details of 23828-92-4)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) is a medication indicated to alleviate chest congestion associated with conditions that include bronchitis, pneumonia, bronchospasm asthma, cough, and allergy.Product Details of 23828-92-4 Preclinically, ambroxol, the active ingredient of Mucosolvan, has been shown to increase respiratory tract secretion.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pieckowski, Michal’s team published research in Talanta in 2020 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.SDS of cas: 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

SDS of cas: 23828-92-4On May 1, 2020 ,《Combination of large volume sample stacking with polarity switching and cyclodextrin electrokinetic chromatography (LVSS-PS-CDEKC) for the determination of selected preservatives in pharmaceuticalsã€?appeared in Talanta. The author of the article were Pieckowski, Michal; Kowalski, Piotr; Baczek, Tomasz. The article conveys some information:

In this study, a large volume sample stacking (LVSS) with polarity switching (PS) and cyclodextrin electrokinetic chromatog. (CDEKC) method has been developed for the simultaneous separation and determination of 8 preservatives: methylparaben (MP), ethylparaben (EP), propylparaben (PP), butylparaben (BP), isobutylparaben (IBP), sorbic acid (SA), benzoic acid (BA), p-hydroxybenzoic acid (PHBA) in pharmaceuticals. The effects of some typical parameters such as sample volume, applied voltage, composition and pH of the running buffer and organic modifier concentration were examined and optimized. Moreover, the impact of type and concentration of cyclodextrin as electrolyte modifiers was also investigated. The detection limits of analytes for the elaborated LVSS-PS-CDEKC method were found to be in 0.8-5 ng mL-1 range, which were around 500 times lower than normal CDEKC without preconcentration technique. All analytes were completely resolved in less than 11 min in an uncoated fused-silica capillary of 75μm internal diameter (I.D) x 50 cm length. The electrophoretic separation was performed in a 2 mM α-cyclodextrin and 25 mM tetraborate system (pH = 9.3) with an applied voltage of 25 kV. The established method was validated and confirmed to be applicable for the determination of the preservatives in a quality control of pharmaceuticals.trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4SDS of cas: 23828-92-4) was used in this study.

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.SDS of cas: 23828-92-4 It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Manyu’s team published research in AAPS PharmSciTech in 2020 | CAS: 23828-92-4

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Electric Literature of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

《Exploring the Potential of Hydrophilic Matrix Combined with Insoluble Film Coating: Preparation and Evaluation of Ambroxol Hydrochloride Extended Release Tabletsã€?was written by Hu, Manyu; Zhu, Zhuangzhi; Wu, Yubo; Meng, Qingqing; Luo, Jing; Wang, Hao. Electric Literature of C13H19Br2ClN2O And the article was included in AAPS PharmSciTech on April 30 ,2020. The article conveys some information:

To explore the potential utility of combination of hydrophilic matrix with membrane-controlled technol., the present study prepared tablets of a water-soluble model drug (ambroxol hydrochloride), through process of direct compression and spray coating. Single-factor experiments were accomplished to optimize the formulation. In vivo pharmacokinetics was then performed to evaluate the necessity and feasibility of further development of this simple process and low-cost approach. Various release rates could be easily obtained by adjusting the viscosity and amount of hypromellose, pore-former ratios in coating dispersions and coating weight gains. Dissolution profiles of coated tablets displayed initial delay, followed by near zero-order kinetics. The pharmacokinetic study of different formulations showed that lag time became longer as the permeability of coating membrane decreased, which was consistent with the in vitro drug release trend. Besides, in vitro/in vivo correlation study indicated that coated tablets exhibited a good correlation between in vitro release and in vivo absorption. The results, therefore, demonstrated that barrier-membrane-coated matrix formulations were extremely promising for further application in industrialization and commercialization. After reading the article, we found that the author used trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4Electric Literature of C13H19Br2ClN2O)

trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride(cas: 23828-92-4) enhances pulmonary surfactant production and stimulates ciliary activity.Electric Literature of C13H19Br2ClN2O It promotes mucus clearance, facilitates expectoration and eases productive cough, allowing patients to breathe.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts