Tag: 300-400

Study of dehydration and water states in new and worn soft contact lens materials was written by Krysztofiak, Katarzyna;Szyczewski, Andrzej. And the article was included in Optica Applicata in 2014.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The purpose of this study was to examine the in vitro dehydration characteristics of new and worn conventional and silicone-hydrogel contact lenses. Four contact lens materials were investigated: three conventional hydrogels (etafilcon, nelfilcon, omafilcon) and one silicone-hydrogel (narafilcon). Gravimetric data were obtained with anal. balance with 1 min intervals. Quant. parameters of water content and dehydration rate were calculated allowing quant. description of dehydration process. Differential scanning calorimetry was used to monitor changes in water states in samples studied. As expected, dehydration behavior of each material is different in terms of mean dehydration rate values and phases of dehydration. Gravimetric data allowed us to distinguish three phases of dehydration. Interestingly, the effect of the osmolality of storing solutions on dehydration was found – lenses stored in hyperosmotic solutions needed more time to achieve equilibrium with the environment. Effect of wearing on dehydration patterns and water properties was confirmed. In worn samples, a decrease in water content was observed Addnl., there was a change in water structure after 6 h of wearing in all lenses studied. This behavior may be ascribed to tear film components deposition and changes in surface wettability that appear during wearing. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polycationic Nanoparticles for siRNA Delivery: Comparing ARGET ATRP and UV-Initiated Formulations was written by Forbes, Diane C.;Peppas, Nicholas A.. And the article was included in ACS Nano in 2014.Product Details of 109-17-1 This article mentions the following:

In this work, we develop and evaluate polycationic nanoparticles for the delivery of small interfering RNA (siRNA). Delivery remains a major challenge for translating siRNA to the clinic, and overcoming the delivery challenge requires effective siRNA delivery vehicles that meet the demands of the specific delivery strategy. Crosslinked polycationic nanoparticle formulations were synthesized using ARGET ATRP or UV-initiated polymerization The one-step, one-pot, surfactant-stabilized monomer-in-water synthesis technique may provide a simpler and faster alternative to complicated, multistep techniques and an alternative to methods that rely on toxic organic solvents. The polymer nanoparticles were synthesized using the cationic monomer 2-(diethylamino)ethyl methacrylate, the hydrophobic monomer tert-Bu methacrylate to tune pH responsiveness, the hydrophilic monomer poly(ethylene glycol) Me ether methacrylate to improve biocompatibility, and crosslinking agent tetraethylene glycol dimethacrylate to enhance colloidal stability. Four formulations were evaluated for their suitability as siRNA delivery vehicles in vitro with the human embryonic kidney cell line HEK293T or the murine macrophage cell line RAW264.7. The polycationic nanoparticles demonstrated efficient and rapid loading of the anionic siRNA following complexation. Confocal microscopy as well as flow cytometry anal. of cells treated with polycationic nanoparticles loaded with fluorescently labeled siRNA demonstrated that the polycationic nanoparticles promoted cellular uptake of fluorescently labeled siRNA. Knockdown experiments using polycationic nanoparticles to deliver siRNA demonstrated evidence of knockdown, thus demonstrating potential as an alternative route to creating polycationic nanoparticles. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Product Details of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recent advances in managing overactive bladder. was written by Araklitis, George;Baines, Georgina;da Silva, Ana Sofia;Robinson, Dudley;Cardozo, Linda. And the article was included in F1000Research in 2020.HPLC of Formula: 128607-22-7 This article mentions the following:

Overactive bladder syndrome (OAB) is defined as urinary urgency, usually accompanied by frequency and nocturia, with or without urgency incontinence, in the absence of urinary tract infection or other obvious pathology. In this review, we focus on recent advances in the management of OAB. We examine the evidence on the effect of anticholinergic load on OAB patients. Advances in medical treatment include a new beta-3 agonist, vibegron, which is thought to have fewer drug interactions than mirabegron. Treatment of genitourinary syndrome of the menopause with oestrogens and ospemifene have also shown promise for OAB. Botulinum toxin has been shown to be an effective treatment option. We discuss the new implantable neuromodulators that are on the market as well as selective bladder denervation and laser technology. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7HPLC of Formula: 128607-22-7).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 128607-22-7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommendation to include hydroxyethyl (meth)acrylate in the British baseline patch test series was written by Rolls, S.;Chowdhury, M. M.;Cooper, S.;Cousen, P.;Flynn, A. M.;Ghaffar, S. A.;Green, C. M.;Haworth, A.;Holden, C.;Johnston, G. A.;Naidoo, K.;Orton, D. I.;Reckling, C.;Sabroe, R. A.;Scorer, M.;Stone, N. M.;Thompson, D.;Wakelin, S.;Wilkinson, M.;Buckley, D. A.. And the article was included in British Journal of Dermatology in 2019.Synthetic Route of C16H26O7 This article mentions the following:

(Meth)acrylates are potent sensitizers and a common cause of allergic contact dermatitis (ACD). The frequency of (meth)acrylate ACD has increased with soaring demand for acrylic nails. A preliminary audit has suggested a significant rate of pos. patch tests to (meth)acrylates using aimed testing in patients providing a clear history of exposure. To determine whether inclusion of 2-hydroxyethyl methacrylate (2-HEMA) 2% in petrolatum (pet.) in the baseline series detects cases of treatable (meth)acrylate ACD. During 2016-2017, 15 U.K. dermatol. centers included 2-HEMA in the extended baseline patch test series. Patients with a history of (meth)acrylate exposure, or who tested pos. to 2-HEMA, were selectively tested with a short series of eight (meth)acrylate allergens. In total 5920 patients were consecutively patch tested with the baseline series, of whom 669 were also tested with the (meth)acrylate series. Overall, 102 of 5920 tested pos. to 2-HEMA and 140 to at least one (meth)acrylate. Had 2-HEMA been excluded from the baseline series, (meth)acrylate allergy would have been missed in 36 of 5920. The top (meth)acrylates eliciting a pos. reaction were 2-HEMA, 2-hydroxypropyl methacrylate and 2-hydroxyethyl acrylate. 2-HEMA 2% pet. be added to the British baseline patch test series. We also suggest a standardized short (meth)acrylate series, which is likely to detect most cases of (meth)acrylate allergy. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Synthetic Route of C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Synthetic Route of C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A precision structured smart hydrogel for sensing applications was written by Menges, J.;Kleinschmidt, P.;Bart, H.-J.;Oesterschulze, E.. And the article was included in Journal of Applied Physics (Melville, NY, United States) in 2017.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The authors report on a macroinitiator based smart hydrogel film applied on a microcantilever for sensing applications. The studied hydrogel features a comparatively wide dynamic range for changes in the electrolyte’s ionic strength. Also, it offers a simple spin coating process for thin film deposition as well as the capability to obtain high aspect ratio microstructures by reactive ion etching. This makes the hydrogel compatible to microelectromech. system integration. As a proof of concept, the authors study the response of hydrogel functionalized cantilevers in aqueous sodium chloride solutions of varying ionic strength. In contrast to the majority of hydrogel materials reported in the literature, the authors’ hydrogel still responds in high ionic strength environments. This may be of future interest for sensing e.g., in sea water or physiol. environments like urine. (c) 2017 American Institute of Physics. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bacteria incorporated with calcium lactate pentahydrate to improve the mortar properties and self-healing occurrence was written by Chaerun, Siti Khodijah;Syarif, Ridwan;Wattimena, Ridho Kresna. And the article was included in Scientific Reports in 2020.Synthetic Route of C6H20CaO11 This article mentions the following:

Concrete can be harmful to the environment due to its high energy consumption and CO₂ emission and also has a potential crack formation, which can promote a drop in its strength. Therefore, concrete is considered as a non-sustainable material. The mechanisms by which bacterial oxidation of organic carbon can precipitate calcite that may fill the voids and cracks on cement-based materials have been extensively investigated to prevent and heal the micro-cracks formation. Hence, this study focused on utilizing a new alkaliphilic bacterial strain indigenous to an Indonesian site, Lysinibacillus sphaericus strain SKC/VA-1, incorporated with calcium lactate pentahydrate, as a low-cost calcium source, with various bacterial inoculum concentrations The bacterium was employed in this study due to its ability to adapt to basic pH, thus improving the phys. properties and rejuvenating the micro-cracks. Exptl., the addition of calcium lactate pentahydrate slightly affected the mortar properties. Likewise, bacteria-incorporated mortar exhibited an enhancement in the phys. properties of mortar. The highest improvement of mech. properties (an increase of 45% and 36% for compressive and indirect tensile strength, resp.) was achieved by the addition of calcium lactate pentahydrate incorporated with 10% volume/volume bacterial inoculum [about 7 × 107 CFU/mL (colony-forming unit/mL)]. The self-healing took place more rapidly on bacterial mortar supplemented with calcium lactate pentahydrate than on the control specimen. XRD anal. demonstrated that the mineralogical composition of self-healing precipitates was primarily dominated by calcite (CaCO₃), indicating the capacity of L. sphaericus strain SKC/VA-1 to precipitate calcite through organic carbon oxidation for self-healing the artificial crack on the mortar. To our knowledge, this is the first report on the potential utilization of the bacterium L. sphaericus incorporated with calcium lactate pentahydrate to increase the mortar properties, including its self-healing ability. However, further study with the water-cement ratio variation is required to investigate the possibility of using L. sphaericus and calcium lactate pentahydrate as an alternative method rather than reducing the water-cement ratio to enhance the mortar properties. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Synthetic Route of C6H20CaO11).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C6H20CaO11

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An update on drugs for the treatment of menopausal symptoms was written by Palacios, Santiago;Mejias, Andrea. And the article was included in Expert Opinion on Pharmacotherapy in 2015.Category: alcohols-buliding-blocks This article mentions the following:

Vasomotor symptoms (VMS) and the genitourinary syndrome of menopause (GSM) are recognized as the most frequent and bothersome symptoms associated with menopause. There are different treatments for both groups of symptoms, being necessary to individualize them. There are different therapies for VMS including hormonal treatments with estrogen, with and without progestins; the new alternative, tissue-selective estrogen complex (TSEC), tibolone, phytoestrogens and only progestins. Evidence also shows efficacy with selective serotonin reuptake inhibitors. Other nonhormonal alternatives exist as second-line treatments, all with not conclusive results. The GSM can be treated with nonhormonal treatments such as vaginal lubricants and moisturizers, other alternatives as vaginal laser needs to have more evidence. On the other hand, there is the possibility to use the hormonal treatments with systemic or local estrogen, which are the most effective treatment, the TSEC and the newest selective estrogen receptor modulator (SERM), ospemifene. Therapies with testosterone and dehydroepiandrosterone (DHEA) are still under study. The GSM can be treated with nonhormonal treatments such as vaginal lubricants and moisturizers, and other alternatives as vaginal laser need to have more evidence. On the other hand, there is the possibility to use the hormonal treatments with systemic or local estrogen, which are the most effective treatment, the TSEC and the newest SERM, ospemifene. Therapies with testosterone and DHEA are still under study. The increasing numbers of therapies for menopausal symptoms open up new options, but we must individualize treatments. New possibilities arise in patients who did not have them and which can improve compliance and is also important to design strategies using combined or sequential treatments. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Category: alcohols-buliding-blocks).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transport and delivery of interferon-a through epithelial tight junctions via pH-responsive poly(methacrylic acid-grafted-ethylene glycol) nanoparticles was written by Caldorera-Moore, Mary;Vela Ramirez, Julia E.;Peppas, Nicholas A.. And the article was included in Journal of Drug Targeting in 2019.Recommanded Product: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Whereas significant advancements have been made in our fundamental understanding of cancer, they have not yet translated into effective clin. cancer treatments. One of the areas that has the potential to improve the efficacy of cancer therapies is the development of novel drug delivery technologies. In particular, the design of pH-sensitive polymeric complexation hydrogels may allow for targeted oral delivery of a wide variety of chemotherapeutic drugs and proteins. In this work, poly(methacrylic acid-grafted-ethylene glycol) hydrogel nanoparticles were synthesized, characterised, and studied as matrix-type, diffusion-controlled, pH-responsive carriers to enable the oral delivery of the chemotherapeutic agent interferon alpha (IFN-a). The biophys. mechanisms controlling the transport of IFN-a were investigated using a Caco-2/HT29-MTX co-culture as a gastrointestinal (GI) tract model. The synthesized nanoparticles exhibited pH-responsive swelling behavior and allowed the permeation of IFN-a through the tight junctions of the developed cellular GI epithelium model. These studies demonstrate the capabilities of these particles to contribute to the improved oral delivery of protein chemotherapeutics. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Recommanded Product: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mechanically improved sol-gel derived methacrylate-siloxane hybrid materials with urethane linkage was written by Kim, Yun Hyeok;Choi, Gwang-Mun;Kim, Yong Ho;Bae, Byeong-Soo. And the article was included in Journal of Sol-Gel Science and Technology in 2019.Formula: C16H26O7 This article mentions the following:

UV-curable and highly condensed (>86%) methacrylate Ph oligo-siloxane (MPO) was synthesized by non-hydrolytic sol-gel condensation reaction between methacrylate and Ph silane precursor. The MPO resin was then cured by an UV-initiated free-radical polymerization to fabricate a transparent (>90% at 550 nm) methacrylate-siloxane hybrid material (methacrylate hybrimer). An urethane butanediol dimethacrylate (UBDM) monomer was synthesized as a cross-linker into the methacrylate hybrimer networks without micro-phase separation The UBDM increased methacrylate conversion and mech. properties due to the hydrogen bonding of the urethane linkage. The hardness, modulus, and strength were improved by UBDM insertion, the flexibility was even increased with 140% elongation, compared to neat MH. In addition, a storage modulus related to the thermo-mech. properties was also enhanced by a denser cross-linkage with the urethane linkage. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Direct and indirect eluates from bulk fill resin-based-composites was written by Durner, Juergen;Schrickel, Klaus;Watts, David C.;Becker, Marc;Draenert, Miriam E.. And the article was included in Dental Materials in 2022.SDS of cas: 109-17-1 This article mentions the following:

To compare elutable substances directly released from bulk-fill (BF) resin-based composites (RBCs) with indirect elution from teeth restored with a BF composite. In addition to (co)monomers, the anal. focus was on other potentially toxic ingredients or impurities. Furthermore, the barrier function of the residual dentin/adhesive layer was studied.Six BF-RBC materials were studied. For each material subgroup, ten human third molar teeth with standard Class-I occlusal cavities were prepared and provided with a three-step adhesive system and the resp. composite restoration (tooth groups). Same sized control specimens of the restorative material were prepared (′direct BF-RBC′ groups). Each specimen was placed in an elution chamber such that the elution media (ethanol/water, 3:1) only contacted the tooth root or 3/4 height of each specimen. They were incubated at 37 °C for up to 7 d. Samples of eluate were taken after 1, 2, 4 and 7 d and were analyzed by high-temperature gas chromatog./mass spectrometry.(Co)monomers such as Bisphenol A ethoxylate dimethacrylate (bisEMA) or tetraethylene glycol dimethacrylate (TEEGDMA) were mostly found in the eluates of the ′direct BF-RBC′ groups in statistically significantly greater amounts than in the eluates of the ′tooth groups′. The residual dentin and/or adhesive layers acted as a diffusion barrier for most of the substances except for triethylene glycol dimethacrylate (TEGDMA) or diethylene glycol dimethacrylate (DEGDMA). For TEGDMA up to 3 orders of magnitude more were found in the ′tooth groups′ compared to the ′direct BF-RBC′ groups, evidently released by the adhesive system.Substances of Very High Concern (SVHC) including TINUVIN 328 and BPA were found mainly in the eluates of ′direct BF-RBC′ groups.For estimation of biocompatibility, a total system, specifically BF-RBC + adhesive, should always be investigated since individual considerations, such as only elution from a BF-RBC, do not correctly reflect the total clin. situation. The focus of elution tests should not only be on the co(monomers), but also on other ingredients or impurities that may be released. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1SDS of cas: 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts