Tag: 300-400

Category: alcohols-buliding-blocks《Biomass antioxidant silica supported tea polyphenols with green and high-efficiency free radical capturing activity for rubber composites》 was published in 2022. The authors were Guo, Xiaohui;Luo, Yuanfang;Chen, Lijuan;Zhang, Bowen;Chen, Yongjun;Jia, Demin, and the article was included in《Composites Science and Technology》. The author mentioned the following in the article:

To achieve simultaneous environment protecting, high-efficiency rubber antioxidant is still an enormous and long-term challenge in green rubber industry. Hence, a novel biomass antioxidant (denoted as silica-s-TP) was obtained by silica supported with green tea polyphenols exhibited prominent anti-aging functionality. Silica-s-TP hybrid particles were uniformly dispersed in rubber matrix with remarkable interfacial interaction, and the high-efficiency free radical capturing activity was stem from the construction of polyphenol structure on silica surface. Therefore, silica-s-TP brought to simultaneously enhance the performance of anti-aging property of SBR composites and surpass the achievements of the com. antioxidants. Interesting, the biomass antioxidant silica-s-TP exhibited remarkable free radical-scavenging activities and stability in SBR matrix than the TP directly added in SBR matrix, due to the chem. anchor TP on silica surface. Such clay surface treatment technol. with natural antioxidant may also bring to a new path for the preparation of green and eco-friendly functionalization rubber additives. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Category: alcohols-buliding-blocks2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Formula: C23H32O2《Evaluation of the antimicrobial activity and compressive strength of a dental cement modified using plant extract mixture》 was published in 2020. The authors were Singer, Lamia;Bierbaum, Gabriele;Kehl, Katja;Bourauel, Christoph, and the article was included in《Journal of Materials Science: Materials in Medicine》. The author mentioned the following in the article:

Literature lacks sufficient data regarding addition of natural antibacterial agents to glass ionomer cement (GICs). Hence, the aim of the study was to increase the antimicrobial properties of GICs through its modification with mixture of plant extracts to be evaluated along with an 0.5% chlorohexidine-modified GIC (CHX-GIC) with regard to biol. and compressive strength properties. Conventional GIC (freeze-dried version) and CHX were used. Alc. extract of Salvadora persica, Olea europaea, and Ficus carcia leaves were prepared using a Soxhlet extractor for 12 h. The plant extract mixture (PE) was added in three different proportions to the water used for preparation of the dental cement (Group 1:1 PE, 2:1 PE, and 1:2 PE). Specimens were then prepared and tested against the unmodified GIC (control) and the 0.5% CHX-GIC. Chem. anal. of the extract mixture was performed using Gas chromatog.-mass spectrometry. Antimicrobial activity was evaluated using agar diffusion assay against Micrococcus luteus and Streptoccocus mutans. Compressive strength was evaluated according to ISO 9917-1:2007 using a Zwick testing machine at a crosshead speed of 0.5 mm/min. Antimicrobial activity against Streptoccocus mutans was significantly increased for all the extract-modified materials compared to the unmodified cement, and the highest concentration was comparable to the CHX-GIC mixture The activity against Micrococcus luteus was also significantly increased, but only for the material with the highest extract concentration, and here the CHX-GIC group showed statistically the highest antimicrobial activity. Compressive strength results revealed that there was no statistically significant difference between the different mixtures and the control except for the highest tested concentration that showed the highest mean values. The plant extracts (PEs) enhanced the antimicrobial activity against S. mutans and also against M. luteus in the higher concentration while compressive strength was improved by addition of the PE at higher concentrations To complete the study, the researchers used 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Formula: C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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HPLC of Formula: 119-47-1In 2022, Zhan, Lingxi;Huang, Huanfang;Zhao, Shizhen;Wang, Zuwu;Zhang, Gan;Cheng, Hairong published 《Comparison of atmospheric polycyclic aromatic hydrocarbons (PAHs) over six years at a CAWNET background site in central China: Changes of seasonal variations and potential sources》. 《Chemosphere》published the findings. The article contains the following contents:

Total suspended particles (TSP) and gaseous samples were collected by using a high-volume sampler from March 2012 to March 2013 and Jan. 2018 to Jan. 2019 at a background site (Jinsha, JSH) in central China to study the chem. characteristics, seasonal variations, and potential sources of polycyclic aromatic hydrocarbons (PAHs). The average concentrations of ∑15PAHs were 24.55 ± 9.19 ng m-3 in 2012/2013 and 20.98 ± 9.77 ng m-3 in 2018/2019. Low-ring PAHs were more concentrated in gas phase while high-ring PAHs were prone into particle phase. The concentrations of PAHs in the two sampling years were high in winter but low in summer and autumn. The relationships between the gas concentrations of PAHs and temperature indicated that most PAHs were influenced by long-range atm. transport (LRAT) in 2012/2013 and in 2018/2019, excluding anthracene (Ant) and pyrene (Pyr) were partially affected by air-surface re-volatilization in 2012/2013. The source of atm. PAHs at JSH was similar in 2012/2013 and 2018/2019,which was mainly due to the LRAT of PAHs emitted from biomass/fossil fuel combustion in the northern area of JSH. From 2012/2013 to 2018/2019, there was no significant difference between the concentrations of PAHs in spring and winter, whereas the concentrations of PAHs decreased from 2012/2013 to 2018/2019 in summer. In all, the control of PAHs at the source region was partially effective from 2012/2013 to 2018/2019. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

HPLC of Formula: 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Marchetti, Sara;Mollerup, Steen;Gutzkow, Kristine Bjerve;Rizzi, Cristiana;Skuland, Tonje;Refsnes, Magne;Colombo, Anita;Oevrevik, Johan;Mantecca, Paride;Holme, Joern Andreas published 《Biological effects of combustion-derived particles from different biomass sources on human bronchial epithelial cells》. The research results were published in《Toxicology In Vitro》 in 2021.Computed Properties of C23H32O2 The article conveys some information:

Combustion-derived particles (CDPs), in particular from traffic, are regarded as a central contributor for adverse health effects linked to air pollution. Recently, also biomass burning has been recognized as an important source for CDPs. Here, the effects of CDPs (PM10) originating from burning of pellet, charcoal and wood on key processes associated to lung carcinogenesis were explored. Human bronchial epithelial cells (HBEC3-KT) were exposed to 2.5μg/cm2 of CDPs for 24 h and biol. effects were examined in terms of cytotoxicity, inflammation, epithelial to mesenchymal transition (EMT)-related effects, DNA damage and genotoxicity. Reduced cell migration, inflammation and modulation of various PM-associated genes were observed mainly after exposure to wood and pellet. In contrast, only particles from pellet burning induced alteration in cell proliferation and DNA damage, which resulted in cell cycle alterations. Charcoal instead, appeared in general less effective in inducing pro-carcinogenic effects. These results illustrate differences in the toxicol. profile due to the CDPs source. The different chem. compounds adsorbed on CDPs seemed to be central for particle properties, leading to an activation of various cellular signaling pathways involved in early steps of cancer progression. The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Computed Properties of C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Song, Xue-Chao;Canellas, Elena;Dreolin, Nicola;Goshawk, Jeff;Nerin, Cristina published 《A Collision Cross Section Database for Extractables and Leachables from Food Contact Materials》 in 2022. The article was appeared in 《Journal of Agricultural and Food Chemistry》. They have made some progress in their research.Electric Literature of C23H32O2 The article mentions the following:

The chems. in food contact materials (FCMs) can migrate into food and endanger human health. In this study, we developed a database of traveling wave collision cross section in nitrogen (^TWCCS_N2) values for extractables and leachables from FCMs. The database contains a total of 1038 ^TWCCS_N2 values from 675 standards including those commonly used additives and nonintentionally added substances in FCMs. The ^TWCCS_N2 values in the database were compared to previously published values, and 85.7, 87.7, and 64.9% [M + H]⁺, [M + Na]⁺, and [M – H]^– adducts showed deviations <2%, with the presence of protomers, post-ion mobility spectrometry dissociation of noncovalent clusters and inconsistent calibration are possible sources of CCS deviations. Our exptl. ^TWCCS_N2 values were also compared to CCS values from three prediction tools. Of the three, CCSondemand gave the most accurate predictions. The ^TWCCS_N2 database developed will aid the identification and differentiation of chems. from FCMs in targeted and untargeted anal. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Electric Literature of C23H32O22,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2021, Wang, Jisheng;Bao, Binghao;Meng, Fanchao;Deng, Sheng;Dai, Hengheng;Feng, Junlong;Li, Haisong;Wang, Bin published 《To study the mechanism of Cuscuta chinensis Lam. And Lycium barbarum L. in the treatment of asthenospermia based on network pharmacology》. 《Journal of Ethnopharmacology》published the findings. The article contains the following contents:

Cuscuta chinensis Lam. and Lycium barbarum L.(SC-FL) is a commonly used kidney tonic Chinese medicine combination that is widely used in the clin. treatment of oligoasthenospermia. However, its specific mechanism remains unclear and requires in-depth study. To explore the potential targets of SC-FL in the treatment of oligoasthenospermia using network pharmacol., and to verify the results with in vivo and in vitro experiments A herb-compound-target-disease network and PPI network were constructed with Cytoscape software. The targets of SC-FL for the treatment of male sterility were introduced into a bioinformatics annotation database, and the GO and KEGG databases were used for pathway enrichment anal. Subsequently, Tripterygium wilfordii Hook. f. (GTW) polyglycoside was used to induce a spermatogenic dysfunction model in GC-1 spg cells and SD male rats in in vitro and in vivo experiments, resp. The SC-FL and PI3K pathway inhibitor LY294002 was used to intervene in the spermatogenic dysfunction model to detect the expression of proteins and mRNA related to the PI3K pathway and to detect the indicators related to proliferation and apoptosis. In in vitro experiments, the percentage of spermatogenic cells and the proportion of GC-1 spg cells at G0/G1 and G2/M stages in the model group (GTW group) and the inhibitor group (LY group) were significantly decreased (P < 0.01) compared with the blank control group (NC group). The apoptosis rate of the GTW group was significantly increased (P < 0.01). The ultrastructures of GC-1 spg cells in the GTW group and LY group were obviously destroyed. Compared with the GTW group, the SC-FL group had a significantly reduced apoptosis rate of GC-1 spg cells, reduced percentage of cells in S phase, and a significantly improved mitochondrial membrane potential. SC-FL can repair the ultrastructure of GC-1 spg cells damaged by GTW. The above effects of SC-FL are closely related to up-regulation of GFRa1, RET, PI3K, p-AKT, and Bcl-2 and down-regulation of BAD and BAX proteins and mRNA expression. In vivo, compared with the GTW group, the body mass, testicular mass, and epididymal weight of the GTW + SC-FL group were significantly increased (P < 0.01). Sperm concentrations and the PR + NP of GTW + SC-FL were significantly higher than in the GTW group (P < 0.01 or P < 0.05). FSH, LH, and T levels in the GTW + SC-FL and LY + SC-FL groups were significantly higher than those in the GTW and LY group (P < 0.01 or P < 0.05). HE staining results showed that the morphol. of testicular tissue in the GTW + SC-FL and LY + SC-FL groups was superior to that in the GTW and LY group. The above effects of SC-FL are closely related to the up-regulation of proteins and mRNA expression of PI3K, p-AKT, and Bcl-2. Through the PI3K/Akt signaling pathway, SC-FL up-regulates GFRa1, RET, PI3K, p-AKT, and Bcl-2, and down-regulates the expression of BAD and BAX proteins and mRNA, thus reducing the percentage of GC-1 spg cells in S-phase, significantly increasing the mitochondrial membrane potential, significantly reducing cell apoptosis, and improving sperm counts and viability.2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) were involved in the experimental procedure.

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Recommanded Product: 2,2-Methylenebis(6-tert-butyl-p-cresol)In 2022, Dai, Chenbo;Yang, Libin;Wang, Jun;Li, Dezhen;Zhang, Yalei;Zhou, Xuefei published 《Enhancing anaerobic digestion of pharmaceutical industries wastewater with the composite addition of zero valent iron (ZVI) and granular activated carbon (GAC)》. 《Bioresource Technology》published the findings. The article contains the following contents:

Anaerobic digestion of pharmaceutical wastewater is challenged by its contained toxic compounds which limits the stability and efficiency of methane production and organic degradation In this study, zero valent iron (ZVI) and granular activated carbon (GAC) were added with different strategies to improve anaerobic digestion of pharmaceutical wastewater. The results confirmed synergy effects of ZVI + GAC for both COD removal (increased by 13.4%) and methane production (increased by 11.0%). Furthermore, ZVI + GAC improved the removal of pharmaceutical intermediates, in particular, the residues (%) of dehydroepiandrosterone (DHEA) and 2,2′-methylenebis(6-tert-butyl-4-methylphenol) were only 30.48 ± 6.53 and 39.92 ± 4.50, and effectively reduced biotoxicity. The promoted results were attributed to the establishment of direct interspecies electron transfer (DIET). Microbial community anal. revealed that ZVI + GAC decreased species evenness and richness in bacterial whereas increased in archaeal. The relative abundance of acetotrophic methanogens decreased but hydrogenotrophic and methylotrophic methanogens increased, which broadening the pathway of methane production The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Recommanded Product: 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Xu, Min;Wu, Ruixia;Liang, Yuan;Fu, Ke;Zhou, You;Li, Xiaoli;Wu, Lei;Wang, Zhang published 《Protective effect and mechanism of Qishiwei Zhenzhu pills on cerebral ischemia-reperfusion injury via blood-brain barrier and metabonomics》. The research results were published in《Biomedicine & Pharmacotherapy》 in 2020.Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol) The article conveys some information:

Stroke is an acute cerebrovascular disease caused by the sudden rupture of cerebral blood vessels or vascular obstruction from brain tissue damage or dysfunction, thereby preventing blood flow into the brain. Cerebral ischemia-reperfusion injury (CI/RI), a common syndrome of ischemic stroke, is a complex pathol. process whose physiol. mechanism is still unclear. Qishiwei Zhenzhu pills (QSW), a famous Tibetan medicine preparation, has the effect of tranquilizing by heavy settling, dredging channels and activating collaterals, harmonizing Qi and blood, restoring consciousness, and inducing resuscitation. Here, we investigated the protective effect of QSW on CI/RI in rats and its potential mechanism. First, the volatile and liposol. components in QSW were determined using gas chromatog.-mass spectrometry (GC-MS). After 24 h of CI/RI, the neuroprotective effect was determined by evaluating the neurol. function, cerebral infarction, histopathol., and blood-brain barrier (BBB) function. Immunofluorescence, real-time quant. PCR (RT-qPCR), and western blot (WB) were used to detect the expression of matrix metalloproteinase 9 (MMP-9), claudin-5, and occludin. Finally, GC-MS metabonomics was used to identify different metabolites and analyze metabolic pathways. The results showed that 88 volatile components and 63 liposol. components were detected in QSW. Following the exptl. stroke operation, it was observed that rats administered QSW pretreatment had improved neurol. function, reduced infarct volume (P < 0.01), increased Nissl bodies (P < 0.05), improved histopathol., and reduced BBB disruption. Immunofluorescence, RT-qPCR, and WB results showed that MMP-9 level in the brain tissue of the QSW pretreatment group had a decreasing trend and the expression of claudin-5 and occludin had a tendency to increase. Eleven metabolites related to lipid metabolism, fatty acid metabolism, and energy metabolism, were identified via GC-MS metabonomics. Our study shows that QSW preconditioning has a neuroprotective effect on CI/RI; however, its mechanism requires further study.2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) were involved in the experimental procedure.

Quality Control of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)《Determination of antioxidants in food and water-based food simulants by supercritical fluid chromatography》 was published in 2021. The authors were Huang, Lin;Xiao, Lei;Zhu, Yan;Shou, Dan;Jin, Micong;Han, Xinghao, and the article was included in《Fenxi Shiyanshi》. The author mentioned the following in the article:

A novel pretreatment method based on syringe for filter solid-phase extraction was developed and combined with supercritical fluid chromatog. (SFC) to determine the migration of antioxidants in packaging materials to two water-based food simulants, and applied to test real sample. The amount of sorbent and SFC conditions were optimized. Under the optimized conditions, all the studied six target antioxidants have good linearity (R²>0.999) in their resp. concentration ranges with limits of detection (LODs) ranging from 25 to 35 ng/mL. Mean recoveries of targets were between 82.0% and 96.0% in ultrapure water, and between 76.2% and 103.0% in 3% acetic acid solution, with the relative standard deviations (RSD) no more than 8.8%. The method is adaptable for analyzing the antioxidants in com. non-alc. beverage and their packaging materials (soaking in different food simulants). The experimental procedure involved many compounds, such as 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) .

Safety of 2,2-Methylenebis(6-tert-butyl-p-cresol)2,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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Smith, Paul C.;Huf, Joel P.;Williams, Christopher A. published 《Rocket Propellant Comparison: Conventional Planetary Mixing and Resonant Acoustic Mixing》 in 2022. The article was appeared in 《Propellants, Explosives, Pyrotechnics》. They have made some progress in their research.Related Products of 119-47-1 The article mentions the following:

A standard HTPB/AP/Al composite rocket propellant formulation was prepared with a conventional vertical planetary action mixer and resonant acoustic mixer (RAM). Ingredients and process conditions were standardised as much as possible to facilitate a direct comparison of the two process regimes. Cured propellant specimens were characterised for sensitiveness, ballistic properties and mech. properties at 3 temperatures (-54°C, 25°C and 74°C). No significant differences were noted for sensitiveness between the planetary and RAM mixes. A slightly lower burn rate at 1000 psi (6.89 MPa) was noted for the RAM mixes. Maximum stress results at 25°C were similar but significant differences in maximum strain and modulus were recorded. Maximum strain for the 1 Pt, 2 Gal and RAM were 7.4%, 9.1% and 17.6%, resp. Modulus results were 26.0 MPa, 19.3 MPa and 11.1 MPa, resp. Similar improvements in strain capability for the RAM propellant were recorded at -54°C and 74°C, with increases of 66% and 117%, resp. A greater strain capability results from stronger interfacial adhesion between the solid fill and the binder, which is in turn generally a result of improved wetting of solid particles. This result, therefore, indicates more thorough mixing in the case of the RAM process but this requires confirmation through a more direct examination of the underlying mechanism. And 2,2-Methylenebis(6-tert-butyl-p-cresol) (cas: 119-47-1) was used in the research process.

Related Products of 119-47-12,2′-Methylenebis(4-methyl-6-tert-butylphenol)(CAS: 119-47-1) is a natural product found in Streptomyces and Aspergillus fumigatus .

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