Tag: 300-400

Graphene-reinforced biodegradable resin composites for stereolithographic 3D printing of bone structure scaffolds was written by Feng, Zuying;Li, Yan;Hao, Liang;Yang, Yihu;Tang, Tian;Tang, Danna;Xiong, Wei. And the article was included in Journal of Nanomaterials in 2019.Recommanded Product: 109-17-1 This article mentions the following:

A biodegradable UV-cured resin has been fabricated via stereolithog. apparatus (SLA). The formulation consists of a com. polyurethane resin as an oligomer, trimethylolpropane trimethacrylate (TEGDMA) as a reactive diluent and phenylbis (2, 4, 6-trimethylbenzoyl)-phosphine oxide (Irgacure 819) as a photoinitiator. The tensile strength of the three-dimensional (3D) printed specimens is 68 MPa, 62% higher than that of the reference specimens (produced by direct casting). The flexural strength and modulus can reach 115 MPa and 5.8 GPa, resp. A solvent-free method is applied to fabricate graphene-reinforced nanocomposite. Porous bone structures (a jawbone with a square architecture and a sternum with a round architecture) and gyroid scaffold of graphene-reinforced nanocomposite for bone tissue engineering have been 3D printed via SLA. The UV-crosslinkable graphene-reinforced biodegradable nanocomposite using SLA 3D printing technol. can potentially remove important cost barriers for personalized biol. tissue engineering as compared to the traditional mold-based multistep methods. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Recommanded Product: 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of inhomogeneous spatial distribution of aroma compounds on perceived aroma intensity and human eating behavior for neutral pH gels was written by Nakao, Satomi;Ishihara, Sayaka;Nakauma, Makoto;Funami, Takahiro. And the article was included in Food Science and Technology Research in 2013.Related Products of 5743-47-5 This article mentions the following:

Effects of inhomogeneous spatial distribution of aroma compounds were investigated on the perceived aroma intensity and human eating behavior using polysaccharide gels as a food model. Gels tested were structured using gel-in-gel configuration to create different degrees of inhomogeneous spatial aroma distribution, and their pH values were set at neutral (6.7 – 6.8). There were no differences in mech. properties between the structured gels. A greater degree of inhomogeneous spatial aroma distribution increased the perceived aroma intensity, increased the duration of oral processing and suprahyoid musculature activity during oral processing, decreased the particle size of the bolus, and increased the saliva content in the bolus. Effects of pH were compared with our previous report using the same exptl. design but different pH (approx. 4.2), confirming a similar trend in the results. A strategy of food structure design for enhanced perceived aroma intensity and human eating behavior was suggested regardless of gel pH. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5Related Products of 5743-47-5).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 5743-47-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hydrogel of poly (SSNa-cross-TeEGDMA): preparation, characterization, and Swelling behavior was written by Bradai, Masika;Ould Kada, Seghier;Sebba, Fatima Zohra;Sebti, Houari. And the article was included in Pharma Chemica in 2016.Formula: C16H26O7 This article mentions the following:

Series of novel hydrogels based on sodium styrene sulfonate(SSNa) and tetraethylene glycol dimethacrylate (TeEGDMA) copolymers, were prepared by free radical crosslinking copolymerization and were characterized using Spectra of Fourier transform IR spectroscopy (FTIR), and differential scanning calorimetry (DSC). The swelling properties of these hydrogels were achieved in distilled water at different pH at 25°C, the results showed that the swelling ratio are proportional to the sodium styrene sulfonate (SSNa) percent molar composition of 40, 50 and 80 incorporated in each hydrogel, The values swelling ratio of the basic medium are higher than those observed in acidic and neutral medium. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Determination of ospemifene in human plasma by LC-MS/MS and its application to a human pharmacokinetic study was written by Yadlapalli, Siva Sankara Rao;Katari, Naresh Kumar;Manabolu Surya, Surendra Babu. And the article was included in Biomedical Chromatography in 2019.Synthetic Route of C24H23ClO2 This article mentions the following:

A highly sensitive, specific and rapid liquid chromatog.-tandem mass spectrometry (LC-MS/MS) anal. method has been developed and validated for the determination of ospemifene in human plasma using ospemifene-d4 as an internal standard Solid-phase extraction technique with Phenomenex Strata X-33 μM polymeric sorbent cartridges (30 mg/1 mL) was used to extract the analytes from the plasma. The chromatog. separation was achieved on Agilent Eclipse XDB-Ph, 4.6 × 75 mm, 3.5 μm column using the mobile phase composition of methanol and 20 mM ammonium formate buffer (90:10, volume/volume) at a flow rate of 0.9 mL/min. A detailed method validation was performed as per the US Food and Drug Administration guidelines and the calibration curve obtained was linear (r2 = 99) over the concentration range 5.02-3025 ng/mL. The API-4500 MS/MS was operated under multiple reaction monitoring mode during the anal. The proposed method was successfully applied to a pharmacokinetic study in healthy human volunteers after oral administration of an ospemifene 60 mg tablet under fed conditions. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Synthetic Route of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ospemifene, vulvovaginal atrophy, and breast cancer was written by Wurz, Gregory T.;Soe, Lin H.;DeGregorio, Michael W.. And the article was included in Maturitas in 2013.Formula: C24H23ClO2 This article mentions the following:

The incidence and severity of vulvovaginal atrophy (VVA) in postmenopausal breast cancer patients has a significant impact on quality of life. While the etiol. of VVA is primarily related to low estrogen levels seen in menopause, women with breast cancer have an added risk of VVA induced by a combination of chemotherapy, hormonal therapy, and menopause. Ospemifene is a new, non-hormonal selective estrogen receptor modulator (SERM) triphenylethylene derivative that is effective in treating VVA in postmenopausal women. Although other SERMs have antagonistic effects on the vagina, ospemifene exerts an estrogen-like effect on the vaginal epithelium. This review will focus on data demonstrating the antiestrogenic activity of ospemifene in several unique breast cancer animal models, and the implications for utilizing ospemifene in patients with breast cancer suffering from VVA. Addnl. research addressing the expanded use of ospemifene in breast cancer patients is also warranted. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fortification of buttermilk with calcium, magnesium and whey proteins was written by Ziarno, Malgorzata;Zareba, Dorota;Piskorz, Jolanta. And the article was included in Zywnosc in 2009.COA of Formula: C6H20CaO11 This article mentions the following:

The preparation of buttermilk fortified with Ca and Mg salts and whey protein concentrate (WPC-68) was studied. Different amounts of Ca lactate or citrate, Mg gluconate or hydroaspartate, and WPC or their mixtures were added to milk samples. The impact on milk thermal stability during 15-s re-pasteurization at 74°C and resulting pH was determined Protein clots were formed after the milk thermal processing. When a mixture of Ca citrate, Mg hydroaspartate, and Mg gluconate was used, it was possible to fortify the milk at least to 72 mg% Ca and ∼30 mg% Mg. The addition of the 2 Mg salts did not coagulate the milk proteins during re-pasteurization and the active acidity was pH >6.52. Buttermilk was then produced under laboratory conditions from the milk fortified according to the above procedure with the additives mixed with milk before re-pasteurization (74°C/15 s). The buttermilk sensory and physicochem. properties deteriorated during 14-day refrigerated storage at 6°C. The largest changes were found in buttermilk samples fortified with Ca citrate, Mg gluconate, and WPC. The best fortified buttermilk was made with Ca salts, Mg hydroaspartate, and WPC. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5COA of Formula: C6H20CaO11).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C6H20CaO11

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Enhanced mechanical and thermal properties of stereolithography 3D printed structures by the effects of incorporated controllably annealed anatase TiO₂ nanoparticles was written by Mubarak, Suhail;Dhamodharan, Duraisami;Divakaran, Nidhin;Kale, Manoj B.;Senthil, T.;Wu, Lixin;Wang, Jianlei. And the article was included in Nanomaterials in 2020.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

Fabrication of low-cost, durable and efficient metal oxide nanocomposites were successfully synthesized and reinforced with photo-resin via 3-dimensional printing. Here, we put forward a novel approach to enhance the mech. and thermal behaviors of stereolithog. (SLA) 3D printed architecture by adding TiO₂ nanoparticles (TNPs) in different crystalline phases (anatase and rutile), which were obtained at different annealing temperatures from 400°C to 1000°C. The heat-treated anatase TNPs were scrutinized by X-ray diffraction, XPS, Raman spectroscopy, diffusive reflectance spectroscopy, and transmission electron microscopy anal. Among all the samples, at 800°C, annealed anatase TNPs exposed a highly crystalline anatase phase, having a low energy band gap and a comparably high tensile strength (47.43 MPa) and high elastic modulus (2.261 GPa) for the 3D printed samples, showing improvement by 103% and 32%, resp., compared with the printed pristine stereolithog. resin (SLR) sample. Moreover, enhanced storage modulus and tan δ values were achieved via the better interfacial interactions between the incorporated nanofillers and the SLR matrix. In addition to this, enhanced thermal conductivity and thermal stability of the SLR matrix were also noted. The low energy bandgap and nanoscale size of the fillers helped to achieve good dispersion and allowed the UV light to penetrate at a maximum depth through the photo resin. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visible-Light-Promoted Desulfurative Alkylation of Alkyl Thianthrenium Salts with Activated Olefins was written by Li, Xin;Si, Weili;Liu, Zhanhui;Qian, Haitao;Wang, Tingxue;Leng, Shengnan;Sun, Jinwei;Jiao, Yan;Zhang, Xuan. And the article was included in Organic Letters in 2022.Computed Properties of C24H23ClO2 This article mentions the following:

Reactions involving an alkyl radical generated from a primary alc. by photochem. are rare and challenging. Herein, authors present a photocatalyst- and metal-free approach that enables the generation of an alkyl radical from the corresponding alc. and the subsequent C(sp³)-C(sp³) bond formation with activated olefin, via an alkyl thianthrenium salt/Hantzsch ester electron donor-acceptor complex. This protocol for the conversion of a C-OH bond to a C-C bond is highly functionality tolerant and can successfully be used in late-stage functionalization of pharmaceuticals. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Computed Properties of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Stoichiometric and kinetic analysis of extreme halophilic Archaea on various substrates in a corrosion resistant bioreactor was written by Lorantfy, Bettina;Seyer, Bernhard;Herwig, Christoph. And the article was included in New Biotechnology in 2014.HPLC of Formula: 5743-47-5 This article mentions the following:

Extreme halophilic Archaea are extremophile species which can thrive in hypersaline environments of up to 3-5 M sodium chloride concentration Although their ecol. and physiol. are widely identified on the microbiol. level, little emphasis has been laid on quant. bioprocess development with extreme halophiles.The goal of this study was to establish, on the one hand, a methodol. basis for quant. bioprocess anal. of extreme halophilic Archaea with an extreme halophilic strain as an example. Firstly, as a novel usage, a corrosion resistant bioreactor setup for extreme halophiles has been implemented. Then, paying special attention to total bioprocess quantification approaches, an indirect method for biomass quantification using online process signals was introduced. Subsequently, robust quant. data evaluation methods for halophiles could be developed, providing defined and controlled cultivation conditions in the bioreactor and therefore obtaining suitable quality of online as well as off-line datasets.On the other hand, new physiol. results of extreme halophiles in bioreactor have also been obtained based on the quant. methodol. tools. For the first time, quant. data on stoichiometry and kinetics were collected and evaluated on different carbon sources. The results on various substrates were interpreted, with proposed metabolic mechanisms, by linking to the reported primary carbon metabolism of extreme halophilic Archaea. Moreover, results of chemostat cultures demonstrated that extreme halophilic organisms show Monod-kinetics on different sole carbon sources. A diauxic growth pattern was described on a mixture of substrates in batch cultivations.In addition, the methodologies presented here enable one to characterize the utilized strain Haloferax mediterranei (HFX) as a potential new host organism. Thus, this study offers a strong methodol. basis as well as a fundamental physiol. assessment for bioreactor quantification of extreme halophiles that can serve as primary knowledge for applications of extreme halophiles in biotechnol. In the experiment, the researchers used many compounds, for example, Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5HPLC of Formula: 5743-47-5).

Calcium 2-hydroxypropanoate pentahydrate (cas: 5743-47-5) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.HPLC of Formula: 5743-47-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Method development for the simultaneous estimation of ospemifine by using RP-HPLC was written by Chaitanya, Mitta;Swathi, Kalepu;Raju, P. Narayan;Swathi, Koduru. And the article was included in International Journal of Pharma Research and Health Sciences in 2015.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

A selective and sensitive stability-indicating high-performance liquid chromatog. method was developed and validated for the determination of Ospemifine. 10 mg of Ospemifine was dissolved in mobile phase. The solution was scanned from 200-400 nm the spectrum was obtained. The overlay spectrum was used for selection of wavelength for Ospemifine. The isobestic point was taken as detection wavelength. The separation was good, peak shape was good, so we conclude that there is no required for decrease the retention times of peak, so it is taken as final method. Mix a mixture of 40 mL water (40%) and 60 mL of Acetonitrile (60%) and degassed in ultrasonic water bath for 5 min. Filter through 0.22 μ filter under vacuum filtration.10 mg of Ospemifine working standard was accurately weighed and transferred into a 10 mL clean dry volumetric flask and add about 2 mL of diluent and sonicate to dissolve it completely and make volume up to the mark with the same solvent (Stock solution). Further pipet out 1.0 mL from the above stock solution into a 10 mL volumetric flask and was diluted up to the mark with diluent. The chromatog. method development for the estimation of Ospemifine were optimized by several trials for various parameters as different column, flow rate and mobile phase, finally the following chromatog. method was selected for the separation and quantification of Ospemifine in API and pharmaceutical dosage form by RP-HPLC method. The retention time of Ospemifine was found to be 2.425 mins. The system suitability parameters for Ospemifine such as theor. plates and tailing factor were found to be 4146, 1.2. The % purity Ospemifine in pharmaceutical dosage form was found to be 99.56%. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts