Tag: 300-400

Dual-responsive nanogels based on oligo(ethylene glycol) methacrylates and acidic co-monomers was written by Macchione, Micaela A.;Sacarelli, M. Florencia;Racca, Ana C.;Biglione, Catalina;Panzetta-Dutari, Graciela M.;Strumia, Miriam C.. And the article was included in Soft Matter in 2019.Formula: C16H26O7 This article mentions the following:

Ethylene glycol-based nanogels (NGs) have demonstrated their potential for the development of next-generation formulations for biomedical applications due to their interesting properties. In this work, monodispersed NGs based on oligo(ethylene glycol) methacrylates (OEG) were synthesized through free radical precipitation/dispersion polymerization assisted by ultrasonication. Di(ethylene glycol)methyl ether methacrylate (DEGMA) and oligo(ethylene glycol) methacrylate (OEGMA; M_n 475 g mol^-1) were used as the main monomers, acrylic acid (AA) or itaconic acid (IA) as co-monomers (OEG-co-AA and OEG-co-IA, resp.) and tetraethylene glycol dimethacrylate (TEGDMA) as crosslinker. The physicochem. properties of OEG-co-AA and OEG-co-IA NGs were studied including hydrodynamic diameter, poly-dispersity index, zeta potential and pH/temperature responsiveness. Samples with 4 mol% of both AA and IA showed nanometric sizes. Regarding their thermo-responsiveness, unexpected differences between NGs with AA or with IA were observed Besides, NGs did not impair the cell viability of a breast tumor cell line even when high concentrations were added to the culture medium. The properties of the synthesized NGs showed that either NGs with 4% AA or with 4% IA are outstanding candidates for biomedical applications. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of a comprehensive quality control method for the quantitative analysis of volatiles and lignans in Magnolia biondii Pamp. by near infrared spectroscopy was written by Li, Junni;Wen, Jinfeng;Tang, Gengqiu;Li, Rong;Guo, Huanjia;Weng, Wenfeng;Wang, Dong;Ji, Shengguo. And the article was included in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2020.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) This article mentions the following:

The quality of drug is vital to its curative effect, thus it is important to develop a comprehensive quality control method for commonly used drugs. In this study, we developed a Gas chromatog.-mass spectrometry separation method for the qual. and quant. anal. of volatiles, together with a High-performance liquid chromatog.-mass spectrometry separation method for lignans in Magnolia biondii Pamp.. 79 volatiles and 11 lignans were identified via comparing their chromatog. behavior and mass spectra data with those in the literature. The methods were then used to determine the contents of volatiles (1, 8-cineole, D-Limonene, α-terpineol, linalool, L-camphor and bornyl acetate) and lignans (epieudesmin, magnolin, epi-magnolin A and fargesin) in Magnolia biondii Pamp. Subsequently, 13 qual. models including volatiles (1, 8-cineole, D-Limonene, α-terpineol, linalool, L-camphor and bornyl acetate), water-soluble extractive, lignans (pinoresinol di-Me ether, magnolin, epi-magnolin A and fargesin) and moisture were developed by Near-IR Spectroscopy based on partial least square regression herein. The reference values were obtained by High-performance liquid chromatog., Gas chromatog. and etc., while the predicted values were attained from the NIR spectrum. Compared with the traditional detection methods, NIR technique methodol. significantly improved the ability to evaluate the quality of Magnolia biondii Pamp., which had the advantages of convenience, celerity, highly efficiency, low cost, no harm to samples, no reagent consumption, and no pollution to the environment. Moreover, the systematic anal. method combined pharmaceutical anal. with pharmacochem. was proposed to prepare volatiles, water-soluble extractive and lignans parts from the same sample. This way could extract more index components to be beneficial in the quality control of Magnolia biondii Pamp. roundly. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application In Synthesis of ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective estrogen receptor modulators and the combination therapy conjugated estrogens/bazedoxifene: A review of effects on the breast. was written by Pickar, James H;Komm, Barry S. And the article was included in Post reproductive health in 2015.Electric Literature of C24H23ClO2 This article mentions the following:

Traditional menopausal hormone therapy containing estrogens/progestin has been associated with an increased risk of breast cancer, and estrogen exposure is known to promote growth and proliferation of a majority of breast cancers. Therefore, it is important for clinicians to consider the breast safety profile of any hormone-based therapy used in postmenopausal women. This review provides an overview of the breast safety and tolerability profiles of currently marketed selective estrogen receptor modulators, antiestrogens, and the first tissue selective estrogen complex combining conjugated estrogens with the selective estrogen receptor modulator bazedoxifene in postmenopausal women. Selective estrogen receptor modulators and antiestrogens act as estrogen receptor antagonists in the breast. Tamoxifen, toremifene, and the selective estrogen receptor degrader fulvestrant are used to treat breast cancer, and tamoxifen and raloxifene protect against breast cancer in high-risk women. Postmenopausal women using selective estrogen receptor modulators for prevention or treatment of osteoporosis (raloxifene, bazedoxifene) can be reassured that these hormonal treatments do not adversely affect their risk of breast cancer and may, in the case of raloxifene, even be protective. There are limited data on breast cancer in women who use ospemifene for dyspareunia. Conjugated estrogens/bazedoxifene use for up to two years did not increase mammographic breast density or breast pain/tenderness, and there was no evidence of an increased risk of breast cancer, suggesting that conjugated estrogens/bazedoxifene has an improved breast safety profile compared with traditional menopausal hormone therapies. Future research will continue to focus on development of selective estrogen receptor modulators and selective estrogen receptor modulator combinations capable of achieving the ideal balance of estrogen receptor agonist and antagonist effects. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Electric Literature of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Assessment of defects at tooth/self-adhering flowable composite interface using swept-source optical coherence tomography (SS-OCT) was written by Park, Kyung-Jin;Schneider, Hartmut;Haak, Rainer. And the article was included in Dental Materials in 2015.Reference of 109-17-1 This article mentions the following:

Assessment of adhesive defects of a self-etch adhesive and a self-adhering flowable composite at the tooth/composite interface before and after water storage by optical coherence tomog. (OCT).16 extracted human molars (n = 8 each) with box-shaped, class-V cavities were restored either with an exptl. self-adhering flowable composite (EF, DMG) or with the filling system Adper Prompt L-Pop/Filtek Supreme XT Flowable composite (PLP, 3M ESPE). Restorations of both groups were non-invasively imaged using swept-source OCT before and after storage in water. The OCT signal for adhesive defects at the tooth/composite interface was quantified.At enamel, significantly fewer adhesive defects were detected at EF restorations than at PLP restorations, before water storage (4%/48%, p < 0.001) and thereafter (8%/49%, p < 0.001); in contrast, at dentin more interfacial defects were observed with EF (before water storage: 75%/11%; p < 0.001, after water storage: 77%/52%; p_i = 0.001). In the case of slight initial adhesive defects, water storage caused a statistically verifiable increase in adhesive defects at the enamel interface with EF (before/after storage: 4%/8%; p = 0.023) and at dentin with PLP (before/after storage: 11%/52%; p = 0.008).Given the high proportion of adhesive defects with the exptl. self-adhering flowable composite, its use as the definitive restorative material in class-V cavities must be critically scrutinized and clin. indications must be investigated further with in vitro and in vivo trials. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Reference of 109-17-1).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Reference of 109-17-1

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficacy and safety of ospemifene in postmenopausal women with moderate-to-severe vaginal dryness: a phase 3, randomized, double-blind, placebo-controlled, multicenter trial. was written by Archer, David F;Goldstein, Steven R;Simon, James A;Waldbaum, Arthur S;Sussman, Steven A;Altomare, Corrado;Zhu, Julie;Yoshida, Yuki;Schaffer, Sam;Soulban, Graziella. And the article was included in Menopause (New York, N.Y.) in 2019.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

OBJECTIVE: To evaluate the safety and efficacy of ospemifene for the treatment of moderate to severe vaginal dryness in postmenopausal women with vulvovaginal atrophy (VVA). METHODS: This 12-week, multicenter, double-blind phase 3 study randomized postmenopausal women (aged 40-80 years) with VVA and moderate to severe vaginal dryness as their most bothersome symptom to daily oral ospemifene 60 mg or placebo. Coprimary efficacy endpoints included changes from baseline to week 12 in percentages of vaginal parabasal and superficial cells, vaginal pH, and vaginal dryness severity with ospemifene versus placebo; other secondary endpoints were evaluated (weeks 4, 8, and 12). Safety was assessed by treatment-emergent adverse events (TEAEs) and endometrial biopsies. RESULTS: Women (n = 631; ospemifene [n = 316], placebo [n = 315]) had a mean age of 59.8 years, a mean body mass index of 27.2 kg/m, and most were white. Ospemifene significantly improved (P < 0.0001) the percentages of parabasal and superficial cells, vaginal pH, and severity of vaginal dryness severity compared with placebo at week 12; significant between-group differences were noted by week 4. Secondary endpoints of dyspareunia (P < 0.001), maturation value (P < 0.0001), and the Female Sexual Function Index (P < 0.05) also significantly improved with ospemifene versus placebo at week 12. Significantly more women responded (31.5% vs 6.0%; P < 0.0001) or were satisfied (49.2% vs 33.8%; P = 0.0007) with ospemifene versus placebo at week 12. No unexpected TEAEs, treatment-related serious TEAEs, thrombotic events, or endometrial hyperplasia or carcinoma were observed. CONCLUSIONS: Ospemifene was effective and well tolerated for the treatment of moderate-to-severe vaginal dryness in postmenopausal women with VVA. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Minimizing the interfacial resistance for a solid-state lithium battery running at room temperature was written by Wang, Qianchen;Ding, Xiangyu;Li, Jingbo;Jin, Haibo;Gao, Hongcai. And the article was included in Chemical Engineering Journal (Amsterdam, Netherlands) in 2022.Synthetic Route of C16H26O7 This article mentions the following:

A ceramic solid electrolyte of Li_1.5Al_0.5Ge_1.5(PO₄)₃ (LAGP) with high ionic conductivity (4.28 x 10^-4 S cm^-1 at 30 °C) and low activation energy (0.25 eV) is prepared by a three-step method, and the interfacial properties of the ceramic solid electrolyte are further modified by an in-situ polymerization strategy with the formation of a gel-polymer electrolyte with the thickness of 8.85 μm on the surface of LAGP. The presence of the gel-polymer electrolyte on the surface of LAGP inhibits the side reactions and the growth of lithium dendrites, as evidenced by the stable cycling of the lithium sym. cells with the modified LAGP solid electrolyte for 1000 h at 25 °C. In addition, the high ionic conductivity and the stable interface of the modified LAGP solid electrolyte enable the solid-state lithium battery with a LiFePO₄ cathode, exhibiting superior electrochem. performances which can run stably at 25 °C with initial discharge specific capacity of 159.8 mAh g^-1 at 0.1C. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Synthetic Route of C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effect of carbon fiber and gamma irradiation on acrylonitrile butadiene styrene/high density polyethylene composites was written by Elnaggar, Mona Y.;Fathy, E. S.;Hassan, Medhat M.. And the article was included in Polymer Science, Series B: Polymer Chemistry in 2017.Formula: C16H26O7 This article mentions the following:

In this study, the effect of carbon fiber and gamma irradiation on acrylonitrile butadiene styrene (ABS)/high d. polyethylene matrix was investigated. The ternary composites with short carbon fiber of concentrations 15, 30, and 45 wt % were irradiated with doses of 100 and 300 kGy. In order to characterize the phys. and morphol. properties of all reinforced composites, wide X-ray diffraction, differential scanning calorimetry, thermo gravimetric anal., and SEM were performed. In the experiment, the researchers used many compounds, for example, ((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1Formula: C16H26O7).

((Oxybis(ethane-2,1-diyl))bis(oxy))bis(ethane-2,1-diyl) bis(2-methylacrylate) (cas: 109-17-1) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C16H26O7

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Paired electrolysis enabled annulation for the quinolyl-modification of bioactive molecules was written by You, Shiqi;Ruan, Mengyao;Lu, Cuifen;Liu, Li;Weng, Yue;Yang, Guichun;Wang, Shengchun;Alhumade, Hesham;Lei, Aiwen;Gao, Meng. And the article was included in Chemical Science in 2022.Synthetic Route of C24H23ClO2 This article mentions the following:

A paired electrolysis enabled cascade annulation that enables the efficient synthesis of highly functionalized quinoline-substituted bioactive mols. from readily available starting materials is reported. Using this methodol., two goals, namely, the direct synthesis of quinolines and the introduction of quinoline moieties to bioactive mols., can be simultaneously achieved in one simple operation. The use of electroreduction for the activation of isatin, together with the further anodic oxidation of KI to catalytically result in a cascade annulation, highlight the unique possibilities associated with electrochem. activation methods. This transformation can tolerate a wide range of functional groups and can also be used as a functionalization tactic in pharmaceutical research as well as other areas. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Synthetic Route of C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-Catalyzed Difluoromethylation of Alkyl Iodides Enabled by Aryl Radical Activation of Carbon-Iodine Bonds was written by Cai, Aijie;Yan, Wenhao;Wang, Chao;Liu, Wei. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C24H23ClO2 This article mentions the following:

A novel strategy that leveraged the halogen abstraction ability of aryl radicals, thereby engaging a diverse range of alkyl iodides in copper-catalyzed Negishi-type cross-coupling reactions at room temperature Specifically, aryl radicals generated via copper catalysis efficiently initiate the cleavage of the carbon-iodide bonds of alkyl iodides. The alkyl radicals thus generated enter the copper catalytic cycles to couple with a difluoromethyl zinc reagent, thus furnished the alkyl difluoromethane products. This unprecedented Negishi-type difluoromethylation approach was applied to the late-stage modification of densely functionalized pharmaceutical agents and natural products. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7COA of Formula: C24H23ClO2).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C24H23ClO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ospemifene plus fractional CO₂ laser: a powerful strategy to treat postmenopausal vulvar pain was written by Murina, F.;Felice, R.;Di Francesco, S.;Nelvastellio, L.;Cetin, I.. And the article was included in Gynecological Endocrinology in 2020.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol This article mentions the following:

This study is a single-center, retrospective anal. of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60 mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene + laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene + laser group compared with the laser treatment group (-87% vs – 34%, resp.), and the vestibular health score started declining faster in the ospemifene + laser group. Although, addnl. research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clin. effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. In the experiment, the researchers used many compounds, for example, (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol).

(Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol (cas: 128607-22-7) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Name: (Z)-2-(4-(4-Chloro-1,2-diphenylbut-1-en-1-yl)phenoxy)ethan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts