Tag: 200-300

A Synthetic Approach to Dimetalated Arenes Using Flow Microreactors and the Switchable Application to Chemoselective Cross-Coupling Reactions was written by Ashikari, Yosuke;Kawaguchi, Tomoko;Mandai, Kyoko;Aizawa, Yoko;Nagaki, Aiichiro. And the article was included in Journal of the American Chemical Society in 2020.Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

In spite of their potential utility, the chem. of dimetallated arenes is still in its infancy because it is extremely difficult to synthesize them. Herein is reported a method of synthesizing arenes bearing a boryl group and a metallic substituent such as boryl, silyl, stannyl or zincyl group, based on generation and reactions of aryllithiums bearing a trialkyl borate moiety in a integrated flow microreactor. The bimetallic arenes showed a remarkable chemoselectivity in palladium-catalyzed cross-coupling reactions. The selectivity was switched by selection of the metal species constituting the dimetallated arenes together with appropriate catalysts. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis of functionalized helical BN-benzo[c]phenanthrenes was written by Abengozar, Alberto;Garcia-Garcia, Patricia;Sucunza, David;Perez-Redondo, Adrian;Vaquero, Juan J.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2018.Application In Synthesis of (2-Bromo-5-chlorophenyl)methanol This article mentions the following:

A novel parent BN-benzo[c]phenanthrene, with helical chirality and remarkable structural features, has been easily obtained in three steps with a global yield of 55%. Moreover, Cl-substituted derivatives have been prepared and these have served as useful starting materials for the development of palladium-catalyzed cross-coupling reactions. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Application In Synthesis of (2-Bromo-5-chlorophenyl)methanol).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (2-Bromo-5-chlorophenyl)methanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mono- and Dinuclear Coinage Metal Complexes Supported by an Imino-Pyridine-NHC Ligand: Structural and Photophysical Studies was written by Simler, Thomas;Moebius, Karen;Mueller, Kerstin;Feuerstein, Thomas J.;Gamer, Michael T.;Lebedkin, Sergei;Kappes, Manfred M.;Roesky, Peter W.. And the article was included in Organometallics in 2019.SDS of cas: 49669-14-9 This article mentions the following:

A new imino-pyridine-NHC (NHC = N-heterocyclic carbene) hybrid ligand was accessed through a multistep synthesis, and its coordination chem. was examined among coinage metals. Mononuclear copper, silver, and gold complexes as well as dinuclear homo- and heterometallic complexes were isolated and fully characterized by spectroscopic methods as well as x-ray crystallog. A comparative study of the structural and photophys. properties of the complexes was performed to get more insight into structure-property relationships. The photoluminescence (PL) properties were investigated in the solid state at temperatures between 20 and 295 K, and systematically compared with those of related complexes bearing a bipyridine-NHC ligand and previously reported by our group. The PL properties can be finely “tuned” depending on the coordinated metals, and the weak emission of the complexes can be traced back to the structural flexibility of the imino-pyridine-NHC framework. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9SDS of cas: 49669-14-9).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.SDS of cas: 49669-14-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

From vicinal azido alcohols to Boc-amino alcohols or oxazolidinones, with trimethylphosphine and Boc₂O or CO₂ was written by Ariza, X.;Pineda, O.;Urpi, F.;Vilarrasa, J.. And the article was included in Tetrahedron Letters in 2001.Electric Literature of C11H21NO3 This article mentions the following:

A practical solution to the problem of converting directly 1,2-azido alcs. to Boc-amino alcs., without recourse to catalytic hydrogenation, involves the use of Me₃P/Boc₂O in THF (or CH₂Cl₂) and aqueous NaOH at rt (90-98% yields). The same azido alcs. can be converted in one-pot to the corresponding oxazolidinones with Boc₂O/DMAP/Me₃P or even better with CO₂ and Me₃P under basic catalysis (91-96% yields). In the experiment, the researchers used many compounds, for example, tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0Electric Literature of C11H21NO3).

tert-Butyl (trans-2-hydroxycyclohexyl)carbamate (cas: 121282-70-0) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Electric Literature of C11H21NO3

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Integrating the rapid constituent profiling strategy and multivariate statistical analysis for herb ingredients research, with Chinese official rhubarb and Tibetan rhubarb as an example was written by Luo, Dewei;He, Mingzhen;Li, Junmao;Du, Hui;Mao, Qiping;Pei, Na;Zhong, Guoyue;Ouyang, Hui;Yang, Shiling;Feng, Yulin. And the article was included in Arabian Journal of Chemistry in 2021.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

The Chinese official rhubarb (COR), from the genus Rheum, is listed in the Chinese Pharmacopoeia, while many rhubarb plant sources include in the Tibetan rhubarb (TR) are not attributable to Chinese Pharmacopoeia. Tibetan rhubarb is widely used as a natural medicine in Tibet; however, the difference in plant endogenous phytochems. between the COR and TR remains largely unclear.To establish a method for evaluating the chem. composition and metabolic difference between COR and TR.Using UHPLC-QTOF-MS/MS, we established a strategy to quickly and comprehensively identify the chem. components of COR and TR. Furthermore, multivariate statistical anal. was applied to identify the significant metabolic differences between the two.In total, 209 chem. compounds, including 51 anthraquinones, 44 stilbenes, 26 tannins, 52 acyl glycosides, and 36 other compounds, were identified using the data mining strategy. Importantly, 47 compounds may be the potential new compounds, while 35 significant metabolic differences were revealed between COR and TR.This study offers significant insight into the chem. composition and differences between COR and TR that could be used to develop their varieties and clin. applications. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cardioprotective effect of rheum turkenstanicum against doxorubicin-induced toxicity in rats was written by Hosseini, Azar;Safari, Mohammad-Kazem;Rajabian, Arezoo;Boroumand-Noughabi, Samaneh;Eid, Ali H.;Al Dhaheri, Yusra;Gumpricht, Eric;Sahebkar, Amirhossein. And the article was included in Frontiers in Pharmacology in 2022.Synthetic Route of C14H12O4 This article mentions the following:

Doxorubicin as an anti-cancer drug causes cardiotoxicity, limiting its tolerability and use. The mechanism of toxicity is due to free radical production and cardiomyocytes injury. This research evaluated Rheum turkestanicum (R.turkestanicum) extract against doxorubicin cardiotoxicity due to its considerable in vitro antioxidant activity. Male Wistar rats received 2.5 mg/kg doxorubicin i.p. every otherday for 2 wk to create an accumulative dose. R. turkestanicum was administrated at a dose of 100 and 300 mg/kg i.p. from the second week for 7 days. On the 15th day, the animals were anesthetized and blood was collected from cardiac tissue for evaluation of alanine aminotransferase (ALT), cardiac muscle creatinine kinase (CK-MB), troponin T (cTn-T), lactate dehydrogenase (LDH), and B-type natriuretic peptide brain natriuretic peptide. A cardiac homogenate was also collected to determine superoxide dismutase (SOD), catalase Catalase Activity, malondialdehyde (MDA), and thiols. Histopathol. was also performed. Doxorubicin increased all cardiac enzymes and malondialdehyde, correlating with a reduction in SOD, catalase, and thiols. Histopathol. revealed extracellular edema, moderate congestion, and hemorrhage of foci. In contrast, administration of R. turkestanicum ameliorated these doxorubicin-induced pathophysiol. changes. This study revealed that the extract ameliorated doxorubicin-induced cardiac toxicity via modulation of oxidative stress-related pathways. Liquid chromatog.-mass spectrometry anal. of R. turkestanicum indicated several components with potent pharmacol. properties. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Synthetic Route of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C14H12O4

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prototypes of nutraceutical products from microparticles loaded with stilbenes extracted from grape cane was written by Avendano-Godoy, Javier;Ortega, Elisa;Urrutia, Manuel;Escobar-Avello, Danilo;Luengo, Javiana;von Baer, Dietrich;Mardones, Claudia;Gomez-Gaete, Carolina. And the article was included in Food and Bioproducts Processing in 2022.Recommanded Product: 10083-24-6 This article mentions the following:

Grape canes (Vitis vinifera L.) are an important source of bioactive stilbenes, but they are considered a pruning residue. Despite the potential advantages for human health, the low aqueous solubility and stability limits their usage in com. goods. This research aimed to improve knowledge about the solubility and stability of the main stilbenes present in important residues of the wine industry, such as grape canes (V. vinifera L. cv Pinot Noir), through the formation of inclusion complexes with cyclodextrins (CDs) and subsequent polymeric microencapsulation. The formation of inclusion complexes between stilbenes presents in grape cane extracts and 15 mM hydroxypropyl-β-cyclodextrin (HP-β-CD) increased the aqueous solubility of (E)-resveratrol, (E)-ε-viniferin and (E)-piceatannol by 2.8, 5.4 and 1.9 times, resp. The microencapsulation (by spray drying) of the inclusion complexes using maltodextrin (MD) (10% w/v) allowed us to improve the stability of the stilbenes, obtaining a retention percentage of 81.9 ± 2.2% after 60 min of UV irradiation (254 nm). The lower size microparticles (MPs) formulation was 10.9 ± 0.9 μm and had a stilbene loading of 0.61 ± 0.01 mg/100 mg of MPs. The prototype tablets and capsules made from the MPs presented suitable characteristics for their eventual use. The microencapsulation of inclusion complexes between stilbenes presents in grape cane extracts and HP-β-CD, using MD as a matrix component, is useful to increase the solubility and stability of stilbenes. The prepared MPs can be used for the development of nutraceutical products. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Recommanded Product: 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Suspect screening of emerging pollutants and their major transformation products in wastewaters treated with fungi by liquid chromatography coupled to a high resolution mass spectrometry was written by Llorca, Marta;Lucas, Daniel;Ferrando-Climent, Laura;Badia-Fabregat, Marina;Cruz-Morato, Carles;Barcelo, Damia;Rodriguez-Mozaz, Sara. And the article was included in Journal of Chromatography A in 2016.Formula: C16H16O3 This article mentions the following:

A new approach for the screening of 33 pharmaceuticals and 113 of their known transformation products in wastewaters is based on the anal. of samples by liquid chromatog. coupled to high resolution mass spectrometry (HRMS) followed by data processing using specific software and manual confirmation. A home-made library was built with the transformation products reported in literature for the target pharmaceuticals after treatment with various fungi. The method was applied to the search of these contaminants in 67 samples generated along treatment of wastewaters with white-rot fungus Trametes versicolor. The screening methodol. allowed the detection of different transformation products (TPs) generated from degradation of parent compounds after fungal treatment. This approach can be a useful tool for the rapid screening and tentative detection of emerging contaminants during water treatment in both full and batch-scale studies when pure standards are not available. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C16H16O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Effects of nanoparticles on photopolymerization of acrylate monomers in forming nano-composites was written by Check, Casey;Chartoff, Richard;Chang, Sean. And the article was included in European Polymer Journal in 2015.Reference of 4074-88-8 This article mentions the following:

The UV photopolymerization of diethylene glycol-diacrylate and isobornyl-acrylate based nano-composites was studied with respect to reaction conversion with variations in UV light exposure. The composites contained various amounts of well dispersed ZrO₂ nanoparticles. The degree of conversion achieved vs light intensity was measured by DSC for various compositions ranging from 0 to 30% by weight of nanoparticles. It was found that including nanoparticles in the monomer increased the conversion achieved considerably. This is attributed to the acceleration of the reaction through interactions with the silane surface ligand on the nanoparticles. The upper limit for conversion was limited because of vitrification and was different for each monomer. Also noted was that the detailed effects of particle concentration on conversion are quite different for the two monomers. Conversion vs. UV exposure data such as those presented provide information necessary for determining the appropriate UV exposure required for creating nano-composites by inkjet printing with optimized phys., mech., and optical properties. The results indicate that it is important to determine this information for forming nano-composites from any specific monomer/nanoparticle combination. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reductive Electrophotocatalysis: Merging Electricity and Light To Achieve Extreme Reduction Potentials was written by Kim, Hyunwoo;Kim, Hyungjun;Lambert, Tristan H.;Lin, Song. And the article was included in Journal of the American Chemical Society in 2020.SDS of cas: 68716-49-4 This article mentions the following:

We describe a new electrophotocatalytic strategy that harnesses the power of light and electricity to generate an excited radical anion with a reducing potential of -3.2 V vs SCE, which can be used to activate substrates with very high reduction potentials (E_red ≈ -1.9 to -2.9 V). The resultant aryl radicals can be engaged in various synthetically useful transformations to furnish arylboronate, arylstannane, and biaryl products. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4SDS of cas: 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.SDS of cas: 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts