Tag: 200-300

Acrylate and methacrylate contact allergy and allergic contact disease: a 13-year review was written by Spencer, Ashley;Gazzani, Paul;Thompson, Donna A.. And the article was included in Contact Dermatitis in 2016.Application of 4074-88-8 This article mentions the following:

Summary : Background : (Meth)acrylates are important causes of contact allergy and allergic contact disease, such as dermatitis and stomatitis, with new and emerging sources resulting in changing clin. presentations. Objectives : To identify the (meth)acrylates that most commonly cause allergic contact disease, highlight their usefulness for screening, and examine their relationship with occupational and clin. data. Methods : A retrospective review of results from patch tests performed between July 2002 and Sept. 2015, in one tertiary Cutaneous Allergy Unit, was performed Results : A series of 28 (meth)acrylates was applied to 475 patients. Results were pos. in 52 cases, with occupational sources being identified in 24. Industrial exposures and acrylic nails were responsible for 13 and 10 cases, resp., with wound dressings being implicated in 7. We found that four individual (meth)acrylates (2-hydroxyethyl acrylate, 2-hydroxypropyl methacrylate, bisphenol A glycerolate dimethacrylate, and Et acrylate), if used as a screening tool, could have identified 47 (90.4%) of our pos. cases. Conclusions : Our 13-yr experience indicates a changing landscape of (meth)acrylate contact allergy and allergic contact disease, with an observed shift in exposures away from manufacturing and towards acrylic nail sources. Wound dressings are highlighted as emerging sources of sensitization. Larger studies are required to establish the sensitivity and specificity of the four (meth)acrylates proposed for potential screening. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Copper-Photocatalyzed Hydroboration of Alkynes and Alkenes was written by Zhong, Mingbing;Gagne, Yohann;Hope, Taylor O.;Pannecoucke, Xavier;Frenette, Mathieu;Jubault, Philippe;Poisson, Thomas. And the article was included in Angewandte Chemie, International Edition in 2021.COA of Formula: C16H20B2N2O2 This article mentions the following:

The photocatalytic hydroboration of alkenes and alkynes is reported. The use of newly-designed copper photocatalysts with B₂Pin₂ permits the formation a boryl radical, which is used for hydroboration of a large panel of alkenes and alkynes. The hydroborated products were isolated in high yields, with excellent diastereoselectivities and a high functional group tolerance under mild conditions. The hydroboration reactions were developed under continuous flow conditions to demonstrate their synthetic utility. The reaction mechanism was studied and suggested an oxidation reaction between an in situ formed borate and the Cu-photocatalyst in its excited state for the boryl radical formation. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6COA of Formula: C16H20B2N2O2).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C16H20B2N2O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Passion fruit seed extract enriched in piceatannol obtained by microwave-assisted extraction was written by Silva, Gislaine C.;Rodrigues, Rodney A. F.;Bottoli, Carla B. G.. And the article was included in Sustainable Chemistry and Pharmacy in 2021.Electric Literature of C14H12O4 This article mentions the following:

Apart from being food, passion fruit (Passiflora edulis Sims) offers seeds to be used as an oil source, and the residual seed cake from oil extraction contains piceatannol, a mol. that can prevent skin damages. In this work, microwave-assisted extraction (MAE) was evaluated as a technique for the preparation of piceatannol-rich seed cake extracts, and its performance was compared to the conventional Soxhlet extraction MAE and Soxhlet exhibited different selectivities for the seed cake compounds A sequential MAE at 87掳C, with 70% EtOH, for 30 min each cycle, provided a fine brown powder with 27.17 卤 0.9渭g of piceatannol per mg of the extract, while Soxhlet extraction for 120 min resulted in a dark lumpy extract containing 13.03 卤 0.4渭g mg-1. Thus, MAE was shown to be a promising alternative to produce a passion fruit seed extract for cosmetic purposes, adding value to a residue from the passion fruit chain by providing a faster extraction and a more color friendly and easier-to-handle product with higher levels of piceatannol in comparison to the conventional method. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Electric Literature of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nickel-Catalyzed Thermal Redox Functionalization of C(sp³)-H Bonds with Carbon Electrophiles was written by Gong, Yuxin;Su, Lei;Zhu, Zhaodong;Ye, Yang;Gong, Hegui. And the article was included in Angewandte Chemie, International Edition in 2022.Category: alcohols-buliding-blocks This article mentions the following:

A Ni-catalyzed arylation and alkylation of C(sp₃)-H bonds with organohalides to forge C(sp₃)-C bonds by merging economical Zn and tBuOOtBu (DTBP) as the external reductant and oxidant was reported. The mild and easy-to-operate protocol enabled facile carbofunctionalization of N-/O-伪- and cyclohexane C-H bonds, and preparation of a few intermediates of bioactive compounds and drug derivatives Preliminary mechanistic studies implied addition of an alkyl radical to a NiII salt. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Category: alcohols-buliding-blocks).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

General Method for the Amination of Aryl Halides with Primary and Secondary Alkyl Amines via Nickel Photocatalysis was written by Song, Geyang;Nong, Ding-Zhan;Li, Jing-Sheng;Li, Gang;Zhang, Wei;Cao, Rui;Wang, Chao;Xiao, Jianliang;Xue, Dong. And the article was included in Journal of Organic Chemistry in 2022.Category: alcohols-buliding-blocks This article mentions the following:

It was reported that Ni(II)-bipyridine complex catalyzed efficient C-N coupling of aryl chlorides and bromides with various primary and secondary alkyl amines under direct excitation with light. Intramol. C-N coupling was also demonstrated. The feasibility and applicability of the protocol in organic synthesis was attested by more than 200 examples. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Category: alcohols-buliding-blocks).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R鈥昈鈭?. For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Anti-Alzheimer鈥瞫 potential of different varieties of Piper betle leaves and molecular docking analyses of metabolites was written by Debnath, Mamita;Das, Susmita;Bhowmick, Shovonlal;Karak, Swagata;Saha, Achintya;De, Bratati. And the article was included in Free Radicals and Antioxidants in 2021.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

Introduction: Acetylcholinesterase inhibitors are used to prevent symptoms of Alzheimer鈥瞫 disease which is initiated due to oxidative stress. Piper betle L. is a tropical evergreen perennial vine whose leaves are widely consumed as masticator in Asia and has medicinal properties. Objectives: The present study is aimed to investigate acetylcholinesterase inhibitory property of methanolic extracts of different varieties of Piper betle leaves and chemometrically identify different bioactive ingredients in vitro and in silico. Materials and Methods: Methanol extracts of the leaves collected in Feb. and Oct. from eight varieties of P. betle (Chhanchi, Bagerhati, Manikdanga, Kalibangla, Bangla, Ghanagete, Meetha and Haldi) were studied for acetylcholinesterase inhibitory properties. Chem. components were analyzed by Gas Chromatog. -Mass spectrometry and High Performance Thin Layer Chromatog. Active metabolites were identified chemometrically. The activities were proved in vitro and in silico. Results: All the extracts inhibited acetylcholinesterase. Statistical anal. suggested that several phenolic compounds were correlated to anti-cholinesterase activity. Piceatannol, hydroxychavicol, benzene-1,2,4-triol, and 4-methylcatechol are reported here to have such enzyme inhibitory properties. These four small mols. were further subjected to mol. docking anal. to explore their binding mechanism with the acetylcholinesterase enzyme. All the four small mols. are found to interact with the targeted enzyme in similar fashion like the mol. interactions observed for the standard inhibitor, Donepezil, at the active site of acetylcholiesterase. Conclusion: Thus, consumption of P. betle leaves may have a beneficial effect in the prevention and treatment of this neurodegenerative disease. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In vitro and in vivo biocompatibility of novel zwitterionic poly(beta amino)ester hydrogels based on diacrylate and glycine for site-specific controlled drug release was written by Filipovic, Vuk V.;Babic, Marija M.;Godevac, Dejan;Pavic, Aleksandar;Nikodinovic-Runic, Jasmina;Tomic, Simonida Lj.. And the article was included in Macromolecular Chemistry and Physics in 2019.Reference of 4074-88-8 This article mentions the following:

New (β-aminoester) hydrogels (PBAE) based on di(ethylene glycol)diacrylate and glycine are successfully synthesized and characterized for the first time in this work. PBAE macromers are obtained using Michael addition By changing the diacrylate/amine stoichiometric ratio, but maintaining it >1, samples with different chem. structure containing acrylate end-groups are obtained. The hydrogels are synthesized from macromers utilizing free radical polymerization Chem. structure of macromers and hydrogels is confirmed by proton NMR, and Fourier transform infra-red spectroscopy. Swelling and degradation rates in physiol. pH range change notably with pH and monomer molar ratio, validating pH sensitivity and zwitterionic behavior, which can be finely tuned by changing any of these parameters. In vitro cytotoxicity and in vivo acute embryotoxicity in zebrafish (Danio rerio) performed to assess the biocompatibility of the novel hydrogel materials and their degradation products reveal that materials are nontoxic and biocompatible. The Cephalexin in vitro drug release study, at pH values 2.20, 5.50, and 7.40, demonstrates pH-sensitive delivery with the release profiles effectively controlled by pH and the hydrogel composition PBAE hydrogels exhibit great potential for a variety of biomedical applications, including tissue regeneration and intelligent drug delivery systems. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Reference of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Severe bullous allergic contact dermatitis caused by glycidyl methacrylate and other acrylates was written by Vogel, Tatiana Alexandra;Christoffers, Wietske Andrea;Engfeldt, Malin;Bruze, Magnus;Coenraads, Pieter-Jan;Schuttelaar, Marie-Louise Anna. And the article was included in Contact Dermatitis in 2014.Product Details of 4074-88-8 This article mentions the following:

A research illustrates a rarer case of a severe allergic contact dermatitis caused by acrylates glycidyl methacrylate and 1,6 hexanediol diacrylate in an occupational setting. The multiple reactivity to various acrylates in this patient can be explained by two different phenomena: cross-reactivity, and sub sequent exposure to other acrylates. This case report reveals the importance of patch testing with a dilution series of acrylates to distinguish between a contact allergy and an irritant reaction. And moreover, it emphasizes the importance of investigating the products in a patient’s workplace and testing the purity of these products. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Product Details of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Product Details of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

ToF-SIMS and Machine Learning for Single-Pixel Molecular Discrimination of an Acrylate Polymer Microarray was written by Gardner, Wil;Hook, Andrew L.;Alexander, Morgan R.;Ballabio, Davide;Cutts, Suzanne M.;Muir, Benjamin W.;Pigram, Paul J.. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2020.Related Products of 4074-88-8 This article mentions the following:

Combinatorial approaches to materials discovery offer promising potential for the rapid development of novel polymer systems. Polymer microarrays enable the high-throughput comparison of material phys. and chem. properties-such as surface chem. and properties like cell attachment or protein adsorption-in order to identify correlations that can progress materials development. A challenge for this approach is to accurately discriminate between highly similar polymer chemistries or identify heterogeneities within individual polymer spots. Time-of-flight secondary ion mass spectrometry (ToF-SIMS) offers unique potential in this regard, capable of describing the chem. associated with the outermost layer of a sample with high spatial resolution and chem. sensitivity. However, this comes at the cost of generating large scale, complex hyperspectral imaging data sets. We have demonstrated previously that machine learning is a powerful tool for interpreting ToF-SIMS images, describing a method for color-tagging the output of a self-organizing map (SOM). This reduces the entire hyperspectral data set to a single reconstructed color similarity map, in which the spectral similarity between pixels is represented by color similarity in the map. Here, we apply the same methodol. to a ToF-SIMS image of a printed polymer microarray for the first time. We report complete, single-pixel mol. discrimination of the 70 unique homopolymer spots on the array while also identifying intraspot heterogeneities thought to be related to intermixing of the polymer and the pHEMA coating. In this way, we show that the SOM can identify layers of similarity and clusters in the data, both with respect to polymer backbone structures and their individual side groups. Finally, we relate the output of the SOM anal. with fluorescence data from polymer-protein adsorption studies, highlighting how polymer performance can be visualized within the context of the global topol. of the data set. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Related Products of 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Related Products of 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Palladium-Catalyzed Annulation of Alkynes with Ortho-Halide-Containing Benzyl Alcohols in Aqueous Medium was written by Feng, Jie;Lu, Guoping;Lv, Meifang;Cai, Chun. And the article was included in Journal of Organic Chemistry in 2014.Synthetic Route of C7H6BrClO This article mentions the following:

The Pd-catalyzed annulations of ortho-halide-containing benzyl alcs. with alkynes for the synthesis of indenones were achieved in aqueous Triton X-100 micelles with good yields and wide substrate scopes. Moreover, the indenones obtained in this procedure can be further functionalized to form some more synthetic useful derivatives via an environmental-friendly way. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Synthetic Route of C7H6BrClO).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Synthetic Route of C7H6BrClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts