Tag: 100-200

Asymmetric Transfer Hydrogenation Catalyzed by Mesoporous MCM-41-Supported Chiral Ru-Complex was written by Sarkar, Shaheen M.;Yusoff, Mashitah Mohd.;Rahman, Lutfor Md.. And the article was included in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2015.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol This article mentions the following:

Chiral N-sulfonyldiamine was successfully anchored on mesoporous MCM-41 silica. The MCM-41-supported chiral N-sulfonyldiamine was used as an efficient heterogeneous chiral ligand in the asym. transfer hydrogenation of ketones. This heterogeneous system offered satisfactory enantioselectivities up to 94% with excellent conversions. In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: (R)-1-(3-Chlorophenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Scandium Triflate Catalyzed Tandem Transfer Hydrogenation and Cyclization Reaction of o-Aminobenzaldehydes and o-Aminoacetophenone with Alcohols was written by Gou, Bo-Bo;Yang, Sen;Sun, Huai-Ri;Jian, Qing-Song;Sharif, Atif;Zhou, Ling;Chen, Jie. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol This article mentions the following:

An effective Sc-catalyzed transfer hydrogenation and cyclization tandem reaction has been achieved. This process showed excellent functional group compatibility and good yields. A variety of benzoxazines I (R = H, Me; R¹ = H, Me, Et; R² = Me, Ph, naphthalen-1-yl, thiophen-2-ylmethyl, etc.; R¹R² = -(CH₂)₅-; R³ = H, F, Cl, Me, Br; R⁴ = H, Me; R⁵ = H, Me, Cl, Br) were produced with primary or secondary alcs. R²(R³)CH₂OH as a hydrogen source. Furthermore, the utility of this newly developed protocol is demonstrated through scaled-up experiment, late-stage modification, and preliminary exploration of enantioselective synthesis. In the experiment, the researchers used many compounds, for example, 2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol).

2-(4-(Trifluoromethyl)phenyl)ethanol (cas: 2968-93-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of 2-(4-(Trifluoromethyl)phenyl)ethanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electrochemical Ring-Opening Dicarboxylation of Strained Carbon-Carbon Single Bonds with CO₂: Facile Synthesis of Diacids and Derivatization into Polyesters was written by Liao, Li-Li;Wang, Zhe-Hao;Cao, Ke-Gong;Sun, Guo-Quan;Zhang, Wei;Ran, Chuan-Kun;Li, Yiwen;Chen, Li;Cao, Guang-Mei;Yu, Da-Gang. And the article was included in Journal of the American Chemical Society in 2022.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

A novel electrochem. ring-opening dicarboxylation of C-C single bonds in strained rings with CO₂ was reported. Structurally diverse glutaric acid and adipic acid derivatives HO(O)CC(Ar¹)R(CH₂)_nCH(Ar²)C(O)OH (R = H, Me, Ph; Ar¹ = Ph, 3-methylphenyl, 2,3-dihydro-1-benzofuran-6-yl, etc.; n = 1, 2; Ar² = Ph, 4-fluorohenyl, 3-methylphenyl) and HO(O)CC(R¹)(R²)CH₂CH(C(O)OR³)C(O)OH [R¹ = H, Me, Ph; R² = 4-tert-butylphenyl, C(O)OEt, 4-chlorophenyl, etc.; R³ = Et, (2S,5S)-5-methyl-2-(propan-2-yl)cyclohexyl, Ph, etc.] are synthesized from substituted cyclopropanes I, II and cyclobutanes III in moderate-to-high yields. In contrast to oxidative ring openings, it is also the first time to realize electro-reductive ring-opening reaction of strained rings, including commercialized ones. Control experiments suggest that radical anions and carbanions might be the key intermediates in this reaction. Moreover, this process features high step and atom economy, mild reaction conditions (1 atm, room temperature), good chemoselectivity and functional group tolerance, low electrolyte concentration, and easy derivatization of products. Furthermore, the polymerization of the corresponding diesters with diols is conducted to obtain a potential UV-shielding material with self-healing function and a fluorine-containing polyester, whose performance tests show a promising application. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dietary exposure to low-calorie sweeteners in a sample of Brazilian pregnant women was written by Duarte, Larissa Marinho;Ferreira, Sila Mary Rodrigues;Almeida, Claudia Choma Bettega;Duran, Ana Clara da Fonseca Leitao;Grilo, Mariana Fagundes;Macedo, Mariana de Souza;Franceschini, Sylvia do Carmo Castro;Crispim, Sandra Patricia. And the article was included in Food Additives & Contaminants, Part A in 2022.Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

The dietary exposure to low-calorie sweeteners (LCS) was estimated in a sample of pregnant Brazilian women. Consumption data were obtained with a 24-h Dietary Recall interview. Because of the uncertainty in assessing foods with LCS, they were classified into three scenarios to ensure inclusion of the 15 LCS allowed for use in Brazil: ranging from a less to a more conservative scenario. The concentration of LCS was estimated using the amount declared on the label or the maximum permitted levels and anal. determination data for table-top sweeteners. The frequency of consumption was higher for acesulfame-K, aspartame, and cyclamate. The food groups contributing the most to the consumption of LCS were non-alc. beverages, table-top sweeteners, confectionary and desserts. The level of dietary exposure to LCS was within the safety limit. However, continued efforts to monitor their dietary exposure are necessary given the limitations highlighted in this study. In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Comprehensive investigation on non-volatile and volatile metabolites in four types of green teas obtained from the same tea cultivar of Longjing 43 (Camellia sinensis var. sinensis) using the widely targeted metabolomics was written by Shi, Yali;Zhu, Yin;Ma, Wanjun;Shi, Jiang;Peng, Qunhua;Lin, Zhi;Lv, Haipeng. And the article was included in Food Chemistry in 2022.Computed Properties of C8H16O This article mentions the following:

In this study, we produced roasted, baked, steamed, and sun-dried green tea products using the same batch of fresh tea leaves (FTL) of Longjing 43 (Camellia sinensis var. sinensis), and explored processing effects on the metabolic profiles of four types of green teas (FGTs) using the widely targeted metabolomics. Results showed that 146 differential metabolites including flavonoids, amino acids, lipids, and phenolic acids were screened among 1034 non-volatiles. In addition, nineteen differential metabolites were screened among 79 volatiles. Most of non-volatiles and volatiles metabolites changed notably in different manufacturing processes, whereas there were no significant differences (p>0.05) in the levels of total catechins between FGTs and FTL. The transformation of metabolites was the dominant trend during green tea processing. The results contribute to a better understanding of how the manufacturing process influences green tea quality, and provide useful information for the enrichment of tea biochem. theory. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Computed Properties of C8H16O).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Computed Properties of C8H16O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A new catalytic approach for aerobic oxidation of primary alcohols based on a Copper(I)-thiophene carbaldimines was written by Lagerspets, Emi;Valbonetti, Evelyn;Eronen, Aleksi;Repo, Timo. And the article was included in Molecular Catalysis in 2021.Related Products of 1777-82-8 This article mentions the following:

Novel Cu(I) thiophene carbaldimine catalysts for the selective aerobic oxidation of primary alcs. to their corresponding aldehydes and various diols to lactones or lactols was reported. In the presence of the in-situ generated Cu(I) species, a persistent radical (2,2,6,6-tetramethylpiperdine-N-oxyl (TEMPO)) and N-methylimidazole (NMI) as an auxiliary ligand, the reaction proceeds under aerobic conditions and at ambient temperature Especially the catalytic system of 1-(thiophen-2-yl)-N-(4-(trifluoromethoxy)phenyl)methanimine with copper(I)-iodide showed high reactivity for all kind of alcs. (benzylic, allylic and aliphatic). In the case of benzyl alc. even 2.5 mol% of copper loading gave quant. yield. Beside high activity under aerobic conditions, the catalysts ability to oxidize 1,5-pentadiol to the corresponding lactol (86% in 4 h) and N-phenyldiethanolamine to the corresponding morpholine derivate lactol (86% in 24 h) is particularly noteworthy. In the experiment, the researchers used many compounds, for example, (2,4-Dichlorophenyl)methanol (cas: 1777-82-8Related Products of 1777-82-8).

(2,4-Dichlorophenyl)methanol (cas: 1777-82-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 1777-82-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dual-stimuli-responsive glycopolymer bearing a reductive and photo-cleavable unit at block junction was written by Fang, Jia-You;Lin, Yin-Ku;Wang, Shiu-Wei;Yu, Yung-Ching;Lee, Ren-Shen. And the article was included in RSC Advances in 2016.Computed Properties of C7H7NO4 This article mentions the following:

New dual-stimuli-responsive and bio-recognizable glycopolymers (Glyco-ONB-s-s-PXCL) containing a photodegradable 5-hydroxy-2-nitrobenzyl alc. (ONB), and a redox-cleavable disulfide (-s-s-) as junction point between bio-recognizable hydrophilic sugar mol. (Glyco) and hydrophobic poly(4-substituted ε-caprolactone) (PXCL) chains were synthesized using a combination of ring-opening polymerization and nucleophilic substitution reactions. When the polymer solution was exposed to UV irradiation and/or the reducing agent DL-dithiothreitol (DTT), substantial structural and morphol. changes were observed in the particles. The polymers formed micelles in the aqueous solution, had hydrodynamic sizes ≤200 nm, and were spherical. Under the combined stimulation of UV irradiation and DTT, the micellar nanoparticles dissociated and the loaded mols. could be released from the assemblies more efficiently than under the stimulation of only one of the two stimuli. Selective lectin binding experiments confirmed that glucosylated Gluco-ONB-s-s-PXCL can be used for bio-recognition. The nanoparticles exhibited nonsignificant toxicity against HeLa cells at concentrations of ≤300 μg mL^-1. The DOX-loaded Gluco-ONB-s-s-PMCL₂₀ micelles effectively inhibited the proliferation of HeLa cells with a half-maximal inhibitory concentration (IC₅₀) of 1.5 μg mL^-1. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Computed Properties of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Bidentate Boryl Ligand-Enabled Iridium-Catalyzed Enantioselective Dual C-H Borylation of Ferrocenes: Reaction Development and Mechanistic Insights was written by Zou, Xiaoliang;Li, Yinwu;Ke, Zhuofeng;Xu, Senmiao. And the article was included in ACS Catalysis in 2022.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol This article mentions the following:

Ferrocenes with planar chirality are an important class of privileged scaffolds for diverse chiral ligands and organocatalysts. The development of efficient catalytic asym. methods under mild reaction conditions is a long-sought goal in this field. Though many transition-metal-catalyzed asym. C-H activation methods were recorded during the last decade, most of them are related to C-C bond-forming reactions. Owing to the useful attribute of the C-B bond, the authors herein report an amide-directed Ir-catalyzed enantioselective dual C-H borylation of ferrocenes. The key to the success of this transformation relies on a chiral bidentate boryl ligand and a judicious choice of a directing group. The current reaction could tolerate a vast array of functionalities, affording a variety of chiral borylated ferrocenes with good to excellent enantioselectivities (35 examples, up to 98% enantiomeric excess). The authors also demonstrated the synthetic utility by preparative-scale reaction and transformations of a borylated product. Finally, from the observed exptl. data, the authors performed DFT calculations to understand its reaction pathway and chiral induction, which reveals that Me C(sp³)-H borylation is crucial to conferring high enantioselectivity through an amplified steric effect caused by an interacted B-O fragment in the transition state. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Iridium-catalyzed asymmetric transfer hydrogenation of aromatic ketones with a cinchona alkaloid derived NNP ligand was written by Li, Linlin;Ma, Nana;Chen, Qian;Sun, Hao;Tian, Jie;Xu, Qian;Li, Chun;Zhang, Lin. And the article was included in Organic & Biomolecular Chemistry in 2022.Electric Literature of C8H9FO This article mentions the following:

An iridium complex generated in situ from [Ir(COD)Cl]₂ and a cinchona alkaloid derived NNP ligand has been developed for the asym. transfer hydrogenation of aromatic ketones. In this study, 30 aromatic ketones and heteroaryl ketones were hydrogenated to produce valuable chiral alcs. with up to 99% ee using i-PrOH as the hydrogen source and the solvent. The easily prepared Ir(L8)(COD)Cl also exhibited excellent activity and enantioselectivity in asym. transfer hydrogenation of aromatic ketones with a high S/C ratio (up to 2000). In the experiment, the researchers used many compounds, for example, (S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4Electric Literature of C8H9FO).

(S)-1-(2-Fluorophenyl)ethanol (cas: 171032-87-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Electric Literature of C8H9FO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vibration mill-assisted complex enzyme hydrolysis for flavoring of freeze-dried sea cucumber powder was written by Jin, Dan-li;Chen, Yue-wen;Hong, Xing-de;Chai, Ting-ting;Ren, Shao-tian;Ou, Yang-zhi;Huang, Xing-xin;Hu, Hao-ben. And the article was included in Journal of Food Biochemistry in 2022.Related Products of 3391-86-4 This article mentions the following:

This study aims to analyze the flavor differences of freeze-dried sea cucumber powder, processed for different time intervals, under vibration mill-assisted complex enzyme hydrolysis using electronic nose (E-nose) and gas chromatog.-ion mobility spectrometry (GC-IMS). The results of principal component anal. by E-nose showed distinction among the four groups of freeze-dried sea cucumber powder (papain-neutral protease (PN) and flavorzyme-neutral protease (FN), processed for 60 and 80 min). The GC-IMS revealed 35 volatile compounds Subsequently, based on the fingerprint and heat map results, the flavor differences among the samples were clearly distinguished. When compared to the other three groups, the 60-FN group exhibited a greater variety and quantity of volatile compounds such as octanal, heptanal, hexanal, (E, Z)-2,6-nonadienal, and nonanal. The 80-PN group exhibited high amounts of 2-propanone, ethylbenzene, Et acetate, and 2,5-dimethylpyrazine. In addition, the vibration mill technique was considered to be a mild enzyme-assisted method. This study found that different enzyme types and phys. technol. operation time can affect the different volatile flavor compounds of freeze-dried sea cucumber powder, which can be quickly and effectively be identified by E-nose and GC-IMS technol. to improve the flavor and quality of the product, while facilitating the rapid adjustment and development of the industry. Meanwhile, the results of the study could provide a reference for the deep processing and flavor improvement of the sea cucumber industry and make an important contribution to the related literature. In addition, this could also promote the development and application of non-thermal processing technologies such as vibratory mill in the freeze-dried sea cucumber powder industry. In the experiment, the researchers used many compounds, for example, Oct-1-en-3-ol (cas: 3391-86-4Related Products of 3391-86-4).

Oct-1-en-3-ol (cas: 3391-86-4) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 3391-86-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts