Tag: 100-200

Design of hydrophilic photocleavage o-nitrobenzyl acrylate-modified nanogels with outstanding biocompatibility prepared by RAFT polymerization for drug carrier was written by Xin, Fuhua;Wei, Meng;Jiang, Shengling;Gao, Yanjing;Nie, Jun;Wu, Yuejiao;Sun, Fang. And the article was included in European Polymer Journal in 2020.Formula: C7H7NO4 This article mentions the following:

Three kinds of hydrophilic photocleavage o-nitrobenzyl acrylate-modified nanogels with different particle size and narrow particle size distribution (1.8-0.24) were designed and synthesized by reversible addition-fragmentation chain transfer radical (RAFT) polymerization based on methoxy polyethylene glycol methacrylate (MPEGMA) and UV-light responsive crosslinker 5-(acryloyloxy)-2-nitrobenzyl acrylate (ONB) prepared with acryloyl chloride and 2-hydroxy-5-nitrobenzyl alc. The influences of particle size and distribution of the nanogel on its loading, encapsulation and photo-responsive release properties were investigated via the measurements of the final drug loading, the encapsulation efficiency and final cumulative release of coumarin 102 in the nanogel. The final drug loading, the encapsulation efficiency and the final cumulative release of coumarin 102 in the nanogel NG-ONB-300 with narrow particle size distribution were nearly twice more than those in the nanogel NG-ONB-300_AIBN with wide particle size distribution (0.33) at the same concentration of coumarin 102 and reached 8.31%, 39.5% and 67%, resp. With the increase of the particle size of the nanogel, the drug loading and encapsulation efficiency of the nanogel were decreased. Significantly, the in vitro cytotoxicity of the nanogel was also evaluated against HeLa cervical cancer cells by the MTT cell viability assay and its cell viability at different concentrations was greater than 91%, demonstrating that the photocleavage nanogel has an excellent biocompatibility and great potential in drug delivery fields. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Formula: C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Formula: C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms was written by Rammal, Fatima;Gao, Di;Boujnah, Sondes;Hussein, Aqeel A.;Lalevee, Jacques;Gaumont, Annie-Claude;Morlet-Savary, Fabrice;Lakhdar, Sami. And the article was included in ACS Catalysis in 2020.Reference of 1122-71-0 This article mentions the following:

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions. In the experiment, the researchers used many compounds, for example, 6-Methyl-2-pyridinemethanol (cas: 1122-71-0Reference of 1122-71-0).

6-Methyl-2-pyridinemethanol (cas: 1122-71-0) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Reference of 1122-71-0

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Production of (R)-chiral alcohols by a hydrogen-transfer bioreduction with NADH-dependent Leifsonia alcohol dehydrogenase (LSADH) was written by Inoue, Kousuke;Makino, Yoshihide;Itoh, Nobuya. And the article was included in Tetrahedron: Asymmetry in 2005.COA of Formula: C8H9ClO This article mentions the following:

Alc. dehydrogenase (LSADH) isolated from Leifsonia sp. S749 was used to produce (R)-chiral alcs. The enzyme with a broad substrate range reduced various prochiral ketones and keto esters to yield optically active secondary alcs. with a high enantiomeric excess. LSADH transferred the pro-S hydrogen of NADH to the carbonyl moiety of Ph trifluoromethyl ketone (13) through its re face to give (S)-1-phenyl-2,2,2-trifluoroethanol (40). LSADH was able to efficiently reproduce NADH when 2-propanol was used as a hydrogen donor in the reaction mixture In the experiment, the researchers used many compounds, for example, (R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9COA of Formula: C8H9ClO).

(R)-1-(3-Chlorophenyl)ethanol (cas: 120121-01-9) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C8H9ClO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery and Identification of Tastants and Taste-Modulating N-Acyl Amino Acid Derivatives in Traditional Korean Fermented Dish Kimchi Using a Sensomics Approach was written by Christa, Peter;Dunkel, Andreas;Krauss, Alin;Stark, Timo D.;Dawid, Corinna;Hofmann, Thomas. And the article was included in Journal of Agricultural and Food Chemistry in 2022.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol This article mentions the following:

Sensory-guided fractionation by means of ultrafiltration and gel permeation chromatog. followed by high-performance liquid chromatog., synthesis, liquid chromatog.-tandem mass spectrometry (LC-MS/MS) quantitation, and taste re-engineering experiments revealed taste-active and taste-enhancing compounds contributing to the umami, mouthful and complex taste profile of the fermented Korean dish, kimchi. Besides basic taste-active compounds, in particular, various N-acylated amino acids deriving from succinic acid and lactic acid imparted taste-modulating properties in food matrixes. Taste threshold concentrations were determined to evaluate intrinsic and modulating effects. Quantitation of N-acylated amino acids in kimchi following synthesis revealed the presence of numerous derivatives showing taste-active properties. Sensory evaluation including recombination and partial addition experiments highlighted that both the N-lactoyl- and the N-succinoyl amino acid derivatives contribute to increasing the fullness, volume, and complexity of food matrixes, whereas the latter directly contributes to the overall taste of kimchi in natural concentrations In the experiment, the researchers used many compounds, for example, (2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol).

(2R,3S)-rel-Butane-1,2,3,4-tetraol (cas: 149-32-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Name: (2R,3S)-rel-Butane-1,2,3,4-tetraol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficacy of supercritical carbon dioxide integrated hydrothermal extraction of Khmer medicinal plants with potential pharmaceutical activity was written by Chhouk, Kimthet;Wahyudiono;Kanda, Hideki;Goto, Motonobu. And the article was included in Journal of Environmental Chemical Engineering in 2018.Electric Literature of C10H22O3 This article mentions the following:

Khmer medicinal plants have been employed to treat human diseases for nearly a thousand years. Several studies have shown that the principal phytochem. constituents of such medicinal plants are phenolic acids, flavonoids, tannins, and alkaloids, which possess diverse bioactivities such as antioxidant, anti-inflammatory, anticancer, antidiabetic, antiallergic, and antimicrobial. In the present study, the extraction of the phytochem. constituents of Khmer medicinal plants (Dialium cochinchinense Pierre, Cinnamomum cambodianum Lecomte, Gardenia angkorensis Pitard, Cananga latifolia (Hook.f. & Thomson) Finet & Gagnep, and Oroxylum indicum (L.) Kurz bark) is performed using a supercritical carbon dioxide integrated hydrothermal process (SC-CO₂-H) at a temperature of 150°C, pressure of 10MPa, water flow rate of 2mL/min, CO₂ flow rate of 0.15mL/min, and extraction time of 4h. The total phenolic compounds content and antioxidant activity of the Khmer medicinal plants were determined by using the Folin-Ciocalteu and DPPH scavenging activity methods, resp. The phytochem. constituents of such plants were identified using GC-MS anal. The results showed that the extracts obtained by SC-CO₂-H contained a high amount of total phenolic compounds with potential antioxidant activity. The GC-MS results also suggested that the Khmer medicinal plants contained many bioactive compounds with a broad range of biol. activities, which could be employed in the food, pharmaceutical, and cosmetic industries. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6Electric Literature of C10H22O3).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Electric Literature of C10H22O3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Visible-light-induced radical cascade reaction to prepare oxindoles via alkyl radical addition to N-arylacryl amides was written by Cheng, Hanchao;Luo, Yunfeng;Lam, Tsz-Lung;Liu, Yungen;Che, Chi-Ming. And the article was included in Organic Chemistry Frontiers.Formula: C10H20O This article mentions the following:

A photochem. approach towards oxindoles I (R = H, OMe; R¹ = H, SMe, Br, Bz, etc.; RR¹ = -N=CHS-; R² = H, OMe; R³ = H; R²R³ = -CH=CH-CH=CH-; R⁴ = Me, 2-cyanoethyl, Ph, Bn; R³R⁴ = -(CH₂)₃-; R⁵ = 2-(4-methoxyphenyl)-2-oxoethyl, 1,1,2,2,3,3,4,4,4-nonafluorobutyl, 2-(1-benzofuran-2-yl)-2-oxoethyl, etc.) by the radical cascade reaction of α,β-unsaturated N-arylacryl amides with alkyl bromides or iodides upon visible light irradiation was described. This transition metal- and photosensitizer-free protocol afforded diverse oxindoles I with C3 quaternary centers in high product yields under mild reaction conditions. Importantly, the method was applicable to prepare the core skeletons of (±)-physovenine, (±)-esermethole and (±)-physostigmine. In the experiment, the researchers used many compounds, for example, (1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5Formula: C10H20O).

(1R,2S,5R)-2-Isopropyl-5-methylcyclohexanol (cas: 2216-51-5) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Formula: C10H20O

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bottlebrush polymers with self-immolative side chains was written by Wu, Ying;Zhang, Liangcai;Zhang, Minghui;Liu, Zhengping;Zhu, Wen;Zhang, Ke. And the article was included in Polymer Chemistry in 2018.Electric Literature of C7H7NO4 This article mentions the following:

A series of bottle-brush polymers with self-immolative side chains were prepared by a grafting-onto method. Poly(3-azido-2-hydroxypropyl methacrylate) (PGA) and propargyl-capped poly(carbamates) were used as the backbone and side chains, resp. A copper-catalyzed azide-alkyne cycloaddition reaction was used to graft the side chains onto the backbone with a high grafting d. A UV cleavable o-nitrobenzyl (ONB) linker was designed at the junction site of the backbone and side chain. Under UV irradiation, the ONB linkers cleaved to break the bottle-brush mol. architecture by detaching phenylamine terminated side chains from PGA backbones. The self-immolative disassembly of the detached side chains was then followed to generate aromatic amine small mols. The model functional bottle-brush polymers were further constructed using acrylate substituted poly(carbamates) as side chains, whose self-immolative disassembly continuously released fluorescence signals. Moreover, the total disassembly rate of the bottle-brush polymers could be conveniently tuned by tailoring the substituent group of poly(carbamate) side chains. In the experiment, the researchers used many compounds, for example, 3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9Electric Literature of C7H7NO4).

3-(Hydroxymethyl)-4-nitrophenol (cas: 60463-12-9) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C7H7NO4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Self-healing and printable elastomer with excellent shear stiffening and magnetorheological properties was written by Ding, Li;Zhang, Shuaishuai;Wang, Qi;Wang, Yu;Xuan, Shouhu;Gong, Xinglong;Zhang, Dongsheng. And the article was included in Composites Science and Technology in 2022.Recommanded Product: 2,2′-Oxybis(ethan-1-ol) This article mentions the following:

This work reports a novel kind of hybrid magnetorheol. elastomer (HMRE) that possesses multi-functions including excellent shear stiffening and magnetorheol. (MR) effects, as well as self-healing and printable abilities. The HMRE materials are prepared by embedding carbonyl iron particles (CIPs) into a blend of silicon rubber (SR) and low crosslinking gel-like polyurethane (PU). The relative shear stiffening effect of HMRE-3:1 (the mass ratio of PU and SR is 3:1, and 50 weight% CIPs) is 6095% as the shear frequency increases from 0.1 Hz to 100 Hz, which is about 150 times that of SR based magnetorheol. elastomer (MRE). With the magnetic flux d. from 0 to 1T, MR effect of isotropic HMRE-3:1 is as high as 266%, which is 3.5 times that of SR based MRE. Notably, HMRE obtains extraordinary mech. and elec. healing capabilities. HMRE with a destructive cut-through injury can sustain an extensibility of 425% (the initial extensibility ∼650%) after healing. Meanwhile, possible mechanisms are proposed to explain the shear stiffening properties, MR effect, and self-healing performance of HMRE. Moreover, the extruded modeling 3D printing of flexible HMRE actuators can be achieved due to the plasticine property of pre-polymerized HMRE, which bestows HMRE with magnetic particle distribution programmability and shape designability. This work may provide a new way for the next-generation multifunctional materials with exceptional shear stiffening behavior, magnetically mech. properties, self-healabilities, and printable performance. In the experiment, the researchers used many compounds, for example, 2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6Recommanded Product: 2,2′-Oxybis(ethan-1-ol)).

2,2′-Oxybis(ethan-1-ol) (cas: 111-46-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 2,2′-Oxybis(ethan-1-ol)

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and antiproliferative evaluation of some 1,4-naphthoquinone derivatives against human cervical cancer cells was written by Kacmaz, Aysecik;Deniz, Nahide Gulsah;Aydinli, Serdar Goksin;Sayil, Cigdem;Onay-Ucar, Evren;Mertoglu, Elif;Arda, Nazli. And the article was included in Open Chemistry in 2019.Reference of 29364-29-2 This article mentions the following:

In the course of biol. properties of quinone derivatives, the N(H)-, S- and S,S-substituted-1,4-naphthoquinones were synthesized by reactions of 2,3-dichloro-1,4-naphthoquinone with different amines (2-morpholinoaniline, tert-Bu 4-aminobenzoate, 4-tertbutylbenzylamine, N-(3-aminopropyl)-2-pipecoline, 2-amino-5,6-dimethylbenzothiazole, N,N’-diphenyl-p-phenylenediamine) and thiolate (sodium 2-methyl-2-propanethiolate). The antiproliferative activities of these compounds against human cervical cancer (HeLa) cells were evaluated by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) assay. Although all derivatives inhibited cell growth, the most active compound was 2-(tert-butylthio)-3-chloronaphthalene-1,4-dione (IC₅₀ = 10.16μM) against the HeLa cells. In the experiment, the researchers used many compounds, for example, Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2Reference of 29364-29-2).

Sodium 2-methyl-2-propanethiolate (cas: 29364-29-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 29364-29-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical Composition and Antioxidant Activities of the Essential oil of Olax acuminata was written by Chetia, Bolin;Phukan, Alakesh. And the article was included in Journal of Essential Oil-Bearing Plants in 2014.SDS of cas: 2451-01-6 This article mentions the following:

In the present study, chem. composition and antioxidant activities of the essential oil of Olax acuminata was investigated. The essential oils obtained by hydrodistillation was analyzed by gas chromatog.-mass spectrometry (GC-MS). α-Terpineol (11.5 %) was the major component of the essential oil of O. acuminata. Further the antioxidant activity of the essential oil of the leaves of the plant was evaluated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) and superoxide radical scavenging assay. In the experiment, the researchers used many compounds, for example, rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6SDS of cas: 2451-01-6).

rel-(1s,4s)-4-(2-Hydroxypropan-2-yl)-1-methylcyclohexanol hydrate (cas: 2451-01-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.SDS of cas: 2451-01-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts