Tag: 100-200

SDS of cas: 110-03-2In 2020, Duffy, Ian R.;Vasdev, Neil;Dahl, Kenneth published 《Copper(I)-Mediated ¹¹C-Carboxylation of (Hetero)arylstannanes》. 《ACS Omega》published the findings. The article contains the following contents:

A novel copper-mediated carboxylation strategy of aryl- and heteroaryl-stannanes was described. The method served as a mild (i.e., 1 atm) carboxylation method using stable carbon dioxide and was transferable as a radiosynthetic approach for carbon-11-labeled aromatic and heteroaromatic carboxylic acids using sub-stoichiometric quantities of [¹¹C]CO₂. The methodol. was applied to the radiosynthesis of the retinoid X receptor agonist, [¹¹C]bexarotene, with a decay-corrected radiochem. yield of 32 ± 5% and molar activity of 38 ± 23 GBq/μmol (n = 3).2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.SDS of cas: 110-03-2

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Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride《Synthesis of 2,4-dimethyl-3-hydroxy-5-hydroxymethylpyridine》 was published in 1966. The authors were Balyakina, M. V.;Rubtsov, I. A.;Zhdanovich, E. S.;Preobrazhenskii, N. A., and the article was included in《Zb. Prikl. Khim.》. The author mentioned the following in the article:

2,4-Dimethyl- 3 – hydroxy-5- hydroxymethylpyridine (4- deoxypyridoxine) (I) was synthesized via the following intermediates: 2,4-dimethyl-5-cyano-6-pyridone (II), 2,4-dimethyl-3-nitro-5-cyano-6-pyridone (III), and 2,4-dimethyl-3-nitro-5-cyano-6-chloropyridine (IV). Reduction of IV was carried out in 1 step in dilute HCl over Pd-C. 2,4-Dimethyl-3-amino-5-aminomethylpyridine was converted without isolation to I by treatment with NaNO₂. Thus, 33 ml. NH₄OH (d²⁰ 0.9) was added with stirring to 40 g. EtO₂CCH₂CN, the mixture cooled with ice to 0-2° and the precipitate filtered off, washed at 0° with 20 ml. cold EtOH, and dried to yield 23.8 g. cyanoacetamide (V), m. 120-2°. The filtrate was evaporated to dryness to yield an addnl. 3.95 g. Acetylacetone (10.0 g.) was added at 70° to 8.4 g. V in 50 ml. MeOH and 1.12 ml. Me₂NH to precipitate 88.1% II, m. 293.1-4.2°. A suspension of 4.44 g. II in 15 ml. Ac₂O is treated with stirring with 2.3 ml. HNO₃ (d₂₀ 1.4) and 2.3 ml. Ac₂O at 35-40°, and the mixture stirred 2 hrs. at 18-20° and poured upon 23 g. crushed ice, to precipitate 56.4% yellow III, m. 272.0-2.6° (alc.). P₂O₅ (5.3 g.) is added to a suspension of 3.6 g. III in 36 ml. PhCl, the mixture heated with stirring 3 hrs. at 118-120° the solvent removed at 45-50°/10 mm., the residue treated with 3.6 ml. absolute alc., stirred, and left 8 hrs. at 0-4°, the precipitate filtered off, washed at 0° with 2 ml. alc., and dried, and the residue extracted with petr. ether (b. 60-70°) to give 62.2% yellow IV, m. 114-15°. IV (2.4 g.) in 25 ml. ice water was added to a pre-hydrogenated mixture of 0.10 g. PdCl₂ with H₂O, HCl, and C, the hydrogenation continued until the theoretical H absorption, the catalyst separated and washed with 2 ml. H₂O, 2.4 ml. HCl (d₂₀ 1.18) added to the solution and washings, and the solution heated 1.5 hrs. at 80-5° during which 1.6 g. NaNO₂ in 5 ml. H₂O was added, the heating continued 30 more min. (neg. starch-iodide test), the solution evaporated in vacuo, the residue extracted with absolute alc., the extracts treated with activated C and concentrated until the appearance of crystals, the mixture kept 8 hrs. at 0-4°, and the precipitate filtered off, washed at 0° with 1 ml. alc., and dried to give 42.2% I, m. 256.1-7.2°. To complete the study, the researchers used 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Recommanded Product: 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

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Safety of 3,7-Dimethyloctan-3-ol《Biogenic volatile organic compound (BVOC) emissions from various endemic tree species in Turkey》 was published in 2015. The authors were Yaman, Baris;Aydin, Yagmur Meltem;Koca, Husnu;Dasdemir, Okan;Kara, Melik;Altiok, Hasan;Dumanoglu, Yetkin;Bayram, Abdurrahman;Tolunay, Doganay;Odabasi, Mustafa;Elbir, Tolga, and the article was included in《Aerosol and Air Quality Research》. The author mentioned the following in the article:

Compositions of biogenic volatile organic compound (BVOC) emissions from seven endemic tree species (Troy Fir, Uludag Fir, Cilician Fir, Oriental Sweetgum, Boz Pirnal Oak, Ispir Oak and Vulcanic Oak) in Turkey were determined Field samplings were carried out in the forested areas using a specific dynamic enclosure system during the summers of 2011 and 2012. The selected branches of tree species were enclosed in a chamber consisted of a transparent Nalofan bag. The air-flows were sampled from both inlet and outlet of the chamber by Tenax-filled sorbent tubes in the presence of sunlight. Isoprene, monoterpenes, sesquiterpenes, oxygenated sesquiterpenes and other oxygenated compounds including sixty five BVOC species were analyzed with a GC/MS system. Temperature, humidity, photosynthetically active radiation (PAR) and CO₂ concentrations were monitored both inside the enclosure and in ambient air. Calculated emission rates were normalized to standard conditions (1000 μmol/m² s PAR and 30 °C temperature). Ispir Oak, Oriental Sweetgum and Cilician Fir were the highest BVOC emitters with total normalized emission rates of 19.4 ± 19.2, 16.3 ± 16.1 and 15.5 ± 11.4 μg/g/h, resp. while Boz Pirnal Oak had the lowest emission rate of 0.84 ± 0.68 μg/g/h. Alpha-pinene, beta-pinene, beta-myrcene and limonene were the compounds dominating the monoterpene emission profiles while trans-caryophyllene, isolongifolene, alpha-humulene and copaene were the prominent sesquiterpenes. Predominant oxygenated compounds were also found as eucalyptol, linalool-L and alpha-terpineol. As reported in the literature, coniferous and broad-leaved species were predominantly monoterpene and isoprene emitters, resp. Oxygenated compounds were the third most prominent BVOC group and sesquiterpenes had relatively lower contributions for all species. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Safety of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Electric Literature of C8H18O2《Evaluation of TOPKAT, Toxtree, and Derek Nexus in Silico Models for Ocular Irritation and Development of a Knowledge-Based Framework To Improve the Prediction of Severe Irritation》 was published in 2016. The authors were Bhhatarai, Barun;Wilson, Daniel M.;Parks, Amanda K.;Carney, Edward W.;Spencer, Pamela J., and the article was included in《Chemical Research in Toxicology》. The author mentioned the following in the article:

Assessment of ocular irritation is an essential component of any risk assessment. A number of (Q)SARs and expert systems have been developed and are described in the literature. Here, the authors focus on three in silico models (TOPKAT, BfR rulebase implemented in Toxtree, and Derek Nexus) and evaluate their performance using 1644 inhouse and 123 European Center for Toxicol. and Ecotoxicol. of Chems. (ECETOC) compounds with existing in vivo ocular irritation classification data. Overall, the in silico models performed poorly. The best consensus predictions of severe ocular irritants were 52 and 65% for the inhouse and ECETOC compounds, resp. The prediction performance was improved by designing a knowledge-based chem. profiling framework that incorporated physicochem. properties and electrophilic reactivity mechanisms. The utility of the framework was assessed by applying it to the same test sets and three addnl. publicly available in vitro irritation data sets. The prediction of severe ocular irritants was improved to 73-77% if compounds were filtered on the basis of AlogP_MR (hydrophobicity with molar refractivity). The predictivity increased to 74-80% for compounds capable of preferentially undergoing hard electrophilic reactions, such as Schiff base formation and acylation. This research highlights the need for reliable ocular irritation models to be developed that take into account mechanisms of action and individual structural classes. It also demonstrates the value of profiling compounds with respect to their chem. reactivity and physicochem. properties that, in combination with existing models, results in better predictions for severe irritants. The experimental procedure involved many compounds, such as 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) .

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) was used in the synthesis of six- and seven-membered heterocyclic boron compounds containing intramolecular N-B bond.Electric Literature of C8H18O2

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Zhao, Jing;Liu, Wei;Chen, Dong;Zhou, Chunli;Song, Yi;Zhang, Yuyu;Ni, Yuanying;Li, Quanhong published 《Microbiological and Physicochemical Analysis of Pumpkin Juice Fermentation by the Basidiomycetous Fungus Ganoderma lucidum》 in 2015. The article was appeared in 《Journal of Food Science》. They have made some progress in their research.Recommanded Product: 80-46-6 The article mentions the following:

A new protocol for processing of pumpkin juice was set up which included fermentation by the basidiomycete Ganoderma lucidum at 28 °C for 7 d. The growth curve of G. lucidum in pumpkin juice was successfully (R² = 0.99) fitted by a 4-parameter logistic model and the ideal highest biomass was estimated to be 4.79 g/L. G. lucidum was found to have a significant acidification effect on pumpkin juice. The lowest pH (4.05 ± 0.05) and highest total titratable acidity (14.31 ± 0.16 mL 0.1 M NaOH/100 mL) were found on the 4th day during fermentation Sugars in pumpkin juice fermented with G. lucidum showed a significant decrease, especially glucose and fructose. On the contrary, the release of exo-polysaccharides and free amino acids greatly enriched the pumpkin juice. The variation of color index and viscosity also mirrored the above behavior. Based on headspace solid phase microextraction and gas chromatog.-mass spectrometry, 68 volatile compounds were identified, including 17 esters, 14 alcs., 13 Ph compounds, 11 aldehydes, 8 ketones, 3 acids, 1 furan, and 1 benzothiazole. The pumpkin juices fermented for different days were markedly differentiated with principal component anal. and the fermentation process was tentatively divided into 3 periods: the booming (from the 1st to 4th day), steady (from the 5th to 6th day), and decline (the 7th day) period. The experimental procedure involved many compounds, such as 4-tert-Amylphenol (cas: 80-46-6) .

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Owing to the presence of the polar OH alcohols are more water-soluble than simple hydrocarbons. Methanol, ethanol, and propanol are miscible in water. Butanol, with a four-carbon chain, is moderately soluble.Recommanded Product: 80-46-6

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HPLC of Formula: 110-03-2In 2019, Bhaladhare, Sachin;Kim, Soeun;Carter, Kenneth R. published 《Mechanical Properties and Moisture Transport Behavior of Acid-Sensitive Hydrogels》. 《ACS Applied Polymer Materials》published the findings. The article contains the following contents:

Thin hydrogel films containing the acid sensitive cross-linker 2,5-dimethyl-2,5-hexanediol dimethacrylate (DHDMA) were synthesized as part of a larger project to create protective layers against chem. and biol. (CB) threats. In order to operate efficiently as fabric coatings, the mech. and moisture vapor transport properties of these materials must be understood. The hydrogels were composed primarily of poly(ethylene glycol) dimethacrylate (PEGDMA) and 2-hydroxyethyl methacrylate (HEMA) and were prepared by free radical crosslinking polymerization The influence of different compositions of DHDMA, PEGDMA, and HEMA on the moisture vapor transmission rate (MVTR), mech. properties, and swelling properties of PEGDMA/DHDMA/HEMA copolymer hydrogels has been investigated. The characterization by Fourier transform IR (FTIR) spectroscopy confirmed the presence of all monomers used in the gel structure. The hydrogels showed high MVTR, which are comparable to the widely accepted breathable membrane of Gore-Tex fabric and expanded polytetrafluoroethylene (ePTFE). The swelling data indicated that the equilibrium water content depends on the composition of hydrogels. It was found that addition of HEMA into the PEGDMA-based hydrogels was very helpful to improve the swelling properties but decrease in water contact angle. Rheol. study of hydrogels showed that the hydrogels are very stiff and their stiffness increases with increasing PEGDMA content in the hydrogels. And 2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) was used in the research process.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.HPLC of Formula: 110-03-2

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Alcohol – Wikipedia,
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