Tag: 100-200

Related Products of 148-51-6《Effects of alterations in the metabolism of γ-aminobutyrate on convulsant potencies》 was published in 1977. The authors were Stone, William E., and the article was included in《Epilepsia》. The author mentioned the following in the article:

Drugs that alter γ-aminobutyrate (GABA) [56-12-2] metabolism and presumably affect the availability of GABA in synaptic regions were tested for their relative effects on the potencies of 4 convulsants: 3-mercaptopropionate (3-MP) [107-96-0], pentamethylenetetrazole (PTZ) [54-95-5], bicuculline [485-49-4], and picrotoxin [124-87-8] in mice. Aminooxyacetic acid hemichloride [2921-14-4] given prior to the convulsant tended to decrease the potency of 3-MP more than that of PTZ. It decreased the potency of bicuculline more than that of PTZ but less than that of 3-MP, and did not alter that of picrotoxin. Thiocarbohydrazide (TCH) [2231-57-4], DL–C-allylglycine [7685-44-1], and 4-deoxypyridoxine-HCl (DOP) [148-51-6] tended to potentiate 3-MP more than PTZ. The effects of allylglycine on bicuculline and picrotoxin were intermediate. DOP potentiated bicuculline and picrotoxin only to the extent that it potentiated PTZ. TCH resembled DOP in its effect on bicuculline. Valproic acid [99-66-1] decreased the potency of each convulsant; it was most effective against PTZ, slightly less so against 3-MP, and still less effective against bicuculline and picrotoxin. Its anticonvulsive action probably is not primarily via the GABA system. Phenelzine [51-71-8] slightly decreased the potency of bicuculline, but potentiated 3-MP and picrotoxin and did not affect the potency of PTZ. Diacetyl monoxime [57-71-6] was anticonvulsive against PTZ, bicuculline, and picrotoxin, but not against 3-MP. The results do not support the view that bicuculline and picrotoxin induce seizures by blocking GABA-mediated inhibition. The experimental procedure involved many compounds, such as 5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride (cas: 148-51-6) .

5-(hydroxymethyl)-2,4-dimethylpyridin-3-ol hydrochloride(cas:148-51-6 Related Products of 148-51-6) is a strong antagonist of vitamin B6. Deoxypyridoxine hydrochloride has been used as an analytical reference standard for the quantification of the analyte in food samples using high performance liquid chromatography.

Reference:
Alcohol – Wikipedia,
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Recommanded Product: 2,5-Dimethyl-2,5-hexanediol《Hydrogenation of alkynes to cis-alkenes with hydrazine in air》 was published in 2017. The authors were Wang, Jintao;Xiong, Jiukai;Li, Juanjuan;Wang, Jiali;Wang, Kerang;Li, Xiaoliu, and the article was included in《Youji Huaxue》. The author mentioned the following in the article:

In this paper, a simple approach of selectively hydrogenation of alkynes to cis-alkenes with NH₂NH₂·H₂O as a transfer hydrogenation agent in the presence of air without any catalysts or metals was developed. Furthermore, the configuration of cis-alkene was confirmed by the 2D NOESY spectrum.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) is used as an intermediate in the preparation of 2.5-Dimethyl-2.5-bis(tertbutyl-peroxy)hexane. It is also used in the synthesis of six- and seven-membered heterocyclic boron compounds.Recommanded Product: 2,5-Dimethyl-2,5-hexanediol

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Alcohol – Wikipedia,
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Cozzolino, Rosaria;De Giulio, Beatrice;Marena, Pasquale;Martignetti, Antonella;Gunther, Kathrin;Lauria, Fabio;Russo, Paola;Stocchero, Matteo;Siani, Alfonso published 《Urinary volatile organic compounds in overweight compared to normal-weight children: results from the Italian I.Family cohort》 in 2017. The article was appeared in 《Scientific Reports》. They have made some progress in their research.Recommanded Product: 78-69-3 The article mentions the following:

Accumulating evidence shows that urinary volatile organic compounds (VOCs) could be perturbed in many physiol. and pathol. states, including several diseases and different dietary exposures. Few studies investigated the urinary metabolic signature associated to excess body weight and obesity in adult populations, while a different VOCs profile was found in exhaled breath in obese as compared to lean children. Aim of this study was to evaluate the VOCs profile in the urine of 21 overweight/obese (OW/Ob) and 28 normal-weight (NW) children belonging to the Italian cohort of the I. Family study. Urine samples were analyzed by Solid Phase Micro-Extraction (SPME) GC-MS under both acidic and alk. conditions, in order to profile a wider range of urinary volatiles with different physicochem. properties. Multivariate statistics techniques were applied to bioanal. data to visualize clusters of cases and detect the VOCs able to differentiate OW/Ob from NW children. Under alk. conditions, fourteen VOCs were identified, distinguishing OW/Ob from NW children. Our results suggest that VOCs signatures differ between OW/Ob and NW children. However, the biol. and pathophysiol. meaning of the observed differences needs to be elucidated, in order to better understand the potential of urinary VOCs as early metabolic biomarkers of obesity. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Recommanded Product: 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

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Alcohol – Wikipedia,
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Liu, En-Chih;Topczewski, Joseph J. published 《Enantioselective Copper Catalyzed Alkyne-Azide Cycloaddition by Dynamic Kinetic Resolution》. The research results were published in《Journal of the American Chemical Society》 in 2019.Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol The article conveys some information:

In the presence of [Cu(OTf)]₂·PhMe and a nonracemic bis(chlorophenyl)pyridinebis(oxazoline), allylic azides such as I underwent enantioselective azide-alkyne cycloaddition reactions via dynamic kinetic resolution to yield nonracemic allylic triazoles such as II. A nonracemic propargyl alc. and propargyl-substituted natural products underwent enantioselective azide-alkyne cycloaddition reactions in high diastereoselectivities. The azide reactants are potentially explosive and should be handled with care; reaction mixtures should not be worked up with acid to avoid the formation of hydrazoic acid and their wastes should be kept sep. from other organic wastes. The experimental procedure involved many compounds, such as (S)-2-Amino-2-(4-fluorophenyl)ethanol (cas: 224434-01-9) .

(S) – 2-amino-2 – (4-fluorophenyl) ethanol (cas: 224434-01-9) has the characteristics of alcohol. In general, the hydroxyl group makes alcohols polar. Those groups can form hydrogen bonds to one another and to most other compounds. Safety of (S)-2-Amino-2-(4-fluorophenyl)ethanol

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Alcohol – Wikipedia,
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Rahman, Mahmudur Md;Kim, Ki-Hyun published 《Potential hazard of volatile organic compounds contained in household spray products》 in 2014. The article was appeared in 《Atmospheric Environment》. They have made some progress in their research.Quality Control of 3,7-Dimethyloctan-3-ol The article mentions the following:

To assess the exposure levels of hazardous volatile pollutants released from common household spray products, a total of 10 spray products consisting of six body spray and four air spray products have been investigated. The body spray products included insect repellents (two different products), medicated patch, deodorant, hair spray, and humectant, whereas the air spray products included two different insecticides (mosquito and/or cockroach), antibacterial spray, and air freshener. The main objective of this study was to measure concentrations of 15 model volatile organic compounds (VOCs) using GC/MS coupled with a thermal desorber. In addition, up to 34 ‘compounds lacking authentic standards or surrogates (CLASS)’ were also quantified based on the effective carbon number (ECN) theory. According to our anal., the most common indoor pollutants like benzene, toluene, styrene, Me Et ketone, and Bu acetate have been detected frequently in the majority of spray products with the concentration range of 5.3-125 mg L^-1. If one assumes that the amount of spray products released into air reaches the 0.3 mL level for a given space size of 5 m³, the risk factor is expected to exceed the carcinogenic risk level set for benzene (10^-5) by the U. S. EPA. The experimental procedure involved many compounds, such as 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Quality Control of 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Eggink, P. M.;Maliepaard, C.;Tikunov, Y.;Haanstra, J. P. W.;Bovy, A. G.;Visser, R. G. F. published 《A taste of sweet pepper: Volatile and non-volatile chemical composition of fresh sweet pepper (Capsicum annuum) in relation to sensory evaluation of taste》 in 2012. The article was appeared in 《Food Chemistry》. They have made some progress in their research.Application of 110-03-2 The article mentions the following:

In this study volatile and non-volatile compounds, as well as some breeding parameters, were measured in mature fruits of elite sweet pepper (Capsicum annuum) lines and hybrids from a com. breeding program, several cultivated genotypes and one gene bank accession. In addition, all genotypes were evaluated for taste by a trained descriptive sensory expert panel. Metabolic contrasts between genotypes were caused by clusters of volatile and non-volatile compounds, which could be related to metabolic pathways and common biochem. precursors. Clusters of phenolic derivatives, higher alkanes, sesquiterpenes and lipid derived volatiles formed the major determinants of the genotypic differences. Flavor was described with the use of 14 taste attributes, of which the texture related attributes and the sweet-sour contrast were the most discriminatory factors. The attributes juiciness, toughness, crunchiness, stickiness, sweetness, aroma, sourness and fruity/apple taste could be significantly predicted with combined volatile and non-volatile data. Fructose and (E)-2-hexen-1-ol were highly correlated with aroma, fruity/apple taste and sweetness. New relations were found for fruity/apple taste and sweetness with the compounds p-menth-1-en-9-al, (E)-β-ocimene, (Z)-2-penten-1-ol and (E)-geranylacetone. Based on the overall biochem. and sensory results, the perspectives for flavor improvement by breeding are discussed.2,5-Dimethyl-2,5-hexanediol (cas: 110-03-2) were involved in the experimental procedure.

2,5-Dimethyl-2,5-hexanediol(cas:110-03-2) on heteropoly acid catalyzed dehydration yields cyclic ethers via stereospecific intramolecular SN2 mechanism. It reacts with nitriles in concentrated sulfuric acid to yield Δ1-pyrrolines.Application of 110-03-2

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Alcohol – Wikipedia,
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Heiger-Bernays, Wendy J.;Wegner, Susanna;Dix, David J. published 《High-throughput in Vitro Data To Inform Prioritization of Ambient Water Monitoring and Testing for Endocrine Active Chemicals》. The research results were published in《Environmental Science & Technology》 in 2018.Quality Control of 4-tert-Amylphenol The article conveys some information:

The presence of industrial chems., consumer product chems., and pharmaceuticals is well documented in waters in the US and globally. Most of these chems. lack health-protective guidelines and many have been shown to have endocrine bioactivity. There is currently no systematic or national prioritization for monitoring waters for chems. with endocrine disrupting activity. The authors propose Ambient Water Bioactivity Concentrations (AWBCs) generated from high throughput data as a health-based screen for endocrine bioactivity of chems. in water. The US EPA ToxCast program has screened over 1800 chems. for estrogen receptor (ER) and androgen receptor (AR) pathway bioactivity. AWBCs are were calculated for 110 ER and 212 AR bioactive chems. using high throughput ToxCast data from in vitro screening assays and predictive pathway models, high-throughput toxicokinetic data, and data-driven assumptions about consumption of water. Chem.-specific AWBCs are compared with measured water concentrations in datasets from the greater Denver area, Minnesota lakes, and Oregon waters, demonstrating a framework for identifying endocrine bioactive chems. This approach can be used to screen potential cumulative endocrine activity in drinking water and to inform prioritization of future monitoring, chem. testing and pollution prevention efforts. And 4-tert-Amylphenol (cas: 80-46-6) was used in the research process.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Quality Control of 4-tert-Amylphenol

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Shuler, William G.;Johnson, Shea L.;Hilinski, Michael K. published 《Organocatalytic, Dioxirane-Mediated C-H Hydroxylation under Mild Conditions Using Oxone》. The research results were published in《Organic Letters》 in 2017.Related Products of 78-69-3 The article conveys some information:

Dioxiranes are among the most selective and useful reagents for C(sp³)-H hydroxylation, but the development of a general dioxirane-mediated catalytic method has been an elusive goal. A trifluoromethyl ketone catalyst in combination with Oxone is shown to enable the first dioxirane-mediated catalytic hydroxylations that approx. the reactivity and selectivity of isolated dioxiranes. The mild reaction conditions allow for selective 3° hydroxylation and 2° oxidation and are tolerant of acid-sensitive functionality and electron-neutral arenes.3,7-Dimethyloctan-3-ol (cas: 78-69-3) were involved in the experimental procedure.

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Related Products of 78-69-3 Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Xiao-yue;Xu, Huai-de;Yang, Rong-xiang published 《Optimization of fermentation conditions of green tea wine and changes in its main components during fermentation》. The research results were published in《Shipin Kexue (Beijing, China)》 in 2014.Name: 3,7-Dimethyloctan-3-ol The article conveys some information:

The fermentation process of green tea wine was optimized, and the changes in polyphenols, catechins and aroma components during fermentation were investiated. Orthogonal array experiments were used to optimize the fermentation process. The changes in catechins and aroma components were determined by high performance liquid chromatog. (HPLC) and gas chromatog.-mass spectrometry (GC-MS). The optimal fermentation parameters were determined as follows: 4 g/L green tea infusion with 20% glucose and 50 g/L honey added, 5 g/L wine yeast inoculum size, and fermentation at 28°C for 10 days. The contents of six catechins were increased during fermentation Specifically, the contents of (-)-epigallocatechin (EGC), (-)-gallocatechin gallate (GCG), epicatechin gallate (ECG), and epicatechin (EC) were slightly increased; however, the contents of catechin (C) and epigallocatechin-3-gallate catechin (EGCGC) were increased by 10.88 and 17.33-folds, resp. These results indicate that the increase of catechins plays an important role in the health-promoting function of green tea wine. There were 87, 88 and 94 aroma components in the wine at the initial and the last stages of fermentation and the aged wine, which accounted for 92.93%, 98.26% and 91.87% of the total volatile components, resp. The significant differences in the types and amounts of aroma components indicate the transition from the tea flavor to the wine aroma components. Green tea can be fermented into wine; the health-promoting components (catechins) of green tea are increased to different extents and the green tea wine is mellow. To complete the study, the researchers used 3,7-Dimethyloctan-3-ol (cas: 78-69-3) .

3,7-Dimethyloctan-3-ol(cas:78-69-3) is a fatty alcohol that is 3-octanol substituted by methyl groups at positions 3 and 7.Name: 3,7-Dimethyloctan-3-ol Metabolite observed in cancer metabolism. It has a role as a human metabolite.

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deng, Xiaolong;Tan, Siqiao;Yuan, Chen;Yuan, Zheming published 《QSAR Study on the toxicities of alcohols and phenols based on minimal redundancy maximal relevance and distance correlation feature selection methods》. The research results were published in《Research Journal of BioTechnology》 in 2016.Recommanded Product: 4-tert-Amylphenol The article conveys some information:

Toxicity prediction can provide important information for environmental protection. The toxicity predictions of 228 alcs. and phenols were performed by quant. structure-activity relationship (QSAR). Feature selection can reduce the training time of modeling, improve the prediction accuracy and enhance the interpretability of a model. Both dependent variables (toxicity) and independent variables (mol. descriptors) of the QSAR data sets are usually continuous variables. The well-known feature selection method, minimal redundancy maximal relevance (mRMR) can eliminate redundancy and extract relevant features effectively but can only be applied to discrete dependent variables. The distance correlation (dCor) can detect the nonlinear correlation of two continuous variables. In the present work, a new mRMR-dCor feature selection method was developed by combining mRMR with dCor and used to construct the QSAR models for three datasets based on the retained mol. descriptors and support vector regression (SVR). mRMR-dCor feature selection method showed better predication performance (the Q2 of three datasets are 0.954, 0.941 and 0.981 resp.) than the reference feature selection methods and other methods reported in literature. In all, mRMR-dCor feature selection has a promising application prospect in the numerous domains of high dimensional feature selections such as QSAR.4-tert-Amylphenol (cas: 80-46-6) were involved in the experimental procedure.

4-tert-acylphenol (cas:80-46-6) contains hydroxyl group.Some low molecular weight alcohols of industrial importance are produced by the addition of water to alkenes. Ethanol, isopropanol, 2-butanol, and tert-butanol are produced by this general method. Recommanded Product: 4-tert-Amylphenol

Reference:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts