Tag: 0-100

Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates was written by Kalcic, Filip;Dracinsky, Martin;Janeba, Zlatko. And the article was included in Organic & Biomolecular Chemistry in 2021.Reference of 5856-63-3 This article mentions the following:

Herein we describe and compare five convenient approaches leading to key synthetic 6-chloropurine acyclic nucleoside phosphonates (ANPs), e.g. I, bearing the 9-phosphonomethoxyethyl (PME) moiety branched at the C₁‘ position. These intermediates can be further vastly diversified into target C1′-branched ANPs bearing either natural or unnatural nucleobases. The importance of C1′-branched ANPs is emphasized by their analogy with C1’-substituted cyclic nucleotides (such as remdesivir, a broad-spectrum antiviral agent) and evaluation of their biol. activity (e.g. antiviral, antineoplastic, and antiprotozoal) will be a tempting subject of further research. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Magnetically-separable acid-resistant CoFe₂O₄@Polymer@MIL-100 core-shell catalysts for the acetalization of benzaldehyde and methanol was written by Cheng, Yaran;Chen, Jing;Wang, Tong;Wu, Qin;Shi, Daxin;Zhang, Yaoyuan;Chen, Kangcheng;Li, Hansheng. And the article was included in Journal of Colloid and Interface Science in 2023.Electric Literature of C3H8O2 This article mentions the following:

Novel reusable acid-resistant magnetic polymer nanospheres-immobilized MIL-100 (CoFe₂O₄@Polymer@MIL-100) catalyst was prepared by a layer-by-layer method to achieve a controllable structure. The obtained core-shell catalyst consisted of modified magnetic nanoparticles as the core, a carboxylic-functionalized polymer as the protective layer, and an MIL-100 shell as the active catalytic layer by chem. bonds on the polymer. The catalysts showed good stability, good magnetic saturation, and acid corrosion resistance. The thickness of the MIL-100 shell could be adjusted by controlling the metal salt concentration and the number of layer-by-layer cycles. Nano-sized MIL-100 showed better mass transfer efficiency and catalytic activity. A conversion of 97.7% after 10 min was observed during acetalization when using CoFe₂O₄@Polymer@MIL-100 as the catalyst. CoFe₂O₄@Polymer@MIL-100 could be reused at least five times. The use of a polymer layer on CoFe₂O₄@Polymer@MIL-100 prevented acidic ligands from corroding the magnetic core. Chem. bonds between MIL-100 and functional magnetic polymer cores improved the catalyst′s stability. CoFe₂O₄@Polymer@MIL-100 exhibited high activity, excellent stability, and easy magnetic separation In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Electric Literature of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Volumetric and Ultrasonic Studies on Interactions of Hexylene and Propylene Glycols in Aqueous Solutions of Glutaraldehyde at Different Temperatures was written by Kaur, Parminder;Chakraborty, Nabaparna;Kumar, Harsh;Singla, Meenu;Juglan, Kailash Chandra. And the article was included in Journal of Solution Chemistry in 2022.HPLC of Formula: 57-55-6 This article mentions the following:

To determine the various interactions between glutaraldehyde and glycols (hexylene and propylene), various thermodn. and acoustic properties have been analyzed by using the d. (ρ) and ultrasonic velocity (c) of liquid mixtures of (hexylene or propylene + aqueous glutaraldehyde solutions), resp., in the concentration ranges from (0.01 to 0.04) mol·kg^-1 at the temperatures of 293.15, 298.15, 303.15, 308.15 K. Thermodn. parameters including the apparent molar volume (V_Φ) and partial molar volume (V⁰Φ) have been calculated from the d. values. These parameters show that the (solute-solvent) interaction for propylene glycol is weaker as compared to hexylene glycol. Acoustic parameters including the apparent molar isentropic compressibility (K_Φ,s) and partial molar isentropic compression (K⁰Φ,s) have been determined by using ultrasonic velocity values. Pair and triplet interaction coefficients have also been determined by using partial molar volume of transfer and partial molar isentropic compression of transfer. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6HPLC of Formula: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.HPLC of Formula: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vertex protein PduN tunes encapsulated pathway performance by dictating bacterial metabolosome morphology was written by Mills, Carolyn E.;Waltmann, Curt;Archer, Andre G.;Kennedy, Nolan W.;Abrahamson, Charlotte H.;Jackson, Alexander D.;Roth, Eric W.;Shirman, Sasha;Jewett, Michael C.;Mangan, Niall M.;Olvera de la Cruz, Monica;Tullman-Ercek, Danielle. And the article was included in Nature Communications in 2022.Safety of 1,2-Propanediol This article mentions the following:

Abstract: Engineering subcellular organization in microbes shows great promise in addressing bottlenecks in metabolic engineering efforts; however, rules guiding selection of an organization strategy or platform are lacking. Here, we study compartment morphol. as a factor in mediating encapsulated pathway performance. Using the 1,2-propanediol utilization microcompartment (Pdu MCP) system from Salmonella enterica serovar Typhimurium LT2, we find that we can shift the morphol. of this protein nanoreactor from polyhedral to tubular by removing vertex protein PduN. Anal. of the metabolic function between these Pdu microtubes (MTs) shows that they provide a diffusional barrier capable of shielding the cytosol from a toxic pathway intermediate, similar to native MCPs. However, kinetic modeling suggests that the different surface area to volume ratios of MCP and MT structures alters encapsulated pathway performance. Finally, we report a microscopy-based assay that permits rapid assessment of Pdu MT formation to enable future engineering efforts on these structures. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Using COSMO-RS to Predict Hansen Solubility Parameters was written by Wojeicchowski, Jose Pedro;Ferreira, Ana M.;Okura, Tifany;Pinheiro Rolemberg, Marlus;Mafra, Marcos R.;Coutinho, Joao A. P.. And the article was included in Industrial & Engineering Chemistry Research in 2022.COA of Formula: C3H8O2 This article mentions the following:

Hansen solubility parameters (HSP) provide essential information on the nature of solvents, being a useful tool in their selection for product and process design. In this work, linear models were developed to estimate HSP based on the use of COSMO-RS (conductor-like screening model for realistic solvents) descriptors. Hansen solubility parameters for 195 compounds were obtained from the literature and classified into two categories: training set (133 compounds) and testing set (62 compounds). Then a factorial regression was carried out to predict dispersion, hydrogen-bonding interaction, and polar contribution of HSP (δ_D, δ_H, and δ_P, resp.) based on σ-moments and energy COSMO-RS descriptors. The description of the dispersion contribution was the least successful due to the low variability of the exptl. data, despite the database containing compounds of a widely different chem. nature. The models obtained proved to be more than simple math. equations since a phys. meaning is achieved when COSMO-RS descriptors are used. The models developed were then applied to the test database. An excellent performance was observed, with δ_H showing the highest R² (0.90), and the MAE obtained were 0.98, 1.74, and 1.44 MPa^1/2 for δ_D, δ_H, and δ_P, resp., which are lower than those found in previous works. Finally, HSP data for caffeine, nicotine, paracetamol, and D-camphor were estimated The results were close to the literature data and those predictive by the HSPiP software. Moreover, it was shown that δ_P and δ_H drive the mols.’ polarity, impacting their log K_ow (a quant. measure of polarity). This work shows that COSMO-RS descriptors are a tool to predict HSP through linear models, opening new doors in the screening, design, and selection of solvents to be used in chem. processes. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6COA of Formula: C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, synthesis and anticonvulsant-analgesic activity of new N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols was written by Rapacz, Anna;Waszkielewicz, Anna M.;Panczyk, Katarzyna;Pytka, Karolina;Koczurkiewicz, Paulina;Piska, Kamil;Pekala, Elzbieta;Budziszewska, Boguslawa;Starek-Swiechowicz, Beata;Marona, Henryk. And the article was included in MedChemComm in 2017.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

New derivatives of N-[(phenoxy)alkyl]- and N-[(phenoxy)ethoxyethyl]aminoalkanols have been synthesized and evaluated for their anticonvulsant activity in maximal electroshock (MES), maximal electroshock seizure threshold (MEST), and pentylenetetrazol (PTZ) tests. Their neurotoxicity was evaluated via rotarod and chimney tests. The compounds exhibiting the most beneficial activity and protection indexes were evaluated for analgesic activity using the formalin test for neurogenic pain. They were also evaluated for their influence on cytotoxic activity using in vitro cellular models (HepG2 and CRL-2534 cell lines). Experiments performed using MTT and neutral red cytotoxicity assays showed that all evaluated compounds were safe for normal, glial cells (astrocytes) and did not induce hepatotoxic effects. Based on the results from the in vitro studies, the safety of the evaluated compounds was inferred. The most promising compound in this research was 1-{2-[2-(2,3-dimethylphenoxy)ethoxy]ethyl}piperidin-3-ol hydrochloride. Addnl., in silico metabolism prediction for the compound has been performed. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Co-Assembly of Chiral Amines and a Four-Armed Cyano-Substituted Luminophore through Hydrogen Bonds for Potential Development of Smart Chiroptical Materials was written by Liu, Yiping;Hao, Aiyou;Xing, Pengyao. And the article was included in Chemistry – A European Journal in 2022.Category: alcohols-buliding-blocks This article mentions the following:

Chirality transfer from chiral mols. to assemblies is of vital importance to the design of functional chiral materials. In this work, selective co-assembly behaviors between chiral mols. and an achiral luminophore, potentially driven by the intermol. salt-bridge type hydrogen bonds are reported. Cyano-substituted tetrakis(arylthio)benzene carboxylic acid (TA) served as the luminophore and hydrogen bond donors, which underwent co-assembly with different chiral amines. It was found that structures of chiral amines affect the chirality transfer and the properties of co-assemblies due to effects on hydrogen bonds and stacking pattern. Only in specific co-assemblies, the chiroptical properties occurred at both ground state and excited states based on the emerged Cotton effects and circularly polarized luminescence (CPL) signals, revealing that the chirality was successfully transferred from mol. level to supramol. level. In addition, accurate quant. examination of chiral amines was realized by CD spectra. This work demonstrates the characteristic chirality response and transfer through co-assembly, providing a potential method to develop smart chiroptical materials. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Novel Inorganic Mesoporous Material with Chiral Nematic Structure Derived from Nanocrystalline Cellulose for High-Resolution Gas Chromatographic Separations was written by Zhang, Jun-Hui;Xie, Sheng-Ming;Zhang, Mei;Zi, Min;He, Pin-Gang;Yuan, Li-Ming. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2014.Synthetic Route of C4H11NO This article mentions the following:

Chiral nematic mesoporous silica (CNMS) has attracted widespread attention due to some unique features, such as its nematic structure, chirality, large pore size, high temperature resistance, low cost, and ease of preparation The authors 1st reported the use of CNMS as a stationary phase for capillary gas chromatog. (GC). The CNMS-coated capillary column not only gives good selectivity for the separation of linear alkanes, aromatic hydrocarbons, polycyclic aromatic hydrocarbons (PAHs), and isomers but also offers excellent enantioselectivity for chiral compounds Compared with enantioseparations on com. β-DEX 120 and Chirasil-L-Val columns, a CNMS-coated capillary column offers excellent enantioselectivity, chiral recognition complementarity, and the separation of analytes within short elution times. It can also be potentially applied in high-temperature GC at >350°. CNMS could soon become very attractive for separations In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formulation and evaluation of nasal insert for nose-to-brain drug delivery of rivastigmine tartrate was written by Shaghlil, Lena;Alshishani, Anas;Sa’aleek, Asmaa Abu;Abdalkader, Hamdy;Al-ebini, Yousef. And the article was included in Journal of Drug Delivery Science and Technology in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Nose-to-Brain drug delivery can bypass blood-brain-barrier though the olfactory region using different devices and dosage forms. This work aimed to fabricate and characterize a novel dosage form, nasal inserts, containing rivastigmine tartrate. Four formulas were fabricated using gelatin/HPMC matrix in a different ratios and grades. The fabricated nasal inserts were characterized in terms of phys. appearance, surface pH, diameter and length, mech. properties, and mucoadhesive behavior. The content uniformity, release profile, Ex-vivo permeation of rivastigmine tartrate were also investigated. The release profiles for all nasal inserts were fitted to kinetics model. Phys. and chem. stability of the dosage form were evaluated. F2 appears to have the best sustained release profile, where F1 appears to have the best immediate release profile. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Efficient and simple method for the quantification of alkyl polyglycosides by hydrolysis and photometric determination of reducing sugars was written by Buttler, Judith R.;Bechtold, Thomas;Pham, Tung. And the article was included in Arabian Journal of Chemistry in 2022.Quality Control of 1,2-Propanediol This article mentions the following:

Alkyl polyglycosides (APG) are important biodegradable surfactants for many applications. The lack of a chromophoric group and the mixture of stereoisomers and oligomers make the quantification by merely chromatic separation difficult. A simple and efficient quantification assay was developed based on the acid hydrolysis of alkyl polyglycoside and subsequent quantification of the hydrolytically cleaved glucose using the neocuproine assay. Complete hydrolysis of alkyl polyglycoside is achieved with 16 wt% sulfuric acid at 100 °C after 30 min and the separation of fatty alc. and clouding of the reaction mixture is prevented by adding 1,2-propylene-glycol. Hydrolytically cleaved sugars reduce the Cu(II)-neocuproine complex, leading to a color shift which permits the spectrophotometric quantification at 452 nm. A linear correlation between the absorbance of reduced Cu(II)-neocuproine complex and glucose or alkyl polyglycoside concentration is observed up to an analyte concentration of 25 mg/L. Statistical anal. according to one-tailled T-test (S′ 95%), has shown that the lower detection limit for alkyl polyglycosides is 2.97 mg/L and the limit of quantification 8.24 mg/L, resp. Apart from the simple execution, the assay is reliable and can be utilized both as scientific technique to quantify APG as well as for process and quality control in the industry. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Quality Control of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Quality Control of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts