Tag: 0-100

《Ethylene glycol-rich thermosensitive poly(ss-hydroxyl amine)s》 was written by Oh, Junki; Hong, Jeonghui; Khan, Anzar. Quality Control of 4-Aminobutan-1-ol And the article was included in Journal of Macromolecular Science, Part A: Pure and Applied Chemistry in 2020. The article conveys some information:

This work illustrates a new mol. design for preparing amphiphilic ethylene glycol-rich poly(ss-hydroxyl amine) polymers. In this design, the backbone and the termini of the side-chain represents hydrophilic parts of the polymer chain. Incorporation of a short hydrophobic alkyl segment between the hydrophilic parts endows an amphiphilic character to the material. Due to this amphiphilic nature, the polymer chains show alkyl-length-dependent thermoresponsive aggregation behavior in aqueous solutions In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

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The author of 《Design and Synthesis of Galactose-Biotin Lipid Materials for Liposomes to Promote the Hepatoma Cell-Targeting Effect》 were Ding, Ruihua; Li, Zhenjie; Wang, Jianyi; Zhu, Xueyan; Zhao, Zhuang; Wang, Mian. And the article was published in Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) in 2019. SDS of cas: 534-03-2 The author mentioned the following in the article:

A series of novel low-toxic hepatoma cell-targeting lipid materials were designed and synthesized, in which monogalactose, digalactose, and galactose-biotin were used as targeting moieties and hydrophilic heads while stearate was used as hydrophobic tail (Mono-Gal-ST, Di-Gal-ST, and Gal-Biotin-ST). The corresponding galactose-biotin-modified liposomes (Mono-Gal-LPs, Di-Gal-LPs, and Gal-Biotin-LPs) and conventional liposomes (LPs) were prepared These galactose-biotin-modified liposomes can distinguish hepatoma cells from other tissue cells owing to the recognition of asialoglycoprotein receptor by galactose group. Moreover, the ability of liposomes to distinguish hepatoma cells from normal hepatocytes follows a trend of LPs < Mono-Gal-LPs < Di-Gal-LPs < Gal-Biotin-LPs, which is attributed to the cluster glycoside effect and the synergistic effect of galactose and biotin. In addition, the endocytosis of these galactose-biotin-modified liposomes were competitively inhibited by galactose, further confirming these liposomes entered hepatoma cells via asialoglycoprotein receptor-mediated pathway. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.SDS of cas: 534-03-2

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In 2019,Acta Crystallographica, Section E: Crystallographic Communications included an article by Uprety, Bhawna; Arderne, Charmaine. HPLC of Formula: 156-87-6. The article was titled 《The crystal structure of the zwitterionic co-crystal of 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate and 2,4-dichlorophenol》. The information in the text is summarized as follows:

The title compound, C10H13Cl2NO2.C6H4Cl2O, was formed from the incomplete Mannich condensation reaction of 3-aminopropan-1-ol, formaldehyde and 2,4-dichlorophenol in methanol. This resulted in the formation of a co-crystal of the zwitterionic Mannich base, 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate and the unreacted 2,4-dichlorophenol. The compound crystallizes in the monoclinic crystal system (in space group Cc) and the asym. unit contains a mol. each of the 2,4-dichlorophenol and 2,4-dichloro-6-{[(3-hydroxypropyl)azaniumyl]methyl}phenolate. Examination of the crystal structure shows that the two components are clearly linked together by hydrogen bonds. The packing patterns are most interesting along the b and the c axes, where the co-crystal in the unit cell packs in a manner that shows alternating aromatic dichlorophenol fragments and polar hydrogen-bonded channels. The 2,4-dichlorophenol rings stack on top of one another, and these are held together by π-π interactions. The crystal studied was refined as an inversion twin. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 156-87-6

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《In-silico approach of 7-azaindole derivatives as inhibitors of bromodomain and insulin growth factor receptors for the treatment of diabetes-related cancer》 was published in International Journal of Pharmacy and Pharmaceutical Research in 2020. These research results belong to Samani, Kamrudeen; Sharma, Uday Raj; Joshi, Abhishek Raj; V., Surendra; Pm, Manjunath; D., Giles. Computed Properties of C3H6O2 The article mentions the following:

Several 7-azaindole derivatives were designed for its dual targeted inhibition towards 1K3A and 4HY3. Drug likeness, ADME studies, virtual toxicity studies and mol. docking studies were carried out using Accelrys drug discovery studio 3.5. All the compounds were found to follow Lipinski rule of 5. Mol. docking was performed for 21 designed ligands against 1K3A and 4HY3 receptors. Some of the designed compounds possess good binding affinity towards 1K3A and 4HY3. The 21 designed 7-azaindole derivatives were then docked against 1K3A (Insulin growth factor) and 4HY3 (bromodomain) receptors. The compounds were found to be having good interaction with amino acids such as VAL 215, GLY 105, LYS 325, ASP 164, LYS 1138, LEU 1143. The compounds 3a4-(1 H-pyrrolo{2,3-b}pyridin-2-yl)benzene-1,2-diol,4a 5-(1 Hpyrrolo{2,3-b}pyridin-2-yl)benzene-1,3-diol and 20a 2-(2- iodophenyl)-1 H-pyrrolo{2,3-b}pyridine having hydroxyl- and Iodo- substitution possess dual inhibition towards bromodomain and insulin growth factor receptor. Hence, these derivatives could be effective as a dual target in drug discovery for the cancer treatment. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

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Application of 57044-25-4On May 15, 2019 ,《Photo-control of cancer cell growth by benzodiazo N-substituted pyrrole derivatives》 appeared in Journal of Photochemistry and Photobiology, A: Chemistry. The author of the article were Imperatore, Concetta; Scuotto, Maria; Valadan, Mohammadhassan; Rivieccio, Elisa; Saide, Assunta; Russo, Annapina; Altucci, Carlo; Menna, Marialuisa; Ramunno, Anna; Mayol, Luciano; Russo, Giulia; Varra, Michela. The article conveys some information:

In order to expand the class of diazocompounds able to act as photo-activable microtubule inhibitors the potential of azo-heteroarenes has been explored. In this paper we focus on the synthesis, phys. properties and biol. effects of Me rac-2-(2-((E)-(4-((R)-2,3-dihydroxypropoxy)phenyl) diazenyl)-1H-pyrrol-1-yl)-3-hydroxypropanoate (1a) and Me rac-2-(2-((E)-(4-((S)-2,3-dihydroxypropoxy)phenyl) diazenyl)-1H-pyrrol-1-yl)-3-hydroxypropanoate (1b). Preliminary biol. studies on the HCT-116 p53-/- cancer cell line have shown that the weak antiproliferative action of the trans isomers of these mols., especially of 1a, is enhanced upon LED light irradiation at 435 nm. On A375 cells the mols. have not shown any effect on cell viability either in the dark or under irradiation Moreover, the two diastereomeric components of 1a as pure stereomers have been synthesized and characterized for their chem.-phys. properties. Interestingly, upon irradiation, 1a has shown an antiproliferative activity on the HCT-116 p53-/- cells greater than that of the pure stereomers, 1RR and 1RS. Tubulin polymerization assay has also demonstrated that 1a, 1RR and 1RS inhibit tubulin aggregation mostly after exposure of the samples to LED light irradiation The experimental part of the paper was very detailed, including the reaction process of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application of 57044-25-4)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application of 57044-25-4

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In 2019,Research Journal of Pharmaceutical, Biological and Chemical Sciences included an article by Ivanchenko, Dmytro; Romanenko, Mykola; Goloborodko, Oleksandr; Kamyshnyi, Oleksandr; Polishchuk, Natalia. HPLC of Formula: 13325-10-5. The article was titled 《Synthesis and biological activity of 8-aminosubstituted 7-(2-hydroxy-3-methylphenoxypropyl-1)-3-methylxanthine》. The information in the text is summarized as follows:

The reaction of 8-bromo-3-methylxanthine with m-ethylphenoxymethyloxirane in propanol-1 medium in the presence of N,N-dimethylbenzylamine led to formation of 8-bromo-7-(2-hydroxy-3-methylphenoxypropyl-1)-3-methylxanthine which was then interacted with amines to afford 8-aminosubstituted 7-(2-hydroxy-3-m-ethylphenoxypropyl-1)-3-methylxanthines I [R1 = H, Me, Et; R2 = Me, n-Pr, cyclohexyl, etc.]. Structures of the synthesized compounds I were proved by 1H NMR-spectroscopy. The synthesized compounds I revealed moderate to weak antibacterial and antifungal activities in concentrations 50-200 mcg/mL. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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Gampa, Muralimohan; Padmaja, Pannala; Aravind, Seema; Reddy, Pedavenkatagari Narayana published an article in 2021. The article was titled 《An efficient one-pot synthesis of indolyl-4H-chromene derivatives》, and you may find the article in Chemistry of Heterocyclic Compounds (New York, NY, United States).Category: alcohols-buliding-blocks The information in the text is summarized as follows:

A new one-pot three-component reaction for the synthesis of indolyl-4H-chromene derivatives I (R1 = H, 6-Cl, 6-Br, 6,8-(Cl)2; R2 = 2-Me, 5-OH, 6-Br, etc.; R3 = CH, N) has been developed. The synthesis was achieved by reacting salicylaldehydes 1-CHO-2-OHC6H3R1 (R1 = H, 5-Cl, 5-Br, 3,5-Cl2), (E)-N-methyl-1-(methylsulfanyl)-2-nitroethenamine, and indoles II in the absence of solvent using triethylamine as a catalyst. The final products I were isolated by precipitation after the addition of ethanol to the reaction mixture This transformation involves the formation of indole-substituted chromene ring by creation of two C-C bonds and one C-O bond in a single synthetic operation. This rapid one-pot reaction does not require chromatog. purification and provides the indolyl-4H-chromene derivatives I in good yields. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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In 2019,International Journal of Pharmaceutics (Amsterdam, Netherlands) included an article by Chaudhari, Kapil S.; Akamanchi, Krishnacharya G.. Recommanded Product: 156-87-6. The article was titled 《Novel bicephalous heterolipid based self-microemulsifying drug delivery system for solubility and bioavailability enhancement of efavirenz》. The information in the text is summarized as follows:

There is an increasing demand for new lipidic biocompatible and safe materials for self-microemulsifying drug delivery system (SMEDDS). The present work reports the synthesis, characterization, oral mucosal irritation study, and application of novel erucic acid ester of G0-PETIM dendron based bicephalous heterolipid (BHL) as an oil phase in SMEDDS using Efavirenz (EFA), a BCS class II drug with poor water solubility and poor bioavailability. Studies were conducted to optimize EFA SMEDDS using different ratios of the BHL as oil phase and surfactant: co-surfactant weight ratios (Km). At Km (1.5), the microemulsion was spontaneously formed in water with mean globule size of 22.78 ± 0.25 nm and polydispersity index (PDI) of 0.23 ± 0.031 with high drug loading efficiency of 80.35 ± 3.1%. Standard stability tests were performed on EFA SMEDDS and the results indicated it to be highly stable. The in vitro dissolution profile of EFA SMEDDS showed >95% of the drug release within an hour and expectedly substantial enhancement in in vivo bioavailability was observed; almost 6-fold increase in bioavailability with parameters Cmax 5.2 μg/mL, Tmax 3 h, and AUC(0-∞) 23.48 μg/h/mL resp. as compared the plain suspension of the drug. In conclusion, the BHL can be used effectively as an oil phase in SMEDDS to enhance solubility and bioavailability of BCS Class II drugs. Further, it holds, in general, a great promise as a new excipient for solubility and bioavailability enhancements. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: 156-87-6

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《HARC as an open-shell strategy to bypass oxidative addition in Ullmann-Goldberg couplings》 was published in Proceedings of the National Academy of Sciences of the United States of America in 2020. These research results belong to Lavagnino, Marissa N.; Liang, Tao; MacMillan, David W. C.. HPLC of Formula: 7748-36-9 The article mentions the following:

Herein, an alternative aryl halide activation strategy, in which the critical oxidative addition (OA) mechanism was replaced by a halogen abstraction-radical capture (HARC) sequence that allowed the generation of the Cu(III)-aryl intermediate albeit via a photoredox pathway was presented. This alternative mechanistic paradigm decoupled the bond-breaking and bond-forming steps of the catalytic cycle to enable the use of many previously inert aryl bromides. Overall, this mechanism allowed access to both traditional C-N adducts at room temperature as well as a large range of previously inaccessible Ullmann-Goldberg coupling products including sterically demanding ortho-substituted heteroarenes, e.g., I. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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《In situ genetic engineering of tumors for long-lasting and systemic immunotherapy》 was written by Tzeng, Stephany Y.; Patel, Kisha K.; Wilson, David R.; Meyer, Randall A.; Rhodes, Kelly R.; Green, Jordan J.. Computed Properties of C3H9NO And the article was included in Proceedings of the National Academy of Sciences of the United States of America in 2020. The article conveys some information:

Cancer immunotherapy has been the subject of extensive research, but highly effective and broadly applicable methods remain elusive. Moreover, a general approach to engender endogenous patient-specific cellular therapy, without the need for a priori knowledge of tumor antigen, ex vivo cellular manipulation, or cellular manufacture, could dramatically reduce costs and broaden accessibility. Here, we describe a biotechnol. based on synthetic, biodegradable nanoparticles that can genetically reprogram cancer cells and their microenvironment in situ so that the cancer cells can act as tumor-associated antigen-presenting cells (tAPCs) by inducing coexpression of a costimulatory mol. (4-1BBL) and immunostimulatory cytokine (IL-12). In B16-F10 melanoma and MC38 colorectal carcinoma mouse models, reprogramming nanoparticles in combination with checkpoint blockade significantly reduced tumor growth over time and, in some cases, cleared the tumor, leading to long-term survivors that were then resistant to the formation of new tumors upon rechallenge at a distant site. In vitro and in vivo analyses confirmed that locally delivered tAPC-reprogramming nanoparticles led to a significant cell-mediated cytotoxic immune response with systemic effects. The systemic tumor-specific and cell-mediated immunotherapy response was achieved without requiring a priori knowledge of tumor-expressed antigens and reflects the translational potential of this nanomedicine. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Computed Properties of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Computed Properties of C3H9NO

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