Tag: 0-100

《Synthesis and characterization of the Anderson-Evans tungstoantimonate [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbW6O24]》 was written by Sifaki, Kleanthi; Gumerova, Nadiia I.; Giester, Gerald; Rompel, Annette. COA of Formula: C3H9NO2This research focused ontungstoantimonate polyoxometalate Anderson Evan; POM; POT; crystal structure; organic-inorganic hybrid; polyoxometalate; polyoxotungstate; serinol. The article conveys some information:

A novel tungstoantimonate, [Na5(H2O)18{(HOCH2)2-CHNH3}2][SbVWVI6O24] (SbW6), was synthesized from an aqueous solution and structurally characterized by single-crystal X-ray diffraction, which revealed C2/c symmetry. The structure contains two serinol [(HOCH2)2CHNH3]+ and five Na+ cations, which are octahedrally surrounded by 18 water mols., and one [SbVWVI6O24]7- anion. The serinol mols. also play a critical role in the synthesis by acting as a mild buffering agent. Each of the WVI and SbV ions is six-coordinated and displays a distorted octahedral motif. A three-dimensional supramol. framework is formed via hydrogen-bonding interactions between the tungstoantimonates and cations. Powder X-ray diffraction, elemental anal., thermogravimetric anal. and IR spectroscopy were performed on SbW6 to prove the purity, to identify the water content and to characterize the vibrational modes of the crystallized phase. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Warne, Nicole M.; Finnegan, John R.; Feeney, Orlagh M.; Kempe, Kristian published an article in 2021. The article was titled 《Using 2-isopropyl-2-oxazine to explore the effect of monomer distribution and polymer architecture on the thermoresponsive behavior of copolymers》, and you may find the article in Journal of Polymer Science (Hoboken, NJ, United States).Quality Control of 3-Aminopropan-1-ol The information in the text is summarized as follows:

Poly(cyclic imino ether)s (PCIE) have emerged as a highly promising class of polymer for use in biomedical applications with their value being derived from their excellent biocompatibility, diverse chem., and tunable hydrophilicity. Here, we investigate the properties of poly(2-isopropyl-2-oxazine) (PiPrOz), a relatively unexplored PCIE, determining it to have a cloud point temperature (Tcp) below physiol. temperature, not to crystallize from bulk or in solution, and to be highly biocompatible. Furthermore, a series of copolymers consisting of iPrOz and 2-methyl-2-oxazine (MeOz) was investigated with regard to the effect of monomer distribution and polymer architecture on thermoresponsive properties. To this end, linear block and statistical co-poly(2-oxazine)s (co-POz), along with three comb-shaped POz with block or statistical POz side chains were prepared Each of the five polymers showed distinct thermoresponsive behavior, with the linear block co-POz undergoing micelle formation and the other polymers macroscopic phase-separation at different Tcps. The variety observed in response to heating clearly highlights the importance of monomer sequence and polymer architecture when designing thermoresponsive polymers. We anticipate that our findings will prove useful to polymer chemists seeking to prepare novel thermoresponsive biomaterials. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Protecting-group-free synthesis of hydroxyesters from amino alcohols》 was written by Reynard, Guillaume; Joseph-Valcin, Eve-Marline; Lebel, Helene. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

The synthesis of hydroxyesters such as RCOOCH2(CH)nOH [R = MeC≡C, 2-furyl, Ph, etc.; n = 1,2,3,4,7] from carboxylic acids RCOOH and unprotected amino alcs. H2NCH2(CH)nOH in both continuous flow and batch processes was reported. The formation of a transient diazonium species with a dinitrite reagent was key in this transformation. The reaction conditions were compatible with a variety of functional groups. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Category: alcohols-buliding-blocksIn 2019 ,《Rapid Solution-Phase Hydrogen/Deuterium Exchange for Metabolite Compound Identification》 was published in Journal of the American Society for Mass Spectrometry. The article was written by Majuta, Sandra N.; Li, Chong; Jayasundara, Kinkini; Kiani Karanji, Ahmad; Attanayake, Kushani; Ranganathan, Nandhini; Li, Peng; Valentine, Stephen J.. The article contains the following contents:

Rapid, solution-phase hydrogen/deuterium exchange (HDX) coupled with mass spectrometry (MS) is demonstrated as a means for distinguishing small-mol. metabolites. HDX is achieved using capillary vibrating sharp-edge spray ionization (cVSSI) to allow sufficient time for reagent mixing and exchange in micrometer-sized droplets. Different compounds are observed to incorporate deuterium with varying efficiencies resulting in unique isotopic patterns as revealed in the MS spectra. Using linear regression techniques, parameters representing contribution to exchange by different hydrogen types can be computed. In this proof-of-concept study, the exchange parameters are shown to be useful in the retrodiction of the amount of deuterium incorporated within different compounds On average, the exchange parameters retrodict the exchange level with ∼ 2.2-fold greater accuracy than treating all exchangeable hydrogens equally. The parameters can be used to produce hypothetical isotopic distributions that agree (± 16% RMSD) with exptl. measurements. These initial studies are discussed in light of their potential value for identifying challenging metabolite species. [Figure not available: see fulltext.]. In the part of experimental materials, we found many familiar compounds, such as 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Takahashi, Kaito published an article in 2022. The article was titled 《Theoretical analysis on reactions between syn-methyl Criegee intermediate and amino alcohols》, and you may find the article in Journal of the Chinese Chemical Society (Weinheim, Germany).SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Due to their strong zwitterionic character, Criegee intermediates can interact strongly with hydrogen bonding mols. in the atm., such as water vapor, alcs., acids, amines, and thiols. To gain a phys. understanding of the reactivity of Criegee intermediates toward these mols., we theor. studied the reaction of syn-CH3CHOO with linear n-amino alc. and branched amino alcs. that contain three carbon atoms. We found that the interaction contribution is the determining factor for the increase in reactivity when we elongate the alkyl chain length and when we place a Me group in the amino group. This finding was rationalized by evaluating the electron-donating ability of the amino alc. Consistent with the increase in reactivity for NH(CH3)C2H4OH and NH2C4H8OH compared to NH2C2H4OH, we found that these two amino alcs. have vertical ionization energies ∼0.5 eV smaller than NH2C2H4OH. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aizawa, Miho; Akiyama, Haruhisa; Matsuzawa, Yoko published their research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2021. The article was titled 《Convenient preparation of stimulus-responsive molecular layers containing anthracene molecules to control surface properties》.Quality Control of 3-Aminopropan-1-ol The article contains the following contents:

For controlling the surface properties by depositing mols. on the material surface, the selection of the functional groups of the stacked mols. is crucial. By introducing anthracenes in the mol. layer, which promote photodimerization and thermal/cleavage on photoirradiation or heating, it is possible to form a stimuli-responsive surface that enables changes in the mol. layer composition In this study, we improve the fabrication process of the stimulus-responsive mol. layer with anthracene in order to facilitate the design of mol. layers according to the desired purpose. This is achieved by employing acid-base interactions for forming the mol. layers, with different functions for each layer. Thermal/photocleavage reactions of anthracene dimers are induced in the stacked mol. layer. Multilayers stacked with amine mols. exhibit different behavior on the cleavage reaction and the contact angle varies, depending on the type of mols. The wettability on the surface covered with the mol. layer changes in response to the stimulation, proving the successful fabrication of a stimuli-responsive surface. The designed thermo- and photoresponsive mol. layer can potentially expand the scope of practical application as a control system for surface conditions. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Control of 4-Aminobutan-1-olIn 2022 ,《Axial-ligand-cleavable silicon phthalocyanines triggered by near-infrared light toward design of photosensitizers for photoimmunotherapy》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Takakura, Hideo; Matsuhiro, Shino; Kobayashi, Masato; Goto, Yuto; Harada, Mei; Taketsugu, Tetsuya; Ogawa, Mikako. The article contains the following contents:

Near-IR photoimmunotherapy (NIR-PIT) is a novel phototherapy for the treatment of cancer that uses NIR light and conjugates of antibody-IR700, a silicon phthalocyanine photosensitizer. A key feature of NIR-PIT is light-induced axial ligand cleavage of IR700, which finally causes cytotoxicity. Here, we focused on protonation of the axial ligand on the IR700 anion radical during the photochem. process. The Gibbs energy in the protonation reaction of IR700 derivatives with different axial ligands was calculated These calculations suggested the order of the cleavage efficiency corresponds to the basicity of the axial ligand (i.e. alkoxy > siloxy (IR700) > phenoxy > oxycarbonyl), which was confirmed by the photoirradiation experiments with synthesized compounds Thus, axial ligand cleavage is significantly dependent on the basicity of the axial ligand. Our findings suggest that PIT reagent with an IR700 derivative bearing alkoxy group would show better efficacy than IR700. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Recommanded Product: 534-03-2In 2019 ,《The use of serinol nucleic acids as ultrasensitive molecular beacons》 was published in Methods in Molecular Biology (New York, NY, United States). The article was written by Murayama, Keiji; Kashida, Hiromu; Asanuma, Hiroyuki. The article contains the following contents:

Mol. beacons composed of the artificial serinol nucleic acid (SNA) have demonstrated utility as novel fluorescence probes for visualization of RNA in fixed cells using both conventional fluorescence in situ hybridization (FISH) and wash-free FISH protocols. The SNA mol. beacons have higher affinity for target RNA and greater sensitivity than mol. beacons composed of DNA. Here we describe facile synthesis of the SNA using a conventional DNA synthesizer and protocols for purification by PAGE and HPLC as well as methods for use of the SNA mol. beacon in FISH. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Formula: C3H9NOIn 2021 ,《Ice Recrystallization Inhibition Activity of Protein Mimetic Peptoids》 appeared in Journal of Inorganic and Organometallic Polymers and Materials. The author of the article were Hua, Weiwen; Wang, Yuanguang; Guo, Cun-Yue; Wang, Jianjun; Li, Songjun; Guo, Li. The article conveys some information:

Natural antifreeze proteins are known for their excellent control of ice formation and growth, while synthetic mols. seldom have the similar effects. Here we report a series of protein mimetic peptoids with different side chains exhibiting significant ice recrystallization inhibition activity, and their structure-property relationships are also studied. The presence of peptoid can clearly slow down ice growth and decrease ice crystal grain size, but shows no thermal hysteresis, which make peptoids great antifreeze agent candidates in cryopreservation. Peptoids with Me, Et and amino groups on side chains can modulate ice crystal shape, while peptoids bearing hydroxyl and Et groups decrease ice growth rate the most. All peptoids can reduce ice crystal grain size and the one with hydroxyl groups give the smallest grain size. This study reveals peptoid structure effects on ice growth and points to the design rules for biomimetic antifreeze agents. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Ekta; Matada, Gurubasavaraja Swamy Purawarga published their research in International Journal of Pharmacy and Pharmaceutical Research in 2021. The article was titled 《Chemical features responsible for the antioxidant property in 7-azaindoles and related compounds》.Formula: C3H6O2 The article contains the following contents:

The pro-oxidant mols. are reactive towards the cell organelles due to instability in their electronic composition Thus, pro-oxidants interact with and cause damages to cell organelles. This damage can be prevented by antioxidant mols. as they neutralize the pro-oxidants and render them harmless. The ability of mols. to act as an antioxidant is exhibited by its chem. feature. Alpha tocopherol and its analogs are well established antioxidants. The antioxidants can be designed based on the structure of alpha tocopherol. Some research articles have compared the antioxidant properties of alpha tocopherol and small mols. with different heterocylic rings. In continuation to the development of small antioxidant mols. azaindole analogs have also been compared with alpha tocopherol. Azaindoles are a novel class of compounds that can be developed as antioxidant mols. based on their similarity with heterocyclic rings present in reported antioxidants. In the current research we have studied some azaindole related compounds and their antioxidant properties. The objective of this study is to study some 7-azaindole related compounds as antioxidants. In this research work, small substituted azaindoles and related structures have been studied for their antioxidant properties by DPPH assay method. The structure with Ketone and double bond functional group show antioxidant property in DPPHA assay. The presence of chlorine on aromatic ring increases the antioxidant property of azaindoles. Azaindole scaffold can be used to design and develop novel antioxidant mols. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts