Tag: 0-100

The author of 《Morphology control of magnesium carbonate for CO2 utilization using Mg2+ ions in industrial wastewater depending on length of alkyl chain of primary alkanolamine, reaction temperature, CO2 concentration, and Mg2+/Na+ ratio》 were Yoo, Yunsung; Kang, Dongwoo; Choi, Eunji; Park, Jinwon; Huh, Il-Sang. And the article was published in Chemical Engineering Journal (Amsterdam, Netherlands) in 2019. HPLC of Formula: 156-87-6 The author mentioned the following in the article:

Because global warming has been a constant issue in the environmental field, many studies on the mitigation of CO2 have been conducted. This study for carbon dioxide utilization dealt with the characteristics of magnesium carbonate formation using Mg2+ ions separated from seawater-based industrial wastewater and alkanolamine absorbent depending on the alkyl chain length of the primary alkanolamine type absorbent, reaction temperature, CO2 concentration, and Mg2+/Na+ ratio as part of the investigation. First, nesquehonite was formed with a relatively short length and amorphous MgCO3·3H2O was formed with a relatively long length in the alkyl chain length experiment Second, nesquehonite at low temperature was produced, and hydromagnesite was produced as temperature increased in the reaction temperature experiment In addition, nesquehonite was only magnesium carbonate depending on CO2 concentration, but each product had different purities. Finally, increasing of Mg2+/Na+ ratio derived production of not nesquehonite but hydromagnesite with high purity of over 98 wt%. Through this study, the morphol. and purity control of magnesium carbonate can reach commercialization levels in the particular conditions, and industrial application of carbon capture and utilization processes using wastewater and alkanolamine absorbent would be achieved.3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.HPLC of Formula: 156-87-6

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《Palladium-Catalyzed Aminocarbonylation Reaction to Access 1,2,3-Triazole-5-carboxamides Using Dimethyl Carbonate as Sustainable Solvent》 was written by de Albuquerque, Danilo Yano; de Moraes, Juliana R.; Schwab, Ricardo S.. Name: 4-Aminobutan-1-olThis research focused ontriazole carboxamide preparation; amine iodotriazole formic acid carbonylative coupling. The article conveys some information:

A simple and direct palladium-catalyzed aminocarbonylation of 5-iodo-1,2,3-triazoles backbone for the incorporation of an amide functional group was presented. The approach was based on the palladium catalyzed carbonylative coupling reaction of iodo-triazole with different amines employing formic acid and sulfuric acid as CO source (Morgan’s reaction) to provide the 1,2,3-triazole-5-carboxamides I [R = Bn, 4-OMeC6H4, C10H21, etc.; R1 = H, n-Bu, Ph, etc.] in good to excellent yields. The important features of this methodol. included short reaction time, high yields, the use of di-Me carbonate as a sustainable solvent and the use of efficient alternative source of carbon monoxide, avoiding pressurized cylinder. The methodol. described herein for the synthesis of 1,4,5-trisubstituted 1,2,3-triazole-5-carboxamides I, could offer an alternative path for functionalization of other heterocycles. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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In 2022,Wang, Chenfei; Huang, Xiaobei; Sun, Litao; Li, Qiuxia; Li, Zhili; Yong, Haiyang; Che, Delu; Yan, Cong; Geng, Songmei; Wang, Wenxin; Zhou, Dezhong published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Cyclic poly(β-amino ester)s with enhanced gene transfection activity synthesized through intra-molecular cyclization》.COA of Formula: C4H11NO The author mentioned the following in the article:

Topol. structure plays a critical role in gene delivery of cationic polymers. Cyclic poly(β-amino ester)s (CPAEs) are successfully synthesized via sequential Michael addition and free radical initiating ring-closure reaction. The CPAEs exhibit superior gene transfection efficiency and safety profile compared to their linear counterparts. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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《Enantioselective [3+2] annulation of isatin-derived MBH-carbonates and 3-nitroindoles enabled by a bifunctional DMAP-thiourea》 was written by Mei, Ming-Shun; Wang, Yu-Hui; Hu, Qing; Li, Qing-Hua; Shi, Da-Yu; Gao, Dingding; Ge, Guangbo; Lin, Guo-Qiang; Tian, Ping. Category: alcohols-buliding-blocks And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020. The article conveys some information:

A highly enantioselective [3+2] annulation of isatin-derived Morita-Baylis-Hillman (MBH) carbonates I (R = Me, Bn, prop-2-en-1-yl, (tert-butoxy)carbonyl; R1 = methoxycarbonyl, ethoxycarbonyl, cyano; R2 = H, Me, Cl, F, etc; R3 = H, Br; R4 = H, Me, F, Br) and 3-nitroindoles II (R5 = (4-tert-butylphenyl)carbonyl, Bz, Ts, (naphthalen-1-yl)carbonyl, etc; X = CH, N) was enabled by a chiral DMAP-thiourea bifunctional catalyst III, affording the corresponding polycyclic spirooxindoles IV bearing three consecutive stereocenters with good to excellent yields and enantioselectivities. Transformations of the annulation product were subsequently elaborated and the preliminary biol. assays demonstrated that these artificial spirooxindoles potentially inhibited pancreatic lipase in a dose-dependent manner. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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《Phoenix dactylifera fruit extract ameliorates altered biochemical parameters in streptozotocin-induced diabetes mellitus albino rats》 was written by Ogo, A. O.; Abah, S. F.; Inalegwu, B.; Eru, U. E.. Safety of 2-Aminopropane-1,3-diol And the article was included in International Journal of Current Pharmaceutical Research in 2020. The article conveys some information:

Objective: Consistent projections have indicated a steady increase in the global burden of diabetes mellitus. Given the increased cost in conventional management of the condition in addition to reported side effects and cost of orthodox management, attention is shifting to the use of alternative methods such as plants materials with dual benefits as food and medicine. Thus, this study was designed to investigate the effect of date palm fruit on some biochem. parameters in streptozotocin-induced wistar rats. Methods: Animals were divided into 5 groups of 6 rats each (I as normal control, II as diabetic control and 3-5 as extract-treated groups) maintained for 14 d. At the end of the treatment, the animals were fasted overnight, then sacrificed and blood samples collected for anal. of biochem. parameters (including blood glucose, blood lipids and enzymes). Results: The results show that treatment of diabetic animals with extract of date palm fruit show a significant (P<0.05) reduction in glucose levels in groups II-V compared to group I. Similar pos. effects were observed in the levels of lipids and enzymes in treated groups compared to diabetic control group II. A GC-MS anal. of the fraction of the fruit extract revealed some bioactive compounds that may be responsible for the effects exhibited in the study. Conclusion: These findings which demonstrate the ameliorative effect on hyperglycemia and hyperlipidemia, further support the use of date palm fruit as a nutraceutical agent. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 2-Aminopropane-1,3-diol

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In 2020,International Journal of Molecular Sciences included an article by Imperatore, Concetta; Valadan, Mohammadhassan; Tartaglione, Luciana; Persico, Marco; Ramunno, Anna; Menna, Marialuisa; Casertano, Marcello; Dell’Aversano, Carmela; Singh, Manjot; d’Aulisio Garigliota, Maria Luisa; Bajardi, Francesco; Morelli, Elena; Fattorusso, Caterina; Altucci, Carlo; Varra, Michela. Category: alcohols-buliding-blocks. The article was titled 《Exploring the photodynamic properties of two antiproliferative benzodiazopyrrole derivatives》. The information in the text is summarized as follows:

The identification of mols. whose biol. activity can be properly modulated by light is a promising therapeutic approach aimed to improve drug selectivity and efficacy on the mol. target and to limit the side effects compared to traditional drugs. Recently, two photo-switchable diastereomeric benzodiazopyrrole derivatives 1RR and 1RS have been reported as microtubules targeting agents (MTAs) on human colorectal carcinoma p53 null cell line (HCT 116 p53-/-). Their IC50 was enhanced upon Light Emitting Diode (LED) irradiation at 435 nm and was related to their cis form. Here we have investigated the photo-responsive behavior of the acid derivatives of 1RR and 1RS, namely, d1RR and d1RS, in phosphate buffer solutions at different pH. The comparison of the UV spectra, acquired before and after LED irradiation, indicated that the trans→cis conversion of d1RR and d1RS is affected by the degree of ionization. The apparent rate constants were calculated from the kinetic data by means of fast UV spectroscopy and the conformers of the putative ionic species present in solution (pH range: 5.7-8.0) were modelled. Taken together, our exptl. and theor. results suggest that the photo-conversions of transd1RR/d1RS into the corresponding cis forms and the thermal decay of cisd1RR/d1RS are dependent on the presence of diazonium form of d1RR/d1RS. Finally, a photo-reaction was detected only for d1RR after prolonged LED irradiation in acidic medium, and the resulting product was characterized by means of Liquid Chromatog. coupled to High resolution Mass Spectrometry (LC-HRMS) and NMR spectroscopy.(R)-Oxiran-2-ylmethanol(cas: 57044-25-4Category: alcohols-buliding-blocks) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Category: alcohols-buliding-blocks

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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Toda, Yasunori; Tanaka, Shoya; Gomyou, Shuto; Kikuchi, Ayaka; Suga, Hiroyuki. Application In Synthesis of (R)-Oxiran-2-ylmethanol. The article was titled 《4-Hydroxymethyl-substituted oxazolidinones synthesis by tetraarylphosphonium salt-catalyzed reactions of glycidols with isocyanates》. The information in the text is summarized as follows:

Preparation of 4-hydroxymethyl-substituted oxazolidinones including optically active ones, in which tetraarylphosphonium salts catalyze the reaction of glycidol with isocyanates effectively, is described. The neutral catalysis facilitates glycidol addition to isocyanates followed by intramol. cyclization. Mechanistic studies suggest that hydrogen-bonding interactions with the catalyst play an important role in the reaction progress. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application In Synthesis of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application In Synthesis of (R)-Oxiran-2-ylmethanol

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Safety of 3-Aminopropan-1-olIn 2019 ,《Syntheses and structural characterizations of 2-pyridyl(N/O)spirocyclotriphosphazene derivatives》 appeared in Phosphorus, Sulfur and Silicon and the Related Elements. The author of the article were Elmas, Gamze. The article conveys some information:

The Cl exchange reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), with one equimolar amount of sodium salt of N/O donor type bidentate ligand containing a 2-pyridyl pendant arm (2) afforded, regioselectively, the partly substituted 2-pyridyl(N/O)spirocyclotriphosphazene (3; with a yield of 65%) in THF. The reactions of 3 with excess pyrrolidine, morpholine and 1,4-dioxa-8-azaspiro[4,5]decane (DASD) gave the tetraamino-2-pyridyl(N/O)spirocyclotriphosphazenes (3a-3c) in high yields. Compound 3 also gave both tetrapiperidino (3d) and gem-bispiperidino (3e) products with excess piperidine. The structures of all the compounds were determined by elemental analyses, ESI-MS, FTIR, HSQC, HMBC and 1H, 13C, and 31P NMR techniques. The crystal structure of 3e was identified by single crystal x-ray crystallog. Besides, the compound had one stereogenic P atom, and its chirality was verified by 31P NMR spectroscopy in the presence of (S)-(+)-2,2,2-trifluoro-1-(9′-anthryl)-ethanol (CSA). In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Safety of 3-Aminopropan-1-ol

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Alcohol – Wikipedia,
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Osawa, Shigehito; Kurokawa, Sosuke; Otsuka, Hidenori published an article in 2022. The article was titled 《Controlled polymerization of metal complex monomers – fabricating random copolymers comprising different metal species and nano-colloids》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Application In Synthesis of 3-Aminopropan-1-ol The information in the text is summarized as follows:

Acrylate monomers with metal complexes were designed to build polymer metal complexes. The ideal copolymerization of monomers with zinc and platinum was performed to obtain random copolymers with a feeding metal composition The successful nano-colloid preparation from the polymers further highlighted the potential of the method for building multimetallic materials. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Application In Synthesis of 3-Aminopropan-1-ol

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Sawano, Takahiro; Matsui, Takeshi; Koga, Marina; Ishikawa, Eri; Takeuchi, Ryo published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Iridium-catalyzed C3-selective asymmetric allylation of 7-azaindoles with secondary allylic alcohols》.Name: Oxetan-3-ol The article contains the following contents:

Iridium-catalyzed C3-selective asym. allylation of 7-azaindoles with racemic secondary allylic alcs. to give only branched allylation products in good to high yields with high enantioselectivity (up to >99.5% ee) was reported. Allylic alcs. and 7-azaindoles with a variety of functional groups including halogen and heteroaromatic groups were compatible with the reaction conditions. Furthermore, transformations of the obtained allylation products were demonstrated without a significant loss of enantiomeric excess. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts