Tag: 0-100

In 2022,Sagadevan, Arunachalam; Ghosh, Atanu; Maity, Partha; Mohammed, Omar F.; Bakr, Osman M.; Rueping, Magnus published an article in Journal of the American Chemical Society. The title of the article was 《Visible-Light Copper Nanocluster Catalysis for the C-N Coupling of Aryl Chlorides at Room Temperature》.Recommanded Product: 7748-36-9 The author mentioned the following in the article:

A copper nanocluster-based catalyst, [Cu61(StBu)26S6Cl6H14] (Cu61NC) that enabled C-N bond-forming reactions of aryl chlorides under visible-light irradiation at room temperature A range of N-heterocyclic nucleophiles and electronically and sterically diversed aryl/hetero chlorides react in this new Cu61NC-catalyzed process to afford the C-N coupling products in good yields. Mechanistic studies indicated that a single-electron-transfer (SET) process between the photoexcited Cu61NC complex and aryl halide enabled the C-N-arylation reaction. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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Dang, Le Hang; Doan, Phuong; Nhi, Tran Thi Yen; Nguyen, Dinh Trung; Nguyen, Bich Tram; Nguyen, Thi Phuong; Tran, Ngoc Quyen published an article in 2021. The article was titled 《Multifunctional injectable pluronic-cystamine-alginate-based hydrogel as a novel cellular delivery system towards tissue regeneration》, and you may find the article in International Journal of Biological Macromolecules.Reference of 3-Aminopropan-1-ol The information in the text is summarized as follows:

This paper presents a new thermal sensitive hydrogel system based on cystamine-functionalised sodium alginate-g-pluronic F127 (ACP). The introduction of cystamine to the alginate backbone not only creates a covalent bond with pluronic F127 but also provides intrinsic anti-bacterial activity for the resultant hydrogel. The amount of water uptake inside the hydrogel remained ∼200% for 6 days and the degradation was completed in 12 days in physiol. media. The ACP copolymer solution could form a hydrogel at body temperature (∼37 °C) and could return to the solution phase if the temperature decreased below 25°C. Fibroblast encapsulated in situ in the ACP hydrogel maintained their viability (≥90% based on the live/dead assay) for 7 days, demonstrating the good biocompatibility of the ACP hydrogel for long-term cell cultivation. In addition, three-dimensional (3D) culture showed that fibroblast attached to the hydrogels and successfully mimicked the porous structure of the ACP hydrogel after 5 days of culture. Fibroblast cells could migrate from the cell-ACP clusters and form a confluent cell layer on the surface of the culture dish. Altogether, the obtained results indicate that the thermal-responsive ACP hydrogel synthesized in this study may serve as a cellular delivery platform for diverse tissue engineering applications. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Reference of 3-Aminopropan-1-ol

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Kim, Joseph Byung-Kyu; Mackeyev, Yuri; Raghuram, Subhiksha; Cho, Sang Hyun; Krishnan, Sunil published an article in 2021. The article was titled 《Synthesis and characterization of gadolinium-decorated [60]fullerene for tumor imaging and radiation sensitization》, and you may find the article in International Journal of Radiation Biology.Product Details of 534-03-2 The information in the text is summarized as follows:

The excellent contrast of high at. number (Z) elements compared to soft tissues has advanced their use as contrast agents for computed tomog. imaging and as potential radiation sensitizers. We evaluated whether gadolinium (Gd) could serve as such a theranostic agent for high-resolution magnetic resonance imaging (MRI) due to its paramagnetic properties and radiosensitization due to its high Z. To improve the relaxivity of Gd, we coupled it to [60]fullerene, an elemental carbon allotropic nanoparticle that seamlessly traverses physiol. barriers . By adding serinol, an aliphatic alc. derived from amino acid serine, we turned [60]fullerene, which is otherwise insoluble in water, into a highly water-soluble derivative and decorated it externally with a payload of chelated gadolinium ions. When [60]fullerene was functionalized in this manner with two gadolinium ions (Gd2C60), it displayed considerably higher T1 relaxivity at 4.7 T than the com. used MRI contrast agent, Magnevist, (18.2 mM-1s-1 vs. 4.7 mM-1s-1). Attempts to increase this even further via decoration of [60]fullerene with 12 gadolinium ions was unsuccessful due to a poor water solubility However, the current formulation of Gd2C60 did not result in any appreciable radiosensitization. Our results show a successful generation of a novel contrast agent via decoration of fullerene with two chelated Gd ions. Though this formulation was not successful in generating radiosensitization, other chem. modifications can be further explored to increase radiosensitization potential. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Product Details of 534-03-2

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《Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction》 was written by Slesarchuk, Nikita A.; Khvatov, Evgeny V.; Chistov, Alexey A.; Proskurin, Gleb V.; Nikitin, Timofei D.; Lazarevich, Anastasiya I.; Ulanovskaya, Angelina A.; Ulashchik, Egor A.; Orlov, Alexey A.; Jegorov, Artjom V.; Ustinov, Alexey V.; Tyurin, Anton P.; Shmanai, Vadim V.; Ishmukhametov, Aydar A.; Korshun, Vladimir A.; Osolodkin, Dmitry I.; Kozlovskaya, Liubov I.; Aralov, Andrey V.. HPLC of Formula: 13325-10-5 And the article was included in Bioorganic & Medicinal Chemistry Letters in 2020. The article conveys some information:

Rigid amphipathic fusion inhibitors are potent broad-spectrum antivirals based on the perylene scaffold, usually decorated with a hydrophilic group linked via ethynyl or triazole. We have sequentially simplified these structures by removing sugar moiety, then converting uridine to aniline, then moving to perylenylthiophenecarboxylic acids and to perylenylcarboxylic acid. All these polyaromatic compounds, as well as antibiotic heliomycin, still showed pronounced activity against tick-borne encephalitis virus (TBEV) with limited toxicity in porcine embryo kidney (PEK) cell line. 5-(Perylen-3-yl)-2-thiophenecarboxylic acid (5a) showed the highest antiviral activity with 50% effective concentration of approx. 1.6 nM. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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《Microbial production of 4-amino-1-butanol, a four-carbon amino alcohol》 was written by Prabowo, Cindy Pricilia Surya; Shin, Jae Ho; Cho, Jae Sung; Chae, Tong Un; Lee, Sang Yup. Formula: C4H11NO And the article was included in Biotechnology and Bioengineering in 2020. The article conveys some information:

4-Amino-1-butanol (4AB) serves as an important intermediate compound for drugs and a precursor of biodegradable polymers used for gene delivery. Here, we report for the first time the fermentative production of 4AB from glucose by metabolically engineered Corynebacterium glutamicum harboring a newly designed pathway comprising a putrescine (PUT) aminotransferase(encoded by ygjG) and an aldehyde dehydrogenase (encoded by yqhD) from Escherichia coli, which convert PUT to 4AB. Application of several metabolic engineering strategies such as fine-tuning the expression levels of ygjG and yqhD, eliminating competing pathways, and optimizing culture condition further improved 4AB production Fed-batch culture of the final metabolically engineered C. glutamicum strain produced 24.7 g/L of 4AB. The strategies reported here should be useful for the microbial production of primary amino alcs. from renewable resources. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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Zhang, Qingchun; Feng, Shufan; Zhao, Yulian; Jin, Bo; Peng, Rufang published an article in 2021. The article was titled 《Design and synthesis of N-hydroxyalkyl substituted deferiprone: a kind of iron chelating agents for Parkinson′s disease chelation therapy strategy》, and you may find the article in JBIC, Journal of Biological Inorganic Chemistry.Computed Properties of C4H11NO The information in the text is summarized as follows:

The blood-brain barrier (BBB) permeability of mols. needs to meet stringent requirements of Lipinski′s rule, which pose a difficulty for the rational design of efficient chelating agents for Parkinson′s disease chelation therapy. Therefore, the iron chelators employed N-aliphatic alcs. modification of deferiprone were reasonably designed in this work. The chelators not only meet Lipinski′s rule for BBB permeability, but also ensure the iron affinity. The results of solution thermodn. demonstrated that the pFe3+ value of N-hydroxyalkyl substituted deferiprone is between 19.20 and 19.36, which is comparable to that of clin. deferiprone. The results of 2,2-diphenyl-1-picrylhydrazyl radical scavenging assays indicated that the N-hydroxyalkyl substituted deferiprone also possesses similar radical scavenging ability in comparison to deferiprone. Meanwhile, the Cell Counting Kit-8 assays of neuron-like rat pheochromocytoma cell-line demonstrated that the N-hydroxyalkyl substituted deferiprone exhibits extremely low cytotoxicity and excellent H2O2-induced oxidative stress protection effect. These results indicated that N-hydroxyalkyl substituted deferiprone has potential application prospects as chelating agents for Parkinson′s disease chelation therapy strategy. Graphic abstract: [graphic not available: see fulltext] The experimental part of the paper was very detailed, including the reaction process of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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In 2019,Journal of Chemical & Engineering Data included an article by Shirazi, Sanaz Gharehzadeh; Kermanpour, Fakhri. Name: 3-Aminopropan-1-ol. The article was titled 《Density and Viscosity of 2-Butanol + (1-Propanol, 2-Propanol, or 3-Amino-1-propanol) Mixtures at Temperatures of (293.15 to 323.15) K: Application of the ERAS Model》. The information in the text is summarized as follows:

D., ρ, and viscosity, η, of pure components 1-propanol, 2-propanol, 3-amino-1-propanol, and 2-butanol along with binary mixtures of {x12-butanol + x21-propanol}, {x12-butanol + x22-propanol}, and {x12-butanol + x23-amino-1-propanol} were determined over the entire composition range at temperatures of (293.15 to 323.15) K. The exptl. data of d. and viscosity were used to calculate the excess molar volumes, VmE, and viscosity deviations, Δη, of the mixtures The obtained results show that the VmE values of the mixtures are neg. over the whole composition range and increase with increasing temperature Viscosity deviations of the {x12-butanol + x21-propanol} mixture are neg. at low temperatures and pos. at high temperatures, while the Δη values of {x12-butanol + x22-propanol} and {x12-butanol + x23-amino-1-propanol} mixtures are neg. over the whole composition range and decrease with increasing temperature The excess molar quantities were correlated by the Redlich-Kister equation. The ERAS model was used to correlate the excess molar volumes of the mixtures at temperatures of (298.15, 303.15, 313.15) K. Comparison between the calculated and exptl. VmE values shows good agreement for all three mixtures The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Name: 3-Aminopropan-1-ol

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Recommanded Product: 156-87-6In 2021 ,《Prediction of Surface Tension of Various Aqueous Amine Solutions Using the UNIFAC Model and Artificial Neural Networks》 was published in Industrial & Engineering Chemistry Research. The article was written by Mousavi, Nayereh Sadat; Vaferi, Behzad; Romero-Martinez, Ascencion. The article contains the following contents:

In the first stage of this work, a thermodn. approach based on the equality of chem. potentials together with the original UNIFAC activity coefficient model was used to predict the surface tension of 11 different aqueous amine solutions over the entire concentration range at the temperature range of 293.15-348.15 K. The considered aqueous amine solutions include one of the following amines: monoethanolamine, diethanolamine, di-isopropanolamine, Me diethanolamine, 1-amino-2-propanol, triethanolamine, 3-dimethylamino-1-propylamine, 3-amino-1-propanol, dimethylethanolamine, 2-methylamino ethanol, and 2-ethylamino ethanol. The effect of temperature, amine concentration in the aqueous solution, and hydrophobic groups such as -CH2 and -CH3 on the surface tension of primary, secondary, and tertiary amines was investigated. In the second stage, the multilayer perceptron neural network model is designed to predict the surface tension of the aqueous solutions from two different classes of independent variables. The UNIFAC and two developed multilayer perceptron models were used to predict 650 surface tension values, which were in turn used to compare to exptl. data points with the average absolute relative deviations of 6.79, 1.17, and 1.12%, resp. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Recommanded Product: 156-87-6

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In 2022,Lin, Hui-Shan; Chen, Shu-Jun; Huang, Jing-Mei published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Electrosynthesis of (hetero)aryl nitriles from α-imino-oxy acids via oxidative decarboxylation/N-O cleavage》.Related Products of 7748-36-9 The author mentioned the following in the article:

A new method for the synthesis of (hetero)aryl nitriles via iminyl radicals was developed through the electrochem. oxidative decarboxylation of α-imino-oxy acids. This protocol provides an efficient approach to nitriles with a broad range of functional-group tolerance under ambient conditions and can be applied for one-pot gram-scale synthesis. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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In 2022,Shohrat, Annanurov; Zhang, Mi; Hu, Hui; Yang, Xueying; Liu, Li; Huang, Hao published an article in International Journal of Greenhouse Gas Control. The title of the article was 《Mechanism study on CO2 capture by ionic liquids made from TFA blended with MEA and MDEA》.Quality Control of 3-Aminopropan-1-ol The author mentioned the following in the article:

Ionic liquids are presenting a great potential to increase the efficiency and reduce the cost of CO2 capture process. TFA was selected as anion in the produced ionic liquids to study its absorption capacity, and CO2 capture by [3-AP][TFA] and [MDEA][TFA] were tested under different conditions with various solvents such as water, MEA and MDEA. Results showed that ionic liquids blended with MEA improved the absorption capacity up to 0.50 mol CO2/mol absorbent, which was much higher than that of aqueous ionic liquid solution (less than 0.30 mol CO2/mol absorbent), and the aqueous solution of ionic liquids blended with MDEA could improve its absorption capacity up to 0.93 mol CO2/mol absorbent. Different ratios of ionic liquids blended with MDEA were investigated, and ratios of ionic liquids vs. MDEA was set from 2:1 to 1:6. The CO2 absorption capacity reached the maximum of 0.91 mol CO2/mol IL at ratio 1:6 for [3-AP][TFA] and 0.93 mol CO2/mol IL at ratio 1:4 for [MDEA][TFA], which indicated that the CO2 absorption capacity increased with ascending amount of MDEA. Characterizations of aqueous blends were performed by FT-IR and 13C NMR, which showed that the formation of bicarbonate was observed, indicating the mechanism of CO2 absorption was a two-step reaction via the formation of zwitterion. The produced zwitterions contributed to CO2 absorption by increasing both the capacity and reaction rate. Reaction of MDEA with CO2 in water was considered to be a catalyzed hydrolysis, because the lack of eliminating hydrogen atom prevented MDEA from forming carbamate but produced bicarbonate instead. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 3-Aminopropan-1-ol

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