Tag: 0-100

Recommanded Product: 156-87-6In 2021 ,《Development of polymer-based nanoparticles for zileuton delivery to the lung: PMeOx and PMeOzi surface chemistry reduces interactions with mucins》 appeared in Nanomedicine (New York, NY, United States). The author of the article were Drago, Salvatore E.; Craparo, Emanuela F.; Luxenhofer, Robert; Cavallaro, Gennara. The article conveys some information:

In this paper, two amphiphilic graft copolymers were synthesized by grafting polylactic acid (PLA) as hydrophobic chain and poly(2-methyl-2-oxazoline) (PMeOx) or poly(2-methyl-2-oxazine) (PMeOzi) as hydrophilic chain, resp., to a backbone of α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide (PHEA). These original graft copolymers were used to prepare nanoparticles delivering Zileuton in inhalation therapy. Among various tested methods, direct nanopptn. proved to be the best technique to prepare nanoparticles with the smallest dimensions, the narrowest dimensional distribution and a spherical shape. To overcome the size limitations for administration by inhalation, the nano-into-micro strategy was applied, encapsulating the nanoparticles in water-soluble mannitol-based microparticles by spray-drying. This process has allowed to produce spherical microparticles with the proper size for optimal lung deposition, and, once in contact with fluids mimicking the lung district, able to dissolve and release non-aggregated nanoparticles, potentially able to spread through the mucus, releasing about 70% of the drug payload in 24 h. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 156-87-6

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In 2022,Elberskirch, Linda; Le Harzic, Ronan; Scheglmann, Dietrich; Wieland, Gerhard; Wiehe, Arno; Mathieu-Gaedke, Maria; Golf, Hartwig R. A.; von Briesen, Hagen; Wagner, Sylvia published an article in European Journal of Pharmaceutical Sciences. The title of the article was 《A HET-CAM based vascularized intestine tumor model as a screening platform for nano-formulated photosensitizers》.Application of 534-03-2 The author mentioned the following in the article:

The development of new tumor models for anticancer drug screening is a challenge for preclin. research. Conventional cell-based in vitro models such as 2D monolayer cell cultures or 3D spheroids allow an initial assessment of the efficacy of drugs but they have a limited prediction to the in vivo effectiveness. In contrast, in vivo animal models capture the complexity of systemic distribution, accumulation, and degradation of drugs, but visualization of the individual steps is challenging and extracting quant. data is usually very difficult. Furthermore, there are a variety of ethical concerns related to animal tests. In accordance with the 3Rs principles of Replacement, Reduction and Refinement, alternative test systems should therefore be developed and applied in preclin. research. The Hen’s egg test on chorioallantoic membrane (HET-CAM) model provides the generation of vascularized tumor spheroids and therefore, is an ideal test platform which can be used as an intermediate step between in vitro anal. and preclin. evaluation in vivo. We developed a HET-CAM based intestine tumor model to investigate the accumulation and efficacy of nano-formulated photosensitizers. Irradiation is necessary to activate the phototoxic effect. Due to the good accessibility of the vascularized tumor on the CAM, we have developed a laser irradiation setup to simulate an in vivo endoscopic irradiation The study presents quant. as well as qual. data on the accumulation and efficacy of the nano-formulated photosensitizers in a vascularized intestine tumor model. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Application of 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 534-03-2

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《Self-assembly of pH-sensitive micelles for enhanced delivery of doxorubicin to melanoma cells》 was published in Journal of Drug Delivery Science and Technology in 2020. These research results belong to Long, Miaomiao; Liu, Shenhuan; Shan, Xiaotian; Mao, Jing; Yang, Fuwei; Wu, Xiaoyu; Qiu, Lipeng; Chen, Jinghua. Name: 2-Aminopropane-1,3-diol The article mentions the following:

Polymeric micelles have attracted much attention in the field of anticancer drug delivery system because of their special properties. However, the slow drug release rate of micelles after reaching tumor cells is still considered to be a major problem. Therefore, we constructed a new orthoester-based pH-sensitive polyethylene glycol-hydroxydodecanoic acid (PAE) polymer to form doxorubicin-loaded micelles (DOX/PAE). DOX/PAE micelles with uniform particle size showed pH-sensitive drug release behavior in vitro. And the in vitro cytotoxicity studies showed that blank PAE micelles were nontoxic to cells while DOX/PAE micelles could inhibit the growth of tumor cells in a concentration-dependent manner. Furthermore, cellular uptake studies showed that DOX/PAE micelles were uptaken by tumor cells and transported into the nucleus to achieve the effect of killing tumor cells. The results of the uptake mechanism showed that clathrin and macrophage mediated endocytic pathways played important roles in internalization of DOX/PAE micelles. Altogether, the above results show that pH-sensitive PAE micelles have potential in anticancer drug delivery. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Name: 2-Aminopropane-1,3-diol

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《Visible-Light-Induced Metal-Free Trifluoromethylselenolation of Electron-Rich Heteroarenes Using the Nucleophilic [Me4N][SeCF3] Reagent》 was written by De Zordo-Banliat, Arnaud; Barthelemy, Lucas; Bourdreux, Flavien; Tuccio, Beatrice; Dagousset, Guillaume; Pegot, Bruce; Magnier, Emmanuel. Name: Oxetan-3-ol And the article was included in European Journal of Organic Chemistry in 2020. The article conveys some information:

A metal-free visible-light-promoted regioselective trifluoromethylselenolation of electron-rich heteroarenes was developed using C-H functionalization. This eco-friendly, atom-economical, and easy-to-operate protocol provides direct access to a wide range of functionalized SeCF3-containing heteroarenes in high yields, and is amenable to continuous flow techniques. A radical mechanism was supported by EPR experiments In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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In 2019,Angewandte Chemie, International Edition included an article by Silva, Siguara B. L.; Oberhaensli, Francois; Tribalat, Marie-Aude; Genta-Jouve, Gregory; Teyssie, Jean-Louis; Dechraoui-Bottein, Marie-Yasmine; Gallard, Jean-Francois; Evanno, Laurent; Poupon, Erwan; Thomas, Olivier P.. Product Details of 13325-10-5. The article was titled 《Insights into the Biosynthesis of Cyclic Guanidine Alkaloids from Crambeidae Marine Sponges》. The information in the text is summarized as follows:

Among the outstanding chem. diversity found in marine sponges, cyclic guanidine alkaloids, present in species of the family Crambeidae, are particularly attractive, not only because of their unique chem. features, but also due to a broad range of biol. activities. Despite a growing interest in these natural products as therapeutic agents, their metabolic pathway has not been exptl. investigated. Ex situ feeding experiments using radiolabeled precursors performed on the Mediterranean sponge Crambe crambe suggest arginine and fatty acids as precursors in the metabolic pathway of crambescins. A subsequent bio-inspired approach supported the change of paradigm in the metabolic pathway of cyclic guanidine alkaloids. A large part of the chem. diversity of this family would therefore originate from a tethered Biginelli-like reaction between C-2/C-3 activated fatty acids and a central guanidinylated pyrrolinium. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

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In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Liu, Yi-Yin; Liang, Dong; Lu, Liang-Qiu; Xiao, Wen-Jing. Computed Properties of C3H9NO. The article was titled 《Practical heterogeneous photoredox/nickel dual catalysis for C-N and C-O coupling reactions》. The information in the text is summarized as follows:

Efficient C-N and C-O coupling reactions of aryl halides with amines and alcs. have been developed by using the strategy of heterogeneous visible light photoredox and nickel dual catalysis. Obviously, the joint use of inexpensive and bench-stable CdS and nickel salts, together with mild reaction conditions, makes these two transformations attractive for the synthetic community. This heterogeneous dual catalysis system also proved to be successful in the ligand-free catalytic hydroxylation of aryl bromide with water as a nucleophile. The practicality of this protocol is further emphasized by the scaled-up reaction and the reusability of heterogeneous photocatalysts. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Computed Properties of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Computed Properties of C3H9NO

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In 2019,Biochimica et Biophysica Acta, Biomembranes included an article by Sivaramakrishna, D.; Prasad, Muvva D.; Swamy, Musti J.. Name: 2-Aminopropane-1,3-diol. The article was titled 《A homologous series of apoptosis-inducing N-acylserinols: Thermotropic phase behavior, interaction with cholesterol and characterization of cationic N-myristoylserinol-cholesterol-CTAB niosomes》. The information in the text is summarized as follows:

N-Acylserinols (NASOHs) exhibit anti-cancer activity by elevating ceramide levels, and/or by activating proapoptotic effectors. In the present work we investigated the thermotropic phase behavior and supramol. organization of a homologous series of NASOHs (number of C-atoms in the acyl chain, n = 8-18), and the interaction of N-myristoylserinol (NMSOH) with cholesterol, and characterized cationic niosomes made up of NMSOH, cholesterol and cetyltrimethylammonium bromide (CTAB). Differential scanning calorimetric studies revealed that NASOHs exhibit a major chain-melting phase transition in both dry and hydrated states. The thermodn. parameters, transition enthalpy and entropy show linear dependence on the acyl chain length in the dry state, but exhibit odd-even alternation in the hydrated state. Powder X-ray diffraction studies revealed that NASOHs adopt a tilted bilayer structure, wherein the bilayer repeat distances (d-spacings) also showed odd-even alteration, with even-chainlength compounds exhibiting slightly higher d-spacings. Studies on the interaction between NMSOH and cholesterol revealed that both lipids mix well with up to 55 mol% cholesterol, whereas phase separation was observed at higher cholesterol content. The transition enthalpy corresponding to the NMSOH-cholesterol complex increases up to 55 mol% cholesterol and decreases at higher cholesterol content. Presence of the cationic surfactant CTAB affects the phase behavior, fluidity and size of the NMSOH-cholesterol (45,55, mol/mol) niosomes, with unilamellar vesicles of about 85 (±20) nm in diameter being obtained at 10 mol% CTAB. These results provide a thermodn. and structural basis for further investigations on these cationic niosomes towards their use in drug delivery applications, especially for anticancer drugs. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: 2-Aminopropane-1,3-diol

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The author of 《A colorimetric and fluorescent lighting-up sensor based on ICT coupled with PET for rapid, specific and sensitive detection of nitrite in food》 were Wu, Juanjuan; Jiang, Lirong; Verwilst, Peter; An, Jusung; Zeng, Hongyan; Zeng, Lintao; Niu, Guangle; Kim, Jong Seung. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Recommanded Product: 3-Aminopropan-1-ol The author mentioned the following in the article:

An anthracene carboxyimide derivative was synthesized as a colorimetric and fluorogenic sensor to determine NO2- with a rapid response (<4 min), excellent selectivity and a low detection limit (84 nM). Paper strips containing the sensor were applied to visually determine the NO2- content in food. The results came from multiple reactions, including the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Recommanded Product: 3-Aminopropan-1-ol

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《Reaction of indoles with aromatic fluoromethyl ketones: an efficient synthesis of trifluoromethyl(indolyl)phenyl-methanols using K2CO3/n-Bu4PBr in water》 was written by Pillaiyar, Thanigaimalai; Sedaghati, Masoud; Schnakenburg, Gregor. Product Details of 7748-36-9This research focused ontrifluoromethyl indolyl phenyl methanol preparation regioselective; indole fluoromethyl ketone Friedel Crafts alkylation; C3-funtionalization of indole; C–C-bond formation; Friedel–Crafts reaction; diindolylmethane; indole; indole-3-carbinol; large-scale synthesis; recyclability. The article conveys some information:

A new, mild and efficient protocol is provided for the synthesis of trifluoromethyl(indolyl)phenylmethanols e.g., I by the reaction of indoles e.g., 5-methoxyindole with a variety of aromatic fluoromethyl ketones RC(O)C(R1)F2 (R = Ph, Bn, thiophen-2-yl, etc.; R1 = H, F, Cl, CF3, etc.) in the presence of K2CO3 (15 mol) and n-Bu4PBr (15 mol) in water. The desired products were obtained in good to excellent yields without requiring a column chromatog. purification The reusability of the catalytic system and large-scale synthesis of indolyl(phenyl)methanols e.g., I, which would further transform into biol. active indole-derived compounds, are further advantages of this protocol. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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HPLC of Formula: 13325-10-5In 2019 ,《Aggregation of Ag(0) nanoparticles to unexpected stable chain-like assemblies mediated by 2,2′-bipyridine decorated peptoids》 was published in Journal of Colloid and Interface Science. The article was written by Tigger-Zaborov, Hagar; Maayan, Galia. The article contains the following contents:

We report a unique example of Ag(0) nanoparticles (NPs)-assemblies stabilized by 2,2-bipyridine (BP), via the incorporation of BP at the N-terminus of a peptoid heptamer bearing phenylethyl groups in the other positions. We show that this peptoid mediates the aggregation of the Ag(0) NPs into nanochain-like assemblies. Transmission electron microscopy, supported by UV-Vis spectroscopy anal., revealed pre-assembly of the BP-peptoid oligomers into elongated pearl-like morphol., which serve as a template for the NPs. The fact that completely synthetic biomimetic oligomers can template and control the assembly of metal NPs, and specifically Ag(0), represents a conceptual mimic of the interaction between biomols. and minerals for the production of nanostructured inorganic materials with complex morphologies.4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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