Tag: 0-100

In 2019,Industrial & Engineering Chemistry Research included an article by Meng, Xiangzhan; Zhang, Yongqiang; Li, Zengxi; Wang, Hui; Zhang, Suojiang. Application of 156-87-6. The article was titled 《Selective Oxidation of Amino Alcohols to Amino Acids over Au Supported on Monoclinic ZrO2: Dominant Active Sites and Kinetic Study》. The information in the text is summarized as follows:

Au supported on monoclinic ZrO2 (Au/m-ZrO2) prepared by deposition-precipitation method showed excellent catalytic performance in the aerobic oxidation of amino alcs. to amino acids, i.e., glycine, alanine, serine, β-alanine, and 2-aminobutyric acid. The Au particle size and valence distribution of the gold species were adjusted by calcination temperature, as demonstrated by XRD, TEM, UV-vis DRS, XPS, and H2-TPR, which significantly influenced the catalytic activity but not the selectivity of amino acids. Metallic gold atoms on the surface were shown to be the active sites by the correlation between reaction rate per mol of metallic Au and Au particle size. The kinetics of oxidation of monoethanolamine (MEA) was studied in detail, and the results indicated that MEA oxidation is a first-order reaction with an activation energy of 52.8 kJ·mol-1. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Application of 156-87-6

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Application of 534-03-2In 2019 ,《Immunosuppressive effect of a non-proteinogenic amino acid from Streptomyces through inhibiting allogeneic T cell proliferation》 was published in Bioscience, Biotechnology, and Biochemistry. The article was written by Yashiro, Takuya; Sakata, Fumiya; Sekimoto, Takahiro; Shirai, Tomohiro; Hasebe, Fumihito; Matsuda, Kenichi; Kurosawa, Sumire; Suzuki, Shodai; Nagata, Kazuki; Kasakura, Kazumi; Nishiyama, Makoto; Nishiyama, Chiharu. The article contains the following contents:

The immunosuppressive activity of myriocin (ISP-1), a lead compound of fingolimod (FTY720), is derived from its 2-amino-1,3-propandiol structure. A non-proteinogenic amino acid, (2S,6R)-diamino-(5R,7)-dihydroxy-heptanoic acid (DADH), that contains this structure, was recently identified as a biosynthetic intermediate of a dipeptide secondary metabolite, vazabitide A, in Streptmyces sp. SANK 60404; however its effect on adaptive immunity has not yet been examined In this study, we examined whether DADH suppresses mixed lymphocyte reaction using mouse bone marrow-derived dendritic cells (BMDCs) and allogeneic splenic T cells. Although T cell proliferation induced by crosslinking CD3 and CD28 were not suppressed by DADH unlike ISP-1, the pre-incubation of BMDCs with DADH but not ISP-1 significantly decreased allogeneic CD8+ T cell expansion. Based on these results, we concluded that DADH suppresses DC-mediated T cell activation by targeting DCs. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Application of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Application of 534-03-2

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Electric Literature of C4H11NOIn 2021 ,《Recent progress in production of amino acid-derived chemicals using Corynebacterium glutamicum》 appeared in World Journal of Microbiology & Biotechnology. The author of the article were Tsuge, Yota; Matsuzawa, Hiroki. The article conveys some information:

A review. Green chem. production by microbial processes is critical for the development of a sustainable society in the twenty-first century. Among the important industrial microorganisms, the gram-pos. bacterium Corynebacterium glutamicum has been utilized for amino acid fermentation, which is one of the largest microbial-based industries. To date, several amino acids, including L-glutamic acid, L-lysine, and L-threonine, have been produced by C. glutamicum. The capability to produce substantial amounts of amino acids has gained immense attention because the amino acids can be used as a precursor to produce other high-value-added chems. Recent developments in metabolic engineering and synthetic biol. technologies have enabled the extension of metabolic pathways from amino acids. The present review provides an overview of the recent progress in the microbial production of amino acid-derived bio-based monomers such as 1,4-diaminobutane, 1,5-diaminopentane, glutaric acid, 5-aminolevulinic acid, L-pipecolic acid, 4-amino-1-butanol, and 5-aminolevulinic acid, as well as building blocks for healthcare products and pharmaceuticals such as ectoine, L-theanine, and gamma-aminobutyric acid by metabolically engineered C. glutamicum. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Electric Literature of C4H11NO

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Synthetic Route of C3H9NO2In 2019 ,《Synthesis of Porphyrinoids, BODIPYs, and (Dipyrrinato)ruthenium(II) Complexes from Prefunctionalized Dipyrromethanes》 appeared in European Journal of Organic Chemistry. The author of the article were Hohlfeld, Benjamin F.; Flanagan, Keith J.; Kulak, Nora; Senge, Mathias O.; Christmann, Mathias; Wiehe, Arno. The article conveys some information:

The introduction of functional groups into the meso-position of dipyrromethanes, boron-dipyrromethenes (BODIPYs) and porphyrinoids, is of fundamental importance in designing such dye systems for material sciences or photomedicine. One route that proved to be particularly useful in this respect is the nucleophilic aromatic substitution (SNAr) on porphyrinoids and their precursors carrying electron-withdrawing substituents. To further expand this methodol., the potential of the 4-fluoro-3-nitrophenyl and the 3,4,5-trifluorophenyl moieties for the synthesis of functionalized dipyrromethanes, BODIPYs, and porphyrinoids was evaluated. The 3,4,5-trifluorophenyl moiety proved not to be applicable in the SNAr with nucleophiles. The introduction of the 4-fluoro-3-nitrophenyl group, however, allowed fast and efficient SNAr with various amine nucleophiles. The synthesized 4-amino-3-nitrophenyl-substituted dipyrromethanes were successfully applied in the synthesis BODIPYs and were tested in the synthesis of “”trans””-A2B2 porphyrins and A2B corroles. Furthermore, the dipyrromethanes – after oxidation to the dipyrromethenes – are suitable ligands for metal ions giving access to functionalized ruthenium(II) metal complexes.2-Aminopropane-1,3-diol(cas: 534-03-2Synthetic Route of C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Synthetic Route of C3H9NO2

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Name: 4-Aminobutan-1-olIn 2020 ,《Efficiency of Cytosolic Delivery with Poly(β-amino ester) Nanoparticles is Dependent on the Effective pKa of the Polymer》 appeared in ACS Biomaterials Science & Engineering. The author of the article were Routkevitch, Denis; Sudhakar, Deepti; Conge, Marranne; Varanasi, Mahita; Tzeng, Stephany Y.; Wilson, David R.; Green, Jordan J.. The article conveys some information:

The mechanism by which cationic polymers containing titratable amines mediate effective endosomal escape and cytosolic delivery of nucleic acids is not well understood despite the decades of research devoted to these materials. Here, we utilize multiple assays investigating the endosomal escape step associated with plasmid delivery by polyethylenimine (PEI) and poly(β-amino esters) (PBAEs) to improve the understanding of how these cationic polymers enable gene delivery. To probe the role of these materials in facilitating endosomal escape, we utilized vesicle membrane leakage and extracellular pH modulation assays to demonstrate the influence of polymer buffering capacity and effective pKa on the delivery of the plasmid DNA. Our results demonstrate that transfection with PBAEs is highly sensitive to the effective pKa of the overall polymer, which has broad implications for transfection. In more acidic environments, PBAE-mediated transfection was inhibited, while PEI was relatively unaffected. In neutral to basic environments, PBAEs have high buffering capacities that led to dramatically improved transfection efficacy. The cellular uptake of polymeric nanoparticles overall was unchanged as a function of pH, indicating that microenvironmental acidity was important for downstream intracellular delivery efficiency. Overall, this study motivates the use of polymer chem. characteristics, such as effective pKa values, to more efficiently evaluate new polymeric materials for enhanced intracellular delivery characteristics. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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Lemir, Ignacio D.; Oksdath-Mansilla, Gabriela; Castro-Godoy, Willber D.; Schmidt, Luciana C.; Arguello, Juan E. published an article in 2022. The article was titled 《Photochemical Csp2-H bond thiocyanation and selenocyanation of activated arenes, batch and continuous-flow approaches》, and you may find the article in Photochemical & Photobiological Sciences.Recommanded Product: Oxetan-3-ol The information in the text is summarized as follows:

An eco-friendly photochem. oxidative Csp2-H thiocyanation and selenocyanation of activated arenes were reported. The reaction proceeded under Violet LED irradiation in the presence of K2S2O8, which quickly oxidized KSCN and KSeCN, finally producing arylthio/selenocyanates. Using this benign, atom-economic protocol, the desired chalcogenide products were obtained regioselectively, with isolated yields that range from very good to excellent. Although, mechanistic study indicated that it is difficult to distinguish between a radical to a SEAr reaction mechanism between the photo-induced formed •SCN, for the former, or NCSSCN, for the latter, to the aromatic heterocycles. The inhibition experiment together with the observed reactivity and regioselectivity, would be in agreement with the latter. The synthetic methodol. designed could be successfully adapted to continuous-flow systems in a segmented-flow regime, employing the organic phase as the product reservoir. Using this setup, the advantage of the latter could be demonstrated by reducing the reaction time and improving the product yields. Similarly, the scaling up of the reaction to gram scale resulted in favorable outcomes by the flow setup, which installed the photo-flow chem. as a powerful tool to be included into routine reaction procedures, which had great relevance for the pharmaceutical industry.Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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Noroozi, Javad; Smith, William R. published their research in Journal of Chemical Information and Modeling in 2021. The article was titled 《Force-Field-Based Computational Study of the Thermodynamics of a Large Set of Aqueous Alkanolamine Solvents for Post-Combustion CO2 Capture》.Related Products of 534-03-2 The article contains the following contents:

The ability to predict the thermodn. properties of amine species in CO2-loaded aqueous solutions, including their deprotonation (pKa) and carbamate to bicarbonate reversion (pKc) equilibrium constants and their corresponding standard reaction enthalpies, is of critical importance for the design of improved carbon capture solvents. In this study, we used isocoulombic forms of both reactions to determine these quantities for a large set of aqueous alkanolamine solvent systems. Our hybrid approach involves using classical mol. dynamics simulations with the general amber force field (GAFF) and semi-empirical AM1-BCC charges (GAFF/AM1-BCC) in the solution phase, combined with high-level composite quantum chem. ideal-gas calculations We first determined a new force field (FF) for the hydronium ion (H3O+) by matching to the single exptl. pKa data point for the well-known monoethanolamine system at 298.15 K. We then used this FF to predict the pKa values for 76 other amines at 298.15 K and for all 77 amines at elevated temperatures Addnl., we indirectly relate the H3O+ hydration free energy to that of H+ and provide expressions for intrinsic hydration free energy and enthalpy of the proton. Using the derived H3O+ FF, we predicted the pKa values of a diverse set of alkanolamines with an overall average absolute deviation of less than 0.72 pKa units. Furthermore, the derived H3O+ FF is able to predict the protonation enthalpy of these amines when used with the GAFF. We also predicted the carbamate reversion constants of the primary and secondary amine species in the data set and their corresponding standard heats of reaction, which we compared with the scarcely available exptl. data, which are often subject to significant uncertainty. Finally, we also described the influence of electronic and steric effects of different mol. fragments/groups on the stabilities of the carbamates. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Related Products of 534-03-2

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《Synthesis and evaluation of 7-azaindole derivatives bearing benzocycloalkanone motifs as protein kinase inhibitors》 was written by Qhobosheane, Malikotsi A.; Legoabe, Lesetja J.; Josselin, Beatrice; Bach, Stephane; Ruchaud, Sandrine; Petzer, Jacobus P.; Beteck, Richard M.. Electric Literature of C3H6O2 And the article was included in Bioorganic & Medicinal Chemistry in 2020. The article conveys some information:

The synthesis and biol. evaluation of new 7-azaindole derivatives I [X = O, CH2, (CH2)2, CH2O, CH2S; R = H, 6-OH, 6,7-(MeO)2, etc.] bearing benzocycloalkanone motifs as potential protein kinase inhibitors are reported. Four compounds I [X = (CH2)2, R = H, 6-OH; X = CH2, R = 5,6-(MeO)2; X = O, R = 6-OH] were discovered to inhibit cyclin-dependent kinase 9 (CDK9/CyclinT) and/or Haspin kinase in the micromolar to nanomolar range. The compound I [X = O, R = 6-OH] was identified as the most potent Haspin inhibitor (IC50 = 14 nM), while I [X = (CH2)2; R = H, 6-OH] acted as dual inhibitors of CDK9/CyclinT and Haspin. These novel compounds constitute a promising starting point for the discovery of dual protein kinase inhibitors that have potential to be developed as anticancer agents, since both CDK9/CyclinT and Haspin are considered to be drug targets in oncol. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Electric Literature of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Electric Literature of C3H6O2

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The author of 《A naphthalimide-based fluorescence “”off-on-off”” chemosensor for relay detection of Al3+and ClO-》 were Sun, Xue-Jiao; Liu, Ting-Ting; Fu, Hong; Li, Na-Na; Xing, Zhi-Yong; Yang, Fan. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2019. SDS of cas: 534-03-2 The author mentioned the following in the article:

A novel Al3+ chemosensor NPA was designed and synthesized on basis of the mechanism of ICT and CHEF. Upon addition of Al3+, the probe NPA displayed a bright green fluorescence under UV radiation and visual color change from yellow to colorless. Spectrum titrations showed that NPA could be recognized as a fluorescent turn-on probe with 10-8 M detection level. The probe was successfully applied in real water sample and test paper. More important, NPA-Al3+ complex were used as a fluorescent turn-off probe for the detection of ClO- with the detection as low as 2.34 ×x 10-8 M. The performance of NPA to Al3+ and NPA-Al3+ complex to ClO- demonstrated that NPA could be served as a sensitive probe and exhibit INHIBIT logic gate behavior with Al3+ and ClO- as inputs. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.SDS of cas: 534-03-2

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The author of 《Heavy atom labeling enables silanol defect visualization in silicalite-1 crystals》 were Li, Teng; Krumeich, Frank; Ihli, Johannes; Ma, Zhiqiang; Ishikawa, Takashi; Pinar, Ana B.; van Bokhoven, Jeroen A.. And the article was published in Chemical Communications (Cambridge, United Kingdom) in 2019. Safety of 3-Aminopropan-1-ol The author mentioned the following in the article:

Using heavy-atom labeling in conjunction with electron microscopy, the authors here visualize the distribution of point defects, i.e. internal silanol groups, in silicalite-1 zeolites at the single crystal level. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Safety of 3-Aminopropan-1-ol

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