Tag: 0-100

SDS of cas: 156-87-6In 2020 ,《Experimental Study of Some Thermodynamic Properties of Binary Mixtures Containing 3-Amino-1-propanol, 2-Aminoethanol, and 1-Butanol at Temperatures of 293.15-333.15 K to Model the Excess Molar Volumes Using the PFP Theory》 was published in Journal of Chemical & Engineering Data. The article was written by Kermanpour, Fakhri; Kheyrabadi, Zahra Gharagozlo. The article contains the following contents:

D., ρ, and viscosity, η, of pure components of 2-aminoethanol, 1-butanol, and 3-amino-1-propanol, along with the binary mixtures of {x12-aminoethanol + x21-butanol}, {x13-amino-1-propanol + x21-butanol}, and {x13-amino-1-propanol + x22-aminoethanol}, were determined over the whole composition range and in the temperatures of 293.15-333.15 at ambient pressure p = 86 kPa. The exptl. values of d. and viscosity have been used to calculate the excess molar volume, VmE, partial molar volumes, V̅1 and V̅2, excess partial molar volumes, V̅1E and V̅2E, thermal expansion coefficient, α, excess thermal expansion coefficient, αE, and viscosity deviation, Δη, of binary mixtures The results show that excess molar volumes of the mixtures are neg. in the whole composition range and increase with increasing temperature Viscosity deviations, Δη, of two former mixtures are neg. over the entire composition range and decrease with increasing temperature, while the Δη values of the later mixture are pos. over the entire composition range and decrease with the increasing temperature The excess properties were correlated by the Redlich-Kister equation, and their fitting parameters and standard deviations were determined The excess molar volumes were also correlated by applying the Prigogine-Flory-Patterson (PFP) model, and their interaction parameters, χ12, were obtained. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.SDS of cas: 156-87-6

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HPLC of Formula: 156-87-6In 2022 ,《Structure-Activity Correlation Analyses of MEA + 3A1P/MAE Isomers with a Coordinative Effect Study》 was published in Industrial & Engineering Chemistry Research. The article was written by Shi, Huancong; Cheng, Xiaofang; Peng, Jiacheng; Feng, Hongliang; Yang, Xuan; Quan, Luoqiu; Jiang, Linhua; Tontiwachwuthikul, Paitoon. The article contains the following contents:

The “”coordinative effect””, which enhances absorption and desorption performance of single RR’NH at once, was verified repeatedly within MEA + BEA, MEA + DEA, and MEA + BEA + AMP. This work studied the “”coordinative effect”” within specific MEA + 3-amino-1-propanol 3A1P(RNH2) and MEA + 2-(methylamine)ethanol MAE(RR’NH). The amine 3A1P and MAE were isomers with the same formula but different mol. structures. Both CO2 absorption and desorption tests were conducted in bi-solvents MEA + 3A1P and MEA + MAE sep., with the help of CO2 absorption-desorption parameters. Exptl. results demonstrated that the “”coordinative effect”” existed within MEA + 3A1P and MEA + MAE. Both CO2 absorption/desorption performances of MEA + 3A1P/MAE were superior to those of 3A1P/MAE single amine simultaneously. The coordinative effect reached an optimum ratio for amine blends at 0.2-0.3 + 2 mol/L of MEA + 3A1P and 0.3 + 2 mol/L of MEA + MAE. Based on scientific anal., carbamate stability is the dominant factor contributing to strong or negligible coordinative effects of MEA + AMP and 3A1P. The synthesized MEA + RR’NH will be blended with other R3N/AMP to generate tri-solvents with a large concentration and cyclic capacities for industrial applications. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.HPLC of Formula: 156-87-6

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《The source of conductivity and proton dynamics study in TEMPO-oxidized cellulose doped with various heterocyclic molecules》 was published in Cellulose (Dordrecht, Netherlands) in 2020. These research results belong to Culica, Madalina Elena; Avadanei, Mihaela; Baron, Raluca Ioana; Chibac-Scutaru, Andreea Laura; Asandulesa, Mihai; Biliuta, Gabriela; Lisa, Gabriela; Coseri, Sergiu. Reference of Oxetan-3-ol The article mentions the following:

Our manuscript focuses on the study of proton conductivity phenomena caused by a high degree of mobility and dynamic movement of protons that occur in some hybrid composites obtained from TEMPO oxidized cellulose doped with three heterocyclic compounds The first stage consists in the preparation of the organic matrix, the reaction conditions being chosen so as to allow the incorporation of as many carboxyl groups as possible. The numerous COOH groups, introduced after oxidation in the cellulose backbone, allow the successful attachment of N-base mols., such as: 1-hydroxybenzotriazole (HBT), imidazole (IM), and 7-azaindole (AI). The as prepared cellulose-based powder composites (OxC-HBT, OxC-IM, OxC-AI) were firstly analyzed using extensive FTIR study. A good thermal stability of the prepared samples has been revealed by thermal analyses. Moreover, the composites showed good values of proton conductivity both at lower and higher temperatures, for example, under anhydrous conditions, the proton conductivity has been found equal to 1.2 x 10-1 S/m for the composite containing IM and 2.3 x 10-2 S/m for the hybrid material containing HBT. The activation energies were also calculated and discussed for each heterocyclic dopant. The use of derivatives of natural polymers, i.e.TEMPO oxidized cellulose, create the prerequisite conditions for cheap, non-hazardous and environmentally safety approaches to find new biopolymer composites materials with proton conductive properties with potential application in fuel cell technol. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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Wakamiya, Yuma; Ebine, Makoto; Matsumori, Nobuaki; Oishi, Tohru published an article on February 19 ,2020. The article was titled 《Total Synthesis of Amphidinol 3: A General Strategy for Synthesizing Amphidinol Analogues and Structure-Activity Relationship Study》, and you may find the article in Journal of the American Chemical Society.Reference of (R)-Oxiran-2-ylmethanol The information in the text is summarized as follows:

Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce natural product due to the presence of numerous stereogenic centers on the acyclic carbon chain. Since the absolute configuration was partially determined on the basis of insufficient evidence, the originally proposed structure has been revised three times. Although recent progress on structure determination by computational anal. is remarkable, total synthesis is still the most reliable way to confirm structures. The first total synthesis of AM3 was achieved via expeditious assembly of three components in five steps, confirming the revised structure of AM3 after more than 20 years since its first discovery. The established synthetic route would be a general strategy for synthesizing amphidinol congeners. An artificial and simplified analog of AM3, which elicited antifungal activity comparable to that of AM3, was designed and synthesized. This is the first example of a biol. active artificial analog possessing a shorter polyol moiety, providing insight on the antifungal mode-of-action. After reading the article, we found that the author used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Reference of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Reference of (R)-Oxiran-2-ylmethanol

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The author of 《Chiral recognition of homochiral poly (amidoamine) dendrimers substituted with R- and S-glycidol by keratinocyte (HaCaT) and squamous carcinoma (SCC-15) cells in vitro》 were Malinga-Drozd, Malgorzata; Uram, Lukasz; Wrobel, Konrad; Wolowiec, Stanislaw. And the article was published in Polymers (Basel, Switzerland) in 2021. Reference of (R)-Oxiran-2-ylmethanol The author mentioned the following in the article:

The generation 2 and 3 poly(amidoamine) dendrimers (PAMAM G2 and G3) were converted into N-(2,3-dihydroxy)propyl derivatives by the addition of enantiomerically pure S- and R-glycidol. The homochiral dendrimers bind to HaCaT and SCC-15 cell membranes with an R/S glycidol enantioselectivity ratio of 1.5:1, as was quant. determined by fluorescence microscopy and visualized by confocal microscopy. Fully substituted G2 and G3 dendrimers were equipped with 32 and 64 N-(2,3-dihydroxy)propyl residues and showed effectively radial symmetry for homochiral derivatives in 13C NMR spectrum in contrary to analogs obtained by reaction with rac-glycidol. The sub-stoichiometric derivatives of G2 and G3 were also obtained in order to characterize them spectroscopically. The homochiral dendrimers were labeled with two different fluorescent labels, fluorescein, and rhodamine B, using their isothiocyanates to react with G2 and G3 followed by the addition of S- and R-glycidol. Obtained fluorescent derivatives were deficiently filled with N-(2,3-dihydroxy)propyl substituents due to steric hindrance imposed by the attached label. Nevertheless, these derivatives were used to determine their ability to bind to the cell membrane of human keratinocytes (HaCaT) and squamous carcinoma cells (SCC-15). Confocal microscopy images obtained from cells treated with variously labeled conjugates and fluorescence anal. with fluorescence reader allowed us to conclude that R-glycidol derivatives were bound and entered the cells preferentially, with higher accumulation in cancer cells. The G3 polyamidoamine (PAMAM)-based dendrimers were taken up more efficiently than G2 derivatives Moreover, S- and R-glycidol furnished dendrimers were highly biocompatible with no toxicity up to 300 Μ M concentrations, in contrast to the amine-terminated PAMAM analogs. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Reference of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Reference of (R)-Oxiran-2-ylmethanol

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In 2022,Mukherjee, Anurag; Barman, Shubhankar; Ghosh, Anupam; Datta, Ayan; Datta, Anuja; Ghosh, Suhrit published an article in Angewandte Chemie, International Edition. The title of the article was 《A Hierarchical (Macro)molecular Assembly Assisted by Donor-Acceptor Charge-Transfer Interactions Exhibiting Room-Temperature Ferroelectricity》.Related Products of 534-03-2 The author mentioned the following in the article:

This communication reveals co-assembly of an electron-deficient naphthalene-diimide (NDI)-appended polyurethane (P1) and electron-rich pyrene (Py), forming an organogel with prominent room-temperature ferroelectricity. In a non-polar medium, intra-chain hydrogen-bonding among the urethane groups of P1 produces a folded structure with an array of the NDIs in the periphery, which intercalate Py by charge-transfer (CT)-interaction. Such CT-complexation enables slow crystallization of the peripheral hydrocarbons, causing gelation with nanotubular morphol., in which the wall consists of the alternating NDI-Py stack. Such D-A assembly exhibits ferroelectricity (saturation polarization Ps≈0.8μC cm-2 and coercive field Ec≈8 kV cm-1 at 500 V and 10 Hz frequency) with Curie temperature (Tc) of ≈350 K, which can be related to the disassembly of the CT-complex. In the absence of Py, P1 forms spherical aggregates, showing dielec. behavior. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Related Products of 534-03-2

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In 2022,Banerjee, Arghya; Sarkar, Satavisha; Shah, Jagrut A.; Frederiks, Nicoline C.; Bazan-Bergamino, Emmanuel A.; Johnson, Christopher J.; Ngai, Ming-Yu published an article in Angewandte Chemie, International Edition. The title of the article was 《Excited-State Copper Catalysis for the Synthesis of Heterocycles》.Product Details of 7748-36-9 The author mentioned the following in the article:

Herein, the discovery and development of visible-light-induced, synergistic excited-state copper catalysis using a combination of Cu(IPr)I as a catalyst and rac-BINAP as a ligand, which produces more than 10 distinct classes of heterocycles was reported. The reaction tolerated a broad array of functional groups and complex mol. scaffolds, including derivatives of peptides, natural products and marketed drugs. Preliminary mechanistic investigation suggested in situ generations of [Cu(BINAP)2]+ and [Cu(IPr)2]+ catalysts that work cooperatively under visible-light irradiation to facilitate catalytic carbo-aroylation of unactivated alkenes, affording a wide range of useful heterocycles. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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Shin, Kyong-Oh; Kim, Sungeun; Park, Byeong Deog; Uchida, Yoshikazu; Park, Kyungho published an article in 2021. The article was titled 《N-Palmitoyl Serinol Stimulates Ceramide Production through a CB1-Dependent Mechanism in In Vitro Model of Skin Inflammation》, and you may find the article in International Journal of Molecular Sciences.Related Products of 534-03-2 The information in the text is summarized as follows:

Ceramides, a class of sphingolipids containing a backbone of sphingoid base, are the most important and effective structural component for the formation of the epidermal permeability barrier. While ceramides comprise approx. 50% of the epidermal lipid content by mass, the content is substantially decreased in certain inflammatory skin diseases, such as atopic dermatitis (AD), causing improper barrier function. It is widely accepted that the endocannabinoid system (ECS) can modulate a number of biol. responses in the central nerve system, prior studies revealed that activation of endocannabinoid receptor CB1, a key component of ECS, triggers the generation of ceramides that mediate neuronal cell fate. However, as the impact of ECS on the production of epidermal ceramide has not been studied, we here investigated whether the ECS stimulates the generation of epidermal ceramides in an IL-4-treated in vitro model of skin inflammation using N-palmitoyl serinol (PS), an analog of the endocannabinoid N-palmitoyl ethanolamine. Accordingly, an IL-4-mediated decrease in cellular ceramide levels was significantly stimulated in human epidermal keratinocytes (KC) following PS treatment through both de novo ceramide synthesis- and sphingomyelin hydrolysis-pathways. Importantly, PS selectively increases ceramides with long-chain fatty acids (FAs) (C22-C24), which mainly account for the formation of the epidermal barrier, through activation of ceramide synthase (CerS) 2 and Cer3 in IL-4-mediated inflamed KC. Furthermore, blockade of cannabinoid receptor CB1 activation by AM-251 failed to stimulate the production of total ceramide as well as long-chain ceramides in response to PS. These studies demonstrate that an analog of endocannabinoid, PS, stimulates the generation of specific ceramide species as well as the total amount of ceramides via the endocannabinoid receptor CB1-dependent mechanism, thereby resulting in the enhancement of epidermal permeability barrier function. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Related Products of 534-03-2

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《Screening of a Planococcus bacterium producing a cold-adapted protease and its application in low-salt fish sauce fermentation》 was written by Gao, Ruichang; Zhou, Jing; Leng, Weijun; Shi, Tong; Jin, Wengang; Yuan, Li. Application In Synthesis of 4-Aminobutan-1-ol And the article was included in Journal of Food Processing and Preservation in 2020. The article conveys some information:

A strain of bacteria isolated from a traditional fermented shrimp paste showed high protease activity at low-temperature (15°C). The strain was identified as Planococcus maritimus and named Planococcus maritimus XJ2. P. maritimus XJ2 grows well in a low-temperature, low-salt, and alk. environment. The protease produced by P. maritimus XJ2 exhibited the highest enzyme activity at 40°C, pH 9.0 and showed salt tolerance. The amino acid nitrogen content of low-salt fish sauce inoculated with P. maritimus XJ2 was 1.28 ± 0.04 g/100 mL, which was significantly higher than that of the control without P. maritimus XJ2 (0.89 ± 0.02 g/100 mL, p < .01). The amounts of key desirable volatiles, such as alcs., ketones, acids, esters, and pyrazine were higher in P. maritimus XJ2 than in the control (p < .05). P. maritimus XJ2 could be used as a starter culture for low-salt fish sauce incubated at 21°C. Practical applications : The bacteria identified in this study has a good capacity to ferment the fish for good quality of fish sauce. A new method for the rapid fermentation of low-salt fish sauce and the improvement of its flavor by using Planococcus maritimus XJ2 is established. The procedure can help people to produce fish sauce in a shorter time, which will promote the development of fish sauce industry. Therefore, the starter and the method have good practical application in fish sauce produce. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

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《Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF》 was published in Bioorganic & Medicinal Chemistry in 2020. These research results belong to Abdel-Maksoud, Mohammed S.; Ali, Eslam M. H.; Ammar, Usama M.; Mersal, Karim I.; Yoo, Kyung Ho; Oh, Chang-Hyun. Reference of 3-Aminopropan-1-ol The article mentions the following:

Several pyrrolo[2,3-b]pyridine-based B-RAF inhibitors are well known and some of them are currently FDA approved as anticancer agents. Based on the structure of these FDA approved V600EB-RAF inhibitors, two series of pyrrolo[2,3-b]pyridine scaffold were designed and synthesized in attempt to develop new potent V600EB-RAF inhibitors. The 38 synthesized compounds were biol. evaluated for their V600EB-RAF inhibitory effect at single dose (10 μM). Compounds with high percent inhibition were tested to determine their IC50 over V600EB-RAF. Compounds 34e and 35 showed the highest inhibitory effect with IC50 values of 0.085 μM and 0.080 μM, resp. Headed for excessive biol. evaluation, the synthesized derivatives were tested over sixty diverse human cancer cell lines. Only compound 35(I) emerged as a potent cytotoxic agent against different panel of human cancer cell lines. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 3-Aminopropan-1-ol

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