Tag: 0-100

《Nonviral polymeric nanoparticles for gene therapy in pediatric CNS malignancies》 was published in Nanomedicine (New York, NY, United States) in 2020. These research results belong to Choi, John; Rui, Yuan; Kim, Jayoung; Gorelick, Noah; Wilson, David R.; Kozielski, Kristen; Mangraviti, Antonella; Sankey, Eric; Brem, Henry; Tyler, Betty; Green, Jordan J.; Jackson, Eric M.. Recommanded Product: 13325-10-5 The article mentions the following:

Together, medulloblastoma (MB) and atypical teratoid/rhabdoid tumors (AT/RT) represent two of the most prevalent pediatric brain malignancies. Current treatment involves radiation, which has high risks of developmental sequelae for patients under the age of three. New safer and more effective treatment modalities are needed. Cancer gene therapy is a promising alternative, but there are challenges with using viruses in pediatric patients. We developed a library of poly(beta-amino ester) (PBAE) nanoparticles and evaluated their efficacy for plasmid delivery of a suicide gene therapy to pediatric brain cancer models-specifically herpes simplex virus type I thymidine kinase (HSVtk), which results in controlled apoptosis of transfected cells. In vivo, PBAE-HSVtk treated groups had a greater median overall survival in mice implanted with AT/RT (P = 0.0083 vs. control) and MB (P < 0.0001 vs. control). Our data provide proof of principle for using biodegradable PBAE nanoparticles as a safe and effective nanomedicine for treating pediatric CNS malignancies. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 13325-10-5

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Obst, Jon K.; Wang, Jun; Jian, Kunzhong; Williams, David E.; Tien, Amy H.; Mawji, Nasrin; Tam, Teresa; Yang, Yu Chi; Andersen, Raymond J.; Chi, Kim N.; Montgomery, Bruce; Sadar, Marianne D. published their research in ACS Pharmacology & Translational Science on December 13 ,2019. The article was titled 《Revealing Metabolic Liabilities of Ralaniten To Enhance Novel Androgen Receptor Targeted Therapies》.Name: (R)-Oxiran-2-ylmethanol The article contains the following contents:

Inhibition of the androgen receptor (AR) is the mainstay treatment for advanced prostate cancer. Ralaniten (formally EPI-002) prevents AR transcriptional activity by binding to its N-terminal domain (NTD) which is essential for transcriptional activity. Ralaniten acetate (EPI-506) the triacetate pro-drug of ralaniten, remains the only AR-NTD inhibitor to have entered clin. trials (NCT02606123). While well tolerated, the trial was ultimately terminated due to poor pharmacokinetic properties and resulting pill burden. Here we discovered that ralaniten was glucuronidated which resulted in decreased potency. Long-term treatment of prostate cancer cells with ralaniten results in upregulation of UGT2B enzymes with concomitant loss of potency. This has proven to be a useful model with which to facilitate the development of more potent second-generation AR-NTD inhibitors. Glucuronidated metabolites of ralaniten were also detected in the serum of patients in Phase 1 clin. trials. Therefore, we tested an analog of ralaniten (EPI-045) which was resistant to glucuronidation and demonstrated superiority to ralaniten in our resistant model. These data support that analogs of ralaniten designed to mitigate glucuronidation may optimize clin. responses to AR-NTD inhibitors. In addition to this study using (R)-Oxiran-2-ylmethanol, there are many other studies that have used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Name: (R)-Oxiran-2-ylmethanol) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Name: (R)-Oxiran-2-ylmethanol

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《Mild and Chemoselective Thioacylation of Amines Enabled by the Nucleophilic Activation of Elemental Sulfur》 was written by Saito, Masato; Murakami, Sho; Nanjo, Takeshi; Kobayashi, Yusuke; Takemoto, Yoshiji. Reference of 4-Aminobutan-1-ol And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

A mild and chemoselective method for the thioacylation of amines using α-keto acids and elemental sulfur has been developed. The key to the success of this transformation is the nucleophilic activation of elemental sulfur by thiols such as 1-dodecanethiol. A variety of functional groups, including unprotected hydroxyl, carboxyl, amide, sulfide, and tertiary amine moieties, are tolerated under the applied reaction conditions. To demonstrate the advantages of this method compared with conventional O-S exchange reactions using Lawesson’s reagent or P2S5, thioamide moieties were introduced site-specifically into biol. active compounds After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol

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《Antimicrobial Hyperbranched Polymer-Usnic Acid Complexes through a Combined ROP-RAFT Strategy》 was published in Macromolecular Rapid Communications in 2020. These research results belong to Rauschenbach, Moritz; Lawrenson, Stefan B.; Taresco, Vincenzo; Pearce, Amanda K.; O′Reilly, Rachel K.. Computed Properties of C3H9NO2 The article mentions the following:

Polymer-drug conjugates have received considerable attention over the last decades due to their potential for improving the clin. outcomes for a range of diseases. It is of importance to develop methods for their preparation that have simple synthesis and purification requirements but maintain high therapeutic efficacy and utilize macromols. that can be cleared via natural excretory pathways upon breakdown. Herein, the combination of ring-opening polymerization (ROP) and reversible addition-fragmentation chain-transfer (RAFT) polymerization is described for the straightforward synthesis of amphiphilic, stimuli-responsive, biodegradable, and highly functionalizable hyperbranched polymers. These unimol. nanoparticles demonstrate a versatile platform for the synthesis of polymer-drug conjugates owing to the inclusion of a Boc-protected polycarbonate moiety in either a block or random copolymer formation. A proof-of-concept study on the complexation of the poorly water-soluble antimicrobial drug usnic acid results in polymer-drug complexes with powerful antimicrobial properties against gram-pos. bacteria. Therefore, this work highlights the potential of amphiphilic and biodegradable hyperbranched polymers for antimicrobial applications. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Computed Properties of C3H9NO2

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The author of 《Fast and stable optical pH sensor materials for oceanographic applications》 were Staudinger, Christoph; Strobl, Martin; Breininger, Johanna; Klimant, Ingo; Borisov, Sergey M.. And the article was published in Sensors and Actuators, B: Chemical in 2019. Safety of 2-Aminopropane-1,3-diol The author mentioned the following in the article:

The study reports preparation and detailed comparison of four new pH sensor materials for seawater measurements. The composition of the sensors is optimized in several iterations to ensure optimal dynamic range, fast response time at low temperatures, low cross-sensitivities to temperature (dpKa/dT ∼ -0.013 pH units/K) and negligible cross sensitivity to ionic strength above salinity 15 PSU. The first generation (material “”pH-1′′) utilizes a pH indicator which is phys. entrapped into a polyurethane hydrogel. This material shows satisfactory performance only at comparably high temperatures with response times being extremely long at low temperatures (t95 > 2 h at 5 °C). The three other materials utilize cross-linked hydrophilic polymers based on poly(acryloylmorpholine) with indicator dye covalently coupled to the polymer. Moreover, the last two generations (“”pH-3′′ and “”pH-4′′) showed no drift over 54 days at 10 °C and only a drift of 0.003 pH units/day at 25 °C. The material of the fourth generation “”pH-4′′ explores a novel approach of covalent coupling via B-O linkage and is characterized by low synthetic effort and the pKa value optimal for seawater measurements (8.05 at 20 °C). Importantly, all new sensor materials are spectrally compatible to a recently presented seawater optode system for combined pH, pO2 and pCO2 measurements which facilitates their application in marine environment. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 2-Aminopropane-1,3-diol

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The author of 《Color, texture and enzyme activities of Hypsizygus marmoreus as affected by heating combined with color protection and hardening》 were Zhang, Su-min; Bai, Jin-hao; Chang, Ming-chang; Meng, Jun-long; Liu, Jing-yu; Feng, Cui-ping. And the article was published in International Journal of Food Properties in 2019. Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

Different pretreatments can affect the quality of Hypsizygus marmoreus (HM). In this study, the effects of thermal treatment or combined with color protection and hardening on color, texture, microstructure, polyphenol oxidase (PPO) and Peroxidase (POD) C-1: Explain the first time activities, and the volatile components of HM were investigated. The results showed compared with the control group, both heating group (H group) and color protection, hardening and heating (CHH group) significantly enhanced the color difference, and reduced all texture parameters as well as PPO and POD activities. Addnl., in two treatment groups, the structure of HM became loose, the amounts of alcs., ketones, and aldehydes were changed significantly. Compared with the H group, the color difference and PPO activities in CHH group were significantly decreased, while all texture parameters were increased significantly, the fibers of HM showed regular arrangement. In conclusion, the combination of CHH performed better effects on hardness, chewiness, microstructure, and enzymes activities related to enzymic browning. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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In 2019,European Journal of Organic Chemistry included an article by Yokoyama, Soichi; Shibauchi, Hiroshi; Asahara, Haruyasu; Nishiwaki, Nagatoshi. SDS of cas: 13325-10-5. The article was titled 《Metal-Free O-Selective Direct Acylation of Amino Alcohols Through Pseudo-Intramolecular Process》. The information in the text is summarized as follows:

Efficient α-aryl-β-keto ester acylation of amine accompanied by the elimination of Et phenylacetate was achieved owing to the pseudo-intramol. process. The eliminated Et phenylacetate could be recycled by conversion into an α-aryl-β-keto ester upon treatment with an acyl chloride in the presence of lithium bis(trimethylsilyl)amide, by which the atom economy considerably increased. Acylation using an α-aryl-β-keto ester is highly sensitive to the bulkiness of the nucleophile, which facilitated the regioselective-acylation of the less hindered amino group in diamine without protecting the other. The transacylation of α-aryl-β-keto ester with N-alkylamino alc. resulted in chemoselective O-acylation without protecting the amino group because the hydroxy group was attracted to the reaction site of the keto ester by forming an ammonium salt. Transacylation is a practically useful tool for organic synthesis because this protocol can be conducted under mild conditions with simple manipulations in the absence of any additives such as metal catalyst and base. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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In 2022,Corpas, Javier; Gomez-Mendoza, Miguel; Ramirez-Cardenas, Jonathan; de la Pena O’Shea, Victor A.; Mauleon, Pablo; Gomez Arrayas, Ramon; Carretero, Juan C. published an article in Journal of the American Chemical Society. The title of the article was 《One-Metal/Two-Ligand for Dual Activation Tandem Catalysis: Photoinduced Cu-Catalyzed Anti-hydroboration of Alkynes》.Related Products of 7748-36-9 The author mentioned the following in the article:

A dual catalyst system based on ligand exchange of two diphosphine ligands possessing different properties in a copper complex has been devised to merge metal- and photocatalytic activation modes. This strategy has been applied to the formal anti-hydroboration of activated internal alkynes via a tandem sequence in which Cu/Xantphos catalyzes the B2pin2-syn-hydroboration of the alkyne whereas Cu/BINAP serves as a photocatalyst for visible light-mediated isomerization of the resulting alkenyl boronic ester. Photochem. studies by means of UV-vis absorption, steady-state and time-resolved fluorescence, and transient absorption spectroscopy have allowed characterizing the photoactive Cu/BINAP species in the isomerization reaction and its interaction with the intermediate syn-alkenyl boronic ester through energy transfer from the triplet excited state of the copper catalyst. In addition, mechanistic studies shed light into catalyst speciation and the interplay between the two catalytic cycles as critical success factors. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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In 2022,Xu, Haiting; Luo, Ruifeng; Dong, Lingling; Pu, Xiulan; Chen, Qiyan; Ye, Naijing; Qi, Shanshan; Han, Xiaoqin; Nie, Wenbiao; Fu, Chaomei; Hu, Yichen; Zhang, Jinming; Gao, Fei published an article in Nanomedicine (New York, NY, United States). The title of the article was 《pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis》.Formula: C4H11NO The author mentioned the following in the article:

An oral nanoparticle (NPs) encapsulated in chitosan/alginate hydrogel (CA-Gel) with dual-sensitive in pH and reactive oxygen species (ROS) was developed to load curcumin (CUR) based on the intracellular-specific characteristics of macrophages. Chondroitin sulfate (CS) wrapped PBAE-SA-PAPE with intracellular pH/ROS dual-sensitive characteristics and CUR via a simple nanopptn. method to form NPs (CS-CUR-NPs), and mixed CA-Gel to acquire the final preparation (CS-CUR-NPs-Gel). CS-CUR-NPs displayed an ideal average particle size (179.19 ± 5.61 nm) and high encapsulating efficiency (94.74 ± 1.15%). CS showed a good targeting ability on macrophages and the CA-Gel contribution in protecting NPs from being destroyed in the upper gastrointestinal tract. As expected, CS-CUR-NPs-Gel could significantly alleviate inflammation in DSS-induced UC mice via TLR4-MAPK/NF-ΚB pathway. This study is the first to attempt to design a novel pH/ROS dual-stimulated release strategy in helping intracellular CUR delivery and anticipated for efficient anti-UC therapy. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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Verevkin, Sergey P.; Andreeva, Irina V.; Konnova, Maria E.; Portnova, Svetlana V.; Zherikova, Kseniya V.; Pimerzin, Aleksey A. published their research in Journal of Chemical Thermodynamics in 2021. The article was titled 《Paving the way to the sustainable hydrogen storage: Thermochemistry of amino-alcohols as precursors for liquid organic hydrogen carriers》.Recommanded Product: 4-Aminobutan-1-ol The article contains the following contents:

The absolute vapor pressures of four amino-alcs. were measured using the transpiration method. A consistent set of standard molar enthalpies of vaporization for eighteen amino-alcs. was evaluated using empirical and structure-property correlations. The averaged values of vaporization enthalpies are recommended as reliable benchmark properties for thermochem. calculations of the energetics of chem. reactions including synthesis of alkyl-substituted pyrazines, compounds considered as seminal liquid organic hydrogen carriers (LOHC). In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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