Tag: 0-100

In 2022,Liu, Xiaoyang; Bourret, Emmanuel; Noble, Cora A.; Cover, Kevin; Koenig, Ryan M.; Huang, Rong; Franklin, Hannah M.; Feng, Xu; Bodnar, Robert J.; Zhang, Fan; Tao, Chenggang; Sublett, D. Matthew Jr.; Dorn, Harry C.; Stevenson, Steven published an article in Journal of the American Chemical Society. The title of the article was 《Gigantic C120 Fullertubes: Prediction and Experimental Evidence for Isomerically Purified Metallic [5,5] C120-D5d(1) and Nonmetallic [10,0] C120-D5h(10766)》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

We report the first exptl. characterization of isomerically pure and pristine C120 fullertubes, [5,5] C120-D5d(1) and [10,0] C120-D5h(10766). These new mols. represent the highest aspect ratio fullertubes isolated to date; for example, the prior largest empty cage fullertube was [5,5] C100-D5d(1). This increase of 20 carbon atoms represents a gigantic leap in comparison to three decades of C60-C90 fullerene research. Moreover, the [10,0] C120-D5d(10766) fullertube has an end-cap derived from C80-Ih and is a new fullertube whose C40 end-cap has not yet been isolated exptl. Theor. and exptl. analyses of anisotropic polarizability and UV-vis assign C120 isomer I as a [5,5] C120-D5d(1) fullertube. C120 isomer II matches a [10,0] C120-D5h(10766) fullertube. These structural assignments are further supported by Raman data showing metallic character for [5,5] C120-D5d(1) and nonmetallic character for C120-D5h(10766). STM imaging reveals a tubular structure with an aspect ratio consistent with a [5,5] C120-D5d(1) fullertube. With microgram quantities not amenable to crystallog., we demonstrate that DFT anisotropic polarizability, augmented by long-accepted exptl. analyses (HPLC retention time, UV-vis, Raman, and STM) can be synergistically used (with DFT) to down select, predict, and assign C120 fullertube candidate structures. From 10 774 math. possible IPR C120 structures, this anisotropic polarizability paradigm is quite favorable to distinguish tubular structures from carbon soot. Identification of isomers I and II was surprisingly facile, i.e., two purified isomers for two possible structures of widely distinguishing features. These metallic and nonmetallic C120 fullertube isomers open the door to both fundamental research and application development.3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Category: alcohols-buliding-blocks

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Xiong, Jinfeng; Tan, Songwei; Yu, Long; Shen, Hui; Qu, Shen; Zhang, Chong; Ren, Ci; Zhu, Da; Wang, Hui published an article in 2021. The article was titled 《E7-Targeted Nanotherapeutics for Key HPV Afflicted Cervical Lesions by Employing CRISPR/Cas9 and Poly (Beta-Amino Ester)》, and you may find the article in International Journal of Nanomedicine.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Persistent HR-HPV (high-risk human papillomavirus) infection is the main cause of cervical cancer. The HPV oncogene E7 plays a key role in HPV tumorigenesis. At present, HPV preventive vaccines are not effective for patients who already have a cervical disease, and implementation of the recommended regular cervical screening is difficult in countries and regions lacking medical resources. Therefore, patients need medications to treat existing HPV infections and thus block the progression of cervical disease. In this study, we developed nanoparticles (NPs) composed of the non-viral vector PBAE546 and a CRISPR/Cas9 recombinant plasmid targeting HPV16 E7 as a vaginal treatment for HPV infection and related cervical malignancies. Our NPs showed low toxicity and high biol. safety both in vitro (cell line viability) and in vivo (various important organs of mice). Our NPs significantly inhibited the growth of xenograft tumors derived from cervical cancer cell lines in nude mice and significantly reversed the cervical epithelial malignant phenotype of HPV16 transgenic mice. Our NPs have great potential to be developed as a drug for the treatment of HPV-related cervical cancer and precancerous lesions. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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《The synthesis of trifluoromethylated N-nitroaryl-2-amino-1,3-dichloropropane derivatives and their evaluation as potential anti-cancer agents》 was written by Chappel, Lucy; Wong, Lai Chun; Leong, Chee-Onn; Mai, Chun-Wai; Meikle, Ian T.; Stanforth, Stephen P.; Truong, Thang V.. Product Details of 534-03-2This research focused ontrifluoromethylated nitroarylaminodichloropropane derivative preparation antitumor agent; Anti-cancer agents; Nitroaromatic drugs; Nitrogen mustards; Trifluoromethylated drugs. The article conveys some information:

Six N-nitroaryl-2-amino-1,3-dichloropropane derivatives were prepared and evaluated against 18 cancer cell lines and two non-cancerous cell lines. Anal. of cell viability data and IC50 values indicated that the presence of a trifluoromethyl group in the nitroaryl moiety is an important structural feature associated with the compounds’ cytotoxicities. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 534-03-2

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Safety of 2-Aminopropane-1,3-diolIn 2019 ,《Supramolecular Gels Derived from Simple Organic Salts of Flufenamic Acid: Design, Synthesis, Structures, and Plausible Biomedical Application》 was published in ACS Biomaterials Science & Engineering. The article was written by Parveen, Rumana; Jayamma, Bandi; Dastidar, Parthasarathi. The article contains the following contents:

Following supramol. synthon rationale in the context of crystal engineering, a non-steroidal-anti-inflammatory-drug (NSAID) namely Flufenamic acid (FA) and its β-alanine monopeptide derivative (FM) were converted to a series of primary ammonium monocarboxylate (PAM) salts. Majority of the PAM salts (∼90 %) showed gelation with various solvents including water and Me salicylate (important solvents in topical gel formulation). Structure-property correlation studies based on single crystal X-ray diffraction (SXRD) and powder X-ray diffraction (PXRD) data provided intriguing insights into the structure of the gel network. Furthermore, one of the gelator salts (S7) displayed anti-cancer activity on a highly aggressive human breast cancer cell line (MDA-MB-231) as revealed by MTT, PEG2 and cell migration assays. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Safety of 2-Aminopropane-1,3-diol

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《Design and validation of linkers for site-specific preparation of antibody-drug conjugates carrying multiple drug copies per cysteine conjugation site》 was published in International Journal of Molecular Sciences in 2020. These research results belong to Kumar, Amit; Mao, Shenlan; Dimasi, Nazzareno; Gao, Changshou. Quality Control of 2-Aminopropane-1,3-diol The article mentions the following:

First-generation cysteine-based site-specific antibody-drug conjugates (ADCs) are limited to one drug per cysteine. However, certain applications require a high drug to antibody ratio (DAR), such as when low-potency payloads are used. Higher drug load can be achieved using classical cysteine conjugation methods, but these result in heterogeneity, suboptimal efficacy and pharmacokinetics. Here, we describe the design, synthesis and validation of heterobifunctional linkers that can be used for the preparation of ADCs with a DAR of two, three and four in a site-specific manner per single cysteine conjugation site, resulting in site-specific ADCs with a DAR of four, six and eight. The designed linkers carry a sulfhydryl-specific iodoacetyl reactive group, and multiple cyclic diene moieties which can efficiently react with maleimide-carrying payloads through the Diels-Alder reaction. As a proof of concept, we synthesized site-specific DAR four, six and eight ADCs carrying tubulysin (AZ13601508) using engineered antibodies with a cysteine inserted after position 239 in the antibody CH2 domain. We evaluated and compared the in vitro cytotoxicity of ADCs obtained via the site-specific platform described herein, with ADCs prepared using classical cysteine conjugation. Our data validated a novel cysteine-based conjugation platform for the preparation of site-specific ADCs with high drug load for therapeutic applications. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Quality Control of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Quality Control of 2-Aminopropane-1,3-diol

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《Is basicity the sole criterion for attaining high carbon dioxide capture in deep-eutectic solvents?》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Shukla, Shashi Kant; Nikjoo, Dariush; Mikkola, Jyri-Pekka. HPLC of Formula: 156-87-6 The article mentions the following:

A critical anal. of the role of Hammett basicity (H-) and aqueous basicity (pKa) in CO2 uptake in deep-eutectic solvents (DESs) suggests that neither H- nor pKa correlates with the CO2 weight/% capacity in the studied DESs. Instead, strong “”synergistic interactions”” between donor and acceptor moieties satisfactorily relate to the weight/% of CO2 in DESs.3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.HPLC of Formula: 156-87-6

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《Influence of the N atom and its position on electron photodetachment of deprotonated indole and azaindole》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Noble, Jennifer A.; Marceca, Ernesto; Dedonder, Claude; Jouvet, Christophe. SDS of cas: 7748-36-9 The article mentions the following:

Electron photodetachment of cold deprotonated indole and azaindole anions has been studied by use of a mass-selective photofragmentation spectrometer capable of neg. ion and neutral particle detection. The electron affinities of the indolyl radical and the 5-, 6- and 7-azaindolyl radicals have been measured with an uncertainty of less than 0.002 eV. The presence of the nitrogen atom in the six-membered ring of the azaindolide anions stabilizes the electron by 0.3 to 0.4 eV, i.e. about 10-15%, compared to the indolide anion. No fragmentation was observed in either the anionic or radical forms of the species studied. The appearance of dipole-bound states in the spectra of deprotonated 6- and 7-azaindole anions allowed us to analyze the vibrational structure of the neutral 6- and 7-azaindolyl radicals produced following photodetachment. Although no dipole-bound states were clearly identified for deprotonated indole or 5-azaindole, the shape of the photodetachment threshold suggests the presence of a very weakly dipole-bound state or dipole resonance, which cannot be resolved with our laser resolutionOxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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《Influence of the N atom position on the excited state photodynamics of protonated azaindole》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Noble, Jennifer A.; Marceca, Ernesto; Dedonder, Claude; Phasayavan, Witchaya; Feraud, Geraldine; Inceesungvorn, Burapat; Jouvet, Christophe. COA of Formula: C3H6O2 The article mentions the following:

We present a study of the photofragmentation of three protonated azaindole mols. – 7-azaindole, 6-azaindole, and 5-azaindole – consisting of fused pyrrole-pyridine bicyclic aromatic systems, in which the pyridinic (protonated) nitrogen heteroatom is located at the 7, 6, and 5 positions, resp. Photofragmentation electronic spectra of the isolated aforementioned azaindolinium cations reveal that their photodynamics extends over timescales covering nine orders of magnitude and provide evidence about the resultant fragmentation pathways. Moreover, we show how the position of the heteroatom in the aromatic skeleton influences the excited state energetics, fragmentation pathways, and fragmentation timescales. Computed ab initio adiabatic transition energies are used to assist the assignation of the spectra, while geometry optimization in the excited electronic states as well as ab initio calculations along the potential surfaces demonstrate the role of ππ*/πσ* coupling and/or large geometry changes in the dynamics of these species. Evidence supporting the formation of Dewar valence isomers as intermediates involved in sub-picosecond relaxation processes is discussed. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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The author of 《Skeletal Diversity in Catalytic Synthesis of (1,3-Oxazacycloalk-3-ylmethyl)-Substituted Pyrroles》 were Akhmetova, V. R.; Bikbulatova, E. M.; Kunakova, R. V.; Ameta, K. L.; Ibragimov, A. G.. And the article was published in Russian Journal of General Chemistry in 2019. Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

A series of bi- and trinuclear pyrrole derivatives was prepared by the 5 mol% ZrOCl2·8H2O-catalyzed CH-sp2-aminomethylation reaction of pyrrole with bis(1,3-oxazacycloalk-3-yl)methanes. The reaction proceeds at the positions 2,5 or 2 of pyrrole depending on the amount of aminomethylating reagents obtained from formaldehyde and α,ω-amino alcs. (2-aminoethan-1-ol, 3-aminopropan-1-ol, 4-aminobutan-1-ol). The aminomethylation reaction of indole with bis(1,3-oxazolidin-3-yl)methane proceeds at the position 3. In the case of carbazole, N-aminomethylation proceeds under these conditions at the N9 atom.4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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Fallica, Antonino Nicolo; Barbaraci, Carla; Amata, Emanuele; Pasquinucci, Lorella; Turnaturi, Rita; Dichiara, Maria; Intagliata, Sebastiano; Gariboldi, Marzia Bruna; Marras, Emanuela; Orlandi, Viviana Teresa; Ferroni, Claudia; Martini, Cecilia; Rescifina, Antonio; Gentile, Davide; Varchi, Greta; Marrazzo, Agostino published an article in 2021. The article was titled 《Nitric Oxide Photo-Donor Hybrids of Ciprofloxacin and Norfloxacin: A Shift in Activity from Antimicrobial to Anticancer Agents》, and you may find the article in Journal of Medicinal Chemistry.Safety of 3-Aminopropan-1-ol The information in the text is summarized as follows:

The potential anticancer effect of fluoroquinolone antibiotics has been recently unveiled and related to their ability to interfere with DNA topoisomerase II. We herein envisioned the design and synthesis of novel Ciprofloxacin and Norfloxacin nitric oxide (NO) photo-donor hybrids to explore the potential synergistic antitumor effect exerted by the fluoroquinolone scaffold and NO eventually produced upon light irradiation Anticancer activity, evaluated on a panel of tumor cell lines, showed encouraging results with IC50 values in the low micromolar range. Some compounds displayed intense antiproliferative activity on triple-neg. and doxorubicin-resistant breast cancer cell lines, paving the way for their potential use to treat aggressive, refractory and multidrug-resistant breast cancer. No significant additive effect was observed on PC3 and DU145 cells following NO release. Conversely, antimicrobial photodynamic experiments on both Gram-neg. and Gram-pos. microorganisms displayed a significant killing rate in Staphylococcus aureus, accounting for their potential effectiveness as selective antimicrobial photosensitizers. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Safety of 3-Aminopropan-1-ol

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