Tag: 0-100

The author of 《Functionalized Anion-Exchange Membranes Facilitate Electrodialysis of Citrate and Phosphate from Model Dairy Wastewater》 were Paltrinieri, Laura; Huerta, Elisa; Puts, Theo; van Baak, Willem; Verver, Albert B.; Sudhoelter, Ernst J. R.; de Smet, Louis C. P. M.. And the article was published in Environmental Science & Technology in 2019. Safety of 3-Aminopropan-1-ol The author mentioned the following in the article:

Here, the preparation of a new, functional anion-exchange membrane (AEM), containing guanidinium groups as the anion-exchanging sites (Gu-100), is described as well as the membrane characterization by XPS, water uptake, permselectivities, and elec. resistances. The functional membrane was also used in pH-dependent electrodialysis experiments using model dairy wastewater streams. The properties of the new membrane are compared to those of a com. available anion-exchange membrane bearing conventional quaternary ammonium groups (Gu-0). Guanidinium was chosen for its specific binding properties toward oxyanions: e.g., phosphate. This functional moiety was covalently coupled to an acrylate monomer via a facile two-step synthesis to yield bulk-modified membranes upon polymerization Significant differences were observed in the electrodialysis experiments for Gu-0 and Gu-100 at pH 7, showing an enhanced phosphate and citrate transport for Gu-100 in comparison to Gu-0. At pH 10 the difference is much more pronounced: for Gu-0 membranes almost no phosphate and citrate transport could be detected, while the Gu-100 membranes transported both ions significantly. We conclude that having guanidinium groups as anion-exchange sites improves the selectivity of AEMs. As the presented monomer synthesis strategy is modular, we consider the implementation of functional groups into a polymer-based membrane via the synthesis of tailor-made monomers as an important step toward selective ion transport, which is relevant for various fields, including water treatment processes and fuel cells.3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Safety of 3-Aminopropan-1-ol

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Related Products of 156-87-6In 2021 ,《Reactive extraction for the recovery of primary amines from aqueous streams》 appeared in Separation and Purification Technology. The author of the article were Doeker, Moritz; Huettche, Vincent; Jupke, Andreas. The article conveys some information:

Biotechnol. transformations promise to be an ecol. and economically efficient alternative for the production of amines and amino alcs. Limitations in the use of these transformations often arise from inhibitory effects due to amine toxicity or from unfavorable reaction equilibrium One solution to overcome these limitations is the continuous recovery of the amine from the biotechnol. reaction media via a suitable in situ product removal strategy such as liquid-liquid reactive extraction In this study, we investigate liquid-liquid reactive extraction for the recovery of 3-methylbutylamine, 1-phenylethylamine and 3-amino-1-propanol from aqueous streams, using a mixture of oleic acid and 1-octanol. For all investigated amines, high extraction yields of up to 99% and back extraction yields of over 90% of the extracted amine were observed Relevant parameters such as chem. structure of the amine, the aqueous pH and the oleic acid concentration were identified. Furthermore, a mass action law was used to derive individual extraction constants for each amine allowing a math. description of the extraction behavior. This math. description provides a tool for the design of a tailor made reactive extraction system for the efficient recovery of amines while respecting given biotechnol. pH requirements. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Related Products of 156-87-6

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Application of 7748-36-9In 2021 ,《Discovery of a series of 1H-pyrrolo[2,3-b]pyridine compounds as potent TNIK inhibitors》 appeared in Bioorganic & Medicinal Chemistry Letters. The author of the article were Yang, Bowen; Wu, Qian; Huan, Xiajuan; Wang, Yingqing; Sun, Yin; Yang, Yueyue; Liu, Tongchao; Wang, Xin; Chen, Lin; Xiong, Bing; Zhao, Dongmei; Miao, Zehong; Chen, Danqi. The article conveys some information:

In an inhouse screening, 1H-pyrrolo[2,3-b]pyridine scaffold was found to have high inhibition on TNIK. Several series of compounds were designed and synthesized, among which some compounds had potent TNIK inhibition with IC50 values lower than 1 nM. Some compounds showed concentration-dependent characteristics of IL-2 inhibition. These results provided new applications of TNIK inhibitors and new prospects of TNIK as a drug target.Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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Ren, Yiqing; Liu, Xinlong; Ge, Huan; Guo, Yuanyuan; Zhang, Qiushuang; Xie, Miao; Wang, Ping; Zhu, Xinyuan; Zhang, Chuan published an article in 2021. The article was titled 《A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery》, and you may find the article in Chemical Research in Chinese Universities.COA of Formula: C3H9NO The information in the text is summarized as follows:

Acombinatorial strategy based on nucleic acid assembly and electrostatic complexation is developed for efficient small interfering RNA(siRNA) delivery. In this approach, siRNAs are first loaded into a well-defined nanotube through programmable nucleic acid self-assembly. Compared to small rigid siRNA duplex, the obtained siRNA-bearing nanotube with large architecture is more readily to complex with cationic and ionizable poly(β-amino ester), resulting in the formation of a novel platform for efficient siRNA delivery.3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).COA of Formula: C3H9NO

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Name: (R)-Oxiran-2-ylmethanolOn October 15, 2019 ,《Design, synthesis and antibacterial evaluation of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1,2,3-triazole side chain》 was published in European Journal of Medicinal Chemistry. The article was written by Qin, Yinhui; Teng, Yuetai; Ma, Ruixin; Bi, Fangchao; Liu, Zhiyang; Zhang, Panpan; Ma, Shutao. The article contains the following contents:

Macrolides are widely prescribed in clinic to treat various respiratory tract infections. However, due to their inappropriate use, the prevalence of macrolide-resistant strains among clin. isolates has become a concern for public health. Therefore, novel macrolides skeleton structures against resistant pathogens are badly needed. Thus, three series of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1,2,3-triazole side chain were designed and synthesized through creatively opening the ring of clarithromycin (CAM), expanding the ring properly, and introducing a suitable side chain of 1,2,3-triazole at the C12 and C13 positions; they were then evaluated for their antibacterial activity. The antibacterial results indicated that compounds I (R = Q, Q1, Q2) (II) possessed strong antibacterial activity against Staphylococcus aureus ATCC25923 (0.25 μg/mL) and Bacillus subtilis ATCC9372 (0.25 μg/mL). Furthermore, compounds I (R = Q3) (III) and I (R = Q4) (IV) were found to exhibit promising potent activity (8 μg/mL) against Streptococcus pneumonia AB11 expressing the ermB and mefA genes. In addition, the determination of min. bactericidal concentration (MBC) indicated that the most promising compounds II-IV were excellent bacteriostatic agents. The bactericidal curve showed that III exhibited antibacterial activity through bacteriostatic mechanism. Finally, II were confirmed to be non-toxic to MCF-7 breast cancer cells up to a concentration of 32 μg/mL in preliminary cytotoxicity assay. In summary, II-IV can serve as lead compounds to provide a new perspective for further structural optimization. In the part of experimental materials, we found many familiar compounds, such as (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Name: (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Name: (R)-Oxiran-2-ylmethanol

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《1,3,5-Triazine-Cored Maltoside Amphiphiles for Membrane Protein Extraction and Stabilization》 was written by Ghani, Lubna; Munk, Chastine F.; Zhang, Xiang; Katsube, Satoshi; Du, Yang; Cecchetti, Cristina; Huang, Weijiao; Bae, Hyoung Eun; Saouros, Savvas; Ehsan, Muhammad; Guan, Lan; Liu, Xiangyu; Loland, Claus J.; Kobilka, Brian K.; Byrne, Bernadette; Chae, Pil Seok. Name: 2-Aminopropane-1,3-diolThis research focused ontriazine maltoside amphiphiles membrane protein extraction stabilization. The article conveys some information:

Despite their major biol. and pharmacol. significance, the structural and functional study of membrane proteins remains a significant challenge. A main issue is the isolation of these proteins in a stable and functional state from native lipid membranes. Detergents are amphiphilic compounds widely used to extract membrane proteins from the native membranes and maintain them in a stable form during downstream anal. However, due to limitations of conventional detergents, it is essential to develop novel amphiphiles with optimal properties for protein stability in order to advance membrane protein research. Here we designed and synthesized 1,3,5-triazine-cored dimaltoside amphiphiles derived from cyanuric chloride. By introducing variations in the alkyl chain linkage (ether/thioether) and an amine-functionalized diol linker (serinol/diethanolamine), we prepared two sets of 1,3,5-triazine-based detergents. When tested with several model membrane proteins, these agents showed remarkable efficacy in stabilizing three transporters and two G protein-coupled receptors. Detergent behavior substantially varied depending on the detergent structural variation, allowing us to explore detergent structure-property-efficacy relationships. The 1,3,5-triazine-based detergents introduced here have significant potential for membrane protein study as a consequence of their structural diversity and universal stabilization efficacy for several membrane proteins. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Name: 2-Aminopropane-1,3-diol

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Related Products of 7748-36-9In 2020 ,《Solubility and Dissolution Behavior Analysis of 7-Azaindole in Pure and Binary Mixture Solvents at Temperatures Ranging from 278.15 to 323.15 K》 was published in Journal of Chemical & Engineering Data. The article was written by Deng, Zhenmei; Li, Fangzhao; Zhao, Guomin; Yang, Wenge; Hu, Yonghong. The article contains the following contents:

In this paper, the solubility of 7-azaindole was measured in nine pure solvents (ethanol, isopropanol, n-propanol, methanol, EA, acetone, acetonitrile, n-hexane, THF) as well as in three binary mixed solvents (acetone + n-hexane, THF + n-hexane, and isopropanol + n-hexane) by a gravimetric method at temperatures from 278.15 to 323.15 K under atm. pressure. The solubility of 7-azaindole in selected solvents is closely related to the temperature and solvent composition: in nine pure solvents, the order of solubility of 7-zazindole is THF > acetone > methanol > isopropanol ≥ EA > ethanol > acetonitrile > n-hexane when the temperature is below 298.15 K. Nevertheless, as the temperature increases continually (298.15-328.15 K), the order of solubility changes to THF > acetone > methanol > isopropanol > n-propanol > ethanol > EA > acetonitrile > n-hexane; in three binary mixed solvents, both the temperature and solvent composition can influence the solubility of 7-azaindole, and the latter has a greater impact. The modified Apelblat model, λh model, Jouyban-Acree model, and CNIBS/R-K equation were used to correlate the exptl. value. In these models, the Apelblat equation is more suitable for correlating 7-azaindole solubility in nine pure solvents; however, for three binary mixed solvents, the solubility of 7-azaindole is closer to the simulated value of the Jouyban-Acree model. Moreover, the KAT LASER model was used to deeply understand the influence of solvents on the solubility of 7-azaindole by multiple linear regression anal. (MLRA) of the solvent parameters involved in this model. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Self-Assembled Polyurethane Capsules with Selective Antimicrobial Activity against Gram-Negative E. coli》 was published in ACS Biomaterials Science & Engineering in 2020. These research results belong to Barman, Ranajit; Mondal, Tathagata; Sarkar, Jayita; Sikder, Amrita; Ghosh, Suhrit. SDS of cas: 534-03-2 The article mentions the following:

This article reports the antimicrobial activity of two segmented amphiphilic polyurethanes, PU-1 and PU-2, containing a primary or secondary amine group, resp. In acidic water, intrachain H-bonding among the urethanes followed by hierarchical assembly resulted in the formation of capsules (Dh = 120 ± 20 and 100 ± 17 nm for PU-1 and PU-2, resp.) with a highly pos. surface charge. They showed selective interactions with bacterial cell mimicking liposomes over mammalian cell mimicking liposomes with favorable enthalpy and entropy contributions, which was attributed to the electrostatic interaction and hydrophobic effect. Antimicrobial studies with Escherichia coli revealed very low min. inhibitory concentration (MIC) values of 7.8 and 15.6μg/mL for PU-1 and PU-2, resp., indicating their ability to efficiently kill Gram-neg. bacteria. Killing of Gram-pos. Staphylococcus aureus was noticed only at C = 500μg/mL, indicating unprecedented selectivity for E. coli, which was further confirmed by SEM (SEM) studies. Hemolysis assay revealed HC50 values of 453 and 847μg/mL for PU-1 and PU-2, resp., which were >50 times higher than their resp. MIC values, thus making them attractive antimicrobial materials. Ortho-nitrophenyl-β-galactoside (ONPG) assay and live-dead fluorescence assay confirmed that for both the polymers, a membrane disruption pathway was operative for wrapping of the bacterial membrane, similar to what was proposed for antimicrobial peptides. SEM images of polymer-treated E. coli bacteria helped in visualization of the pore formation and the disrupted membrane structure. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.SDS of cas: 534-03-2

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In 2019,Beilstein Journal of Organic Chemistry included an article by Ke, Yuan-Zhen; Huang, Shou-Ling; Lai, Guoqiao; Luh, Tien-Yau. Electric Literature of C4H11NO. The article was titled 《Selective ring-opening metathesis polymerization (ROMP) of cyclobutenes. Unsymmetrical ladderphane containing polycyclobutene and polynorbornene strands》. The information in the text is summarized as follows:

At 0 °C in THF in the presence of Grubbs first generation catalyst, cyclobutene derivatives undergo ROMP readily, whereas norbornene derivatives remain intact. When the substrate contains both cyclobutene and norbornene moieties, the conditions using THF as the solvent at 0 °C offer a useful protocol for the selective ROMP of cyclobutene to give norbornene-appended polycyclobutene. Unsym. ladderphane having polycyclobutene and polynorbornene as two strands is obtained by further ROMP of the norbornene appended polycyclobutene in the presence of Grubbs first generation catalyst in DCM at ambient temperature Methanolysis of this unsym. ladderphane gives polycyclobutene Me ester and insoluble polynorbornene-amide-alc. The latter is converted into the corresponding soluble acetate. Both polymers are well characterized by spectroscopic means. No norbornene moiety is found to be incorporated into polycyclobutene strand at all. The double bonds in the polycyclobutene strand are mainly in cis configuration (ca 70%), whereas the E/Z ratio for polynorbornene strand is 8:1. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Electric Literature of C4H11NO

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Category: alcohols-buliding-blocksIn 2021 ,《Discovery of fast-acting dual-stage antimalarial agents by profiling pyridylvinylquinoline chemical space via copper catalyzed azide-alkyne cycloadditions》 appeared in European Journal of Medicinal Chemistry. The author of the article were Huang, Guang; Solano, Claribel Murillo; Melendez, Joel; Yu-Alfonzo, Sabrina; Boonhok, Rachasak; Min, Hui; Miao, Jun; Chakrabarti, Debopam; Yuan, Yu. The article conveys some information:

The identity of fast-acting, multistage antimalarial agents, a series of pyridylvinylquinoline-triazole analogs I (R = pyrrolidin-1-yl, diethylamino, 4-methylpiperazin-1-yl, 1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl, etc.) and II (R1 = piperidin-1-yl, 2-(piperazin-1-yl)ethan-1-ol, 1H-pyrazol-1-yl, (5Z)-2,4-dioxo-5-(phenylmethylidene)-1,3-thiazolidin-3-yl, etc.; n = 1, 2) have been synthesized via CuAAC. Most of the compounds display significant inhibitory effect on the drug-resistant malarial Dd2 strain at low submicromolar concentrations Among the tested analogs, compound II (R1 = piperidin-1-yl; n = 2) is the most potent mol. with an EC50 value of 0.04 ± 0.01 mM. This study indicates that compound II (R1 = piperidin-1-yl; n = 2) is a fast-acting antimalarial compound and it demonstrates stage specific action at the trophozoite phase in the P. falciparum asexual life cycle. In addition, compound II (R1 = piperidin-1-yl; n = 2) is active against both early and late stage P. falciparum gametocytes. From a mechanistic perspective, compound II (R1 = piperidin-1-yl; n = 2) shows good activity as an inhibitor of β-hematin formation. Collectively, the findings suggest that fast-acting agent II (R1 = piperidin-1-yl; n = 2) targets dual life stages of the malarial parasites and warrant further investigation of pyridylvinylquinoline hybrids as new antimalarials. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Category: alcohols-buliding-blocks

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