Tag: 0-100

Name: 3-Aminopropan-1-olIn 2019 ,《New Insights and Assessment of Primary Alkanolamine/Sulfolane Biphasic Solutions for Post-combustion CO2 Capture: Absorption, Desorption, Phase Separation, and Technological Process》 appeared in Industrial & Engineering Chemistry Research. The author of the article were Liu, Sen; Ling, Hao; Lv, Juan; Gao, Hongxia; Na, Yanqing; Liang, Zhiwu. The article conveys some information:

Surprisingly, sulfolane was determined to be a universal phase splitting solvent in a serial aqueous primary alkanolamine solution for CO2 removal, where carbamate and hydrophilic amine reaction product can be the key factor to trigger CO2 phase change; the phase change can also significantly affect CO2 absorption performance. To comprehensively understand the phase change effect on absorption, stripping, and phase separation performance of primary alkanolamine solution for CO2 capture, a monoethanolamine/sulfolane-based solution was chosen as typical biphasic system. Exptl. results showed phase change can dramatically decrease absorption rate and lead to less CO2 capacity in an absorption process. The MEA-enriched separated solution can substantially decrease energy consumption for CO2 stripping, but exorbitant MEA concentration can significantly reduce CO2 removal efficiency in a quasi absorption/desorption cycle. The MEA/sulfolane emulsion solution phase separation rate can be improved by increasing temperature; fortunately, increasing temperature had a smaller effect on the miscible solubility of MEA and sulfolane in the two separated phases. Considering the absorption rate, energy consumption, and phase separation rate, a new technol. process was proposed for CO2 capture using a primary alkanolamine/sulfolane-based solution to achieve relatively high CO2 removal efficiency and conserve energy. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: 3-Aminopropan-1-ol

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In 2022,Truong, Tan Sang; Retailleau, Pascal; Nguyen, Thanh Binh published an article in Asian Journal of Organic Chemistry. The title of the article was 《TFA/DMSO-Promoted Cross-Dehydrogenative Coupling of Hetaryl Thiols with Indoles: Access to 3-(Hetarylsulfenyl)indole under Mild Conditions》.Safety of Oxetan-3-ol The author mentioned the following in the article:

TFA/DMSO combination was found to efficiently promote the cross-dehydrogenative coupling of a wide range of hetaryl thiols with indole derivatives, leading to 3-(hetarylsulfenyl)indoles in good-to excellent yields under mild heating conditions. Two-fold hetarylsulfenylation of indoles in 2- and 3-positions could be conveniently achieved by simply adapting the molar ratio of the starting materials. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Safety of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Safety of Oxetan-3-ol

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In 2022,Hernandez-Llado, Pol; Garrec, Kilian; Schmitt, Daniel C.; Burton, Jonathan W. published an article in Advanced Synthesis & Catalysis. The title of the article was 《Transition Metal-Free, Visible Light-Mediated Radical Cyclization of Malonyl Radicals onto 5-Ring Heteroaromatics》.COA of Formula: C3H6O2 The author mentioned the following in the article:

Here a metal-free, visible light-mediated cyclization of malonates onto 5-ring heteroaromatics using iodomalonates as key intermediates was reported. The iodomalonates were prepared and photolysed in situ to give the desired annulated products, in yields of 46-94% without the need for external catalysts. The scope of this transformation includes N-alkyl, N-acyl and carbon-tethered malonates adding onto a wide range of 5-membered heteroaromatics The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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Osawa, Shigehito; Kitanishi, Kenichi; Kiuchi, Maho; Shimonaka, Motoyuki; Otsuka, Hidenori published their research in Macromolecular Rapid Communications in 2021. The article was titled 《Accelerated Redox Reaction of Hydrogen Peroxide by Employing Locally Concentrated State of Copper Catalysts on Polymer Chain》.Name: 3-Aminopropan-1-ol The article contains the following contents:

Copper complexes act as catalysts for redox reactions to generate reactive oxygen species that destroy biomols. and, therefore, are utilized to design drugs including antitumor and antibacterial medicines. Especially, catalytic reaction for hydrogen peroxide decomposition is important because it includes the process for generating highly toxic hydroxyl radical, i.e., Fenton-like reaction. Considering that multicoppers/hydrogen peroxide species are the important intermediates for the redox reaction, herein a polymer having copper complexes in the side chains is designed to facilitate the formation of the intermediates by building locally concentrated state of the copper complexes. The polymer increases their catalytic activities for hydrogen peroxide decomposition and promotes reactive oxygen species′ generation, eventually leading to higher antibacterial activity. This reveals the virtue of building a locally concentrated state of catalysts on polymers toward drug design with low amounts of transition metals. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Name: 3-Aminopropan-1-ol

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In 2019,Polymers for Advanced Technologies included an article by Kekec, Nur Cicek; Akolpoglu, Mukrime Birgul; Bozuyuk, Ugur; Kizilel, Seda; Nugay, Nihan; Nugay, Turgut; Kennedy, Joseph P.. COA of Formula: C4H11NO. The article was titled 《Calcification resistance of polyisobutylene and polyisobutylene-based materials》. The information in the text is summarized as follows:

Calcification of implanted biomaterials is highly undesirable and limits clin. applicability. Experiments were carried out to assess the calcification resistance of polyisobutylene (PIB), PIB-based polyurethane (PIB-PU), PIB-PU reinforced with (CH3)3N+CH2CH2CH2NH2 I–modified montmorillonite (PIB-PU/nc), PIB-based polyurethane urea (PIB-PUU), PIB-PU containing S atoms (PIBS-PU), PIBS-PU reinforced with (CH3)3N+CH2CH2CH2NH2 I–modified montmorillonite (PIBS-PU/nc), and poly(isobutylene-b-styrene-b-isobutylene) (SIBS), relative to that of a clin. widely implanted polydimethylsiloxane (PDMS)-based PU, Elast-Eon (the “”control””). Samples were incubated in simulated body fluid for 28 days at 37°C, and the extent of surface calcification was analyzed by SEM (SEM), at. force microscopy (AFM), energy-dispersive X-ray spectroscopy (EDX), XPS, and Fourier-transform-IR (FT-IR) spectroscopy. Whereas the PDMS-based PU showed extensive calcification, PIB and PIB-PU containing 72.5% PIB, ie, a polyurethane whose surface is covered with PIB, were free of calcification. PIBS-PU and PIB-PUU, ie, polyurethanes that contain S or urea groups, resp., were slightly calcified. The amine-modified montmorillonite-reinforcing agent reduced the extent of calcification. SIBS was found slightly calcified. Evidently, PIB and materials fully coated with PIB are calcification resistant.4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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The author of 《Exploration of the structure-activity relationship and druggability of novel oxazolidinone-based compounds as Gram-negative antibacterial agents》 were Ding, Shi; Ji, Jing-Chao; Zhang, Ming-Juan; Yang, Yu-She; Wang, Rui; Zhu, Xing-Long; Wang, Li-Hong; Zhong, Yi; Gao, Le; Lu, Man; Liu, Ju; Chen, Ye. And the article was published in Archiv der Pharmazie (Weinheim, Germany) in 2019. Synthetic Route of C3H6O2 The author mentioned the following in the article:

To gain further knowledge of the structure-activity relationship and druggability of novel oxazolidinone-based UDP-3-O-acyl-N-acetylglucosamine deacetylase (LpxC) inhibitors as Gram-neg. antibacterial agents, compounds containing the hydrophobic tails with different lengths and terminal substitutions were synthesized and their antibacterial activities against standard and clin. isolated Gram-neg. strains were evaluated. We summarized their structure-activity relationships and found that oxazolidinone-based compounds exhibited a narrower antibacterial spectrum compared with threonine-based compounds Furthermore, we parallelly compared the metabolic stabilities of the compounds with the classic threonine scaffold and the novel oxazolidinone scaffold in liver microsomes. The results indicated that the druggability of the oxazolidinone scaffold may be inferior to the classic threonine scaffold in the design of LpxC inhibitors. After reading the article, we found that the author used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Synthetic Route of C3H6O2)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Synthetic Route of C3H6O2

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Politano, Fabrizio; Sandoval, Arturo Leon; Uranga, Jorge G.; Bujan, Elba I.; Leadbeater, Nicholas E. published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Using experimental and computational approaches to probe an unusual carbon-carbon bond cleavage observed in the synthesis of benzimidazole N-oxides》.Formula: C4H11NO The article contains the following contents:

Exptl. and computational studies was performed in order to investigate an unusual carbon-carbon bond cleavage that occurs in the preparation of certain benzimidazole N-oxides from anilines. The key factor determining the outcome of the reaction was found to be the substituents on the amine functionality of the aniline. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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Dou, Haozhen; Xu, Mi; Wang, Baoyu; Zhang, Zhen; Luo, Dan; Shi, Benbing; Wen, Guobin; Mousavi, Mahboubeh; Yu, Aiping; Bai, Zhengyu; Jiang, Zhongyi; Chen, Zhongwei published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Analogous Mixed Matrix Membranes with Self-Assembled Interface Pathways》.Product Details of 156-87-6 The article contains the following contents:

The implementation of mixed matrix membranes (MMMs) for sub-angstrom scale gas separations remains a grand challenge. Herein, a series of analogous mixed matrix membrane (AMMMs) were constructed via mol.-level hybridization by utilizing a reactive ionic liquid (RIL) as the continuous phase and graphene quantum dots (GQD) as nanofiller for sub-angstrom scale ethylene/ethane (0.416 nm/0.443 nm) separation With a small number of GQDs (3.5 wt%) embedded in GQD/RIL AMMMs, ethylene permeability soared by 3.1-fold, and ethylene/ethane selectivity simultaneously boosted by nearly 60% and reached up to 99.5, which outperformed most previously reported state-of-the-art membranes. Importantly, the interfacial pathway structure was visualized and their self-assembly mechanism was revealed, where the non-covalent interactions between RIL and GQDs induced the local arrangement of IL chains to self-assemble into plenty of compact and superfast interfacial pathways, contributing to the combination of superhigh permeability and selectivity. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Product Details of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Product Details of 156-87-6

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《Poly(ethylene glycol)-Poly(beta-amino ester)-Based Nanoparticles for Suicide Gene Therapy Enhance Brain Penetration and Extend Survival in a Preclinical Human Glioblastoma Orthotopic Xenograft Model》 was written by Kim, Jayoung; Mondal, Sujan K.; Tzeng, Stephany Y.; Rui, Yuan; Al-kharboosh, Rawan; Kozielski, Kristen K.; Bhargav, Adip G.; Garcia, Cesar A.; Quinones-Hinojosa, Alfredo; Green, Jordan J.. Related Products of 13325-10-5 And the article was included in ACS Biomaterials Science & Engineering in 2020. The article conveys some information:

Glioblastoma (GBM) is the most devastating brain cancer, and cures remain elusive with currently available neurosurgical, pharmacol., and radiation approaches. While retrovirus- and adenovirus-mediated suicide gene therapy using DNA encoding herpes simplex virus-thymidine kinase (HSV-tk) and prodrug ganciclovir has been suggested as a promising strategy, a nonviral approach for treatment in an orthotopic human primary brain tumor model has not previously been demonstrated. Delivery challenges include nanoparticle penetration through brain tumors, efficient cancer cell uptake, endosomal escape to the cytosol, and biodegradability. To meet these challenges, we synthesized poly(ethylene glycol)-modified poly(beta-amino ester) (PEG-PBAE) polymers to improve extracellular delivery and coencapsulated plasmid DNA with end-modified poly(beta-amino ester) (ePBAE) polymers to improve intracellular delivery as well. We created and evaluated a library of PEG-PBAE/ePBAE nanoparticles (NPs) for effective gene therapy against two independent primary human stem-like brain tumor initiating cells, a putative target to prevent GBM recurrence. The optimally engineered PEG-PBAE/ePBAE NP formulation demonstrated 54 and 82% transfection efficacies in GBM1A and BTIC375 cells resp., in comparison to 37 and 66% for optimized PBAE NPs without PEG. The leading PEG-PBAE NP formulation also maintained sub-250 nm particle size up to 5 h, while PBAE NPs without PEG showed aggregation over time to micrometer-sized complexes. The comparative advantage demonstrated in vitro successfully translated into improved in vivo diffusion, with a higher amount of PEG-PBAE NPs penetrating to a distance of 2 mm from the injection site. A significant increase in median survival from 53.5 to 67 days by PEG-PBAE/pHSV-tk NP and systemic ganciclovir treatment compared to a control group in orthotopic murine model of human glioblastoma demonstrates the potential of PEG-PBAE-based NPs as an effective gene therapy platform for the treatment of human brain tumors. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

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The author of 《Reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate and its self-assembled nanomicelles: Preparation, physicochemical characterization, and thiol-triggered drug release》 were Ngoc, Van Tran Thi; Hwang, Hee Sook; Kim, Yugyeong; Kang, Han Chang; Huh, Kang Moo. And the article was published in Polymers for Advanced Technologies in 2019. Formula: C3H9NO2 The author mentioned the following in the article:

In this study, a reduction-responsive poly (ethylene glycol)-dexamethasone biarm conjugate was synthesized as intracellular targeted drug delivery carriers. The hydroxyl end group of methoxy poly (ethylene glycol) (mPEG) was modified to introduce a biarm structure with bioreducible disulfide bond and amine end groups. Dexamethasone (Dex) as a nuclear targeting moiety was conjugated to the amine end groups of mPEG biarm derivatives, mPEG-(NH2)2 or mPEG-(ss-NH2)2, with or without bioreducible disulfide bonds. The bioreducible and nonreducible mPEG-Dex biarm conjugates, R-mPEG-Dex and N-mPEG-Dex, were synthesized and characterized by various anal. methods, proton NMR (1H-NMR), Fourier transform IR spectroscopy (FT-IR), dynamic light scattering (DLS), and fluorescence measurements. Amphiphilic mPEG-Dex conjugates self-assembled in aqueous solutions to form nanoparticles (NPs) with a size range of 130 to 150 nm, and their critical micelle concentrations (CMCs) were determined to be 12.4 and 15.3 mg/L, resp., for bioreducible and nonreducible ones. The R-mPEG-Dex NPs maintained good colloidal stability in the presence of bovine serum albumin (BSA) for more than 1 wk but demonstrated a significant change in colloidal stability in the presence of dithiothreitol (DTT). In DTT-containing phosphate-buffered saline (PBS), the bioreducible NPs showed not only reduction-responsive destabilization with PEG shedding but also thiol-dependent drug release profile. Our observations indicated that the R-mPEG-Dex NPs have a promising prospective as an efficient nanocarrier for intracellular targeted delivery of various anticancer drugs. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Formula: C3H9NO2

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