Tag: 0-100

3-Vinyl oxindole-chromone synthon as a skeletal reconstruction reactant for the synthesis of 2-hydroxy benzoyl pyridones was written by Zhang, Lei;Liu, Ren-Ming;Wang, Wei-Na;Liu, Xiong-Li;Dai, Yi-Feng;Yu, Zhang-Biao;Peng, Li-Jun. And the article was included in New Journal of Chemistry in 2022.Reference of 5856-63-3 This article mentions the following:

The first example of ring-opening and recyclization reaction of 3-vinyl oxindole-chromones I [R¹ = H, 4-F, 5-Br, etc.; R² = H, 5-F, 4-Cl, etc.] as versatile synthons, which can react with ammonia or primary aliphatic amines as binucleophiles was developed, serving as a fruitful strategy for the eco-friendly and atom-economic synthesis of a new family of skeletally diverse 2-hydroxy benzoyl pyridones II [R³ = H, CH₂CH₂OMe, CH₂CH₂CN, etc.] with high to excellent yields (70-92%). The advantages of this methodol., including the use of easily available raw materials and the catalyst-free, wide functional group tolerance, and gram-scale synthesis, make the developed methodol. a practical way to access important biol. active 2-hydroxy benzoyl pyridone mols. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xanthan gum modified fish gelatin and binary culture modulates the metabolism of probiotics in fermented milk mainly via amino acid metabolism pathways was written by Le, Yi;Yang, Hongshun. And the article was included in Food Research International in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

1H NMR combined with multivariate data anal. were applied to investigate the effects of fish gelatin (FG) addition and co-culture of Lactobacillus acidophilus LA-5 (La-5) and Bifidobacterium lactis BB-12 (Bb-12) on the growth and metabolic pathways of the probiotics themselves. The results showed that the addition of FG had no significant effects on the growth of probiotics, but co-culture did promote the growth of probiotics, especially for Bb-12 (up to 2 log CFU/mL). FG addition inhibited amino acids synthesis and TCA cycling in Lacticaseibacillus paracasei subsp. paracasei CASEI 431 (L431) to some extent. However, for the single La-5 strain, these pathways were promoted. As for mixed bacterial cultures, Bb-12 promoted amino acids metabolism, sugar transport and energy metabolism in La-5. These findings suggested that the metabolic profile of probiotic bacteria can be adequately explained by metabolic pathway anal., which also provides theor. guidance for the industrialization of functional fermented milk. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Diverse synthetic approaches towards C1′-branched acyclic nucleoside phosphonates was written by Kalcic, Filip;Dracinsky, Martin;Janeba, Zlatko. And the article was included in Organic & Biomolecular Chemistry in 2021.Reference of 5856-63-3 This article mentions the following:

Herein we describe and compare five convenient approaches leading to key synthetic 6-chloropurine acyclic nucleoside phosphonates (ANPs), e.g. I, bearing the 9-phosphonomethoxyethyl (PME) moiety branched at the C₁‘ position. These intermediates can be further vastly diversified into target C1′-branched ANPs bearing either natural or unnatural nucleobases. The importance of C1′-branched ANPs is emphasized by their analogy with C1’-substituted cyclic nucleotides (such as remdesivir, a broad-spectrum antiviral agent) and evaluation of their biol. activity (e.g. antiviral, antineoplastic, and antiprotozoal) will be a tempting subject of further research. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Reference of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. The oxygen atom of the strongly polarized O鈥旽 bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Reference of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Magnetically-separable acid-resistant CoFe₂O₄@Polymer@MIL-100 core-shell catalysts for the acetalization of benzaldehyde and methanol was written by Cheng, Yaran;Chen, Jing;Wang, Tong;Wu, Qin;Shi, Daxin;Zhang, Yaoyuan;Chen, Kangcheng;Li, Hansheng. And the article was included in Journal of Colloid and Interface Science in 2023.Electric Literature of C3H8O2 This article mentions the following:

Novel reusable acid-resistant magnetic polymer nanospheres-immobilized MIL-100 (CoFe₂O₄@Polymer@MIL-100) catalyst was prepared by a layer-by-layer method to achieve a controllable structure. The obtained core-shell catalyst consisted of modified magnetic nanoparticles as the core, a carboxylic-functionalized polymer as the protective layer, and an MIL-100 shell as the active catalytic layer by chem. bonds on the polymer. The catalysts showed good stability, good magnetic saturation, and acid corrosion resistance. The thickness of the MIL-100 shell could be adjusted by controlling the metal salt concentration and the number of layer-by-layer cycles. Nano-sized MIL-100 showed better mass transfer efficiency and catalytic activity. A conversion of 97.7% after 10 min was observed during acetalization when using CoFe₂O₄@Polymer@MIL-100 as the catalyst. CoFe₂O₄@Polymer@MIL-100 could be reused at least five times. The use of a polymer layer on CoFe₂O₄@Polymer@MIL-100 prevented acidic ligands from corroding the magnetic core. Chem. bonds between MIL-100 and functional magnetic polymer cores improved the catalyst鈥瞫 stability. CoFe₂O₄@Polymer@MIL-100 exhibited high activity, excellent stability, and easy magnetic separation In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Electric Literature of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Electric Literature of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polyol-assisted hydrothermal synthesis of Mn-doped α – Fe₂O₃(MFO) nanostructures: Spin disorder-induced magnetism and photocatalytic properties. was written by Ramprasath, R.;Manikandan, Velu;Aldawood, S.;Sudha, S.;Cholan, S.;Kannadasan, N.;Sampath, Sridhar;Gokul, B.. And the article was included in Environmental Research in 2022.Computed Properties of C3H8O2 This article mentions the following:

Hierarchical nanostructures play an important role in environmental clean-up and sustainability applications. The magnetic and photocatalytic characteristics of flower-like Mn-doped α-Fe₂O₃ nanostructures were prepared by using a polyol-assisted hydrothermal method. Crystallite sizes are in the range of 35-42 nm, and the existence of 3D hierarchical nanostructures was observed in FESEM pictures. The optical band gap energy varies between 2.08 and 2.16 eV, while XPS examination exposes the ions’ charge states and validates Mn³⁺ inclusion in the Fe³⁺ lattice. At room temperature, the addition of Mn to α-Fe₂O₃ results in a spin disorder ferromagnetism and coercivity of about 600 Oe was achieved. Methylene blue (MB) dye solution degraded by 92% when 2.5% Mn doped with α-Fe₂O₃ under visible conditions for 120 min irradiation time. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Computed Properties of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Computed Properties of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

An enantioselective potentiometric sensor for 2-amino-1-butanol based on chiral porous organic cage CC3-R was written by Wang, Bang-Jin;Duan, Ai-Hong;Zhang, Jun-Hui;Xie, Sheng-Ming;Cao, Qiu-E.;Yuan, Li-Ming. And the article was included in Molecules in 2019.Synthetic Route of C4H11NO This article mentions the following:

Porous organic cages (POCs) have attracted extensive attention due to their unique structures and tremendous application potential in numerous areas. In this study, an enantioselective potentiometric sensor composed of a polyvinyl chloride (PVC) membrane electrode modified with CC3-R POC material was used for the recognition of enantiomers of 2-amino-1-butanol. After optimization, the developed sensor exhibited enantioselectivity toward S-2-amino-1-butanol (log KPotS,R = -0.98) with acceptable sensitivity, and a near-Nernstian response of 25.8 ± 0.3 mV/decade within a pH range of 6.0-9.0. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Do not forget the classical catalyst poisons: The case of biomass to glycols via catalytic hydrogenolysis was written by te Molder, Thimo D. J.;Kersten, Sascha R. A.;Lange, Jean-Paul;Ruiz, M. Pilar. And the article was included in Biofuels, Bioproducts & Biorefining in 2022.Related Products of 57-55-6 This article mentions the following:

The conversion of herbaceous biomass to glycols via tungstate catalyzed hydrogenolysis is challenging owing to its high content of extractives, inorganics and S/N, compared with woody biomass. We tested the hydrogenolysis performance of hay in batch autoclave experiments in the presence of soluble sodium polytungstate and Raney Ni at 245°C, both in excess of catalyst as well as under catalyst-starving conditions. By this method, we found that addnl. tungstate and Raney Ni poisons, or at least their much higher concentrations, are present in the hay feedstock compared with woody biomass. It turns out that N- and in particular S-containing components present in hay are the root cause for deactivation of the hydrogenation catalyst. From the exptl. data we have derived feedstock criteria for N and S that should be targeted in terms of catalyst consumption for operation in an industrially relevant window. These challenging criteria urge the development of effective pretreatments for S/N removal or the employment of S/N-tolerant catalysts in the field of catalytic biomass conversion. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A randomized controlled trial examining the effects of treatment with propylene glycol and injectable cyanocobalamin on naturally occurring disease, milk production, and reproductive outcomes of dairy cows diagnosed with concurrent hyperketonemia and hypoglycemia was written by Hubner, A. M.;Canisso, I. F.;Peixoto, P. M.;Coelho, W. M. Jr.;Ribeiro, L.;Aldridge, B. M.;Lima, F. S.. And the article was included in Journal of Dairy Science in 2022.Synthetic Route of C3H8O2 This article mentions the following:

The objective of this study was to assess the effects of treatment with propylene glycol (PG) and cyanocobalamin (B12) on health, milk production, and reproductive outcomes of cows diagnosed with hyperketonemia (HK), hypoglycemia (HG), or concurrent HKHG. Glucose and β-hydroxybutyric acid (BHBA) concentrations were assessed in whole blood using a handheld device in lactating dairy cows (n = 2,418) between 3 and 9 d postpartum. Cows categorized as HK (n = 232, BHBA ≥1.2 mmol/L), HG (n = 161, glucose ≤2.2 mmol/L), and concurrent HKHG (n = 204, BHBA ≥1.2 mmol/L, and glucose ≤2.2 mmol/L) were randomized to receive treatment or to remain untreated (control). Treatment consisted of a single dose of B12 (10 mg, i.m.) and 300 mL of PG orally for 5 d, starting on the day of cow-side testing. Milk production, health, and reproductive outcomes were analyzed according to groups. Statistical anal. was carried out using SAS version 9.4 (SAS/STAT, SAS Institute Inc.). Treatment in HG cows decreased clin. ketosis, increased milk production in the fifth week of lactation for multiparous cows, and tended to increase 305-d mature-equivalent milk yield (305ME) for primiparous cows compared with untreated cows with the same metabolic profile. For cows with HKHG, treatment increased 305ME in multiparous cows and tended to increase 305ME in primiparous cows. No differences were found for treatment among any of the metabolic groups regarding reproductive outcomes, nor were any treatment effects found among HK cows. Glycemic status may help identify metabolically challenged early postpartum dairy cows, which may have differential response to PG and B12 treatment. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Synthetic Route of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In vitro and in vivo evaluation of cinnamaldehyde Microemulsion-Mucus interaction was written by Dong, Baoqi;Chen, Jingbao;Cai, Ye;Wu, Wenqing;Chu, Xiaoqin. And the article was included in Journal of Food Biochemistry in 2022.Product Details of 57-55-6 This article mentions the following:

The current investigation explores the possible mechanism of the microemulsion drug delivery system to improve the oral bioavailability of cinnamaldehyde (CA), an important food spice, from the perspective of the microemulsion-mucus system. The cinnamaldehyde microemulsion (CA-ME) was prepared by the water titration method combined with the pseudo-ternary phase diagram. The dynamic anal. was applied to detect the drug release in vitro. An intestinal mucosal injury test was conducted to evaluate the safety of CA-ME and drug absorption across the intestinal tract of rats was investigated through an Ussing chamber system. The rheol. of blank mucus and drug-loaded mucus was investigated using a rheometer. The bioavailability of CA-ME in rats was evaluated through pharmacokinetic characteristics. The ratio of optimal prescription was Tween 80: 1,2-propanediol: vitamin E oil: CA: water = 24.3:4.8:5:7.5:58.4. The droplets were uniform in size and evenly dispersed. Rheol. studies showed that the microemulsion-mucus system all exhibit pseudoplastic fluid behavior, and CA-ME increased the viscosity of the mucus to a certain extent. Compared with CA solution, CA-ME promoted the absorption of CA in various intestinal segments, especially the ileum. Pharmacokinetic experiments showed that the relative bioavailability of CA-ME was enhanced 2.5-fold higher than that of CA solution ME as a carrier for lipophobic substances, may increase the viscosity of the intestine mucus system to obtain longer residue time and better absorption. In this study, in vitro absorption Ussing model was combined with rheol. and pharmacokinetic anal. to systematically analyze the intestinal mucus mechanism of microemulsion to improve the oral bioavailability of cinnamic aldehyde. It laid the foundation for exploring the absorption and transport of drugs in the intestinal mucus barrier. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Product Details of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Product Details of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Impact of parylene coating on heating performance of intravenous fluid warmer: a bench study was written by Bayoro, Danielle K.;Groepenhoff, Herman;Hoolihan, Daniel;Rose, Edward A.;Pedro, Michael J.;Waldmann, Andreas D.. And the article was included in BMC Anesthesiology in 2022.Computed Properties of C3H8O2 This article mentions the following:

Abstract: Background: Perioperative hypothermia is a common occurrence, particularly with the elderly and pediatric age groups. Hypothermia is associated with an increased risk of perioperative complications. One method of preventing hypothermia is warming the infused fluids given during surgery. The enFlow i.v. fluid warmer has recently been reintroduced with a parylene coating on its heating blocks. In this paper, we evaluated the impact of the parylene coating on the new enFlows fluid warming capacity. Methods: Six coated and six uncoated enFlow cartridges were used. A solution of 10propylene glycol and 90distd. H₂O was infused into each heating cartridge at flow rates of 2, 10, 50, 150, and 200 mL/min. The infused fluid temperature was set at 4°C, 20°C, and 37°C. Output temperature was recorded at each level. Data for anal. was derived from 18 runs at each flow rate (six cartridges at three temperatures). Results: The parylene coated fluid warming cartridge delivered very stable output of 40°C temperatures at flow rates of 2, 10, and 50 mL/min regardless of the temperature of the infusate. At higher flow rates, the cartridges were not able to achieve the target temperature with the colder fluid. Both cartridges performed with similar efficacy across all flow rates at all temperatures Conclusions: At low flow rates, the parylene coated enFlow cartridges was comparable to the original uncoated cartridges. At higher flow rates, the coated and uncoated cartridges were not able to achieve the target temperature The parylene coating on the aluminum heating blocks of the new enFlow i.v. fluid warmer does not neg. affect its performance compared to the uncoated model. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Computed Properties of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Computed Properties of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts