Tag: 0-100

Wang, Yuechun; Wang, Yuqin; Shen, Jiabing; Chen, Xiang published their research in Latin American Journal of Pharmacy in 2021. The article was titled 《Protective effect of azaindole on cerebral hemorrhage in rat model through down-regulation of TGF-β mediated ERK pathway》.Product Details of 7748-36-9 The article contains the following contents:

The present study investigated azaindole as therapeutic agent for treatment of cerebral hemorrhage in the rat model. Azaindole treatment in dose dependent manner enhanced viability of neurons and decreased escape latency in cerebral hemorrhage rats compared to the untreated group. Moreover, infarct volume showed a significant (p < 0.05) decrease in cerebral hemorrhage rats on treatment with azaindole in 1.0 to 1.75 mg/kg dosage range. Azaindole treatment of cerebral hemorrhage rats significantly (p < 0.05) decreased CWC, improved BBB and increased proportion of Iba1 and MPO +ive cells in neuronal cultures. Treatment with azaindole prevented induction of neuronal apoptosis, promoted Bcl2 and Bclxl proteins and suppressed Bad and Bax protein protein expression. Addnl., Azaindole elevated TGF-β and ERK protein expression in cerebral hemorrhage rats. Thus, azaindole promoted viability of neurons and decreased infarct volume in cerebral hemorrhage rats through TGF-β and ERK/p-ERK pathway up-regulation. Therefore, azaindole inhibits neuronal damage and may be developed for ischemic reperfusion mediated cerebral hemorrhage treatment. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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《A flexible paper-based chemosensor for colorimetric and ratiometric fluorescence detection of toxic oxalyl chloride》 was written by Chen, Tianhong; Jiang, Lirong; Yuan, Hou-Qun; Zhang, Yue; Su, Dongdong; Bao, Guang-Ming. Category: alcohols-buliding-blocks And the article was included in Sensors and Actuators, B: Chemical in 2020. The article conveys some information:

The screening of highly toxic chem. vapor is critical for environmental monitoring and human health maintenance. Herein, we reported a chemosensor (AC-HPD) for rapid and specific detection of highly toxic oxalyl chloride vapor, which adopted anthracene carboxyimide as a fluorophore and 3-aminopropanol as the reaction site. Upon coupling of oxalyl chloride with NH and OH groups, AC-HPD exhibited remarkable colorimetric and ratiometric fluorescence dual-mode responses towards oxalyl chloride via the intramol. charge transfer effect. AC-HPD could determine oxalyl chloride with features of rapid response, excellent specificity, low detection limit (95 nM), as well as obvious color and fluorescence change. Furthermore, AC-HPD-embedded test strip was successfully fabricated and used as a flexible sensing device for rapid, sensitive and visible monitoring oxalyl chloride vapor. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Category: alcohols-buliding-blocks

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Sanceau, Jean-Yves; Maltais, Rene; Poirier, Donald; Marette, Andre published an article on January 18 ,2019. The article was titled 《Total Synthesis of the Antidiabetic (Type 2) Lipid Mediator Protectin DX/PDX》, and you may find the article in Journal of Organic Chemistry.Electric Literature of C3H6O2 The information in the text is summarized as follows:

The first total synthesis of a lipid mediator derived from natural ω-3-fatty acid docosahexaenoic acid (DHA), 10S,17S-diHDHA (also referred to as protectin DX/PDX), was achieved in a convergent route (29 steps). The two chiral hydroxyl groups at C-10 and C-17 were derived from readily available (S)-1,2,4-butanetriol and (R)-glycidol, resp. The two stereodefined E-double bonds were generated by a Takai olefination, and the skipped diene side chain was introduced with a stereocontrolled Wittig olefination. Importantly, the sensitive conjugated E,Z,E-triene intermediate was generated by a Boland reduction of the central triple bond of a E,E-dienyne. Overall, this synthetic strategy should allow the preparation of a larger quantity of PDX, which is inaccessible via previously reported biosynthetic approaches.(R)-Oxiran-2-ylmethanol(cas: 57044-25-4Electric Literature of C3H6O2) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Electric Literature of C3H6O2

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In 2019,Helvetica Chimica Acta included an article by Kuzniewski, Christian N.; Glauser, Simon; Gaugaz, Fabienne Z.; Schiess, Raphael; Rodriguez-Salarichs, Javier; Vetterli, Stefan; Horlacher, Oliver P.; Gertsch, Juerg; Redondo-Horcajo, Mariano; Canales, Angeles; Jimenez-Barbero, Jesus; Diaz, Jose Fernando; Altmann, Karl-Heinz. Quality Control of (R)-Oxiran-2-ylmethanol. The article was titled 《Synthesis, Profiling, and Bioactive Conformation of trans-Cyclopropyl Epothilones》. The information in the text is summarized as follows:

A series of new 3-deoxy-C(12),C(13)-trans-cyclopropyl-epothilones have been prepared, bearing benzothiazole, quinoline, thiazol-5-ylvinyl, or isoxazol-3-ylvinyl side chains (I – IV, resp.). For analogs with fused aromatic side chains, macrocyclic ring-closure was based on ring-closing olefin metathesis (RCM) of a precursor incorporating the fully elaborated heavy atom framework of the target structure (including the side chain moiety), while side chain attachment for the thiazole and isoxazole-containing 16-desmethyl analogs was performed only after establishment of the macrolactone core. Two approaches were elaborated for a macrocyclic aldehyde as the common precursor for the latter analogs that involved ring-closure either by RCM or by macrolactonization. Benzothiazole- and quinoline-based analogs were found to be highly potent antiproliferative agents; the two analogs with a thiazol-5-ylvinyl or an isoxazol-3-ylvinyl side chain likewise showed good antiproliferative activity but were significantly less potent than the parent epothilone A. Surprisingly, the desaturation of the C(10)-C(11) bond in these analogs was associated with a virtually complete loss in antiproliferative activity, which likely reflects a requirement for a ca. 60 ° C(10)-C(11) torsion angle in the tubulin-bound conformation of 12,13-trans-epothilones. In the experiment, the researchers used many compounds, for example, (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Quality Control of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Quality Control of (R)-Oxiran-2-ylmethanol

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《Palladium-Catalyzed Barluenga-Valdes Type Cross-Coupling Reaction: Alkenylation of 7-Azaindoles》 was written by Raina, Gaurav; Kannaboina, Prakash; Ahmed, Qazi Naveed; Mondal, Krishanu; Das, Parthasarathi. Name: Oxetan-3-olThis research focused onvinyl azaindole preparation chemoselective; sulfonylhydrazone azaindole Barluenga Valdes cross coupling alkenylation palladium catalyst. The article conveys some information:

An efficient coupling method between sulfonylhydrazones ArC(CH3)=NNHTs (Ar = 3-nitrophenyl, pyridin-4-yl, naphthalen-2-yl, etc.) and 7-azaindoles I (R1 = H, 5-Br; R2 = H, I; R3 = Me, Bn, 4-methoxyphenyl) using Pd(OAc)2 as catalyst and dppf as ligand providing flexible and convergent access to different vinyl 7-azaindoles II and III is achieved. A wide variety of olefins II were obtained up to 86% yields via the coupling of numerous electronically distinct hydrazones with different 7-azaindoles I under the present catalytic conditions. The protocol was further extended to other heteroarenes such as indoles, quinolines, isoquinolines, and pyridine. The imperative feature of these protocols is its ease at the gram scale and their potential to get transformed into different valuable constructs. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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Safety of 3-Aminopropan-1-olIn 2020 ,《Tunable Structural Color Patterns Based on the Visible-Light-Responsive Dynamic Diselenide Metathesis》 was published in Advanced Materials (Weinheim, Germany). The article was written by Liu, Cheng; Fan, Zhiyuan; Tan, Yizheng; Fan, Fuqiang; Xu, Huaping. The article contains the following contents:

Structural color materials with reversible stimuli-responsiveness to external environment have been widely used in sensors, encryption, display, and other fields. Compared with other stimuli, visible light is highly controllable both temporally and spatially with less damage to materials, which is more suitable for structural color patterning. Herein, a new diselenide-containing shape memory material is prepared and used for creating patterns via visible light stimulus. In this system, the structural color originates from birefringence of stretched materials, whose shapes can be fixed while maintaining the mech. stress. The fixed stress can be released by diselenide metathesis under visible light irradiation By regulating the wavelength or irradiation time with a com. projector, the pattern with tunable structural colors is realized and the structural color pattern can be erased and rewritten arbitrarily. During the patterning process, the optical signal is first stored as mech. signal and then transformed back to optical signal. It is a new method for preparing visible-light-responsive structural color material and has great potential in display devices, anticounterfeiting labels, and data storage. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Safety of 3-Aminopropan-1-ol

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Formula: C3H9NO2In 2020 ,《PH-responsive artesunate polymer prodrugs with enhanced ablation effect on rodent xenograft colon cancer》 was published in International Journal of Nanomedicine. The article was written by Hao, Dan-Li; Xie, Ran; De, Ge-Jing; Yi, Hong; Zang, Chen; Yang, Mi-Yi; Liu, Li; Ma, Hai; Cai, Wei-Yan; Zhao, Qing-He; Sui, Feng; Chen, Yan-Jun. The article contains the following contents:

Purpose: In this study, pH-sensitive poly(2-ethyl-2-oxazoline)-poly(lactic acid)-poly(β-amino ester) (PEOz-PLA-PBAE) triblock copolymers were synthesized and were conjugated with an antimalaria drug artesunate (ART), for inhibition of a colon cancer xenograft model. The as-prepared polymer prodrugs are tended to self-assemble into polymeric micelles in aqueous milieu, with PEOz segment as hydrophilic shell and PLA-PBAE segment as hydrophobic core. The pH sensitivity of the as-prepared copolymers was confirmed by acid-base titration with pKb values around 6.5. The drug-conjugated polymer micelles showed high stability for at least 96 h in PBS and 37°C, resp. The as-preparation copolymer prodrugs showed high drug loading content, with 9.57% ±1.24% of drug loading for PEOz-PLA-PBAE-ART4. The conjugated ART could be released in a sustained and pH-dependent manner, with 92% of released drug at pH 6.0 and 57% of drug released at pH 7.4, resp. In addition, in vitro experiments showed higher inhibitory effect of the prodrugs on rodent CT-26 cells than that of free ART. Animal studies also demonstrated the enhanced inhibitory efficacy of PEOz-PLA-PBAE-ART2 micelles on the growth of rodent xenograft tumor. The pH-responsive artesunate polymer prodrugs are promising candidates for colon cancer adjuvant therapy. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Formula: C3H9NO2

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《Design and synthesis of azaindole heterocycle decorated new scaffold in fluorometric sensing of F- and H2PO4-》 was published in Journal of Heterocyclic Chemistry in 2020. These research results belong to Ghosh, Kumaresh; Ali, Sk. Sarfaraj; Joardar, Soumen. Recommanded Product: 7748-36-9 The article mentions the following:

7-Azaindole has been used in designing new mol. structure 1 on enediyne spacer for its application in anion sensing. New structure 1 has been established as efficient fluorescent sensor of H2PO4- and F- ions in CH3CN containing 1% DMSO. While in presence of H2PO4- the emission at 418 nm is decreased to the significant extent in nonratiometric fashion, a ratiometric response in presence of F- is noted with a sharp isoemissive point and two anions are effectively distinguished over a series of other anions tested. A similar study on model compound 2 with indole motifs is done to prove the pivotal role of extra ring nitrogen in azaindole of 1 in the binding process. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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The author of 《pH-Responsive Nanoparticles Targeted to Lungs for Improved Therapy of Acute Lung Inflammation/Injury》 were Zhang, Can Yang; Lin, Wenjing; Gao, Jin; Shi, Xutong; Davaritouchaee, Maryam; Nielsen, Amy E.; Mancini, Rock J.; Wang, Zhenjia. And the article was published in ACS Applied Materials & Interfaces in 2019. Electric Literature of C3H9NO The author mentioned the following in the article:

Dysregulated vascular inflammation is the underlying cause of acute lung inflammation/injury (ALI). Bacterial infections and trauma cause ALI that may rapidly lead to acute respiratory distress syndrome (ARDS). There are no pharmacol. therapies available to patients with ALI/ARDS, partially as drugs cannot specifically target the lungs. Herein, we developed a stimuli-responsive nanoparticle (NP) to target inflammatory lungs for ALI therapies. The NP is composed of a sharp acid-sensitive segment poly(β-amino esters) as a core for drug loading and controlled release and a polyethylene glycol-biotin on the particle surface available for bioconjugation, enabling lung targeting and extended circulation. The studies on dissipative particle dynamics simulation and characteristics of NPs suggest that anti-ICAM-1 antibodies can be coated to the particle surface and this coating is required to enhance lung targeting of NPs. A model drug of anti-inflammatory agent TPCA-1 is encapsulated in NPs with a high drug-loading content at 24% (weight/weight). In the mouse ALI model, our TPCA-1-loaded NPs coated with anti-ICAM-1 can target inflamed lungs after i.v. injection, followed by drug release triggered by the acid environment, thus mitigating lung inflammation and injury. Our studies reveal the rational design of nanotherapeutics for improved therapy of ALI, which may be applied to treating a wide range of vascular inflammation. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Electric Literature of C3H9NO

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The author of 《Metabolomics as read-across tool: An example with 3-aminopropanol and 2-aminoethanol》 were Sperber, S.; Wahl, M.; Berger, F.; Kamp, H.; Lemke, O.; Starck, V.; Walk, T.; Spitzer, M.; Van Ravenzwaay, B.. And the article was published in Regulatory Toxicology and Pharmacology in 2019. Synthetic Route of C3H9NO The author mentioned the following in the article:

Read-across and grouping is one of the most commonly used alternative approaches for data gap filling in registrations submitted under the REACH Regulation as defined by the European Chems. Agency (ECHA) in their Read-Across Assessment Framework (RAAF, 2017). At the same time, the application of read-across is rejected by ECHA frequently due to various reasons. As a major reason hereof, applicants fail to reduce the level of remaining uncertainty intrinsical to every read-across approach compared to testing a substance exptl. Recently, the use of metabolomics to support read-across cases with biol. information has been reported in a case study with phenoxy herbicides (Ravenzwaay et al., 2016). In the present case-study a weight-of-evidence read-across approach from 2-aminoethanol (MEA = source) to 3-aminopropanol (3AP = target) with metabolomics as supporting evidence reducing the remaining uncertainties is reported. We demonstrate the high structural similarity of the two analogous substances based on the available data and we report how metabolome data add confidence concerning mechanistic similarity in this read-across approach. Finally, the herein described read-across case supported by metabolomics is used to cover the data gaps in repeated dose and reproductive toxicity endpoint of 3AP via weight of evidence for the REACH-registration. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Synthetic Route of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Synthetic Route of C3H9NO

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