Tag: 0-100

Computed Properties of C3H6O2In 2021 ,《Synthesis and properties of syndiotactic 1,2-polybutadiene catalyzed by iron catalyst with phosphate as additive》 was published in Journal of Applied Polymer Science. The article was written by Hu, Zhonghan; Xu, Yuechao; Hu, Wenhong; Luo, Wanwei; Zhao, Yu; Huang, Weizhong; Gong, Dirong. The article contains the following contents:

1,2 Syndiotactic polymerization of butadiene is accessible by iron catalysts prepared from com. available iron sources, trialkylaluminum with addnl. phosphate as additive. The catalyst formation is quite robust in terms of handling and stability under polymerization conditions. Activity equal to 115 kg (polymer)/mol(Fe)·h is achieved at 10,000 equivalent of monomer relative to the catalyst loading in 2 h at 50°C. The resultant polymer possesses 1,2 incorporation up to 80.2-93.1% with syndiotactic configuration (rrrr) of 40.2-85.2%. Crystallinity of polymers can be also tuned over a wide range degree from weak (2.1%) to high crystallinity (68.2%) by varying catalyst component feeding, enabling potential application as both rubber and resin. The higher activity of iron catalyst is preferred at hydrocarbon solvent n-hexane, n-heptane or toluene, higher temperature as well as trialkylalumium, such as tri-iso-butylaluminum, tri-ethylaluminum, and tri-methylaluminum as cocatalyst. Significant stereospecificity stability to variation for monomer concentration, type of alkylaluminum and temperature is also found. The high activity and 1,2-stereoselectivity featured with these thermal robust iron catalysts sheds light on the significance of additive on regulating stereo-polymerization promoted by conventional Ziegler-Natta catalysts. These features collectively could offer advantages for application in industry production of 1,2-syndiotactic polybutadiene. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Computed Properties of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Computed Properties of C3H6O2

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《Experimental and predicted physicochemical properties of monopropanolamine-based deep eutectic solvents》 was written by Nowosielski, Bartosz; Jamrogiewicz, Marzena; Luczak, Justyna; Smiechowski, Maciej; Warminska, Dorota. Electric Literature of C3H9NO And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

In this work, the novel deep eutectic solvents (DESs) based on 3-amino-1-propanol (AP) as hydrogen bond donor (HBD) and tetrabutylammonium bromide (TBAB) or tetrabutylammonium chloride (TBAC) or tetraethylammonium chloride (TEAC) as hydrogen bond acceptors (HBAs) were synthesized with different molar ratios of 1: 4, 1: 6 and 1: 8 salt to AP. Fourier Transform IR Spectroscopy measurements were performed to provide an evidence of any chem. structure changes. Phys. properties of the prepared DESs including densities, viscosities, refractive indexes and sound velocities were measured within the temperature range of 293.15-333.15 K at the pressure of 0.1 MPa. They were analyzed in terms of estimating the effect of HBA to HBD molar ratio, anion and length of alkyl chain in a salt, and their temperature dependences were fitted by empirical equations. Thermal expansion coefficients and activation energies for viscous flow were obtained accordingly. Moreover, exptl. values of d. and refractive index were compared with predicted ones. For prediction of d., Rackett equation modified by Spencer and Danner and the mass connectivity index-based method were used, while refractive index was estimated by the at. contribution method.3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Electric Literature of C3H9NO

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《Chelation Crosslinking of Biodegradable Elastomers》 was published in Advanced Materials (Weinheim, Germany) in 2020. These research results belong to Chen, Ying; Miller, Paula G.; Ding, Xiaochu; Stowell, Chelsea E. T.; Kelly, Katie M.; Wang, Yadong. Safety of 2-Aminopropane-1,3-diol The article mentions the following:

Widely present in nature and in manufactured goods, elastomers are network polymers typically crosslinked by strong covalent bonds. Elastomers crosslinked by weak bonds usually exhibit more plastic deformation. Here, chelation as a mechanism to produce biodegradable elastomers is reported. Polycondensation of sebacic acid, 1,3-propanediol, and a Schiff-base (2-[[(2-hydroxyphenyl) methylene]amino]-1,3-propanediol) forms a block copolymer that binds several biol. relevant metal ions. Chelation offers a unique advantage unseen in conventional elastomer design because one ligand binds multiple metal ions, yielding bonds of different strengths. Therefore, one polymeric ligand coordinated with different metal ions produces elastomers with vastly different characteristics. Mixing different metal ions in one polymer offers another degree of control on material properties. The d. of the ligands in the block copolymer further regulates the mech. properties. Moreover, a murine model reveals that Fe3+ crosslinked foam displays higher compatibility with s.c. tissues than the widely used biomaterial-polycaprolactone. The implantation sites restore to their normal architecture with little fibrosis upon degradation of the implants. The versatility of chelation-based design has already shown promise in hydrogels and highly stretchy nondegradable polymers. The biodegradable elastomers reported here would enable new materials and new possibilities in biomedicine and beyond. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Safety of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Safety of 2-Aminopropane-1,3-diol

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The author of 《Influence of polyethylene glycol molecular weight on the anticancer drug delivery of pH-sensitive polymeric micelle》 were Shan, Xiaotian; Mao, Jing; Long, Miaomiao; Ahmed, Kamel S.; Sun, Changling; Qiu, Lipeng; Chen, Jinghua. And the article was published in Journal of Applied Polymer Science in 2019. Electric Literature of C3H9NO2 The author mentioned the following in the article:

Polyethylene glycol (PEG) and pH-sensitive polymers have been widely utilized in anticancer drug delivery systems due to their characteristics of prolonging circulation time and tumor-responsive drug release. However, the effect of PEG mol. weight on the delivery of anticancer drug-encapsulating pH-sensitive polymer micelles has been poorly studied. Therefore, a simple method was used to prepare pH-sensitive doxorubicin (DOX)-loaded micelles (DOX/POD) based on polyethylene glycol-2-(octadecyloxy)-1, 3-dioxan-5-amine (POD) polymers, and the influence of PEG mol. weights (1 K, 2 K, and 5 K) on in vitro drug release and antitumor effect was further studied. Interestingly, as the mol. weight increased, the release amount of DOX was augmented. While the cytotoxicity and cellular uptake were increased, the mol. weight was decreased. It is reasonable to speculate that the high mol. weight of PEG may promote the dissolution rate of DOX, and their micelles with uncompact structure are being prone to disassembly in an acid environment. However, the low mol. weight of PEG may contribute to the formation of compact POD micelles, which make it easier to be uptaken by tumor cells resulting in the enhanced antitumor effect. Taken together, the results indicate that pH-sensitive POD micelles with low mol. weight can achieve the efficient delivery of drugs, and PEG mol. weight in pH-sensitive nanocarriers may influence the antitumor effect. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47854. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C3H9NO2

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The author of 《Hydrophilic scaffolds of oxime as the potent catalytic inactivator of reactive organophosphate》 were Tang, Shengzhuang; Wong, Pamela T.; Cannon, Jayme; Yang, Kelly; Bowden, Sierra; Bhattacharjee, Somnath; O′Konek, Jessica J.; Choi, Seok Ki. And the article was published in Chemico-Biological Interactions in 2019. Quality Control of 2-Aminopropane-1,3-diol The author mentioned the following in the article:

Despite its efficacy as a skin decontaminant of reactive organophosphates (OP), Dekon 139-a potassium salt of 2,3-butanedione monooxime (DAM)-is associated with adverse events related to percutaneous absorption largely due to its small size and lipophilicity. In order to address this physicochem. issue, we synthesized and evaluated the activity of a focused library of 14 hydrophilic oxime compounds, each designed with either a DAM or monoisonitrosoacetone (MINA) oxime tethered to a polar or charged scaffold in order to optimize the size, hydrophilicity, and oxime acidity. High-throughput colorimetric assays were performed with paraoxon (POX) as a model OP to determine the kinetics of POX inactivation by these compounds under various pH and temperature conditions. This primary screening led to the identification of 6 lead compounds, predominantly in the MINA series, which displayed superb catalytic activity by reducing the POX half-life (t1/2) by 2-3 fold relative to Dekon 139. Our mechanistic studies show that POX inactivation by the oxime compounds occurred faster at a higher temperature and in a pH-dependent manner in which the neg. charged oximate species is = 10-fold more effective than the neutral oxime species. Lastly, using one of the lead compounds, we demonstrated its promising efficacy for POX decontamination in porcine skin ex vivo, and showed its potent ability to protect acetylcholine esterase (AChE) through POX inactivation. In summary, we report the rational design and chem. biol. validation of novel hydrophilic oximes which address an unmet need in therapeutic OP decontamination. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Quality Control of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Quality Control of 2-Aminopropane-1,3-diol

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In 2019,Journal of Controlled Release included an article by Luebtow, Michael M.; Nelke, Lena C.; Seifert, Julia; Kuehnemundt, Johanna; Sahay, Gaurav; Dandekar, Gudrun; Nietzer, Sarah L.; Luxenhofer, Robert. Product Details of 156-87-6. The article was titled 《Drug induced micellization into ultra-high capacity and stable curcumin nanoformulations: Physico-chemical characterization and evaluation in 2D and 3D in vitro models》. The information in the text is summarized as follows:

Here, we report on a novel nanoformulation of CUR that enables CUR concentrations in water of at least 50 g/L with relative drug loadings of >50 wt% and high dose efficacy testing in 3D tumor models. Despite this high loading and concentration, the CUR nanoformulation comprises polymer-drug aggregates with a size <50 nm. Most interestingly, this is achieved using an amphiphilic block copolymer, that by itself does not form micelles due to its limited hydrophilic/lipophilic contrast. The ultra-high loaded nanoformulations exhibit a very good stability, reproducibility and redispersibility. In order to test effects of CUR in conditions closer to an in vivo situation, we utilized a 3D tumor test system based on a biol. de-cellularized tissue matrix that better correlates to clin. results concerning drug testing. We found that in comparison to 2D culture, the invasively growing breast cancer cell line MDA-MB-231 requires high concentrations of CUR for tumor cell eradication in 3D. In addition, we supplemented a 3D colorectal cancer model of the malignant cell line SW480 with fibroblasts and observed also in this invasive tumor model with stroma components a decreased tumor cell growth after CUR application accompanied by a loss of cell-cell contacts within tumor cell clusters. In a flow bioreactor simulating cancer cell dissemination, nanoformulated CUR prevented SW480 cells from adhering to a collagen scaffold, suggesting an anti-metastatic potential of CUR. In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Product Details of 156-87-6) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Product Details of 156-87-6

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Quality Control of 2-Aminopropane-1,3-diolIn 2021 ,《Design, synthesis, and structure-activity relationship of programmed cell death-1/programmed cell death-ligand 1 interaction inhibitors bearing a benzo[d]isothiazole scaffold》 appeared in European Journal of Medicinal Chemistry. The author of the article were Chen, Hao; Wang, Ke; Yang, Yang; Huang, Xupeng; Dai, Xinyan; Feng, Zhiqiang. The article conveys some information:

A novel series of compounds such as I [R = CH2NHCHCO2HCH2OH, CH2(N-piperidin-3-ol), CH2(N-pyrrolidin-3-ol), etc.] bearing a benzo[d]isothiazole scaffold were developed, among which compound I [R = CH2NHCHCO2HCH2OH] exhibited promising activity, with an IC50 value of 8.5 nM. Further cell-based PD-1/PD-L1 blockade bioassays indicated that compound I [R = CH2NHCHCO2HCH2OH] could inhibit the PD-1/PD-L1 interaction at the cellular level, with an EC50 value of 5.6μM compound I [R = CH2NHCHCO2HCH2OH] could had better potency in restoring the activity of effector cells, as the maximal luminescence values (RLUmax) of compound I [R = CH2NHCHCO2HCH2OH] were equivalent to those of PD-L1 mAbs. The docking anal. of compound I [R = CH2NHCHCO2HCH2OH] with the PD-L1 dimer complex (PDB ID: 6R3K) confirmed that I [R = CH2NHCHCO2HCH2OH] was a promising lead compound for the development of inhibitors of the PD-1/PD-L1 interaction. The preliminary structure-activity relationship was investigated in this paper, with the aim of future drug development. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Quality Control of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Quality Control of 2-Aminopropane-1,3-diol

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Electric Literature of C3H9NO2In 2021 ,《Influence of the active layer structure on the photovoltaic performance of water-soluble polythiophene-based solar cells》 appeared in Polymers (Basel, Switzerland). The author of the article were Lanzi, Massimiliano; Quadretti, Debora; Marinelli, Martina; Ziai, Yasamin; Salatelli, Elisabetta; Pierini, Filippo. The article conveys some information:

A new side-chain C60-fullerene functionalized thiophene copolymer bearing tributylphosphine-substituted hexylic lateral groups was successfully synthesized by means of a fast and effective post-polymerization reaction on a regioregular ω-alkylbrominated polymeric precursor. The growth of the polymeric intermediate was followed by NMR spectrometry in order to determine the most convenient reaction time. The obtained copolymer was soluble in water and polar solvents and was used as a photoactive layer in single-material organic photovoltaic (OPV) solar cells. The copolymer photovoltaic efficiency was compared with that of an OPV cell containing a water-soluble polythiophenic homopolymer, functionalized with the same tributylphosphine-substituted hexylic side chains, in a blend with a water-soluble C60-fullerene derivative The use of a water-soluble double-cable copolymer made it possible to enhance the control on the nanomorphol. of the active blend, thus reducing phase-segregation phenomena, as well as the macroscale separation between the electron acceptor and donor components. Indeed, the power conversion efficiency of OPV cells based on a single material was higher than that obtained with the classical architecture, involving the presence of two distinct ED and EA materials (PCE: 3.11% vs. 2.29%, resp.). Moreover, the synthetic procedure adopted to obtain single material-based cells is more straightforward and easier than that used for the preparation of the homopolymer-based BHJ solar cell, thus making it possible to completely avoid the long synthetic pathway which is required to prepare water-soluble fullerene derivatives In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Electric Literature of C3H9NO2

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Eshimbetov, Alisher; Adizov, Shahobiddin; Kaur, Inderpreet; Reymov, Akhmed published an article in 2021. The article was titled 《Is it possible to differentiate between 2-phenylaminodihydro-1,3-thiazine from 2-phenyliminotetrahydro-1,3-thiazine by spectral methods New glance to the old problem》, and you may find the article in European Journal of Chemistry.Category: alcohols-buliding-blocks The information in the text is summarized as follows:

Several studies have reported the presence of amine and imine tautomeric forms for hydrogenated 1,3-thiazine derivatives However, identification of their tautomeric forms by UV, FTIR and mass-spectral methods does not yield expected results. Here, we report the synthesis of 2-phenylaminodihydro-1,3-thiazine and 2-phenyliminotetrahydro-1,3-thiazine and the anal. of their UV, FTIR and NMR (1H and 13C) spectral data. An identical picture of UV spectra was recorded for both compounds However, distinctive characteristics were found in the FTIR, 1H and 13C NMR spectra. The C=N band of amine form was observed in higher frequency region relative to imine form. The signal of C2 carbon of amine form in 13C NMR spectrum was occurred in more downfield (δ 165.3 ppm) relative to C2 signal of imine form (δ 152.1 ppm). In addition, the difference between C2 and C8 carbon signals of amine form was very high (Δδ = 30.6 ppm) relative to imine form (δ 5.4 ppm). The position of C2 and C8 signals and the difference between them in 13C NMR spectrum was found to be more promising in identification of tautomeric forms in case of hydrogenated 1,3-thiazine derivatives In addition to this study using 3-Aminopropan-1-ol, there are many other studies that have used 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Category: alcohols-buliding-blocks

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Zhu, Yan-Ying; Xu, Hui-Bei; Zhang, Jing; Luo, Yi; Dong, Lin published an article in 2021. The article was titled 《Ru(II)-Catalyzed Difluoromethylations of 7-Azaindoles: Access to Novel Fluoro-7-Azaindole Derivatives》, and you may find the article in Asian Journal of Organic Chemistry.Formula: C3H6O2 The information in the text is summarized as follows:

Herein, an efficient Ru(II)-catalyzed site-selective C-H functionalization/difluoromethylated reaction to sep. construct 3-difluoromethylated and remote meta-difluoromethylated 7-azaindole derivatives was developed. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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