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《In silico evaluation of the antibacterial and modulatory activity of lapachol and nor-lapachol derivates》 was written by Figueredo, Fernando Gomes; Ramos, Ingrid T. L.; Paz, Josinete A.; Silva, Tania M. S.; Camara, Celso A.; Oliveira-Tintino, Cicera Datiane de Morais; Relison Tintino, Saulo; Maia de Farias, Pablo Antonio; Coutinho, Henrique Douglas Melo; Fonteles, Marta Maria de F.. Category: alcohols-buliding-blocks And the article was included in Microbial Pathogenesis in 2020. The article conveys some information:

To investigate pharmacol. properties of 2-(2-hydroxyethylamine)-3-(3-methyl-2-butenyl)-1,4-dihydro-1,4-naphthalenedione, 2-(2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone and 2-(3-hydroxy-propylamine)-3-(3-methyl-2-butenyl)-[1,4]naphthoquinone using computational prediction models, in addition to evaluating the in vitro antibacterial and modulatory activity of these compounds against bacterial ATCC strains and clin. isolates. The substances were synthesized from 2-hydroxy-quinones, lapachol and nor-lapachol obtaining the corresponding 2-methoxylated derivatives via di-Me sulfate alkylation in a basic medium, these then reacted chemoselectively with 2-ethanolamine and 3-propanolamine to form the corresponding amino alcs. The antibacterial activity and modulatory activity of the substances were assayed by broth microdilution method to determine MIC. The mol. structures were analyzed using the ChEMBL database to predict possible pharmacol. targets, which pointed to the mol. 2- (2-hydroxy-ethylamine)-3-(2-methyl-propenyl)-[1,4]naphthoquinone as a probable antibacterial agent for the proteins Replicative DNA helicase and RecA. The compounds had low mol. weight and a small number of rotatable bonds. The MICs of the substances were not clin. significant, however, the association with gentamicin and amikacin reduced MICs of these antibiotics. Combination of these substances with aminoglycosides may be therapeutic alternative to bacterial resistance and reduction of side effects. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Category: alcohols-buliding-blocks)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Category: alcohols-buliding-blocks

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《An nπ* gated decay mediates excited-state lifetimes of isolated azaindoles》 was published in Physical Chemistry Chemical Physics in 2020. These research results belong to Lamas, Iker; Montero, Raul; Martinez-Martinez, Virginia; Longarte, Asier; Blancafort, Lluis. Recommanded Product: 7748-36-9 The article mentions the following:

Aiming to serve as a guide to understand the relaxation mechanisms of more complex aza-aromatic compounds, such as purine bases, we have studied the non-radiative channels of a set of azaindole structural isomers: 4-, 5-, 6- and 7-azaindole (AI). The relaxation of the isolated mols., after excitation at the low energy portion of their spectra, has been tracked by femtosecond time-resolved ionization, and the decay paths have been obtained with MS-CASPT2//TD-DFT calculations Although the ultrashort measured lifetimes for 5- and 6-Al are in contrast to the long-living excited state found in 7-Al, the calculations describe a common relaxation pathway. Along it, the initially excited ππ* states decay to the ground state through a conical intersection accessed through an nπ* state that functions as a gate state. The work reveals that the position of the nitrogen atoms in the purine ring determines the barrier to access the gate state and therefore, the rate of the non-radiative relaxation. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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Name: 3-Aminopropan-1-olIn 2022 ,《Synthesis and characterization of new spiro cyclotriphosphazene derivatives》 was published in Inorganic Chemistry Communications. The article was written by Begec, Saliha. The article contains the following contents:

Reactions of spiro-N,N-diisopropylpropane-1,3-diamino-2,2-4,4 tetrachlorocyclotriphosphazatriene (1) with 2,2′-dihydroxybiphenyl (2), and 3-amino-1-propanol (3) were studied. Dispiro (4,6) and trispiro (5) phosphazene derivatives were obtained from these reactions. New spirocyclotriphosphazenes (4-6) were characterized by elemental anal., 1H, 13C and 31P NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.Name: 3-Aminopropan-1-ol

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SDS of cas: 534-03-2In 2021 ,《Reversible Mechanochemistry Enabled Autonomous Sustaining of Robustness of Polymers-An Example of Next Generation Self-healing Strategy》 appeared in Chinese Journal of Polymer Science. The author of the article were Li, Ming-Xuan; Rong, Min-Zhi; Zhang, Ming-Qiu. The article conveys some information:

Even under low external force, a few macromols. of a polymer have to be much more highly stressed and fractured first due to the inherent heterogeneous microstructure. When the materials keep on working under loading, as is often the case, the minor damages would add up, endangering the safety of use. Here we show an innovative solution based on mechanochem. initiated reversible cascading variation of metal-ligand complexations. Upon loading, crosslinking d. of the proof-of-concept metallopolymer networks autonomously increases, and recovers after unloading. Meanwhile, the stress-induced tiny fracture precursors are blocked to grow and then restored. The entire processes reversibly proceed free of manual intervention and catalyst. The proposed mol.-level internal equilibrium prevention mechanisms fundamentally enhance durability of polymers in service. hydroxy benzotriazole. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).SDS of cas: 534-03-2

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In 2022,Fan, You Kun; Feng, Shao Min; Liu, Xi Liang; Li, Kai Qi; Chen, Dong Liang; Xiong, Cheng Dong published an article in Macromolecular Rapid Communications. The title of the article was 《Synthesis and Characterization of Novel Radiopaque Polycarbonate》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Polymeric materials implanted in the human body are usually invisible under X-ray, and the mixing of heavy metal salts into polymeric materials by phys. compounding often poses compatibility problems. A new iodine-containing cyclic carbonate monomer, 4-iodo-N-(2-oxo-1,3-dioxan-5-yl)benzamide (IBTMC), is synthesized, which has a degradable carbonate group as its basic structural unit and iodine atoms attached to the side chain in the form of covalent bonds. The ring-opening polymerization of IBTMC is achieved at room temperature under the catalysis of the solid superbase 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD). The structure and X-ray developing ability of the synthesized polycarbonate are characterized by 1H-NMR, XPS, energy dispersive X-ray spectroscopy (EDS), Gel Permeation Chromatog. (GPC), and micro-computed tomog. (Micro-CT). The iodine atoms remain bound to the polymer as covalent bonds after a series of reactions and exhibit a high level of X-ray opacity. In vitro degradation experiments of the polymer prove that the polymer is degradable. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.Category: alcohols-buliding-blocks

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In 2022,Saadati, Fariba; Cammarone, Silvia; Ciufolini, Marco A. published an article in Chemistry – A European Journal. The title of the article was 《A Route to Lipid ALC-0315: a Key Component of a COVID-19 mRNA Vaccine》.Recommanded Product: 4-Aminobutan-1-ol The author mentioned the following in the article:

This paper described a synthesis of ALC-0315 I by a sequence that more than doubles the overall yield relative to the published one, and that employed much cleaner reactions, thereby facilitating purifications to a considerable extent.4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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In 2022,Rajput, Shruti; Kaur, Ramandeep; Jain, Nidhi published an article in Organic & Biomolecular Chemistry. The title of the article was 《Pd and photoredox dual catalysis assisted decarboxylative ortho-benzoylation of N-phenyl-7-azaindoles》.Application of 7748-36-9 The author mentioned the following in the article:

The directing group assisted decarboxylative ortho-benzoylation of N-aryl-7-azaindoles with α-keto acids was achieved by synergistic visible light promoted photoredox and palladium catalysis. The approach tenders rapid entry to aryl ketone architectures from simple α-keto acid precursors via the in situ generation of a benzoyl radical intermediate. The transformation provided a range of ortho-benzoylated N-aryl-7-azaindoles, with excellent site-selectivity and good functional group compatibility under mild reaction conditions. Biol. target predictions indicate that these mols. may serve as potential anti-cancer and anti-viral agents. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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Vaughan, Hannah J.; Zamboni, Camila G.; Radant, Nicholas P.; Bhardwaj, Pranshu; Revai Lechtich, Esther; Hassan, Laboni F.; Shah, Khalid; Green, Jordan J. published an article in 2021. The article was titled 《Poly(beta-amino ester) nanoparticles enable tumor-specific TRAIL secretion and a bystander effect to treat liver cancer》, and you may find the article in Molecular Therapy–Oncolytics.Recommanded Product: 156-87-6 The information in the text is summarized as follows:

Despite initial promise, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based approaches to cancer treatment have yet to yield a clin. approved therapy, due to delivery challenges, a lack of potency, and drug resistance. To address these challenges, we have developed poly(beta-amino ester) (PBAE) nanoparticles (NPs), as well as an engineered cDNA sequence encoding a secretable TRAIL (sTRAIL) protein, to enable reprogramming of liver cancer cells to locally secrete TRAIL protein. We show that sTRAIL initiates apoptosis in transfected cells and has a bystander effect to non-transfected cells. To address TRAIL resistance, NP treatment is combined with histone deacetylase inhibitors, resulting in >80% TRAIL-mediated cell death in target cancer cells and significantly slowed xenograft tumor growth. This anti-cancer effect is specific to liver cancer cells, with up to 40-fold higher cell death in HepG2 cancer cells over human hepatocytes. By combining cancer-specific TRAIL NPs with small-mol.-sensitizing drugs, this strategy addresses multiple challenges associated with TRAIL therapy and offers a new potential approach for cancer treatment. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Recommanded Product: 156-87-6

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The author of 《Tailored Transition-Metal Coordination Environments in Imidazole-Modified DNA G-Quadruplexes》 were Punt, Philip M.; Clever, Guido H.. And the article was published in Chemistry – A European Journal in 2019. Application In Synthesis of (R)-Oxiran-2-ylmethanol The author mentioned the following in the article:

Two types of imidazole ligands were introduced both at the end of tetramol. and into the loop region of unimol. DNA G-quadruplexes. The modified oligonucleotides were shown to complex a range of different transition-metal cations including NiII, CuII, ZnII and CoII, as indicated by UV/Vis absorption spectroscopy and ion mobility mass spectrometry. Mol. dynamics simulations were performed to obtain structural insight into the investigated systems. Variation of ligand number and position in the loop region of unimol. sequences derived from the human telomer region (htel) allows for a controlled design of distinct coordination environments with fine-tuned metal affinities. It is shown that CuII, which is typically square-planar coordinated, has a higher affinity for systems offering four ligands, whereas NiII prefers G-quadruplexes with six ligands. Likewise, the positioning of ligands in a square-planar vs. tetrahedral fashion affects binding affinities of CuII and ZnII cations, resp. Gaining control over ligand arrangement patterns will spur the rational development of transition-metal-modified DNAzymes. Furthermore, this method is suited to combine different types of ligands, for example, those typically found in metalloenzymes, inside a single DNA architecture. In the experimental materials used by the author, we found (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application In Synthesis of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application In Synthesis of (R)-Oxiran-2-ylmethanol

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Cheviet, Thomas; Wein, Sharon; Bourchenin, Gabriel; Lagacherie, Manon; Perigaud, Christian; Cerdan, Rachel; Peyrottes, Suzanne published their research in Journal of Medicinal Chemistry on August 13 ,2020. The article was titled 《β-Hydroxy- and β-Aminophosphonate Acyclonucleosides as Potent Inhibitors of Plasmodium falciparum Growth》.Safety of (R)-Oxiran-2-ylmethanol The article contains the following contents:

Malaria is an infectious disease caused by a parasite of the genus Plasmodium, and the emergence of parasites resistant to all current antimalarial drugs highlights the urgency of having new classes of mols. We developed an effective method for the synthesis of a series of β-modified acyclonucleoside phosphonate (ANP) derivatives, using com. available and inexpensive materials (i.e., aspartic acid and purine heterocycles). Their biol. evaluation in cell culture experiments and SAR revealed that the compounds’ effectiveness depends on the presence of a hydroxyl group, the chain length (four carbons), and the nature of the nucleobase (guanine). The most active derivative I inhibits the growth of Plasmodium falciparum in vitro in the nanomolar range (IC50 = 74 nM) with high selectivity index (SI > 1350). This compound also showed remarkable in vivo activity in P. berghei-infected mice (ED50 ~0.5 mg/kg) when administered by the i.p. route and is, although less efficient, still active via the oral route. It is the first ANP derivative with such potent antimalarial activity and therefore has considerable potential for development as a new antimalarial drug. The experimental part of the paper was very detailed, including the reaction process of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Safety of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Safety of (R)-Oxiran-2-ylmethanol

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