Tag: 0-100

Kashida, Hiromu; Nishikawa, Keiji; Ito, Yuka; Murayama, Keiji; Hayashi, Ichiyo; Kakuta, Takahiro; Ogoshi, Tomoki; Asanuma, Hiroyuki published their research in Chemistry – A European Journal in 2021. The article was titled 《A Pyrene-Modified Serinol Nucleic Acid Nanostructure Converts the Chirality of Threoninol Nucleic Acids into Circularly Polarized Luminescence Signals》.Recommanded Product: 534-03-2 The article contains the following contents:

Herein is reported a circularly polarized luminescent (CPL) probe that can respond to the chirality of nucleic acids. An achiral nanostructure was prepared by the hybridization of sym. serinol nucleic acid (SNA) containing pyrene-modified residues. When chiral oligomers that were complementary to the SNA were added, they induced helicity into the SNA nanowire. Efficient CD (CD) signal amplification was observed when pyrene was attached to uracil bases through a rigid alkynyl linker. Both CPL and CD signals were observed; they depended on the chirality of the added acyclic threoninol nucleic acid (aTNA) oligomer. This system can be used to convert the chirality of chiral biomols. into chiroptical signals. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 534-03-2

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Alcohols – Chemistry LibreTexts

《Exploring the quinone/inhibitor-binding pocket in mitochondrial respiratory complex I by chemical biology approaches》 was written by Uno, Shinpei; Kimura, Hironori; Murai, Masatoshi; Miyoshi, Hideto. Application of 13325-10-5This research focused onubiquinone analog respiratory complex I quinone binding pocket inhibitor; Complex I; NADH–quinone oxidoreductase; amilorides; bioenergetics; chemical biology; enzyme inhibitor; mitochondria; photoaffinity labeling; ubiquinone. The article conveys some information:

NADH-quinone oxidoreductase (respiratory complex I) couples NADH-to-quinone electron transfer to the translocation of protons across the membrane. Even though the architecture of the quinone-access channel in the enzyme has been modeled by X-ray crystallog. and cryo-EM, conflicting findings raise the question whether the models fully reflect physiol. relevant states present throughout the catalytic cycle. To gain further insights into the structural features of the binding pocket for quinone/inhibitor, we performed chem. biol. experiments using bovine heart sub-mitochondrial particles. We synthesized ubiquinones (UQs) that are oversized ,(i.e., SF-UQs) or lipid-like (i.e., PC-UQs) and are highly unlikely to enter and transit the predicted narrow channel. We found that SF-UQs and PC-UQs can be catalytically reduced by complex I, albeit only at moderate or low rates. Moreover, quinone-site inhibitors completely blocked the catalytic reduction and the membrane potential formation coupled to this reduction Photoaffinity-labeling experiments revealed that amiloride-type inhibitors bind to the interfacial domain of multiple core subunits (49 kDa, ND1, and PSST) and the 39-kDa supernumerary subunit, although the latter does not make up the channel cavity in the current models. The binding of amilorides to the multiple target subunits was remarkably suppressed by other quinone-site inhibitors and SF-UQs. Taken together, the present results are difficult to reconcile with the current channel models. On the basis of comprehensive interpretations of the present results and of previous findings, we discuss the physiol. relevance of these models. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Application of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,Fluid Phase Equilibria included an article by Leontiadis, Konstantinos; Tzimpilis, Evangelos; Aslanidou, Dimitra; Tsivintzelis, Ioannis. Application of 156-87-6. The article was titled 《Solubility of CO2 in 3-amino-1-propanol and in N-methyldiethanolamine aqueous solutions: Experimental investigation and correlation using the CPA equation of state》. The information in the text is summarized as follows:

The solubility of CO2 in 1.3M and 2M aqueous N-methyldiethanolamine (MDEA) and 3-amino-1-propanol (MPA) solutions was exptl. measured at 298, 313, 323 and 333 K, using a pressure decay method. Since only limited exptl. data exist in literature for MPA aqueous systems, the results of this study were compared with literature data mainly for 2M MDEA solutions, showing satisfactory agreement. The obtained new exptl. data were used to parameterize the Cubic-plus-Association (CPA) equation of state using a pseudo chem. reaction approach, i.e. to account for chem. interactions as very strong specific intermol. interactions, which is a crude approximation, but is necessary for applying equation of state models. It was found that the model satisfactorily describes the exptl. data using six or four binary parameters for the CO2-MPA or CO2-MDEA interactions, resp., which, however, are less than the number of adjustable parameters in similar literature models. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 156-87-6

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In 2022,Rizzarelli, Paola; La Carta, Stefania; Mirabella, Emanuele Francesco; Rapisarda, Marco; Impallomeni, Giuseppe published an article in Polymers (Basel, Switzerland). The title of the article was 《Sequencing Biodegradable and Potentially Biobased Polyesteramide of Sebacic Acid and 3-Amino-1-propanol by MALDI TOF-TOF Tandem Mass Spectrometry》.Application of 156-87-6 The author mentioned the following in the article:

Biodegradable and potentially biobased polyesteramide oligomers (PEA-Pro), obtained from melt condensation of sebacic acid and 3-amino-1-propanol, were characterized by NMR, matrix assisted laser desorption/ionization-time of flight/time of flight-mass spectrometry/mass spectrometry (MALDI-TOF/TOF-MS/MS), thermogravimetric anal. (TGA), and pyrolysis-gas chromatog./mass spectrometry (Py-GC/MS). NMR anal. showed the presence of hydroxyl and amino terminal groups as well as carboxylic groups of the sebacate moiety. Hydroxyl and carboxyl termination had the same abundance, while the amine termination was 2.7-times less frequent. Information regarding the fragmentation pathways and ester/amide bond sequences was obtained by MALDI-TOF/TOF-MS/MS anal. performed on sodiated adducts of cyclic species and linear oligomers. Different end groups did not influence the observed fragmentation. Three fragmentation pathways were recognized. The β-hydrogen-transfer rearrangement, which leads to the selective scission of the -O-CH2- bonds, was the main mechanism. Abundant product ions originating from -CH2-CH2- (β-γ) bond cleavage in the sebacate moiety and less abundant ions formed by -O-CO- cleavages were also detected. TGA showed a major weight loss (74%) at 381°C and a second degradation step (22% weight loss) at 447°C. Py-GC/MS performed in the temperature range of 350-400°C displayed partial similarity between the degradation products and the main fragments detected in the MALDI-TOF/TOF-MS/MS experiments Degradation products derived from amide bonds were related to the formation of CN groups, in agreement with the literature. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Application of 156-87-6

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shen, Yang; Wang, Jing-Kun; Li, Yan-Qing; Shen, Kong-Chao; Su, Zhen-Huang; Chen, Li; Guo, Ming-Lei; Cai, Xiao-Yi; Xie, Feng-Ming; Qian, Xiao-Yan; Gao, Xingyu; Zhidkov, Ivan S.; Tang, Jian-Xin published an article in 2021. The article was titled 《Interfacial “”Anchoring Effect”” Enables Efficient Large-Area Sky-Blue Perovskite Light-Emitting Diodes》, and you may find the article in Advanced Science (Weinheim, Germany).Recommanded Product: 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

While tremendous progress has recently been made in perovskite light-emitting diodes (PeLEDs), large-area blue devices feature inferior performance due to uneven morphologies and vast defects in the solution-processed perovskite films. To alleviate these issues, a facile and reliable interface engineering scheme is reported for manipulating the crystallization of perovskite films enabled by a multifunctional mol. 2-amino-1,3-propanediol (APDO)-triggered “”anchoring effect”” at the grain-growth interface. Sky-blue perovskite films with large-area uniformity and low trap states are obtained, showing the distinctly improved radiative recombination and hole-transport capability. Based on the APDO-induced interface engineering, synergistical boost in device performance is achieved for large-area sky-blue PeLED (measuring at 100 mm2) with a peak external quantum efficiency (EQE) of 9.2% and a highly prolonged operational lifetime. A decent EQE up to 6.1% is demonstrated for the largest sky-blue device emitting at 400 mm2. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Recommanded Product: 2-Aminopropane-1,3-diol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parayath, N. N.; Hao, S.; Stephan, S. B.; Koehne, A. L.; Watson, C. E.; Stephan, M. T. published an article in 2021. The article was titled 《Genetic in situ engineering of myeloid regulatory cells controls inflammation in autoimmunity》, and you may find the article in Journal of Controlled Release.Reference of 4-Aminobutan-1-ol The information in the text is summarized as follows:

The ability of myeloid regulatory cells (MRCs) to control immune responses and to promote tolerance has prompted enormous interest in exploiting them therapeutically to treat inflammation, autoimmunity, or to improve outcomes in transplantation. While immunomodulatory small-mol. compounds and antibodies have provided relief for some patients, the dosing entails high systemic drug exposures and thus increased risk of off-target adverse effects. More recently, MRC-based cell-therapy products have entered clin. testing for tolerance induction. However, the elaborate and expensive protocols currently required to manufacture engineered MRCs ex vivo put this approach beyond the reach of many patients who might benefit. A solution could be to directly program MRCs in vivo. Here we describe a targeted nanocarrier that delivers in vitro-transcribed mRNA encoding a key anti-inflammatory mediator. We demonstrate in models of systemic lupus erythematosus that infusions of nanoparticles formulated with mRNA encoding glucocorticoid-induced leucine zipper (GILZ) effectively control the disease. We further establish that these nanoreagents are safe for repeated dosing. Implemented in the clinic, this new therapy could enable physicians to treat autoimmune disease while avoiding systemic treatments that disrupt immune homeostasis. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karlsson, Johan; Tzeng, Stephany Y.; Hemmati, Shayan; Luly, Kathryn M.; Choi, Olivia; Rui, Yuan; Wilson, David R.; Kozielski, Kristen L.; Quinones-Hinojosa, Alfredo; Green, Jordan J. published an article in 2021. The article was titled 《Photocrosslinked Bioreducible Polymeric Nanoparticles for Enhanced Systemic siRNA Delivery as Cancer Therapy》, and you may find the article in Advanced Functional Materials.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

Clin. translation of polymer-based nanocarriers for systemic delivery of RNA has been limited due to poor colloidal stability in the blood stream and intracellular delivery of the RNA to the cytosol. To address these limitations, this study reports a new strategy incorporating photocrosslinking of bioreducible nanoparticles for improved stability extracellularly and rapid release of RNA intracellularly. In this design, the polymeric nanocarriers contain ester bonds for hydrolytic degradation and disulfide bonds for environmentally triggered small interfering RNA (siRNA) release in the cytosol. These photocrosslinked bioreducible nanoparticles (XbNPs) have a shielded surface charge, reduced adsorption of serum proteins, and enable superior siRNA-mediated knockdown in both glioma and melanoma cells in high-serum conditions compared to non-crosslinked formulations. Mechanistically, XbNPs promote cellular uptake and the presence of secondary and tertiary amines enables efficient endosomal escape. Following systemic administration, XbNPs facilitate targeting of cancer cells and tissue-mediated siRNA delivery beyond the liver, unlike conventional nanoparticle-based delivery. These attributes of XbNPs facilitate robust siRNA-mediated knockdown in vivo in melanoma tumors colonized in the lungs following systemic administration. Thus, biodegradable polymeric nanoparticles, via photocrosslinking, demonstrate extended colloidal stability and efficient delivery of RNA therapeutics under physiol. conditions, and thereby potentially advance systemic delivery technologies for nucleic acid-based therapeutics.4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Topical N-palmitoyl serinol, a commensal bacterial metabolite, prevents the development of epidermal permeability barrier dysfunction in a murine model of atopic dermatitis-like skin》 was written by Wen, Si; Ye, Li; Liu, Dan; Bin Yang; Man, Mao-Qiang. HPLC of Formula: 534-03-2 And the article was included in Canadian Journal of Veterinary Research in 2021. The article conveys some information:

Recent studies have demonstrated that commensal bacterial metabolites benefit human health. Because of the crucial role of the epidermal permeability barrier in cutaneous and extracutaneous function, we assessed whether the topical applications of N-palmitoyl serinol (NPS) would improve the epidermal permeability barrier in murine skin. Our results show that the topical application of 0.5% NPS in ethanol twice daily for 1 wk lowered basal transepidermal water loss rates and accelerated barrier recovery in normal mice. Moreover, topical NPS prevented the emergence of epidermal permeability barrier dysfunction in a murine model of allergic contact dermatitis. These results suggest that topical NPS could be used to prevent or treat skin disorders characterized by inflammation and an abnormal epidermal permeability barrier. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 534-03-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《DNA-Targeted NO Release Photoregulated by Green Light》 was written by Parisi, Cristina; Fraix, Aurore; Guglielmo, Stefano; Spyrakis, Francesca; Rolando, Barbara; Lazzarato, Loretta; Fruttero, Roberta; Gasco, Alberto; Sortino, Salvatore. COA of Formula: C3H9NO And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

A novel mol. hybrid has been designed and synthesized in which acridine orange (AO) is covalently linked to an N-nitrosoaniline derivative through an alkyl spacer. Photoexcitation of the AO antenna with the highly biocompatible green light results in intense fluorescence emission and triggers NO detachment from the N-nitroso appendage via an intramol. electron transfer. The presence of the AO moiety encourages the binding with DNA through both external and partially intercalative fashions, depending on the DNA:mol. hybrid molar ratio. Importantly, this dual-mode binding interaction with the biopolymer does not preclude the NO photoreleasing performances of the mol. hybrid, permitting NO to be photogenerated nearby DNA with an efficiency similar to that of the free mol. These properties make the presented compound an intriguing candidate for fundamental and potential applicative research studies where NO delivery in the DNA proximity precisely regulated by harmless green light is required. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6COA of Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Mn(IV), Co(II) and Ni(II) complexes of the Schiff bases of 2-hydroxy-naphthaldehyde with amino alcohols: synthesis, characterization and electrochemical study; DFT study and Catecholase activity of Mn(IV) complex》 was written by Sagar, Shipra; Parween, Arfa; Mandal, Tarun K.; Lewis, William; Naskar, Subhendu. Recommanded Product: 3-Aminopropan-1-ol And the article was included in Journal of Coordination Chemistry in 2020. The article conveys some information:

Four new mononuclear complexes, [MnIV(L1)2] (1), [CoII(HL1)2] (2), [NiII(HL1)2] (3), and [NiII(HL2)2] (4), with ligands H2L1 = (2-hydroxyethylimino)methylnaphthol and H2L2 = (3-hydroxypropylimino)methylnaphthol have been synthesized, characterized, and their catecholase activities have been studied. Single-crystal x-ray diffraction study shows that 1 crystallizes in P43212 space group and adopts an octahedral geometry in meridional fashion, whereas 4 with a square planar geometry crystallizes in P21/n space group. The catecholase activity has been investigated in acetonitrile by UV-Vis spectrophotometric technique. The kinetic study revealed that 1 has a moderate catecholase activity (kcat = 812 h-1), whereas 2-4 are inactive. Electronic structure of 1 and 4 has been established by theor. calculation Structures of both complexes have been optimized by DFT. Exptl. electronic spectra of the complexes have been corroborated by TD-DFT anal. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Recommanded Product: 3-Aminopropan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts