Tag: 0-100

HPLC of Formula: 7748-36-9In 2021 ,《Copper-catalyzed ortho-selective direct sulfenylation of N-aryl-7-azaindoles with disulfides》 was published in Organic & Biomolecular Chemistry. The article was written by Yu, Ru-Jian; Zhang, Chun-Yan; Xiang, Zhou; Xiong, Yan-Shi; Duan, Xue-Min. The article contains the following contents:

A copper-catalyzed direct C-H chalcogenation of N-aryl-azaindoles I (R = H, Me, Cl, etc.; R1 = H, Me, OMe, CF3; R2 = CH or N) with disulfides R3SSR3 (R3 = Ph, thiophen-2-yl, Pr, cyclohexyl, etc.), 1-thiophen-2-yl-1H-pyrrolo[2,3-b]pyridine is described. This transformation was performed using Earth abundant Cu(OAc)2 as a catalyst, benzoic acid as an additive, air as a terminal oxidant, and readily available diaryl and dialkyldisulfides (or (phenyldiselanyl)benzene) as chalcogenation reagents. High functional group tolerance and excellent regioselectivity are demonstrated by the efficient preparation of a wide range of ortho-sulfenylation-7-azaindoles II (X = S or Se), 1-(3-(phenylthio)thiophen-2-yl)-1H-pyrrolo[2,3-b]pyridine. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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Epifanov, Maxim; Mo, Jia Yi; Dubois, Rudy; Yu, Hao; Sammis, Glenn M. published their research in Journal of Organic Chemistry in 2021. The article was titled 《One-Pot Deoxygenation and Substitution of Alcohols Mediated by Sulfuryl Fluoride》.HPLC of Formula: 13325-10-5 The article contains the following contents:

Herein, the SO2F2-mediated alc. substitution and deoxygenation method that relies on the conversion of fluorosulfates to alkyl halide intermediates was reported. This strategy allows the expansion of SO2F2-mediated one-pot processes to include radical reactions, where the alkyl halides was exploited in the one-pot deoxygenation of primary alcs. under mild conditions (52-95% yield). This strategy enhanced the scope of substitutions to nucleophiles that are previously incompatible with one-pot SO2F2-mediated alc. activation and enables substitution of primary and secondary alcs. in 54-95% yield. Chiral secondary alcs. underwent a highly stereospecific (90-98% ee) double nucleophilic displacement with an overall retention of configuration.4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

《Effects of Branching Strategy on the Gene Transfection of Highly Branched Poly(β-amino ester)s》 was written by Wang, Yao; Wang, Chen-Fei; Lie, Ming; Zhou, De-Zhong; Huang, Wei; Wang, Wen-Xin. Reference of 4-Aminobutan-1-ol And the article was included in Chinese Journal of Polymer Science in 2020. The article conveys some information:

Abstract: Highly branched poly(β-amino ester)s (HPAEs) have emerged as one type of the most viable non-viral gene delivery vectors, both in vitro and in vivo. However, the effects of different branching strategies on the gene transfection performance have not yet been explored. Here, using triacrylate (B3) and diamine (B4) as the branching monomers, a series of HPAEs were synthesized via the “”A2 + B3 + C2″” and “”A2 + B4 + C2″” strategies, resp. Results show that the branching strategy plays a pivotal role in dictating the physiol. properties of the HPAE/DNA polyplexes and thus leads to obviously different cell viability and transfection efficiency. Comparatively, HPAEs synthesized via the “”A2 + B3 + C2″” branching strategy are more favorable for DNA transfection than that synthesized via the “”A2 + B4 + C2″” strategy. This study may provide new insights into the development of HPAEs based non-viral DNA delivery system. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Reference of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Reference of 4-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
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《Inverse Thermogelation of Aqueous Triblock Copolymer Solutions into Macroporous Shear-Thinning 3D Printable Inks》 was written by Hahn, Lukas; Maier, Matthias; Stahlhut, Philipp; Beudert, Matthias; Flegler, Vanessa; Forster, Stefan; Altmann, Alexander; Toeppke, Fabian; Fischer, Karl; Seiffert, Sebastian; Boettcher, Bettina; Luehmann, Tessa; Luxenhofer, Robert. HPLC of Formula: 156-87-6 And the article was included in ACS Applied Materials & Interfaces in 2020. The article conveys some information:

Amphiphilic block copolymers that undergo (reversible) phys. gelation in aqueous media are of great interest in different areas including drug delivery, tissue engineering, regenerative medicine, and biofabrication. We investigated a small library of ABA-type triblock copolymers comprising poly(2-methyl-2-oxazoline) as the hydrophilic shell A and different aromatic poly(2-oxazoline)s and poly(2-oxazine)s cores B in an aqueous solution at different concentrations and temperatures Interestingly, aqueous solutions of poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazine)-block-poly(2-methyl-2-oxazoline) (PMeOx-b-PPheOzi-b-PMeOx) undergo inverse thermogelation below a critical temperature by forming a reversible nanoscale wormlike network. The viscoelastic properties of the resulting gel can be conveniently tailored by the concentration and the polymer composition Storage moduli of up to 110 kPa could be obtained while the material retains shear-thinning and rapid self-healing properties. We demonstrate three-dimensional (3D) printing of excellently defined and shape-persistent 24-layered scaffolds at different aqueous concentrations to highlight its application potential, e.g., in the research area of biofabrication. A macroporous microstructure, which is stable throughout the printing process, could be confirmed via cryo-SEM anal. The absence of cytotoxicity even at very high concentrations opens a wide range of different applications for this first-in-class material in the field of biomaterials. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6HPLC of Formula: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.HPLC of Formula: 156-87-6

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《Synthesis and Antitumor Activity of 2-[3-(2-Chloroethyl)-3-Nitrosoureido]-1,3-Propanediol (Chlonisol)》 was published in Pharmaceutical Chemistry Journal in 2020. These research results belong to Stukov, A. N.; Esikov, K. A.; Usmanova, L. M.; Kharitonova, N. N.; Vershinina, S. F.; Zmitrichenko, Yu. G.; Filatova, L. V.; Latipova, D. Kh.; Semenov, A. L.; Bespalov, V. G.; Semiglazova, T. Yu.. SDS of cas: 534-03-2 The article mentions the following:

The reaction of 2-chloroethylisocyanate and 2-amino-1,3-propanediol in MeCN-MeOH yielded 2-[3-(2-chloroethyl) ureido]-1,3-propanediol, which was nitrosated using sodium nitrite in 50% formic acid to obtain 2-[3-(2-chloroethyl)-3-nitrosoureido]-1,3-propanediol (chlonisol). A single administration of chlonisol at a non-toxic dose of 15 mg/kg increased by 170% the median life expectancy of mice with P-388 leukemia and cured 100% of rats with Walker 256 carcinosarcoma. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2SDS of cas: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.SDS of cas: 534-03-2

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The author of 《Reducible Branched Ester-Amine Quadpolymers (rBEAQs) Codelivering Plasmid DNA and RNA Oligonucleotides Enable CRISPR/Cas9 Genome Editing》 were Rui, Yuan; Wilson, David R.; Sanders, Katie; Green, Jordan J.. And the article was published in ACS Applied Materials & Interfaces in 2019. HPLC of Formula: 13325-10-5 The author mentioned the following in the article:

Functional co-delivery of plasmid DNA and RNA oligonucleotides in the same nanoparticle system is challenging due to differences in their phys. properties as well as their intracellular locations of function. In this study, we synthesized a series of reducible branched ester-amine quadpolymers (rBEAQs) and investigated their ability to co-encapsulate and deliver DNA plasmids and RNA oligos. The rBEAQs are designed to leverage polymer branching, reducibility, and hydrophobicity to successfully co-complex DNA and RNA in nanoparticles at low polymer to nucleic acid weight/weight ratios and enable high delivery efficiency. We validate the synthesis of this new class of biodegradable polymers, characterize the self-assembled nanoparticles that these polymers form with diverse nucleic acids, and demonstrate that the nanoparticles enable safe, effective, and efficient DNA-siRNA co-delivery as well as non-viral CRISPR-mediated gene editing utilizing Cas9 DNA and sgRNA co-delivery. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2022,Zhang, Dian; Kanezashi, Masakoto; Tsuru, Toshinori; Yamamoto, Kazuki; Gunji, Takahiro; Adachi, Yohei; Ohshita, Joji published an article in ACS Applied Materials & Interfaces. The title of the article was 《Development of Highly Water-Permeable Robust PSQ-Based RO Membranes by Introducing Hydroxyethylurea-Based Hydrophilic Water Channels》.Product Details of 534-03-2 The author mentioned the following in the article:

Copolymerization of bis[3-(triethoxysilyl)propyl]amine (BTESPA) and N-(2-hydroxyethyl)-N’-[3-(triethoxysilyl)propyl]urea (HETESPU) provided highly permeable robust reverse osmosis (RO) membranes that have an organically bridged polysilsesquioxane (PSQ) structure. The RO experiments with NaCl aqueous solution (2000 ppm) indicated that the introduction of hydroxyethylurea groups markedly improved the permeability of water (1.86 × 10-12 m3/m2sPa) to approx. 19 times higher than that of a membrane prepared via the BTESPA homopolymerization, with NaCl rejection remaining nearly unchanged (96%). This is the highest water permeability obtained so far for PSQ-based membranes that show higher than 90% NaCl rejection. The improvement of water permeability is likely due to aggregation through hydrogen bonding in the PSQ layer, which can be regarded as a hydrophilic water channel.2-Aminopropane-1,3-diol(cas: 534-03-2Product Details of 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 534-03-2

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In 2022,Hwang, Jimin; Qiu, Xiaqiu; Borgelt, Lydia; Haacke, Neele; Kanis, Laurin; Petroulia, Stavroula; Gasper, Raphael; Schiller, Damian; Lampe, Philipp; Sievers, Sonja; Imig, Jochen; Wu, Peng published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Synthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents》.Application In Synthesis of Oxetan-3-ol The author mentioned the following in the article:

Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ubale, Akash S.; Shaikh, Moseen A.; Gnanaprakasam, Boopathy published an article in 2021. The article was titled 《Sequential Oxidative-Fragmentation and Skeletal Rearrangement of Peroxides for the Synthesis of Quinazolinone Derivatives》, and you may find the article in Journal of Organic Chemistry.SDS of cas: 13325-10-5 The information in the text is summarized as follows:

For the first time, sequential reaction of peroxyindole that involves base promoted oxidative-fragmentation to isocyanate formation and primary amine or amino alcs. accelerated skeletal rearrangement to synthesize exo-olefinic substituted quinazolinone or oxazoloquinazolinone was reported. Advantage of this new reaction includes broad substrate scope, transition-metal-free and room temperature condition. The formation of the isocyanate as a key intermediate that accelerate oxidative-skeletal rearrangement was confirmed by trapping experiments and the spectroscopic evidence.4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Yi; Li, LinZhu; Yuan, WeiQiong; Hu, JianZhong; Lv, ZhaoLin published an article in 2021. The article was titled 《Application of GC × GC coupled with TOF-MS for the trace analysis of chemical components and exploration the characteristic aroma profile of essential oils obtained from two tree peony species (Paeonia rockii and Paeonia ostii)》, and you may find the article in European Food Research and Technology.Product Details of 13325-10-5 The information in the text is summarized as follows:

Tree peony essential oil (EO) is a critical material for flavor and function in the industrial fields of perfume, medicine and food. To conduct an overall anal. of different varieties of tree peony EOs, the composition, aroma characteristics and antioxidant activity of ZiBan and FengDan EOs were analyzed by two-dimensional gas chromatog. and time-of-flight mass spectrometry (GC × GC-TOF/MS) and the odor activity value (OAV). A total of 151 and 123 compounds were identified in ZiBan and FengDan EOs, resp., in which ZiBan EO was characterized by alc., alkane and acid, and FengDan EO was represented by aldehyde, alc. and terpene. Nevertheless, there were great differences in the content of coexisting substances in the two kinds of EOs. The aroma result indicated that the characteristic aroma and intensity of the two kinds of tree peony EOs were completely different; the aroma of ZiBan EO was mainly composed of fruity and floral aromas, whereas that of FengDan EO primarily consisted of fruity, fatty, grass and floral odors. The antioxidant activities of ZiBan EO was better than that of FengDan EO. The total antioxidant activities of ZiBan and FengDan EOs were found to be 0.020 mg Vc/mL EO and 0.003 mg Vc/mL EO, while the DPPH radical scavenging abilities of ZiBan and FengDan EOs were 24.77% and 21.60%, resp.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts