Tag: 0-100

In 2022,Wozny, M.; Trzybinski, D.; Dabrowa, K.; Narodowiec, J.; Wozniak, K. published an article in Organic & Biomolecular Chemistry. The title of the article was 《Monosulfonated dibenzo-24-crown-8 and its properties》.SDS of cas: 13325-10-5 The author mentioned the following in the article:

Authors describe a method for preparing a monosulfonated dibenzo-24-crown-8 ether, SDB24C8, by direct sulfonation of the parent crown (DB24C8). Since neutral DB24C8 readily interacts with cationic guests, permanently charged SDB24C8 is an advantageous candidate for future supramol. applications. SDB24C8 can be isolated as a sulfonic acid to be used as it is or converted to a salt of choice. The crystallog. anal. provides the first known host-guest assembly with a DB24C8-based scaffold complexing hydronium and potassium cations. Supramol. studies of the interactions of this anionic macrocycle with alkali cations were also performed. According to the expectations, the introduction of the sulfonic group into the DB24C8 scaffold increases the affinities of the receptor. An unusual selectivity of SDB24C8 towards a sodium cation was also observed and further studied with DFT calculations In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5SDS of cas: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.SDS of cas: 13325-10-5

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Li, Kaiqi; Liu, Xiliang; Chen, Long; Xiong, Zuochun; Xiong, Chengdong; Chen, Dongliang published an article in 2022. The article was titled 《Synthesis of new aliphatic poly(ester-carbonate)s bearing amino groups based on photolabile protecting group and evaluation of antibacterial property》, and you may find the article in Polymers for Advanced Technologies.Reference of 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

Amino-functionalized six-membered cyclic carbonate 5-((2-nitrobenzyl) amino)-1,3-dioxan-2-one (NBAC) was synthesized with 2-nitrobenzyl group as photolabile protecting group. The following copolymerization was carried out by using L-lactide as comonomer and Sn (Oct)2 as catalyst. The amino-functionalized polymer P(LA-co-AC) was obtained by UV irradiation of P(LA-co-NBAC) to remove the protecting group. The structures of products were confirmed by 1H NMR and 13C NMR anal. The pendant amino groups not only resulted in an enhancement of the hydrophilicity, but also played a role of antibacterial effect due to the pos. charge imparted to the material. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Reference of 2-Aminopropane-1,3-diol

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Liu, Fuqiang; Ma, Nan; Liu, Jun; Zhu, Qiongqiong; Yue, Ting; Ma, Junhui; Wang, Yuan; Qu, Wei; Chu, Paul K.; Tang, Yan; Zhang, Wei published an article in 2021. The article was titled 《A cationic alternating copolymer composed of ornithine and glycine with an ordered sequence for enhanced bacterial activity》, and you may find the article in Polymer Engineering & Science.Related Products of 13325-10-5 The information in the text is summarized as follows:

The chains and segments of unordered cationic polypeptides are complex and may produce unexpected biol. activities. Herein, the Ugi’s 4CC reaction is adopted to synthesize a cationic alternating copolymer comprising ornithine and glycine (poly(Orn-alter-Gly)) with an ordered sequence for enhanced bacterial resistance. In this technique, potassium isocyanate, 4-(N-carbobenzyloxyamino)-1-butyraldehyde and 1-(4-Methoxyphenyl)ethylamine react to produce MPE-substituted poly(Orn-alter-Gly) in one step without using a catalyst and then poly(Orn-alter-Gly) is obtained by removing the N-(1-p-methoxyphenethyl) (MPE) group. 1H NMR, Fourier transform IR spectroscopy, and automatic amino acid anal. confirm that ornithine and glycine are linked alternately in the poly(Orn-alter-Gly) chains. Both MPE-substituted poly(Orn-alter-Gly) and poly(Orn-alter-Gly) have excellent antibacterial activity against Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa as well as excellent biocompatibility. The synthesis strategy and materials provide new information on how to obtain ordered sequence cationic polypeptides. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Related Products of 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Related Products of 13325-10-5

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In 2019,Nature (London, United Kingdom) included an article by Meng, Genyi; Guo, Taijie; Ma, Tiancheng; Zhang, Jiong; Shen, Yucheng; Sharpless, Karl Barry; Dong, Jiajia. Electric Literature of C4H11NO. The article was titled 《Modular click chemistry libraries for functional screens using a diazotizing reagent》. The information in the text is summarized as follows:

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Electric Literature of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Electric Literature of C4H11NO

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《Synthesis of the C50 diastereomers of the C33-C51 fragment of stambomycin D》 was published in Organic Chemistry Frontiers in 2022. These research results belong to Wang, Yongchen; Chintalapudi, Venkaiah; Gudmundsson, Haraldur G.; Challis, Gregory L.; Anderson, Edward A.. Formula: C3H6O2 The article mentions the following:

Herein, syntheses of the two C50 diastereomers of the C33-C51 region of the stambomycins I and II, which support the polyketide synthase-based configurational assignment were described, and established a strategy suitable for access to the extended stambomycin framework. The experimental part of the paper was very detailed, including the reaction process of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Formula: C3H6O2)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Formula: C3H6O2

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《Probing the Edges between Stability and Degradation of a Series of ZnSe-Based Layered Hybrid Semiconductors》 was written by Yan, Mengwen; Myers, Christopher A.; John, Gregory M.; Meyers, Vincent E.; Chen, Alan A.; Feldblyum, Jeremy I.. Name: 4-Aminobutan-1-olThis research focused onzinc selenium layered hybrid semiconductor degradation density functional theory. The article conveys some information:

The discovery of layered materials with potentially unique elec. and chem. properties has become a major focus of materials research in the past decade. 2D II-VI layered hybrids (LHs) are a family of ligand-protected layered materials capable of isolation in few-layer form and possess emissive and electronic properties of potential relevance to semiconductor device technologies. The authors showed previously that, akin to black phosphorus and transition metal dichalcogenides, 2D II-VI LHs are sensitive to ambient atm. conditions. However, the causes for degradation of these ligand-protected materials remain unclear. Using ZnSe-based LHs, it is shown herein that the stability of these materials is related to the length and chem. of the organic ligands coordinated to the LH surfaces. Furthermore, exposure to isotopically enriched H218O and 18O2 reveals that H2O and O2 are both reactants contributing to ZnSe-LH degradation An H2O-initiated degradation pathway is proposed and is supported by d. functional theory calculations The findings contribute to the discovery of protection strategies for layered materials and elucidate a degradation pathway that may also be applicable to other layered materials.4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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《Trifluoromethylselenolation and N-acylation of indoles with [Me4N][SeCF3]》 was written by Tan, Kai-Li; Wang, Hao-Nan; Dong, Tao; Zhang, Cheng-Pan. Name: Oxetan-3-ol And the article was included in Organic & Biomolecular Chemistry in 2021. The article conveys some information:

An efficient method for oxidative trifluoromethylselenolation/N-acylation of indoles with excess [Me4N][SeCF3] in the presence of acyl peroxides and their derivatives is described. The reaction is easy to handle, proceeds smoothly at room temperature under metal-free conditions, and shows advantages such as good functional group tolerance, excellent regioselectivity, and compatibility of a number of substrates, producing 1-acyl and 3-trifluoromethylselanyl substituted indoles I (R1 = H, 5-CN, 4-Cl, etc.; R2 = H, Me; Ar = Ph, 3-ClC6H4, 4-FC6H4, etc.) in good yields. Acyl peroxides and peroxycarboxylic acid behave as both oxidants and acyl sources in the transformation. This one-pot procedure provides a convenient access to a new class of indole derivatives, representing the first trifluoromethylselanyl bifunctionalization of indoles with the nucleophilic [Me4N][SeCF3] reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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《Understanding the molecular origin of shear thinning in associative polymers through quantification of bond dissociation under shear》 was written by Mahmad Rasid, Irina; Ramirez, Jorge; Olsen, Bradley D.; Holten-Andersen, Niels. Application In Synthesis of 3-Aminopropan-1-ol And the article was included in Physical Review Materials in 2020. The article conveys some information:

Understanding the physics of associative polymers is often limited by our inability to directly measure bond dissociation under deformation. In this work, we developed a rheo-fluorescence technique and applied it to characterize the nonlinear shear response of linear side-functionalized polymer chains crosslinked via nickel-terpyridine complexation. As the network was sheared, the fraction of dissociated bonds was quant. measured based upon a change in fluorescence with metal dissociation Shear thinning of the gel was accompanied by only a small increase in the fraction of dissociated bonds. Comparison with several transient network models shows that the shear thinning within the constraint of the measured fraction of dissociated bonds cannot be explained by classical theories that include retraction of dangling chains alone; the rheol. response likely involves alternative modes of stress relaxation. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Application In Synthesis of 3-Aminopropan-1-ol

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《Photosensitized Intramolecular [2+2] Cycloaddition of 1H-Pyrrolo[2,3-b]pyridines Enabled by the Assistance of Lewis Acids》 was published in Journal of Organic Chemistry in 2020. These research results belong to Arai, Noriyoshi; Ohkuma, Takeshi. Recommanded Product: 7748-36-9 The article mentions the following:

The [2+2] photocycloaddition of alkenyl-tethered 1H-pyrrolo[2,3-b]pyridine derivatives sensitized with 3′,4′-dimethoxyacetophenone under irradiation by a high-pressure mercury lamp through Pyrex glass was dramatically accelerated by the addition of Lewis acids, preferably Mg(OTf)2, to give the products stereoselectively in high yields. The reaction without a Lewis acid gave only small amounts of the [2+2] cycloaddition products. Conformational fixation of the substrates by coordination with a Lewis acid was presumed to facilitate the cycloaddition In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Detection and phase I metabolism of the 7-azaindole-derived synthetic cannabinoid 5F-AB-P7AICA including a preliminary pharmacokinetic evaluation》 was published in Drug Testing and Analysis in 2020. These research results belong to Giorgetti, Arianna; Mogler, Lukas; Haschimi, Belal; Halter, Sebastian; Franz, Florian; Westphal, Folker; Fischmann, Svenja; Riedel, Jan; Putz, Michael; Auwarter, Volker. Recommanded Product: 7748-36-9 The article mentions the following:

In June 2018, a ′research chemica′l labeled ′AB-FUB7AICA′ was purchased online and anal. identified as 5F-AB-P7AICA, the 7-azaindole analog of 5F-AB-PINACA. Here we present data on structural characterization, suitable urinary consumption markers, and preliminary pharmacokinetic data. Structure characterization was performed by NMR spectroscopy, gas chromatog.-mass spectrometry, IR and Raman spectroscopy. Phase I metabolites were generated by applying a pooled human liver microsome assay (pHLM) to confirm the anal. results of authentic urine samples collected after oral self-administration of 2.5 mg 5F-AB-P7AICA. Analyses of pHLM and urine samples were performed by liquid chromatog.-time-of-flight mass spectrometry and liquid chromatog.-tandem mass spectrometry (LC-MS/MS). An LC-MS/MS method for the quantification of 5F-AB-P7AICA in serum was validated. Ten phase I metabolites were detected in human urine samples and confirmed in vitro. The main metabolites were formed by hydroxylation, amide hydrolysis, and hydrolytic defluorination, though – in contrast with most other synthetic cannabinoids – the parent compound showed the highest signals in most urine samples. The compound detection window was more than 45 h in serum. The concentration-time profile was best explained by a two-phase pharmacokinetic model. 5F-AB-P7AICA was detected in urine samples until 65 h post ingestion. Monitoring of metabolite M07, hydroxylated at the alkyl chain, next to parent 5F-AB-P7AICA, is recommended to confirm the uptake of 5F-AB-P7AICA in urinalysis. It seems plausible that the shift of the nitrogen atom from position 2 to 7 (e.g. 5F-AB-PINACA to 5F-AB-P7AICA) leads to a lower metabolic reactivity, which might be of general interest in medicinal chem. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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