Tag: 0-100

In 2019,Biomaterials Science included an article by Vasey, Catherine E.; Pearce, Amanda K.; Sodano, Federica; Cavanagh, Robert; Abelha, Thais; Cuzzucoli Crucitti, Valentina; Anane-Adjei, Akosua B.; Ashford, Marianne; Gellert, Paul; Taresco, Vincenzo; Alexander, Cameron. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Amphiphilic tri- and tetra-block co-polymers combining versatile functionality with facile assembly into cytocompatible nanoparticles》. The information in the text is summarized as follows:

Here we describe the syntheses of amphiphilic tri- and tetra-block copolymers, using diazabicyclo[5.4.0]undec-5-ene (DBU) as a metal-free catalyst for ring-opening polymerizations of the widely-utilized monomer lactide combined with a functionalised protected cyclic carbonate. These syntheses employed PEGylated macroinitiators with varying chain lengths and architectures, as well as a labile-ester methacrylate initiator, and produced block copolymers with good control over monomer incorporation, molar masses, side-chain and terminal functionality and physico-chem. properties. Regardless of the nature of the initiators, the fidelity of the hydroxyl end group was maintained as confirmed by a second ROP chain extension step, and polymers with acryloyl/methacryloyl termini were able to undergo a second tandem reaction step, in particular thiol-ene click and RAFT polymerizations for the production of hyperbranched materials. Furthermore, the polymer side-chain functionalities could be easily deprotected to yield an active amine which could be subsequently coupled to a drug mol. in good yields. The resultant amphiphilic copolymers formed a range of unimol. or kinetically-trapped micellar-like nanoparticles in aqueous environments, and the non-cationic polymers were all well-tolerated by MCF-7 breast cancer cells. The rapid and facile route to such highly adaptable polymers, as demonstrated here, offers promise for a range of bio materials applications. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Reference of 2-Aminopropane-1,3-diol

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In 2019,Polymers (Basel, Switzerland) included an article by Li, Botian; Shao, Wei; Wang, Yanzan; Xiao, Da; Xiong, Yi; Ye, Haimu; Zhou, Qiong; Jin, Qingjun. Reference of 2-Aminopropane-1,3-diol. The article was titled 《Synthesis and morphological control of biocompatible fluorescent/magnetic janus nanoparticles based on the self-assembly of fluorescent polyurethane and Fe3O4 nanoparticles》. The information in the text is summarized as follows:

Functionalized Janus nanoparticles have received increasing interest due to their anisotropic shape and the particular utility in biomedicine areas. In this work, a simple and efficient method was developed to prepare fluorescent/magnetic composite Janus nanoparticles constituted of fluorescent polyurethane and hydrophobic nano Fe3O4. Two kinds of fluorescent polyurethane prepolymers were synthesized by the copolymerization of fluorescent dye monomers, and the fluorescent/magnetic nanoparticles were fabricated in one-pot via the process of mini-emulsification and self-assembly. The nanostructures of the resulting composite nanoparticles, including core/shell and Janus structure, could be controlled by the phase separation in assembly process according to the result of transmission electron microscopy, whereas the amount of the nonpolar segments of polyurethane played an important role in the particle morphol. The prominent magnetic and fluorescent properties of the Janus nanoparticles were also confirmed by vibrating magnetometer and confocal laser scanning microscope. Furthermore, the Janus nanoparticles featured excellent dispersity, storage stability, and cytocompatibility, which might benefit their potential application in biomedical areas. The experimental process involved the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Reference of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Reference of 2-Aminopropane-1,3-diol

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In 2019,Polymer International included an article by Qiao, Zhuangzhuang; Xu, Deqiu; Yao, Yan; Song, Shaomin; Yin, Meihui; Luo, Jianbin. Recommanded Product: 534-03-2. The article was titled 《Synthesis and antifouling activities of fluorinated polyurethanes》. The information in the text is summarized as follows:

A series of fluorinated polyurethanes (FPUs) with various contents of fluorinated chain extender (EF) and the same amount of poly(oxytetramethylene glycol) and diphenylmethanediisocyanate were synthesized to explore the relationship between the surface physicochem. properties and bulk microphase separation structures of these FPUs and their antifouling activities against model bacteria and platelets. The bulk microphase separation of FPUs increased with the amount of incorporated EF. It was found that the surfaces of all FPUs were saturated by a layer of fluorocarbon chains which resulted in similar chem. composition and wetting activities for the three kinds of FPUs. The FPUs with lower or similar microphase separation compared with non-fluorinated polyurethane chain-extended with 1,4-butanediol showed similar or even increased adhesion of bacteria and platelets. Notably, FPU with a higher degree of microphase separation than non-fluorinated polyurethane displayed excellent antifouling activities against both model bacteria and blood platelets. It is therefore concluded that the increased microphase separation of the FPUs results in enhanced antifouling properties. © 2019 Society of Chem. Industry. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Recommanded Product: 534-03-2

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COA of Formula: C3H9NO2In 2019 ,《Light-Responsive Serinol-Based Polycarbonate and Polyester as Degradable Scaffolds》 was published in ACS Applied Bio Materials. The article was written by Sun, Jingjiang; Jung, Dimitri; Schoppa, Timo; Anderski, Juliane; Picker, Marie-Theres; Ren, Yi; Mulac, Dennis; Stein, Nora; Langer, Klaus; Kuckling, Dirk. The article contains the following contents:

Stimuli-responsive self-immolative aliphatic polycarbonates (APCs) and polyesters (APEs) have attractive advantages for biomedical and pharmaceutical applications. In the present work, polycondensation of o-nitrobenzyl-protected serinol was explored as a simple route to obtain light-responsive polycarbonate (LrPC) and polyester (LrPE). By exposure to UV light, these polymers decomposed rapidly and completely into oligomers and small mols., as detected by size exclusion chromatog. (SEC), UV/vis, and 1H NMR spectroscopies. The degradation mechanism of serinol-based APC and APE was investigated with the help of the Boc-protected model APC and APE, showing that the APC underwent intramol. cyclization, accompanied by intermol. transcarbamation, and degraded into oxazolidinone and 2-aminopropanol terminated oligourethanes. Different from APC, the degradation process of serinol-based APE has been proven by electrospray ionization time-of-flight mass spectrometry (ESI-ToF-MS) to follow intramol. cyclization of the functional amine group with the remote ester group, forming a ten-membered cyclic degradation compound Further processing of the serinol-based polymers was performed by preparation of nanoparticles (NP). With light-responsive characteristics, a drug delivery system could be potentially obtained enabling a controllable drug release. Based on this strategy, a variety of self-immolative polymers responsive to different triggers can be prepared by polycondensation without the limit of ring-opening polymerization and will expand the family of biodegradable polymers. In the experiment, the researchers used many compounds, for example, 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.COA of Formula: C3H9NO2

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Recommanded Product: Oxetan-3-olIn 2021 ,《Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues》 appeared in Nature Communications. The author of the article were Kastan, Nathaniel; Gnedeva, Ksenia; Alisch, Theresa; Petelski, Aleksandra A.; Huggins, David J.; Chiaravalli, Jeanne; Aharanov, Alla; Shakked, Avraham; Tzahor, Eldad; Nagiel, Aaron; Segil, Neil; Hudspeth, A. J.. The article conveys some information:

Hippo signaling is an evolutionarily conserved pathway that restricts growth and regeneration predominantly by suppressing the activity of the transcriptional coactivator Yap. Using a high-throughput phenotypic screen, we identified a potent and non-toxic activator of Yap. In vitro kinase assays show that the compound acts as an ATP-competitive inhibitor of Lats kinases-the core enzymes in Hippo signaling. The substance prevents Yap phosphorylation and induces proliferation of supporting cells in the murine inner ear, murine cardiomyocytes, and human Muller glia in retinal organoids. The RNA sequencing indicates that the inhibitor reversibly activates the expression of transcriptional Yap targets: upon withdrawal, a subset of supporting-cell progeny exits the cell cycle and upregulates genes characteristic of sensory hair cells. Our results suggest that the pharmacol. inhibition of Lats kinases may promote initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the adult mammalian inner ear. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

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In 2022,Iqbal, Sajid; Martins, Alessandro F.; Sohail, Muhammad; Zhao, Jingjing; Deng, Qi; Li, Muhan; Zhao, Zhongxi published an article in Frontiers in Pharmacology. The title of the article was 《Synthesis and characterization of poly (β-amino Ester) and applied PEGylated and non-PEGylated poly (β-amino ester)/plasmid DNA nanoparticles for efficient gene delivery》.Quality Control of 4-Aminobutan-1-ol The author mentioned the following in the article:

Polymer-based nanocarriers require extensive knowledge of their chemistries to learn functionalization strategies and understand the nature of interactions that they establish with biol. entities. In this research, the poly (ss-amino ester) (PβAE-447) was synthesized and characterized, aimed to identify the influence of some key parameters in the formulation process. Initially; PβAE-447 was characterized for aqueous solubility, swelling capacity, proton buffering ability, and cytotoxicity study before nanoparticles formulation. Interestingly, the polymer-supported higher cell viability than the Polyethylenimine (PEI) at 100 μg/mL. PβAE-447 complexed with GFP encoded plasmid DNA (pGFP) generated nanocarriers of 184 nm hydrodynamic radius (+7.42 mV Zeta potential) for cell transfection. Transfection assays performed with PEGylated and lyophilized PβAE-447/pDNA complexes on HEK-293, BEAS-2B, and A549 cell lines showed better transfection than PEI. The outcomes toward A549 cells (above 66%) showed the highest transfection efficiency compared to the other cell lines. Altogether, these results suggested that characterizing physicochem. properties pave the way to design a new generation of PβAE-447 for gene delivery. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

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Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article in 2021. The article was titled 《NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules》, and you may find the article in Journal of Organic Chemistry.Name: Oxetan-3-ol The information in the text is summarized as follows:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Name: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Name: Oxetan-3-ol

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Sanchez-Portillo, Paola; Hernandez-Sirio, Aime; Godoy-Alcantar, Carolina; Lacroix, Pascal G.; Agarwal, Vivechana; Santillan, Rosa; Barba, Victor published their research in Dyes and Pigments in 2021. The article was titled 《Colorimetric metal ion (II) Sensors Based on imine boronic esters functionalized with pyridine》.Related Products of 534-03-2 The article contains the following contents:

The one-step synthesis of three imine boronic esters functionalized with pyridyl groups is described (1a-1c). The presence or absence of a Me group affects the whole conformation, being bent “”L”” or linear as determined by X-ray crystal diffraction. C-H···O, C-H···N, C-H···F and C-H … π hydrogen bond interactions support 2D supramol. arrangements. Ligands were tested as metal ion (M2+) sensors in solution The addition of metal cations (Fe2+, Co2+ and Cu2+) to 1a using methanol as solvent, showed significant color changes (purple, orange and green, resp.), while for metal cations Ni2+, Zn2+, Cd2+ cations no color changes were observed The sensitivity of compound 1a towards Fe2+, Co2+ and Cu2+ was monitored by UV-Vis spectroscopy, where the presence of Fe2+ produces new bands at 360 and 566 nm. For Co2+ and Cu2+ a remarkable intensity increase was observed at 290 nm band and new bands appear at 340 and 462 nm, resp. The stoichiometry of the complexes 1a-Fe2+, 1a-Co2+ and 1a-Cu2+ was determined by Job′s plots being 1:3 (metal:ligand, complex [Fe (1a)3]2+), in contrast with the stoichiometry 1:1 observed for 1b-Fe2+. In fact, the computed ΔG formation associated value showed a strong stabilization for the complex [Fe (1a)3]2+ (-65.5 kcal/mol) in comparison with the possible complex [Fe (1b)3]2+ (-29.7 kcal/mol). Detection limits are in the mM range (determined by UV-Vis) and μM range (determined by Fluorescence). An analogous bis-bidentate derivative (2a) also shows similar behavior but stoichiometric interaction changes to 2:3 (metal:ligand) and detection limits are in the mM range obtained by UV-Vis and Fluorescence techniques. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Related Products of 534-03-2

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Lee, Cayo; Lai, Joey; Epifanov, Maxim; Wang, Cindy Xinyun; Sammis, Glenn M. published their research in Journal of Fluorine Chemistry in 2021. The article was titled 《Efficient protocol for the SO2F2-mediated deoxyfluorination of aliphatic alcohols》.Product Details of 13325-10-5 The article contains the following contents:

Herein the sulfuryl fluoride-mediated deoxyfluorination of alcs. using room temperature reaction conditions in only an hour is reported. A wide range of primary aliphatic alcs. were efficiently converted to the corresponding fluoride in 46-70% isolated yields. Secondary alcs. were also effectively deoxyfluorinated in 50-92% yields. Chiral secondary alcs. were cleanly converted to the corresponding alkyl fluoride with only a minor deterioration of the enantioenrichment. A steroid derivative also underwent deoxyfluorination in 50% yield and 5.9:1 dr, with the major product resulting from net inversion of the stereocenter.4-Aminobutan-1-ol(cas: 13325-10-5Product Details of 13325-10-5) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Product Details of 13325-10-5

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《Aerobic oxidative dehydrogenation of N-heterocycles over OMS-2-based nanocomposite catalysts: preparation, characterization and kinetic study》 was written by Bi, Xiuru; Tang, Tao; Meng, Xu; Gou, Mingxia; Liu, Xiang; Zhao, Peiqing. Application of 7748-36-9 And the article was included in Catalysis Science & Technology in 2020. The article conveys some information:

Sodium phosphotungstate-containing OMS-2-based nanocomposites were prepared and characterized and used as recyclable catalysts for aerobic dehydrogenation/aromatization of nitrogen heterocycles, such as tetrahydroquinolines, tetrahydroquinazolines, indolines, and dihydroquinolines to aromatic nitrogen heterocycles. The mixed crystal phases, increased surface areas, and lattice oxygen atoms of the OMS-2-based nanocomposite catalysts are proposed to explain the activity of the catalysts. The kinetics of dehydrogenation of 1,2,3,4-tetrahydroquinoline and the substrate and catalyst order were determined, and the energy of activation for the aromatization was 29.66 kJ mol-1.Oxetan-3-ol(cas: 7748-36-9Application of 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application of 7748-36-9

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