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《Exfoliation of layered mixed zirconium 4-sulfophenylphosphonate phenylphosphonates》 was written by Kopecka, Katerina; Melanova, Klara; Benes, Ludvik; Knotek, Petr; Mazur, Michal; Zima, Vitezslav. Safety of 4-Aminobutan-1-olThis research focused onzirconium sulfophenylphosphonate phenylphosphonate preparation intercalation amino alc. The article conveys some information:

Mixed zirconium 4-sulfophenylphosphonate phenylphosphonates with formulas Zr(HO3SC6H4PO3)1.8(C6H5PO3)0.2·2.6H2O, Zr(HO3SC6H4PO3)1.3(C6H5PO3)0.7·2H2O, and Zr(HO3SC6H4PO3)0.7(C6H5PO3)1.3·3.6H2O (generally, ZrSPhP) were intercalated with a series of amino alcs., H2N(CH2)nOH, where n = 2 to 6, and triethylamine. It was found that in the case of amino alcs. the basal spacing of the intercalates increases linearly with n. The intercalates prepared can be exfoliated either by sonication or by the action of high-shear forces. The use of a high-shear force disperser is a more efficient exfoliation method, as it provides lamellas with larger lateral dimensions in a much shorter time. It was found that amino alcs. provide roughly the same results regardless of the length of their carbon chain. As follows from at. force microscopy measurements, triethylamine is the most appropriate exfoliation agent for ZrSPhP as it produces platelets with the largest lateral size and the lowest amount of defects. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Safety of 4-Aminobutan-1-ol

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Name: 4-Aminobutan-1-olIn 2019 ,《Sustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions》 appeared in Green Chemistry. The author of the article were Senadi, Gopal Chandru; Kudale, Vishal Suresh; Wang, Jeh-Jeng. The article conveys some information:

Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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Category: alcohols-buliding-blocksIn 2022 ,《Crosslinked Protein Delivery Strategy with Precise Activity Regulation Properties for Cancer Therapy and Gene Editing》 appeared in Advanced Healthcare Materials. The author of the article were Liu, Ning; Zhu, Lianghan; Sun, Honghao; Zhou, Zhanwei; Dong, Jingwen; Sun, Minjie. The article conveys some information:

Protein drugs hold tremendous promise for therapeutic applications due to their direct and superior pharmacol. effects. However, protein drugs can be degraded in blood stream and unable to cross many phys. barriers to exert therapeutic effect. Degradable synthetic crosslinking is a versatile strategy to enhance the stability of the nanoparticle in a complex physiol. medium and is helpful to get through phys. barriers. Herein, crosslinked polypeptide (PABP) composed of poly-amino acids including cystine, tyrosine, lysine, ketal bridge, and polyethylene glycol (PEG) is modularly explored and synthesized for protein delivery. Notably, plasma membrane V-ATPase is the particular pathway which induces the macropinocytosis of the inner peptide analogous core (PAB/protein) after the outer PEG shell disassocn. at tumor intercellular sites. In addition, PABP/protein achieves proteins′ activity shielding in systemic circulation and recovery in tumor cytoplasm precisely. In application, PABP/RNase-A shows satisfying tumor accumulation and antineoplastic efficacy. More importantly, PABP/Cas9 + small guide RNA displays obvious gene editing efficiency. The crosslinked protein delivery strategy not only makes the accurate protein transport and activity regulation possible but also is promising in paving the way for clin. translation of protein drugs. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Category: alcohols-buliding-blocks

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Golbedaghi, Reza; Justino, Licinia L. G.; Bahrampour, Marzyeh; Fausto, Rui published their research in Inorganica Chimica Acta in 2021. The article was titled 《A novel fluorescent chemosensor for Cu2+ ion based on a new hexadentate ligand receptor: X-ray single crystal of the perchlorate salt of the ligand, ion selectivity assays and TD-DFT study》.Electric Literature of C3H9NO The article contains the following contents:

New hexadentate chelates, H2L1 and L1, were synthesized. The Schiff base imine ligand, L1, was prepared by reaction of 2,2′-[ethane-1,2-diylbis(oxy)]dibenzaldehyde and propanolamine, and characterized by IR, 1H NMR and 13C NMR spectroscopies. The amine ligand, H2L1, was prepared as perchlorate salt ([H4L1](ClO4)2,) by reduction of L1 with NaBH4, and was characterized by IR (in KBr pellet), 1H NMR, 13C NMR and 2-dimensional NMR correlation spectroscopy (COSY) (in solution). The x-ray crystal structure of [H4L1](ClO4)2 was also determined and discussed. Fluorescence studies showed that H2L1 is a highly selective novel fluorescence chemosensor for the Cu2+ cation. The sensor shows selectivity for Cu2+ over 12 other metal cations. In presence of Cu2+ (5 equiv in the μM range) the fluorescence emission of the sensor, at 309 nm, is quenched by >98%. TD-DFT calculations show that ligand to metal charge transfer transitions in the complex formed between Cu2+ and the amine ligand contribute to the quenching of the fluorescence. An explanation based on TD-DFT results is also proposed for the weak fluorescence quenching in the presence of Zn2+. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Electric Literature of C3H9NO

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Masson, Thibaut; Guetta, Corinne Landras; Laigre, Eugenie; Cucchiarini, Anne; Duchambon, Patricia; Teulade-Fichou, Marie-Paule; Verga, Daniela published their research in Nucleic Acids Research in 2021. The article was titled 《BrdU immuno-tagged G-quadruplex ligands: a new ligand-guided immunofluorescence approach for tracking G-quadruplexes in cells》.COA of Formula: C4H11NO The article contains the following contents:

G-quadruplexes (G4s) are secondary structures forming in G-rich nucleic acids. G4s are assumed to play critical roles in biol., nonetheless their detection in cells is still challenging. For tracking G4s, synthetic mols. (G4 ligands) can be used as reporters and have found wide application for this purpose through chem. functionalization with a fluorescent tag. However, this approach is limited by a low-labeling degree impeding precise visualization in specific subcellular regions. Herein, we present a new visualization strategy based on the immuno-recognition of 5-bromo-2′-deoxyuridine (5-BrdU) modified G4 ligands, functionalized prior- or post-G4-target binding by CuAAC. Remarkably, recognition of the tag by antibodies leads to the detection of the modified ligands exclusively when bound to a G4 target both in vitro, as shown by ELISA, and in cells, thereby providing a highly efficient G4-ligand Guided Immunofluorescence Staining (G4-GIS) approach. The obtained signal amplification revealed well-defined fluorescent foci located in the perinuclear space and RNase treatment revealed the preferential binding to G4-RNA. Furthermore, ligand treatment affected significantly BG4 foci formation in cells. Our work headed to the development of a new imaging approach combining the advantages of immunostaining and G4-recognition by G4 ligands leading to visualization of G4/ligands species in cells with unrivaled precision and sensitivity. The experimental part of the paper was very detailed, including the reaction process of 4-Aminobutan-1-ol(cas: 13325-10-5COA of Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.COA of Formula: C4H11NO

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Ingale, Ajit P.; Ukale, Dattatraya; Garad, Dnyaneshwar N.; Shinde, Sandeep V. published their research in Synthetic Communications in 2021. The article was titled 《Nanoceria as an efficient and green catalyst for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions》.Reference of 3-Aminopropan-1-ol The article contains the following contents:

Nanocerium oxide mediated an efficient and green protocol has been described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at ambient temperature Various aliphatic, aromatic and heteroaromatic amines were protected using developed protocol and several functional groups such as alc., phenol and ester were well tolerated under these conditions. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability are the advantages of this protocol. This makes the protocol feasible, economical and environmentally benign. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Reference of 3-Aminopropan-1-ol

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Ingale, Ajit P.; Shinde, Sandeep V.; Thorat, Nitin M. published their research in Synthetic Communications in 2021. The article was titled 《Sulfated tungstate: A highly efficient, recyclable and ecofriendly catalyst for chemoselective N-tert butyloxycarbonylation of amines under the solvent-free conditions》.Name: 3-Aminopropan-1-ol The article contains the following contents:

Sulfated tungstate catalyzed an efficient and ecofriendly protocol was described for the chemoselective N-tert-butyloxycarbonylation of amines under the solvent-free conditions at room temperature The variety of functionalized aliphatic, aromatic and heteroaromatic amines efficiently underwent the N-tert-butyloxycarbonylation under the developed protocol. The aminoalc., aminophenol, aminoester as well as various chiral amines underwent the chemoselective N-Boc protection under the optimized reaction condition. The rapid reaction rate, mild conditions, very good functional group tolerance, excellent yield, solvent-free, easy recovery products and excellent catalyst recyclability were the advantages of this protocol. This made the protocol feasible, economical and environmentally benign. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Name: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Name: 3-Aminopropan-1-ol

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《Synthesis, characterization, and antimicrobial evaluation of random poly(ester-carbonate)s bearing pendant primary amine in the main chain》 was written by Dong, Peng; Feng, Jing; Li, Sujuan; Sun, Tingli; Shi, Qingshan; Xie, Xiaobao. HPLC of Formula: 534-03-2 And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:

Starting from primary amine bearing cyclic carbonate tert-butyl-(2-oxo-1,3-dioxan-5-yl) carbamate (TBODC) and caprolactone (CL), amphiphilic poly(caprolactone-ran-amino tri-Me carbonate)s (P(CL-ran-ATC)s) random copolymers with controlled mol. weight and composition were synthesized via ring opening polymerization (ROP) and deprotection, using stannous octoate (Sn(Oct)2) as catalyst and benzyl alc. (BnOH) as initiator. Therefore, hydrophilic/lipophilic ratio (HLR) of the P(CL-ran-ATC)s copolymers can be finely adjusted by the feed ratio of TBODC and CL. The antimicrobial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) of P(CL-ran-ATC)s were proportional to HLR, and P(CL-ran-ATC)s presented more vigorous bactericidal activity towards S. aureus. The min. inhibitory concentration (MIC) values of P(CL-ran-ATC 50.9%) are 2000μg mL-1 and 3000μg mL-1 for S. aureus and E. coli. While P(CL-ran-ATC 50.9%) exhibited deficient hemolytic activity as 1.41%. In addition, the P(CL-ran-ATC)s showed extremely low cytotoxicity towards fibroblast L929 cells. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.HPLC of Formula: 534-03-2

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In 2019,Biomedicine & Pharmacotherapy included an article by Pham, Lyna; Dang, Le Hang; Truong, Minh Dung; Nguyen, Thi Hiep; Le, Ly; Le, Van Thu; Nam, Nguyen Dang; Bach, Long Giang; Nguyen, Van Toan; Tran, Ngoc Quyen. Formula: C3H9NO. The article was titled 《A dual synergistic of curcumin and gelatin on thermal-responsive hydrogel based on Chitosan-P123 in wound healing application》. The information in the text is summarized as follows:

This study aimed to fabricate the potential therapeutic scaffold to efficiently and safely fastening skin wound healing. A biocompatible grafting polymer-based thermal sensitive hybrid hydrogel (Chitosan-P123, CP) containing gelatin and curcumin was designed to be suitable stiffness for tissue regeneration. A detailed in the rheol. study found that the encapsulated agents induced the change in the stiffness of the hydrogel from the hard to the soft. Especial, the thermally induced phase transition of CP hydrogel was governed by the participant of gelatin rather than curcumin. For example, at 25 wt% gelatin, CP hydrogel exhibited a unique gel-sol-gel transition following the function of temperature Moreover, in vitro investigation revealed that the hybrid hydrogel provides the capacity of especially induced curcumin release with a sustainable rate as well as the excellent biocompatibility scaffold. Altogether with in vivo study, the hybrid hydrogel highlighted the advance of the dual synergistic of curcumin and gelatin in development of smart scaffold system, which promoted the efficacy in the regeneration of the structure and the barrier’s function of damaged skin such as wound or skin cancer. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Formula: C3H9NO

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In 2019,New Journal of Chemistry included an article by Ahamad, M. Naqi; Shahid, M.; Ansari, Azaj; Kumar, Manjeet; Khan, Ishaat M.; Ahmad, Musheer; Rahisuddin; Arif, Rizwan. Quality Control of 3-Aminopropan-1-ol. The article was titled 《A combined experimental and theoretical approach to investigate the structure, magnetic properties and DNA binding affinity of a homodinuclear Cu(II) complex》. The information in the text is summarized as follows:

Herein, an antiferromagnetic homodinuclear Cu(II) complex of propanolamine, [Cu2(pa)2(OAc)2] (1), containing an acetate auxiliary was crystallized out. The complex was characterized by spectral, x-ray crystallog., magnetic and DFT/TD-DFT studies. Single crystal x-ray data reveal that 1 crystallizes in the triclinic system with the P1̅ space group, and each Cu(II) ion adopts a four-coordinated square planar geometry with the [N,O,O,O] donor set. The two [Cu(CH3COO)(pa)]+ units are connected through two alkoxy groups of the pa- ligand belonging to each unit; this gave a binuclear Cu(II) system with the bridging Cu1-O1-Cu2 angle = 103.81° and the intradimer Cu···Cu distance = 3.022 Å. The exptl. results obtained via the binding experiments of the present complex with DNA are in line with the theor. results. The auxiliary acetate group and the bridged pa- ligand facilitate the binding tendency of the complex to DNA in the minor groove region (as confirmed by docking anal.), thereby forming stronger H-bonding interactions. The easy transfer of an electron from the HOMO of DNA to the LUMO of the complex further supports the existence of a stronger binding interaction, as confirmed by the DFT anal. Temperature variable magnetic studies (SQUID measurements) revealed strong antiferromagnetic interactions (J = -222.4(2) cm-1) between two Cu(II) nuclei in a mol., and the presence of these interactions was further supported by theor. studies. The larger Cu···Cu distance and Cu-O-Cu angle are the factors behind the antiferromagnetic exchange between two Cu(II) centers. Thus, the present study establishes that the fine tuning of structures in transition metal complexes can gave magnetically and biol. important mols. for future applications. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).Quality Control of 3-Aminopropan-1-ol

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