Tag: 0-100

《3-Amino-1-propanol and N-methylaminoethanol: coordination to zinc(II) vs. decomposition to ammonia》 was written by Podjed, Nina; Stare, Petra; Korosec, Romana Cerc; Alcaide, Maria M.; Lopez-Serrano, Joaquin; Modec, Barbara. Related Products of 156-87-6This research focused onzinc quinaldinate aminopropanol methylaminoethanol ammonia complex preparation crystal structure; DFT calculation zinc quinaldinate aminopropanol methylaminoethanol ammonia complex. The article conveys some information:

To broaden the limited knowledge concerning the zinc(II) coordination chem. with amino alcs., reactions of [Zn(quin)2(H2O)] (quin- = quinaldinate, C10H6NO2) with 3-amino-1-propanol (3-apOH, C3H9NO) and N-methylaminoethanol (N-maeOH, C3H9NO) were studied. The starting material, zinc(II) with two quinaldinates coordinated in a bidentate chelating mode, provides a structurally rigid core with two sites available for interaction with amino alc. ligands. When the reactions were carried out in acetonitrile in autoclaves at 105°, an unforeseen decomposition of amino alcs. to ammonia took place. This was accompanied by crystallization of an ammine complex [Zn(quin)2(NH3)] (1). Mass spectrometry of the gaseous phases confirmed unambiguously the presence of ammonia in such reaction mixtures The desired complexes with coordinated amino alcs. could be obtained in good yield by carrying out the reactions at room temperature and/or in various solvents. Two novel amino alc. complexes were prepared, [Zn(quin)2(3-apOH)] and [Zn(quin)2(N-maeOH)]. The 3-apOH ligand was coordinated to zinc(II) in a monodentate manner via the amino nitrogen. The 3-apOH complex crystallizes as an acetonitrile (2a), ethanol (2b), 2-propanol (2c) or water (2d) solvate. The conversion of 2a to 2d was monitored by IR spectroscopy. In [Zn(quin)2(N-maeOH)] (3), the N-maeOH ligand was coordinated in a bidentate chelating manner through both functional groups. DFT calculations were performed on the isomers of [Zn(quin)2(3-apOH)] and [Zn(quin)2(N-maeOH)], which differ in the binding modes of their amino alc. ligands. Complete characterization of all compounds by x-ray structure anal., IR spectroscopy and NMR spectroscopy is presented. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Related Products of 156-87-6

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《Synthesis and characterization of light-degradable bromocoumarin functionalized polycarbonates》 was written by Mueller, Ann-Kathrin; Jung, Dimitri; Sun, Jingjiang; Kuckling, Dirk. Name: 2-Aminopropane-1,3-diol And the article was included in Polymer Chemistry in 2020. The article conveys some information:

Biocompatible polymeric materials that can degrade in response to external irradiation with high spatial and temporal control show enormous potential in the field of biomedical applications. Herein, two six-membered cyclic carbonate monomers with a light-cleavable bromocoumarin functional pendent moiety attached via a carbamate linkage were prepared from 2-amino-1,3-propanediol (serinol) and 2-(aminomethyl)-2-methylpropane-1,3-diol, resp. A series of light-degradable polycarbonates were synthesized by organo-catalyzed ring opening polymerization (ROP) of both monomers, and meanwhile their polymerization kinetics were investigated. Upon light-induced deprotection, both types of polycarbonates degraded rapidly into low mol.-weight compounds The results of size exclusion chromatog. (SEC), NMR (NMR) spectroscopy and UV/visible (UV/VIS) spectroscopy confirmed the polymer structures and the light-induced degradation behavior. The photo-cleavage rates of bromocoumarin pendent groups and the degradation rates of the polymers were strongly dependent on polymer structures and used solvents. In the experimental materials used by the author, we found 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Name: 2-Aminopropane-1,3-diol

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《Selective Covalent Modification of Layered Double Hydroxide Nanoparticles with Tripodal Ligands on Outer and Interlayer Surfaces》 was written by Muramatsu, Keisuke; Hayashi, Shiori; Kuroda, Yoshiyuki; Oka, Yuya; Wada, Hiroaki; Shimojima, Atsushi; Kuroda, Kazuyuki. Computed Properties of C3H9NO2 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

Layered double hydroxides (LDHs) have occupied an important place in the fields of catalysts, electrocatalysts, and fillers, and their applicability can be greatly enhanced by interlayer organic modifications. In contrast to general organic modification based on noncovalent modification using ionic organic species, this study has clarified in situ interlayer covalent modification of LDH nanoparticles (LDHNPs) with the tripodal ligand tris(hydroxymethyl)aminomethane (Tris-NH2). Interlayer-modified CoAl LDHNPs were obtained by a one-pot hydrothermal treatment of an aqueous solution containing metal salts and Tris-NH2 at 180°C for 24 h. Tris-NH2 was covalently bonded on the interlayer surface of LDHNPs. Interlayer-modified NiAl LDHNPs were also similarly synthesized. Some comparative experiments under different conditions indicate that the important parameters for interlayer modification are the number of bonding sites per a modifier, the electronegativity of a constituent divalent metal element, and the concentration of a modifier; this is because these parameters affect the hydrolytic stability of alkoxy-metal bonds between a modifier and a layer of LDHNPs. The synthesis of interlayer-modified MgAl LDHNPs was achieved by adjusting these parameters. This achievement will enable new potential applications because modification of only the outer surface has been achieved until now. Interlayer-modified LDHNPs possessing CO32- in the interlayer space were delaminated into monolayers under ultrasonication in water. The proposed method provides a rational approach for interlayer modification and facile delamination of LDHNPs. Layered double hydroxide nanoparticles (LDHNPs), whose interlayer surfaces were organically modified with tripodal ligands, were prepared, and they showed improved delamination behavior in water under ambient conditions. Factors affecting the interlayer modification of LDHNPs were discussed on the basis of the stability of alkoxy bonds between the LDH layers and the ligands. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Computed Properties of C3H9NO2

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《Hypoxia-Responsive, Polymeric Nanocarriers for Targeted Drug Delivery to Estrogen Receptor-Positive Breast Cancer Cell Spheroids》 was written by Mamnoon, Babak; Feng, Li; Froberg, Jamie; Choi, Yongki; Sathish, Venkatachalem; Mallik, Sanku. Application In Synthesis of 3-Aminopropan-1-ol And the article was included in Molecular Pharmaceutics in 2020. The article conveys some information:

Uncontrolled cell growth, division, and lack of enough blood supply causes low oxygen content or hypoxia in cancerous tumor microenvironments. 17β-Estradiol (E2), an estrogen receptor (ER) ligand, can be incorporated on the surface of nanocarriers for targeted drug delivery to breast cancer cells overexpressing ER. In the present study, we synthesized estradiol-conjugated hypoxia-responsive polymeric nanoparticles (polymersomes) encapsulating the anticancer drug doxorubicin (E2-Dox-HRPs) for targeted delivery into the hypoxic niches of estrogen-receptor-pos. breast cancer microtumors. Estradiol-conjugated polymersomes released over 90% of their encapsulated Dox in a sustained manner within hypoxia (2% oxygen) after 12 h. However, they released about 30% of Dox in normal oxygen partial pressure (21% oxygen, normoxia) during this time. Fluorescence microscopic studies demonstrated higher cytosolic and nuclear internalization of E2-Dox-HRPs (targeted polymersomes) compared to those of Dox-HRPs (nontargeted polymersomes). Monolayer cell viability studies on ER-pos. MCF7 cells showed higher cytotoxicity of targeted polymersomes in hypoxia compared to in normoxia. Cytotoxicity studies with hypoxic three-dimensional spheroid cultures of MCF7 cells treated with targeted polymersomes indicated significant differences compared to those of normoxic spheroids. The novel estradiol-conjugated hypoxia-responsive polymersomes described here have the potential for targeted drug delivery in estrogen-receptor-pos. breast cancer therapy. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application In Synthesis of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Application In Synthesis of 3-Aminopropan-1-ol

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Name: 4-Aminobutan-1-olIn 2019 ,《Highly sensitive fluorescent bioassay of 2,3,7,8-tetrachloro-dibenzo-p-dioxin based on abnormal expression of cytochrome P450 1A2 in human cells》 was published in Analytica Chimica Acta. The article was written by Shangguan, Li; Wei, Yuanqing; Wang, Kan; Zhang, Yuanjian; Liu, Songqin. The article contains the following contents:

Current in vitro bioassays of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, a major threat carcinogen) are relied on murine cells and fluorescent probe 7-ethoxyresorufin (7-ER), in which TCDD mostly causes abnormal expression of cytochrome P 450 1A1 (CYP1A1). However, for human cells, TCDD mainly leads to a distinct abnormal expression of cytochrome P 450 1A2 (CYP1A2). The poor response of 7-ER to CYP1A2 limits the traditional bioassay for human cells. Herein, we report a fluorescent probe N-(3-hydroxybutyl)-4-methoxy-1,8-naphthalimide (HBMN) for in vitro bioassay of TCDD with human cells. HBMN had ca. 60 times higher affinity to CYP1A2 than 7-ER. As such, the sensing sensitivity increased by 10 times, and different expression of CYP1A2 by TCDD induction in different human cells was found. Besides, HBMN was also feasible in rapid screening of TCDD concentration by naked eye. It would open a new way to highly sensitive detect TCDD and understand the pathogenesis of TCDD in different human organs. After reading the article, we found that the author used 4-Aminobutan-1-ol(cas: 13325-10-5Name: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Name: 4-Aminobutan-1-ol

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In 2022,Hu, Chunyang; Chen, Fangming; Lu, Guo-Ping; Yi, Wen-Bin published an article in Chinese Chemical Letters. The title of the article was 《Deuterated N-difluoromethylthiophthalimide: A stable, scalable reagent for radical and electrophilic deuteriodifluoromethylthiolations》.Related Products of 7748-36-9 The author mentioned the following in the article:

A new, stable and scalable reagent for deuteriodifluoromethylthiolation (deuterated N-difluoromethylthiophthalimide, PhthSCF2D) has been developed. This reagent can be applied for the photocatalytic radical deuteriodifluoromethylthiolation of various olefins and aldehydes (30 examples). Meanwhile, it can achieve the electrophilic deuteriodifluoromethylthiolation of a series of electrophilic substrates including electron-rich arenes, aryl/vinylboronicacids, alkynes, amines, thiols and β-ketoesters (22 examples). Some complex mols. can also be applied in both radical and electrophilic deuteriodifluoromethylthiolation using PhthSCF2D as the reagent. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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《Macrocycle synthesis strategy based on step-wise “”adding and reacting”” three components enables screening of large combinatorial libraries》 was written by Mothukuri, Ganesh K.; Kale, Sangram S.; Stenbratt, Carl L.; Zorzi, Alessandro; Vesin, Jonathan; Bortoli Chapalay, Julien; Deyle, Kaycie; Turcatti, Gerardo; Cendron, Laura; Angelini, Alessandro; Heinis, Christian. Recommanded Product: 4-Aminobutan-1-ol And the article was included in Chemical Science in 2020. The article conveys some information:

Macrocycles provide an attractive modality for drug development, but generating ligands for new targets is hampered by the limited availability of large macrocycle libraries. We have established a solution-phase macrocycle synthesis strategy in which three building blocks are coupled sequentially in efficient alkylation reactions that eliminate the need for product purification We demonstrate the power of the approach by combinatorially reacting 15 bromoacetamide-activated tripeptides, 42 amines, and 6 bis-electrophile cyclization linkers to generate a 3780-compound library with minimal effort. Screening against thrombin yielded a potent and selective inhibitor (Ki = 4.2 ± 0.8 nM) that efficiently blocked blood coagulation in human plasma. Structure-activity relationship and X-ray crystallog. anal. revealed that two of the three building blocks acted synergistically and underscored the importance of combinatorial screening in macrocycle development. The three-component library synthesis approach is general and offers a promising avenue to generate macrocycle ligands to other targets. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 4-Aminobutan-1-ol

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《Synthesis of an oligomeric thickener for supercritical carbon dioxide and its properties》 was written by Zhou, Ming; Tu, Hongjun; He, Yinglan; Peng, Pengao; Liao, Mao; Zhang, Jinfeng; Xu, Xiaoxia; He, Wanying; Zhao, Yaxiong; Guo, Xiao. COA of Formula: C3H9NO2 And the article was included in Journal of Molecular Liquids in 2020. The article conveys some information:

The applications of supercritical CO2 as a solvent are limited by its very low viscosity. A four-armed oligomeric CO2 thickener containing fluorine 1,6-bis(1,3-perfluorooctanoic acid biester-2-Urea)Hexane (BPFAUH) was synthesized with 2-amino-1,3-propanediol, (Boc)2D, pentadecafluorooctanoic acid, thionyl chloride, hexamethylene-1,6-diisocyanate (HMDI) as crude materials by using amino protection, esterification, deprotection, and nucleophilic addition reaction. and characterized using FTIR, 13C NMR and elemental anal. TG anal. showed that the oligomeric thickener was thermally stable below 473.15 K. Its solubility in CO2 correlated well with the pressure. The viscosity of the system increased with increasing thickener concentration, but the viscosity of the thickener decreased with increasing temperature and shear rate. The system viscosity reached 19.2 mPa·s, a 480-fold increase compared to the initial viscosity, when 2.0 wt% thickener was added; this increase greatly exceeds that of other reported thickeners. The CO2-philic fluorocarbon groups promoted the solubility of the thickener; while intra-mol. thickener crosslinking occurred via O···H bonds. Thus, the mol. with four fluorocarbon groups and two urea groups formed a network structure to achieve superstrong CO2-thickening ability. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2COA of Formula: C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.COA of Formula: C3H9NO2

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《Adaptive Se-Te Metathesis Controlled by Cucurbituril-Based Host-Guest Interaction》 was published in Chemistry – An Asian Journal in 2020. These research results belong to Liu, Cheng; Zhang, Zhiheng; Fan, Zhiyuan; He, Chaowei; Tan, Yizheng; Xu, Huaping. Electric Literature of C3H9NO The article mentions the following:

Regulating the reactivity and equilibrium of a dynamic reaction is essential for adaptive chem. and functional materials. Herein, cucurbituril-based host-guest interaction was embedded into the dynamic metathesis between diselenide and ditelluride to establish an equilibrium-adaptive system. In this system, cucurbit[6]uril (CB[6]) selectively bound with diselenide while cucurbit[7]uril (CB[7]) bound with not only diselenide but also ditelluride and exchange product. The dynamic nature of diselenide bond was locked after forming the inclusion complex with CB[6]. Based on this selective locking effect, the Se-Te products were reversed back to diselenide and ditelluride reactants, which was an equilibrium regulating process. Therefore, by combining CB[6]-based host-guest interaction and dynamic diselenide chem., the reactivity of diselenide bond and the equilibrium of Se-Te metathesis was successfully regulated. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Electric Literature of C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Electric Literature of C3H9NO

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《Thiourea-functional bioreducible poly(amido amine)s in gene delivery》 was written by Elzes, M. Rachel; Si, Guoying; Engbersen, Johan F. J.; Paulusse, Jos M. J.. Formula: C4H11NOThis research focused onthiourea bioreducible polyamido amine gene delivery. The article conveys some information:

Successful gene therapy relies on gene delivery vectors with high transfection efficiency and minimal toxicity. Bioreducible cationic polymers were developed as nonviral gene delivery vectors due to their large capacity to carry genes and highly modular synthesis. Poly(amido amine)s (PAAs) with disulfide linkages along the backbone and varying amounts of thiourea moieties in the side-chains were prepared via Michael-type polyaddition of 1-(4-aminobutyl)-3-(pyridin-3-yl)thiourea to N,N’-cystamine bisacrylamide (CBA). The thiourea-containing PAAs are able to condensate plasmid DNA into nanosized polyplexes with pos. surface charge as determined by dynamic light scattering and zeta-potential measurements. The plasmid DNA is readily liberated from the polyplexes upon exposure to reducing environment, as confirmed by gel electrophoresis after treatment with the reducing agent dithiothreitol. Polyplexes of thiourea-functionalized PAAs show no discernible toxicity and markedly higher transfection efficiencies on COS-7 cells as compared to polyplexes of the frequently applied branched polyethylenimine (PEI, 25 kDa), as well as the PAA analog obtained via polyaddition of 1-amino-4-butanol (ABOL) to CBA (pABOL), at their optimal transfection conditions. The high transfection capacity of the thiourea-functionalized PAAs remains largely unaffected in the presence of 10% serum, while the transfection efficiencies of PEI and pABOL are considerably reduced under these conditions. The results demonstrate the potential of thiourea functionalization of PAAs in enhancing their transfection efficiencies while maintaining minimal toxicities. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Formula: C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Formula: C4H11NO

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