Tag: 0-100

In 2022,Kim, Yong-Guy; Lee, Jin-Hyung; Park, Sunyoung; Lee, Jintae published an article in Microbiology Spectrum. The title of the article was 《The anticancer agent 3,3′-diindolylmethane inhibits multispecies biofilm formation by acne-causing bacteria and Candida albicans》.HPLC of Formula: 7748-36-9 The author mentioned the following in the article:

The Gram-pos. anaerobic bacterium Cutibacterium acnes is a major inhabitant of human skin and has been implicated in acne vulgaris formation and in the formation of multispecies biofilms with other skin-inhabiting organisms like Staphylococcus aureus and Candida albicans. Indoles are widespread in nature (even in human skin) and function as important signaling mols. in diverse prokaryotes and eukaryotes. In the present study, we investigated the antibacterial and antibiofilm activities of 20 indoles against C. acnes. Of the indoles tested, indole-3-carbinol at 0.1 mM significantly inhibited biofilm formation by C. acnes without affecting planktonic cell growth, and the anticancer drug 3,3′-diindolylmethane (DIM) at 0.1 mM (32μg/mL) also significantly inhibited planktonic cell growth and biofilm formation by C. acnes, whereas the other indoles and indole itself were less effective. Also, DIM at 0.1 mM successfully inhibited multispecies biofilm formation by C. acnes, S. aureus, and C. albicans. Transcriptional analyses showed that DIM inhibited the expressions of several biofilm-related genes in C. acnes, and at 0.05 mM, DIM inhibited hyphal formation and cell aggregation by C. albicans. These results suggest that DIM and other indoles inhibit biofilm formation by C. acnes and have potential use for treating C. acnes associated diseases. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9HPLC of Formula: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.HPLC of Formula: 7748-36-9

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In 2019,New Journal of Chemistry included an article by Binici, Arzu; Okumus, Aytug; Elmas, Gamze; Kilic, Zeynel; Ramazanoglu, Nagehan; Acik, Leyla; Simsek, Hulya; Cagdas Tunali, Beste; Turk, Mustafa; Guzel, Remziye; Hokelek, Tuncer. Application of 156-87-6. The article was titled 《Phosphorus-nitrogen compounds. Part 42. The comparative syntheses of 2-cis-4-ansa(N/O) and spiro(N/O) cyclotetraphosphazene derivatives: spectroscopic and crystallographic characterization, antituberculosis and cytotoxic activity studies》. The information in the text is summarized as follows:

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, 1H, 13C, and 31P NMR spectroscopy and X-ray crystallog. (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Addnl., the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochem. reversible one-electron oxidation of the Fe-redox center. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Application of 156-87-6

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Application In Synthesis of (R)-Oxiran-2-ylmethanolOn March 19, 2021, Bold, Christian P.; Klaus, Cindy; Pfeiffer, Bernhard; Schurmann, Jasmine; Lombardi, Rafael; Lucena-Agell, Daniel; Diaz, J. Fernando; Altmann, Karl-Heinz published an article in Organic Letters. The article was 《Studies toward the Synthesis of an Oxazole-Based Analog of (-)-Zampanolide》. The article mentions the following:

Studies are described toward the synthesis of an oxazole-based analog I of (-)-zampanolide. Construction of (-)-dactylolide analog 22 was achieved via alc. II and acid III through esterification and Horner-Wadsworth-Emmons (HWE)-based macrocyclization; however, attempts to attach (Z,E)-sorbamide to I proved unsuccessful. The C(8)-C(9) double bond of the macrocycle was prone to migration into conjugation with the oxazole ring, which may generally limit the usefulness of zampanolide analogs with aromatic moieties as tetrahydropyran replacements. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application In Synthesis of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application In Synthesis of (R)-Oxiran-2-ylmethanol

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《Prediction of biological activity of compounds containing a 1,3,5-triazinyl sulfonamide scaffold by artificial neural networks using simple molecular descriptors》 was written by Havrankova, Eva; Pena-Mendez, E. M.; Csollei, Jozef; Havel, Josef. Reference of 3-Aminopropan-1-olThis research focused ontriazinyl sulfonamide carbonic anhydrase inhibition neural network structure activity; 1,3,5-triazinyl sulfonamide derivatives; ANN; Carbonic anhydrase; Structural descriptors. The article conveys some information:

Simple mol. descriptors of extensive series of 1,3,5-triazinyl sulfonamide derivatives, based on the structure of sulfonamides and their physicochem. properties, were designed and calculated These descriptors were successfully applied as inputs for artificial neural network (ANN) modeling of the relationship between the structure and biol. activity. The optimized ANN architecture was applied to the prediction of the inhibition activity of 1,3,5-triazinyl sulfonamides against human carbonic anhydrase (hCA) II, tumor-associated hCA IX, and their selectivity (hCA II/hCA IX). In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Reference of 3-Aminopropan-1-ol

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In 2022,Kim, Woojoo E.; Ishikawa, Fumihiro; Re, Rebecca N.; Suzuki, Takehiro; Dohmae, Naoshi; Kakeya, Hideaki; Tanabe, Genzoh; Burkart, Michael D. published an article in RSC Chemical Biology. The title of the article was 《Developing crosslinkers specific for epimerization domain in NRPS initiation modules to evaluate mechanism》.Category: alcohols-buliding-blocks The author mentioned the following in the article:

Nonribosomal peptide synthetases (NRPSs) are complex multi-modular enzymes containing catalytic domains responsible for the loading and incorporation of amino acids into natural products. These unique mol. factories can produce peptides with nonproteinogenic D-amino acids in which the epimerization (E) domain catalyzes the conversion of L-amino acids to D-amino acids, but its mechanism remains not fully understood. Here, we describe the development of pantetheine crosslinking probes that mimic the natural substrate L-Phe of the initiation module of tyrocidine synthetase, TycA, to elucidate and study the catalytic residues of the E domain. Mechanism-based crosslinking assays and MALDI-TOF MS were used to identify both H743 and E882 as the crosslinking site residues, demonstrating their roles as catalytic bases. Mutagenesis studies further validated these results and allowed the comparison of reactivity between the catalytic residues, concluding that glutamate acts as the dominant nucleophile in the crosslinking reaction, resembling the deprotonation of the Cα-H of amino acids in the epimerization reaction. The crosslinking probes employed in these studies provide new tools for studying the mol. details of E domains, as well as the potential to study C domains. In particular, they would elucidate key information for how these domains function and interact with their substrates in nature, further enhancing the knowledge needed to assist combinatorial biosynthetic efforts of NRPS systems to produce novel compounds In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Category: alcohols-buliding-blocks)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Category: alcohols-buliding-blocks

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In 2022,Djeujo, Francine Medjiofack; Francesconi, Valeria; Gonella, Maddalena; Ragazzi, Eugenio; Tonelli, Michele; Froldi, Guglielmina published an article in Molecules. The title of the article was 《Anti-α-Glucosidase and Antiglycation Activities of α-Mangostin and New Xanthenone Derivatives: Enzymatic Kinetics and Mechanistic Insights through In Vitro Studies》.Reference of 3-Aminopropan-1-ol The author mentioned the following in the article:

Diabetes mellitus is characterized by chronic hyperglycemia that promotes ROS formation, causing severe oxidative stress. Furthermore, prolonged hyperglycemia leads to glycation reactions with formation of AGEs that contribute to a chronic inflammatory state. This research aims to evaluate the inhibitory activity of α-mangostin and four synthetic xanthenone derivatives against glycation and oxidative processes and on α-glucosidase, an intestinal hydrolase that catalyzes the cleavage of oligosaccharides into glucose mols., promoting the postprandial glycemic peak. Antiglycation activity was evaluated using the BSA assay, while antioxidant capacity was detected with the ORAC assay. The inhibition of α-glucosidase activity was studied with multispectroscopic methods along with inhibitory kinetic anal. α-Mangostin and synthetic compounds at 25 μM reduced the production of AGEs, whereas the α-glucosidase activity was inhibited only by the natural compound α-Mangostin decreased enzymic activity in a concentration-dependent manner in the micromolar range by a reversible mixed-type antagonism. CD revealed a rearrangement of the secondary structure of α-glucosidase with an increase in the contents of α-helix and random coils and a decrease in β-sheet and β-turn components. The data highlighted the anti-α-glucosidase activity of α-mangostin together with its protective effects on protein glycation and oxidation damage.3-Aminopropan-1-ol(cas: 156-87-6Reference of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Reference of 3-Aminopropan-1-ol

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Li, Kaiqi; Chen, Long; Xiong, Zuochun; Xiong, Chengdong; Chen, Dongliang published an article in 2022. The article was titled 《New aliphatic poly(ester-carbonate)s bearing amino groups based on t-Butyloxy carbonyl as Protecting Group》, and you may find the article in Journal of Polymer Research.Name: 2-Aminopropane-1,3-diol The information in the text is summarized as follows:

Amino-functionalized six-membered cyclic carbonate tert-butyl(2-oxo-1,3-dioxan-5′-yl) carbamate (TBC) was synthesized with tert-Butyloxycarbonyl (Boc) as protected group. Due to its thermal properties, ring-opening polymerization (ROP) carried out in a relatively low temperature, and Sn (Oct)2 as catalyst. A series of copolymers were prepared with L-lactide (LA), ε-Caprolactone (CL) as co-monomers, searching for proper components and ratios. The protecting Boc-group was easy to remove by using trifluoroacetic acid (TFA). The structures of TBC and copolymers were confirmed by 1H NMR and 13C NMR anal. Copolymers were characterized by DSC, GPC and water contact angle anal. The introduction of pendant amino groups resulted in a significant enhancement of hydrophilicity of the copolymers. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Name: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Name: 2-Aminopropane-1,3-diol

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《Topology-assisted, photo-strengthened DNA/siRNA delivery mediated by branched poly(β-amino ester)s via synchronized intracellular kinetics》 was published in Biomaterials Science in 2020. These research results belong to Duan, Shanzhou; Cao, Desheng; Li, Xudong; Zhu, Huifang; Lan, Min; Tan, Zhengzhong; Song, Ziyuan; Zhu, Rongying; Yin, Lichen; Chen, Yongbing. Recommanded Product: 13325-10-5 The article mentions the following:

The performance of non-viral gene delivery vehicles, especially cationic polymers, is often challenged by the multiple cellular barriers that pose inconsistent requirements for material properties. A most pronounced inconsistency is exemplified by the mol. weight (MW)-related transfection efficiency and cytotoxicity. In this study, we report the development of photo-degradable, branched poly(β-amino ester)s (BPAE-NB) to realize efficient and photo-controlled DNA and siRNA delivery. BPAE-NB possessing built-in light-responsive 2-nitrobenzene moieties in the polymer backbone was synthesized via the A2 (amine) + B3 (triacrylate) + C2 (diacrylate) polycondensation reaction from 4-amino-1-butanol (A2), trimethylolpropane triacrylate (B3), and (2-nitro-1,3-phenylene)bis(methylene) diacrylate (NPBMDA, C2). The highly branched BPAE-NB with the multivalent arrangement of cationic groups provides stronger nucleic acid binding capacity than its linear analog LPAE-NB, and thus features stronger trans-membrane gene delivery capabilities and higher transfection efficiencies. Upon UV light irradiation, the backbone of BPAE-NB can quickly degrade into low-MW fragments as a consequence of the cleavage of the light-responsive 2-nitrobenzene, thus promoting intracellular gene release and diminishing the toxicity of materials at the post-transfection state. In the experiment, the researchers used many compounds, for example, 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 13325-10-5

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The author of 《Hexadentate β-Dicarbonyl(bis-catecholamine) Ligands for Efficient Uranyl Cation Decorporation: Thermodynamic and Antioxidant Activity Studies》 were Zhang, Qingchun; Jin, Bo; Zheng, Tian; Tang, Xingyan; Guo, Zhicheng; Peng, Rufang. And the article was published in Inorganic Chemistry in 2019. Recommanded Product: 13325-10-5 The author mentioned the following in the article:

The special linear dioxo cation structure of the uranyl cation, which relegates ligand coordination to an equatorial plane perpendicular to the O:U:O vector, poses an unusual challenge for the rational design of efficient chelating agents. Therefore, the planar hexadentate ligand rational design employed in this work incorporates two bidentate catecholamine (CAM) chelating moieties and a flexible linker with a β-dicarbonyl chelating moiety (β-dicarbonyl(CAM)2 ligands). The solution thermodn. of β-dicarbonyl(CAM)2 with a uranyl cation was investigated by potentiometric and spectrophotometric titrations The results demonstrated that the pUO22+ values are significantly higher than for the previously reported TMA(2Li-1,2-HOPO)2, and efficient chelation of the uranyl cation was realized by the planar hexadentate β-dicarbonyl(CAM)2. The efficient chelating ability of β-dicarbonyl(CAM)2 was attributed to the presence of the more flexible β-dicarbonyl chelating linker and planar hexadentate structure, which favors the geometric arrangement between ligand and uranyl coordinative preference. Meanwhile, β-dicarbonyl(CAM)2 also exhibits higher antiradical efficiency in comparison to butylated hydroxyanisole. These results indicated that β-dicarbonyl(CAM)2 has potential application prospects as a chelating agent for efficient chelation of a uranyl cation. New planar hexadentate ligands (β-dicarbonyl(CAM)2 ligands) shaped like a headset were designed in this work, which incorporated two bidentate CAM chelating moieties and a flexible linker with a β-dicarbonyl chelating moiety, and realized efficient chelation of a uranyl cation. In the experimental materials used by the author, we found 4-Aminobutan-1-ol(cas: 13325-10-5Recommanded Product: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Recommanded Product: 13325-10-5

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《Zn(II)-Dipicolylamine analogues with amphiphilic side chains endow low molecular weight PEI with high transfection performance》 was written by Chen, Zhaoming; Wang, Xindong; Liu, Shuai; Li, Yumeng; Zhou, Hao; Guo, Tianying. Computed Properties of C4H11NOThis research focused onzinc dipicolylamine polyethylenimine DNA transfection cyctotoxicity. The article conveys some information:

To investigate the effect of amphiphilic balance of Zn(II)-dipicolylamine analogs on the transfection process, we fabricated a series of Zn(II)-dipicolylamine functional modules (DDAC-Rs) with different hydrophilic-phobic side chains to modify low mol. weight PEI (Zn-DP-Rs) by the Michael addition reaction. Zn-DP-Rs with hydrophilic terminal hydroxy group side chains demonstrate superior overall performance compared to those of hydrophobic alkyl side chains. In terms of the influence of the chain lengths in DDAC-Rs, from Zn-DP-A/OH-3 to Zn-DP-A/OH-5, the corresponding transfection efficiency shows an upward trend as the lengths increase. However, decreasing efficacy is observed with further increase in the length of side chains. In addition, the Zn-DP-Rs with amphiphilic side chains show prominent performance in every respect, highlighting the significance of balance in the amphipathy of side chains in DDAC-Rs. This work is of great significance for the development of polycationic gene carrier materials with excellent performance. The results came from multiple reactions, including the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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