Tag: 0-100

Quality Control of 4-Aminobutan-1-olIn 2022 ,《4-Substituted Thieno[3,2-d]pyrimidines as Dual-Stage Antiplasmodial Derivatives》 was published in Pharmaceuticals. The article was written by Lagardere, Prisca; Mustiere, Romain; Amanzougaghene, Nadia; Hutter, Sebastien; Franetich, Jean-Francois; Azas, Nadine; Vanelle, Patrice; Verhaeghe, Pierre; Primas, Nicolas; Mazier, Dominique; Masurier, Nicolas; Lisowski, Vincent. The article contains the following contents:

Malaria remains one of the major health problems worldwide. The increasing resistance of Plasmodium to approved antimalarial drugs requires the development of novel antiplasmodial agents that can effectively prevent and/or treat this disease. Based on the structure of Gamhepathiopine, a 2-tert-butylaminothieno[3,2-d]pyrimidin-4(3H)-one hit, active on the sexual and asexual stages of the parasite and thanked for the introduction of various substituents at position 4 of the thienopyrimidine core e.g., I by nucleophilic aromatic substitution and pallado-catalyzed coupling reactions, a series of 4-substituted thieno[3,2-d]pyrimidines were identified as displaying in vitro activities against both the erythrocytic stage of P. falciparum and the hepatic stage of P. berghei. Among the 28 compounds evaluated, the chloro analog of Gamhepathiopine showed good activity against the erythrocytic stage of P. falciparum, moderate toxicity on HepG2, and better activity against hepatic P. berghei parasites, compared to Gamhepathiopine. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Quality Control of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Quality Control of 4-Aminobutan-1-ol

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Category: alcohols-buliding-blocksIn 2022 ,《C(sp3)-H oxygenation via alkoxypalladium(II) species: an update for the mechanism》 was published in Chemical Science. The article was written by Zhang, Shuaizhong; Zhang, Jinquan; Zou, Hongbin. The article contains the following contents:

In the present study of γ-C(sp3)-H acyloxylation of amine derivatives, a different mechanism was shown when tert-Bu hydroperoxide (TBHP) was used as an oxidant-namely, a bimetallic oxidative addition-oxo-insertion process. This catalytic model results in an alkoxypalladium(II) intermediate from which acyloxylation and alkoxylation products was formed. Exptl. and computational studies, including isolation of the putative post-oxo-insertion alkoxypalladium(II) intermediates, support this mechanistic model. D. functional theory revealed that the classical alkylpalladium(IV) oxidative addition pathway was higher in energy than the bimetallic oxo-insertion pathway. Further kinetic studies revealed second-order dependence on [Pd] and first-order on [TBHP], which was consistent with DFT anal. This procedure was compatible with a wide range of acids and alcs. for γ-C(sp3)-H oxygenation. Preliminary functional group transformations of the products underscore the great potential of this protocol for structural manipulation. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Category: alcohols-buliding-blocks)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Category: alcohols-buliding-blocks

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《Introduction of a 7-aza-6-MeO-indoline auxiliary in Lewis-acid/photoredox cooperative catalysis: highly enantioselective aminomethylation of α,β-unsaturated amides》 was published in Chemical Science in 2020. These research results belong to Pagire, Santosh K.; Kumagai, Naoya; Shibasaki, Masakatsu. Recommanded Product: 7748-36-9 The article mentions the following:

A cooperative catalytic system comprising a chiral Cu(I) complex and an Ir(III) photocatalyst fueled by visible-light irradiation that allows for seamless integration of the catalytic formation of a-amino alkyl radicals and subsequent enantioselective addition to α,β-unsaturated amides I [R = H, OMe; R1 = Me, Ph, pyridin-2-yl, etc.; R2 = H, Me; R3 = H, OMe, Cl; X = CH2, C(CH3)2] was reported. A 7-aza-6-MeO-indoline attachment on the amide substrates plays a pivotal role in suppressing the undesired pathways, resulting in excellent enantioselectivity and enabling expedited access to valuable γ-aminobutyramides II (R4 = Ph, 2-fluorophenyl; R5 = H, Me, i-Pr, Bn). The indoline amide was readily diversified with full recovery of the azaindoline attachment, highlighting the synthetic utility of this cooperative catalytic system. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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《Enthalpies of dilution of amino alcohols in aqueous solutions at 298.15 K》 was published in Thermochimica Acta in 2020. These research results belong to Romero, Carmen M.; Cruz, Yadhi P.; Perez-Casas, Silvia. Quality Control of 3-Aminopropan-1-ol The article mentions the following:

The enthalpies of dilution of aqueous solutions of the amino alcs.: 3-amino-1-propanol, (RS)-1-amino-2-propanol, (RS)-3-amino-1,2-propanediol, and 1,3-diamino-2-propanol were measured as a function of concentration at 298.15 K using a thermal activity monitor (TAM). The results of the exptl. measurements were treated according to the McMillan-Mayer theory, to obtain the enthalpic homogeneous interaction coefficients The pair interaction coefficient hxx shows a clear dependence on the position and number of polar groups. The enthalpic coefficients are discussed in terms of the mol. interaction between solvated solute mols. In the experiment, the researchers used many compounds, for example, 3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Examples of direct uses of amines and their salts are as corrosion inhibitors in boilers and in lubricating oils (morpholine), as antioxidants for rubber and roofing asphalt (diarylamines), as stabilizers for cellulose nitrate explosives (diphenylamine), as protectants against damage from gamma radiation (diarylamines), as developers in photography (aromatic diamines), as flotation agents in mining, as anticling and waterproofing agents for textiles, as fabric softeners, in paper coating, and for solubilizing herbicides.Quality Control of 3-Aminopropan-1-ol

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The author of 《Scalable Synthesis of Sequence-Defined Oligomers via Photoflow Chemistry》 were Van De Walle, Matthias; De Bruycker, Kevin; Junkers, Tanja; Blinco, James P.; Barner-Kowollik, Christopher. And the article was published in ChemPhotoChem in 2019. Application of 156-87-6 The author mentioned the following in the article:

The development of practical routes that enable the synthesis of unimol. non-natural macromols. on multi-gram scales remains a key challenge in polymer chem. Herein, we present a continuous flow setup employing the light-induced chem. based on photocaged dienes as a controlled ligation system to establish a new platform for scalable monodisperse macromol. synthesis. 800 Mg of sequence-defined linear chains with 8 repeating units were obtained in a sequential protecting group based 2-step process. The current study demonstrates that photoflow synthesis is a viable approach to generate large quantities of monodisperse oligomers. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.Application of 156-87-6

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The author of 《Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo》 were Kozielski, Kristen L.; Ruiz-Valls, Alejandro; Tzeng, Stephany Y.; Guerrero-Cazares, Hugo; Rui, Yuan; Li, Yuxin; Vaughan, Hannah J.; Gionet-Gonzales, Marissa; Vantucci, Casey; Kim, Jayoung; Schiapparelli, Paula; Al-Kharboosh, Rawan; Quinones-Hinojosa, Alfredo; Green, Jordan J.. And the article was published in Biomaterials in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and deliver hundreds of siRNA mols. into a single nanoparticle, facilitating combination therapy against multiple GBM-promoting targets. We demonstrate that siRNA delivery with these polymeric nanoparticles is cancer-selective, thereby avoiding potential side effects in healthy cells. We show that we can deliver siRNAs targeting several anti-GBM genes (Robo1, YAP1, NKCC1, EGFR, and survivin) simultaneously and within the same nanoparticles. Robo1 (roundabout homolog 1) siRNA delivery by biodegradable particles was found to trigger GBM cell death, as did non-viral delivery of NKCC1, EGFR, and survivin siRNA. Most importantly, combining several anti-GBM siRNAs into a nanoparticle formulation leads to high GBM cell death, reduces GBM migration in vitro, and reduces tumor burden over time following intratumoral administration. We show that certain genes, like survivin and EGFR, are important for GBM survival, while NKCC1, is more crucial for cancer cell migration. This represents a powerful platform technol. with the potential to serve as a multimodal therapeutic for cancer. The experimental process involved the reaction of 4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

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In 2019,Tetrahedron Letters included an article by Fonte, Melanie; Fagundes, Natalia; Gomes, Ana; Ferraz, Ricardo; Prudencio, Cristina; Araujo, Maria Joao; Gomes, Paula; Teixeira, Catia. HPLC of Formula: 13325-10-5. The article was titled 《Development of a synthetic route towards N4,N9-disubstituted 4,9-diaminoacridines: On the way to multi-stage antimalarials》. The information in the text is summarized as follows:

This is the first multi-step synthetic route, which has been developed towards N4,N9-disubstituted 4,9-diaminoacridines I. The target structures I are likely to reveal interesting biol. activities in the near future, not only due to their mepacrine-like core, but also because they embed simultaneously the pharmacophores of chloroquine and primaquine, antimalarial drugs that act at different stages of malaria infection. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5HPLC of Formula: 13325-10-5)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.HPLC of Formula: 13325-10-5

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In 2019,Inorganica Chimica Acta included an article by Elmas, Gamze; Okumus, Aytug; Hokelek, Tuncer; Kilic, Zeynel. Related Products of 156-87-6. The article was titled 《Phosphorus-nitrogen compounds. Part 52. The reactions of octachlorocyclotetraphosphazene with sodium 3-(N-ferrocenylmethylamino)-1-propanoxide: Investigations of spectroscopic, crystallographic and stereogenic properties》. The information in the text is summarized as follows:

The reaction of octachlorocyclotetraphosphazene (tetramer, N4P4Cl8, 1) with two mole equivalent of Na 3-(N-ferrocenylmethylamino)-1-propanoxide (2) gave the novel ansa-spiro (3), 2-trans-6-dispiro (4), 2-cis-6-dispiro (5), 2-trans-4-dispiro (6) and 2-cis-4-dispiro (7) cyclotetraphosphazenes. However, when the reaction was carried out with 1 and three mole equivalent of 2, seven products observed with respect to the 31P NMR spectrum of the reaction mixture Five of these products were identified as 3, 4, 5, 6 and 7, and the other two products are expected to be 2-trans-4-trans-6-trispiro (8) derived from 4 and/or 6, and 2-trans-4-cis-6-trispiro (9) derived from 5 and/or 7. Both of the trispiro products (8 and 9) were not isolated using column chromatog. Besides, when the reaction was made with 1 and excess amount of 2, the tetraspiro products were not observed by TLC and 31P NMR spectrum of the reaction mixture The structures of cyclotetraphosphazene derivatives were verified by ESI-MS, FTIR, 1H, 13C and 31P NMR spectral data. The mol. and solid state structures of 3, 5 and 6 were established by x-ray diffraction method. The x-ray crystallog. data indicate that compounds 3 and 6 have three-different and two equivalent chiral P centers, resp. The absolute configurations of 3 and 6 also are as SS’S” and RR. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Related Products of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Related Products of 156-87-6

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Recommanded Product: 156-87-6In 2020 ,《Secondary Structure-Governed Polypeptide Cross-Linked Polymeric Hydrogels》 was published in Chemistry of Materials. The article was written by Chen, Chongyi; Lan, Jun; Li, Yuanchao; Liang, Dongran; Ni, Xiuquan; Liu, Qiao. The article contains the following contents:

Modulation of the secondary structures of peptides gives rise to a range of natural peptide-based soft materials with outstanding mech. properties. Here, we discuss detailed insights on how the secondary structure of tailor-made polypeptides governs the mech. properties of polymeric hydrogels. To this end, we developed a series of polymeric hydrogels crosslinked by poly(3-propyl-acrylate-glutamine) with tailorable secondary structures-α-helixes and random coils. Interestingly, the hydrogels crosslinked by the α-helical crosslinker exhibit a high tensile strength and toughness because of the cooperative intramol. hydrogen bonding along the polypeptide backbone. Furthermore, the α-helixes endow the hydrogels with high resilience and rapid recovery because of their reversible cooperative hydrogen bonding. In contrast, the hydrogels crosslinked by the random coil crosslinker show inferior tensile strength and toughness. Our study establishes quant. nanoscale/macroscale structure-property relationships in polymeric hydrogels and has important implications for the rational design of soft materials using polypeptides with a specific secondary structure. In the experimental materials used by the author, we found 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 156-87-6

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Quality Control of 3-Aminopropan-1-olIn 2021 ,《High-Contrast CXCR4-Targeted 18F-PET Imaging Using a Potent and Selective Antagonist》 appeared in Molecular Pharmaceutics. The author of the article were Kwon, Daniel; Lozada, Jerome; Zhang, Zhengxing; Zeisler, Jutta; Poon, Richel; Zhang, Chengcheng; Roxin, Aron; Lin, Kuo-Shyan; Perrin, David; Benard, Francois. The article conveys some information:

C-X-C chemokine receptor 4 (CXCR4) is highly expressed in cancers, contributing to proliferation, metastasis, and a poor prognosis. The noninvasive imaging of CXCR4 can enable the detection and characterization of aggressive cancers with poor outcomes. Currently, no 18F-labeled CXCR4 positron emission tomog. (PET) radiotracer has demonstrated imaging contrast comparable to [68Ga]Ga-Pentixafor, a CXCR4-targeting radioligand. We, therefore, aimed to develop a high-contrast CXCR4-targeting radiotracer by incorporating a hydrophilic linker and trifluoroborate radioprosthesis to LY2510924, a known CXCR4 antagonist. A carboxy-ammoniomethyl-trifluoroborate (PepBF3) moiety was conjugated to the LY2510924-derived peptide possessing a triglutamate linker via amide bond formation to obtain BL08, whereas an alkyne ammoniomethyl-trifluoroborate (AMBF3) moiety was conjugated using the copper-catalyzed [3+2] cycloaddition click reaction to obtain BL09. BL08 and BL09 were radiolabeled with [18F]fluoride ion using 18F-19F isotope exchange. Pentixafor was radiolabeled with [68Ga]GaCl3. Side-by-side PET imaging and biodistribution studies were performed on immunocompromised mice bearing Daudi Burkitt lymphoma xenografts. The biodistribution of [18F]BL08 and [18F]BL09 showed tumor uptake at 2 h postinjection (p.i.) (5.67 ± 1.25%ID/g and 5.83 ± 0.92%ID/g, resp.), which were concordant with the results of PET imaging. [18F]BL08 had low background activity, providing tumor-to-blood, -muscle, and -liver ratios of 72 ± 20, 339 ± 81, and 14 ± 3 (2 h p.i.), resp. [18F]BL09 behaved similarly, with ratios of 64 ± 20, 239 ± 72, and 17 ± 3 (2 h p.i.), resp. This resulted in high-contrast visualization of tumors on PET imaging for both radiotracers. [18F]BL08 exhibited lower kidney uptake (2.2 ± 0.5%ID/g) compared to [18F]BL09 (7.6 ± 1.0%ID/g) at 2 h p.i. [18F]BL08 and [18F]BL09 demonstrated higher tumor-to-blood, -muscle, and -liver ratios compared to [68Ga]Ga-Pentixafor (18.9 ± 2.7, 95.4 ± 36.7, and 5.9 ± 0.7 at 2 h p.i., resp.). In conclusion, [18F]BL08 and [18F]BL09 enable high-contrast visualization of CXCR4 expression in Daudi xenografts. Based on high tumor-to-organ ratios, [18F]BL08 may prove a valuable new tool for CXCR4-targeted PET imaging with potential for translation. The use of a PepBF3 moiety is a new approach for the orthogonal conjugation of organotrifluoroborates for 18F-labeling of peptides.3-Aminopropan-1-ol(cas: 156-87-6Quality Control of 3-Aminopropan-1-ol) was used in this study.

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Quality Control of 3-Aminopropan-1-ol

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