Tag: 0-100

Product Details of 7748-36-9In 2022 ,《Palladium-Catalyzed Three-Component Dearomatization/Sulfonylation Cascade》 was published in Organic Letters. The article was written by Bajohr, Jonathan; Bohme, Matthias D.; Gao, Jiacheng; Hahn, F. Ekkehardt; Lautens, Mark. The article contains the following contents:

The diastereoselective synthesis of sulfonylated indolines is reported. A palladium-catalyzed dearomative sulfination of (aza)indole-tethered aryl iodides generates reactive benzylic sulfinates. These intermediates react with electrophiles in a one-pot, two-step process to generate sulfonylated products in good yields and excellent diastereoselectivity. This three-component sequence demonstrates good scalability and can be applied toward the synthesis of sulfonamides. Addnl., further derivatizations of aryl iodide containing products furnish spiro- and alkynylated indoline products. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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In 2022,Leclair, Alexandre; Wang, Qian; Zhu, Jieping published an article in ACS Catalysis. The title of the article was 《Two-Carbon Ring Expansion of Cyclobutanols to Cyclohexenones Enabled by Indole Radical Cation Intermediate: Development and Application to a Total Synthesis of Uleine》.Related Products of 7748-36-9 The author mentioned the following in the article:

A single-electron transfer (SET) oxidation of indole or benzo[b]thiophene to a radical cation reverses the intrinsic polarity of these π-excessive bicyclic heteroarenes. Here we report an oxidative two-carbon homologation of cyclobutanols to cyclohexenones under a visible-light photoredox catalysis. 1-(Indol-2-yl)cyclobutan-1-ols are converted to 2,3,4,9-tetrahydro-1H-carbazol-1-ones, important structural motifs found in alkaloids and pharmaceuticals, with a broad substrate scope. A mechanistic study suggests that the reaction is initiated by an SET from an indole to an excited acridinium salt to generate the radical cation, which is followed by two consecutive 1,2-alkyl migrations and a rearomatization. Benzo[b]thiophene-substituted cyclobutanols are similarly converted to 2,3-dihydrodibenzo[b,d]thiophen-4(1H)-ones. A total synthesis of (±)-uleine featuring this ring-expansion process is documented. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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Alcohols – Chemistry LibreTexts

In 2022,Tran, Ngon T.; Boyer, Avery J.; Knorr, Daniel B. published an article in Journal of Adhesion. The title of the article was 《Multiple local hydroxyl groups as a way to improve bond strength and durability in structural adhesives》.Recommanded Product: 2-Aminopropane-1,3-diol The author mentioned the following in the article:

Polymer chain-extenders with one (AE, i.e., aminoethanol), two (APD, i.e., 2-amino-1,3-propanediol), and three (tris, i.e., 2-amino-2-(hydroxymethyl)-1,3-propanediol) pendant ethanol groups were used in a model epoxy structural adhesive to investigate their influence on joint strength and durability. While AE and APD showed modest improvements in lap shear strength, the bond durability of adhesive joints was improved dramatically using tris without the need for a chem. surface treatment. Specifically, single lap shear measurements (ASTM D1002 10) using 2024-T3 adherends demonstrated that tris (0.28 – 1.4 wt%) incorporated into a model structural adhesive can improve the lap shear strengths by 50% under dry conditions and by 64% under hot/wet conditions (immersion in water at 63°C for 14 days). The performance under hot/wet conditions is similar to that observed for adherends chem. surface treated with a commonly used silane coupling agent (i.e., 3-aminopropyltriethoxysilane). This enhanced performance of tris is likely a result of improved interfacial interactions because the small amounts of tris additive had an insignificant effect on the mech. properties of the adhesive formulations themselves based on dynamic mech. anal. In addition, XPS measurements on fractured specimens showed that the adhesive remained on the substrate, implying largely cohesive failure in the specimens. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Recommanded Product: 2-Aminopropane-1,3-diol

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In 2022,Sarkar, Souradip; Samanta, Rajarshi published an article in Organic Letters. The title of the article was 《Weakly Coordinating tert-Amide-Assisted Ru(II)-Catalyzed Synthesis of Azacoumestans via Migratory Insertion of Quinoid Carbene: Application in the Total Synthesis of Isolamellarins》.Related Products of 7748-36-9 The author mentioned the following in the article:

A weakly coordinating tert-amide-directed straightforward method was developed for the synthesis of azacoumestans, e.g., I, using the corresponding azaheterocycle derivatives II (R1 = H, Me, Bn, etc., R2 = H, Me, R3 = Cl, F, R4 = MeO, Br, Ph, etc.) and diazonaphthoquinones III (R5 = OH, R6 = Br, COMe, Ph, etc.) under cheap Ru(II)-catalyzed conditions. The reaction proceeds via migratory insertion of quinoid carbene and subsequent Bronsted acid-mediated cyclization. The optimized C2-selective method offered a wide scope of important azaheterocycles. Bioactive natural products like isolamellarins A and B were synthesized via the developed protocol. Preliminary mechanistic studies highlighted the probable mechanistic pathway. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Related Products of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Related Products of 7748-36-9

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Rastelli, Ettore J.; Yue, Doris; Millard, Caroline; Wipf, Peter published an article in 2021. The article was titled 《3D-printed cartridge system for in-flow photo-oxygenation of 7-aminothienopyridinones》, and you may find the article in Tetrahedron.Computed Properties of C4H11NO The information in the text is summarized as follows:

3D-printed polypropylene (PP) continuous-photoflow cell based on a modular cartridge system was developed for the photo-oxygenation of 7-aminothieno[3,2-c]pyridin-4(5H)-ones I (R = Me, 4-(trifluoromethyl)phenyl, 4-(2-morpholinoethoxy)phenyl, etc.), using ambient air as the sole co-reactant. This strategy takes advantage of the versatility of 3D-printing to construct cost-effective meso-scale reactors. In addition to scalability, a short residence time (tR 2 min) in 100-W blue LED light which minimizes the formation of dark, insoluble decomposition Products, is a tangible benefit of this technol. In the experiment, the researchers used 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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Li, M. X.; Rong, M. Z.; Zhang, M. Q. published an article in 2021. The article was titled 《Enhancement of mechanochemical self-blocking and self-healing of early minor damages in hyperbranched polyurethanes》, and you may find the article in eXPRESS Polymer Letters.Electric Literature of C3H9NO2 The information in the text is summarized as follows:

For more effective removal of the hidden troubles from early minor damages before their spreading out, hyperbranched polyurethane crosslinked by dioxyphenylalanine-Fe3+ (DOPA-Fe3+) and histidine-Zn2+ (His-Zn2+) coordination bonds is synthesized. By taking advantage of the cascading variation of the two types of metal-ligand complexations under the applied force, the growth of minor damages is firstly blocked, and then rehabilitation of the blocked damages takes place without manual intervention. Moreover, the exptl. results indicate that the specific structure of hyperbranched macromols., which possess plenty of functional groups and great mobility, benefits to construct a stronger network with rapid response than that derived from the linear macromols. As a result, the stress-induced micro-voids in the crosslinked hyperbranched polyurethane are much smaller, and its robustness is allowed to be maintained to a higher extent, which is consistent with the concept of timely repairing upon destruction. In the experiment, the researchers used 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C3H9NO2

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Alcohol – Wikipedia,
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Ripoll, Magdalena; Velasco-Lozano, Susana; Jackson, Erienne; Diamanti, Eleftheria; Betancor, Lorena; Lopez-Gallego, Fernando published their research in Green Chemistry in 2021. The article was titled 《One-pot biotransformation of glycerol into serinol catalysed by biocatalytic composites made of whole cells and immobilised enzymes》.Computed Properties of C3H9NO2 The article contains the following contents:

Biocatalytic cascades afford the development of economically sustainable and green processes. Herein we examined the unprecedented coupling of co-immobilized Gluconobacter oxydans and an isolated transaminase to synthesize serinol from glycerol. Through this approach, we manufactured up to 36 mM serinol, the highest titer ever reported for a non-fermentative biosynthesis. More importantly, similar productivities are obtained starting from the industrial byproduct crude glycerol, demonstrating the possibilities of this hybrid heterogenenous biocatalyst for valorising bio-based raw materials. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Computed Properties of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Computed Properties of C3H9NO2

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Kamaraj, Santhosh; Shanmugam, Ganesan; Gunasekeran, Ahalya; Selvaraj, Balamurugan; Thirugnanasambandam, Eswaramoorthi; Kandhasamy, Mohanraj; Sambandam, Anandan published their research in Energy & Fuels in 2021. The article was titled 《Performance of 4-Subsituted Pyridine Based Additive and Cobalt Redox in Poly(ethylene glycol)-Hydroxyethylcellulose Polymer Electrolytes with DTTCY Acid Sensitizer on Dye Sensitized Solar Cells》.Recommanded Product: Oxetan-3-ol The article contains the following contents:

The photovoltaic performance of dye-sensitized solar cells fabricated with newly designed and synthesized heterocyclic aromatic pyridine based additive is described. The incorporation of the 4-substituted pyridine based additive into the quasi-solid state polymer blend of poly(ethylene glycol)-hydroxyethylcellulose (PEG-HEC) with Co2+/3+[bnbip] redox mediator as electrolyte and (E)-3-(5-((E)-2-(1-(5-(2,2-bis(4-(dimethylamino)phenyl)vinyl)thiophen-2-yl)-1H-indol-3-yl)-1-cyanovinyl)thiophen-2-yl)-2-cyanoacrylic acid (DTTCY) as organic photosensitizer has been investigated. The influences of synthesized additives in current-voltage characteristics and photoelectro behavior of devices assembled with [TiO2/DTTCY/Co2+/3+[bnbip]/additive/PEG-HEC/Pt] device were investigated. The presence of different additives in the gel polymer matrix enhanced the photovoltage and was related to the neg. shift that occurred in the Quasi Fermi level of TiO2 and also higher charge relaxation time. These additives probably reduce the recombination reaction between the TiO2 surface and the Co3+ ion that boosts the photocurrent (JSC) and PCE of the DSSCs. Furthermore, additives affect the catalytic behavior of the Pt electrode, trap diffusion of the Co3+ species, and charge transfer resistance that limits Jsc produced by the device. The PAZ additive possesses an azaindole moiety with bicyclic ring attached on the fourth position of the pyridine, which greatly supports the device for exhibiting good ionic conductivity (1.46 x 10-3 S cm-1), high chem. capacitance (Cμ = 11.96 μF), high recombination resistance (9.78 Ω), and lower charge transfer resistance (54.98 Ω) compared with other pyridine based additives. The overall results were also sustained with dielec. constant, dielec. loss, and elec. modulus studies. The cell integrated with PAZ additive generates a maximum JSC of 13.59 mA cm-2 and Voc of 912 mV, yielding an overall power conversion efficiency η of 5.82% under simulated sunlight with 1.5AM condition (i.e., 100 mW cm-2). These QS-DSSCs possess long-term stability for 196 h at ambient conditions. In the experiment, the researchers used many compounds, for example, Oxetan-3-ol(cas: 7748-36-9Recommanded Product: Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: Oxetan-3-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In 2019,ACS Synthetic Biology included an article by Luo, Yuchang; Zhao, Qinqin; Liu, Qian; Feng, Yan. HPLC of Formula: 534-03-2. The article was titled 《An artificial biosynthetic pathway for 2-amino-1,3-propanediol production using metabolically engineered Escherichia coli》. The information in the text is summarized as follows:

2-Amino-1,3-propanediol (2-APD) is a chem. building block for the production of various value-added pharmaceuticals. However, the current manufacture of 2-APD predominantly relies on chem. processes by utilizing fossil fuel-derived and highly explosive raw materials. Herein, we established an artificial biosynthetic pathway for converting glucose to 2-APD in a metabolically engineered Escherichia coli. This artificial pathway employs an engineered heterogeneous aminotransferase RtxA for diverting dihydroxyacetone phosphate to generate 2-APD phosphate and an endogenous phosphatase for converting it into the target product 2-APD. Through fine-tuning the activity and solubility of RtxA for efficiently extending the glycolysis pathway, enhancing the metabolic recycling of amino-containing substrate supply via nitrogen-borrowing, and unlocking the dephosphorylation involved in the downstream pathway, the best metabolically engineered E. coli strain LYC-5 was constructed stepwise. Under aerobic conditions, a fed-batch fermentation of the strain LYC-5 produced 14.6 g/L 2-APD with a productivity of 0.122 g/L/h in a 6-L bioreactor, which was the highest reported titer to the best of our knowledge. This work demonstrates the great potential to provide an environmentally friendly and efficient approach for 2-APD production The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.HPLC of Formula: 534-03-2

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Alcohol – Wikipedia,
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Lee, Seung Yong; Jeon, Seong Ik; Sim, Sung Bo; Byun, Youngro; Ahn, Cheol-Hee published an article in 2021. The article was titled 《A supramolecular host-guest interaction-mediated injectable hydrogel system with enhanced stability and sustained protein release》, and you may find the article in Acta Biomaterialia.Electric Literature of C3H9NO2 The information in the text is summarized as follows:

Injectable hydrogels have been studied as drug delivery systems because of their minimal invasiveness and sustained drug release properties. Pluronic F127, consisting of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) triblock copolymers, exhibits thermo-responsive properties and hence is injectable due to its rapid sol-gel transition. Unmodified Pluronic F127-based hydrogels, however, have limited long-term stability and controllable release of drugs entrapped within them. In this study, host-guest interactions between adamantane-conjugated Pluronic F127 (F127-Ad) and polymerized β-cyclodextrin (CDP) were employed to develop a hydrogel-based protein delivery system. Single or multiple adamantane units were successfully introduced at the termini of Pluronic F127 with a 100% conversion yield, and the synthesized F127-Ad polymer produced a phys. crosslinked micelle-packing structure when mixed with CDP. As the number of adamantanes at the terminal ends of Pluronic F127 increased, the critical gelation concentration of F127-Ad/CDP hydrogel decreased from 15 to 6% (w/v). The F127/CDP hydrogel was able to maintain its structure even with lower polymer content, and its injectability improved with a reduction of the hydrogel viscosity. The long-term stability of F127/CDP hydrogels was evaluated in vitro and in vivo, and it was demonstrated that the s.c. injected hydrogel did not disintegrate for up to 30 d. Throughout the drug release test using gelatin and insulin as model drugs, it was demonstrated that their release rates could be regulated via complexation between the protein drugs and the β-cyclodextrin mols. inside the hydrogel. In conclusion, the F127-Ad/CDP hydrogel is expected to be a versatile protein delivery system with controllable durability and drug release characteristics. Pluronic F127 is one of the widely studied polymeric materials for thermo-sensitive injectable hydrogels due to its high biocompatibility and rapid sol-gel transition. Since the Pluronic F127-based hydrogel has some limitations in its long-term stability and mech. property, it is inevitable to modify its structure for the application to drug delivery. In this study, mono- or multi- adamantane-conjugated Pluronic F127s were synthesized and mixed with β-cyclodextrin polymers to form hydrogels with host-guest interaction-mediated micelle-packing structures. The host-guest interaction introduced into the hydrogel system endowed it a sustained protein drug release behavior as well as high durability in vitro and in vivo. By increasing the number of adamantane mols. at the end of the Pluronic F127, both the stability and injectability of the hydrogel could be also modulated. In the part of experimental materials, we found many familiar compounds, such as 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Electric Literature of C3H9NO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts