Tag: 0-100

Quality Control of Oxetan-3-olIn 2020 ,《Reusable, homogeneous water soluble photoredox catalyzed oxidative dehydrogenation of N-heterocycles in a biphasic system: application to the synthesis of biologically active natural productsã€?appeared in Green Chemistry. The author of the article were Srinath, S.; Abinaya, R.; Prasanth, Arun; Mariappan, M.; Sridhar, R.; Baskar, B.. The article conveys some information:

A simple and efficient method for the oxidative dehydrogenation (ODH) of partially saturated N-heterocycles (indolines, tetrahydro-β-carbolines and tetrahydro(iso)quinolines) e.g., I is described using a reusable, homogeneous cobalt-phthalocyanine photoredox catalyst II (R = SO3Na; M = Co) in a biphasic medium. A biphasic system offers an advantage of easy separation of the product and an efficient reusability of the homogeneous photoredox catalyst. Also, the current system significantly helps to overcome the solubility issue of the substrate and catalyst at room temperature Its potential applications to organic transformations are demonstrated by the synthesis of various biol. active N-heterocycles (indoles, β-carbolines, (iso)quinolines) e.g., III and natural products such as eudistomin U, norharmane, and harmane and precursors to perlolyrine and flazin. Without isolation and purification, the catalyst solution can be reused up to 5 times with almost comparable reactivity. Furthermore, the efficiency of the reaction was demonstrated on a gram scale. To the best of our knowledge, this is the first report on ODH reactions using a non noble, reusable and homogeneous cobalt photoredox catalyst under environmentally friendly conditions. In addition to this study using Oxetan-3-ol, there are many other studies that have used Oxetan-3-ol(cas: 7748-36-9Quality Control of Oxetan-3-ol) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Quality Control of Oxetan-3-ol

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In 2022,Pecoraro, Camilla; Parrino, Barbara; Cascioferro, Stella; Puerta, Adrian; Avan, Amir; Peters, Godefridus J.; Diana, Patrizia; Giovannetti, Elisa; Carbone, Daniela published an article in Molecules. The title of the article was 《A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cellsã€?Reference of Oxetan-3-ol The author mentioned the following in the article:

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal form of cancer characterized by drug resistance, urging new therapeutic strategies. In recent years, protein kinases have emerged as promising pharmacol. targets for the treatment of several solid and hematol. tumors. Interestingly, cyclin-dependent kinase 1 (CDK1) is overexpressed in PDAC tissues and has been correlated to the aggressive nature of these tumors because of its key role in cell cycle progression and resistance to the induction of apoptosis. For these reasons, CDK1 is one of the main causes of chemoresistance, representing a promising pharmacol. target. In this study, we report the synthesis of new 1,2,4-oxadiazole compounds and evaluate their ability to inhibit the cell growth of PATU-T, Hs766T, and HPAF-II cell lines and a primary PDAC cell culture (PDAC3). Compound 6b was the most active compound, with IC50 values ranging from 5.7 to 10.7 μM. Mol. docking of 6b into the active site of CDK1 showed the ability of the compound to interact effectively with the ATP binding pocket. Therefore, we assessed its ability to induce apoptosis (which increased 1.5- and 2-fold in PATU-T and PDAC3 cells, resp.) and to inhibit CDK1 expression, which was reduced to 45% in Hs766T. Lastly, compound 6b passed the ADME prediction, showing good pharmacokinetic parameters. These data demonstrate that 6b displays cytotoxic activity, induces apoptosis, and targets CDK1, supporting further studies for the development of similar compounds against PDAC. In the experimental materials used by the author, we found Oxetan-3-ol(cas: 7748-36-9Reference of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Reference of Oxetan-3-ol

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Gu, Shunyan; Chen, Junqi; Musgrave, Charles B.; Gehman, Zoe M.; Habgood, Laurel G.; Jia, Xiaofan; Dickie, Diane A.; Goddard, William A.; Gunnoe, T. Brent published their research in Organometallics in 2021. The article was titled 《Functionalization of RhIII-Me Bonds: Use of “”Capping Arene”” Ligands to Facilitate Me-X Reductive Eliminationã€?Recommanded Product: 7748-36-9 The article contains the following contents:

Authors show how to improve the yield of MeX from CH4 activation catalysts from 12% to 90% through the use of “”capping arene”” ligands. Four (FP)RhIII(Me)(TFA)2 {FP = “”capping arene”” ligands, including 8,8′-(1,2-phenylene)diquinoline (6-FP), 8,8′-(1,2-naphthalene)diquinoline (6-NPFP), 1,2-bis(N-7-azaindolyl)benzene (5-FP), and 1,2-bis(N-7-azaindolyl)naphthalene (5-NPFP)} complexes. These complexes and (dpe)RhIII(Me)(TFA)2 (dpe = 1,2-di-2-pyridylethane) were synthesized and tested for their performance in reductive elimination of MeX (X = TFA or halide). The FP ligands were used with the goal of blocking a coordination site to destabilize the RhIII complexes and facilitate MeX reductive elimination. On the basis of single-crystal x-ray diffraction studies, the 6-FP and 6-NPFP ligated Rh complexes have Rh-arene distances shorter than those of the 5-FP and 5-NPFP Rh complexes; thus, it is expected that the Rh-arene interactions are weaker for the 5-FP complexes than for the 6-FP complexes. Consistent with authors hypothesis, the 5-FP and 5-NPFP RhIII complexes demonstrate improved performance (from 12% to ~60% yield) in the reductive elimination of MeX. The reductive elimination of MeX from (FP)RhIII(Me)(TFA)2 can be further improved by the use of chem. oxidants. For example, the addition of 2 equivalent of AgOTf leads to 87(2)% yield of MeTFA and can be achieved in CD3CN at 90° using (5-FP)Rh(Me)(TFA)2. The experimental process involved the reaction of Oxetan-3-ol(cas: 7748-36-9Recommanded Product: 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Recommanded Product: 7748-36-9

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In 2020,Molecules included an article by Moriyama, Mizuki; Nakata, Kohei; Fujiwara, Tetsuya; Tanabe, Yoo. Category: alcohols-buliding-blocks. The article was titled 《Divergent asymmetric total synthesis of all four pestalotin diastereomers from (R)-glycidolã€? The information in the text is summarized as follows:

All four chiral pestalotin diastereomers were synthesized in a straightforward and divergent manner from common (R)-glycidol. Catalytic asym. Mukaiyama aldol reactions of readily-available bis(TMSO)diene (Chan’s diene) with (S)-2-benzyloxyhexanal derived from (R)-glycidol produced a syn-aldol adduct with high diastereoselectivity and enantioselectivity using a Ti(iOPr)4/(S)-BINOL/LiCl catalyst. Diastereoselective Mukaiyama aldol reactions mediated by catalytic achiral Lewis acids directly produced not only a (1’S,6S)-pyrone precursor via the syn-aldol adduct using TiCl4, but also (1’S,6R)-pyrone precursor via the antialdol adduct using ZrCl4, in a stereocomplementary manner. A Hetero-Diels-Alder reaction of similarly available mono(TMSO)diene (Brassard’s diene) with (S)-2-benzyloxyhexanal produced the (1’S,6S)-pyrone precursor promoted by Eu(fod)3 and the (1’S,6R)-pyrone precursor Et2AlCl. Debenzylation of the (1’S,6S)-precursor and the (1’S,6R)-precursor furnished natural (-)-pestalotin (99% ee, 7 steps) and unnatural (+)-epipestalotin (99% ee, 7 steps), resp. Mitsunobu inversions of the obtained (-)-pestalotin and (+)-epipestalotin successfully produced the unnatural (+)-pestalotin (99% ee, 9 steps) and (-)-epipestalotin (99% ee, 9 steps), resp., in a divergent manner. All four of the obtained chiral pestalotin diastereomers possessed high chem. and optical purities (optical rotations, 1H-NMR, 13C-NMR, and HPLC measurements). After reading the article, we found that the author used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Category: alcohols-buliding-blocks)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Category: alcohols-buliding-blocks

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He, Yu-Tao; Li, Li-Xuan; Lin, Xiaohong; Hou, Bao-Long; Li, Chuang-Chuang published an article on January 14 ,2022. The article was titled 《Synthesis of Various Bridged Ring Systems via Rhodium-Catalyzed Bridged (3+2) Cycloadditionsã€? and you may find the article in Organic Letters.Application of 57044-25-4 The information in the text is summarized as follows:

Here, the authors describe the rhodium-catalyzed bridged [3+2]-cycloaddition cascade reactions of N-sulfonyl-1,2,3-triazoles, which allowed the efficient diastereoselective construction of various functionalized and synthetically challenging bridged ring systems. This simple, direct transformation had a broad substrate scope and excellent functional group tolerance. The highly strained polycyclic bicyclo[2.2.2]octa[b]indole core of fruticosine was synthesized efficiently using this methodol. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Application of 57044-25-4)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Application of 57044-25-4

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COA of Formula: C3H6O2In 2020 ,《Site-Selective Functionalization of 7-Azaindoles via Carbene Transfer and Isolation of N-Aromatic Zwitterionsã€?appeared in Organic Letters. The author of the article were Liu, Junheng; Xu, Guangyang; Tang, Shengbiao; Chen, Qun; Sun, Jiangtao. The article conveys some information:

The first systematic study on metal-carbene transfer reaction of 7-azaindoles has been conducted, and the unprecedented dearomative N7-alkylation reaction has been accomplished via ruthenium catalysis. Importantly, through a sequential dearomatization-aromatization process, an isolable, and new class of azaindole-based N-aromatic zwitterions has been discovered from the reaction of 7-azaindoles and diazoesters. After reading the article, we found that the author used Oxetan-3-ol(cas: 7748-36-9COA of Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.COA of Formula: C3H6O2

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《Visible-light-promoted oxidative halogenation of (hetero)arenesã€?was written by Lu, Lingling; Li, Yiming; Jiang, Xuefeng. Application In Synthesis of Oxetan-3-ol And the article was included in Green Chemistry in 2020. The article conveys some information:

Herein, a compatible oxidative halogenation of (hetero)arenes such as 4-phenylmorpholine, 1,3,5-trimethoxybenzene, imidazo[1,2-a]pyrazine, etc. with air as the oxidant and halide ions as halide sources under ambient conditions (visible light, air, aqueous system, room temperature, and normal pressure) was described. Moreover, this protocol is practically feasible for gram-scale synthesis, showing potential for industrial application. The experimental part of the paper was very detailed, including the reaction process of Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

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《Cu(II)-Catalyzed Ortho C(sp2)-H Diarylamination of Arylamines To Synthesize Triarylaminesã€?was published in Organic Letters in 2020. These research results belong to Kumar, Mohit; Sharma, Rishabh; Raziullah; Khan, Afsar Ali; Ahmad, Ashfaq; Dutta, Himangsu Sekhar; Koley, Dipankar. Synthetic Route of C3H6O2 The article mentions the following:

A copper-catalyzed, directed ortho C-H diarylamination of indoles, indolines, anilines, and N-aryl-7-azaindoles has been established. Only copper salt as the catalyst and oxygen as the terminal oxidant are used to synthesize triarylamines using various diarylamines including carbazole and phenothiazine. Mechanistic interrogation reveals that copper plays a dual role. The results came from multiple reactions, including the reaction of Oxetan-3-ol(cas: 7748-36-9Synthetic Route of C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Synthetic Route of C3H6O2

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Kimoto, Michiko; Soh, Si Hui Gabriella; Tan, Hui Pen; Okamoto, Itaru; Hirao, Ichiro published an article on January 31 ,2021. The article was titled 《Cognate base-pair selectivity of hydrophobic unnatural bases in DNA ligation by T4 DNA ligaseã€? and you may find the article in Biopolymers.COA of Formula: C3H6O2 The information in the text is summarized as follows:

We present cognate base pair selectivity in template-dependent ligation by T4 DNA ligase using a hydrophobic unnatural base pair (UBP), Ds-Pa. T4 DNA ligase efficiently recognizes the Ds-Pa pairing at the conjugation position, and Ds excludes the noncognate pairings with the natural bases. Our results indicate that the hydrophobic base pairing is allowed in enzymic ligation with higher cognate base-pair selectivity, relative to the hydrogen-bond interactions between pairing bases. The efficient ligation using Ds-Pa can be employed in recombinant DNA technol. using genetic alphabet expansion, toward the creation of semi-synthetic organisms containing UBPs. In addition to this study using (R)-Oxiran-2-ylmethanol, there are many other studies that have used (R)-Oxiran-2-ylmethanol(cas: 57044-25-4COA of Formula: C3H6O2) was used in this study.

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.COA of Formula: C3H6O2

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�-(3-Hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde Methyl Hemiacetal�was written by Cordaro, Massimiliano. Recommanded Product: 156-87-6This research focused onuracil aldehyde methyl hemiacetal preparation. The article conveys some information:

The synthesis of 3-(3-hydroxypropyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxaldehyde as a stable Me hemiacetal through a convenient 3-step procedure is reported. The mol. is multifunctional as it contains a formyl group, a hydroxyl group and the imide moiety. Each of these groups can play a role in specific transformations or uses. The experimental process involved the reaction of 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 156-87-6

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