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The author of 《Engineered nanoparticles for systemic siRNA delivery to malignant brain tumours》 were Karlsson, Johan; Rui, Yuan; Kozielski, Kristen L.; Placone, Amanda L.; Choi, Olivia; Tzeng, Stephany Y.; Kim, Jayoung; Keyes, Jamal J.; Bogorad, Max I.; Gabrielson, Kathleen; Guerrero-Cazares, Hugo; Quinones-Hinojosa, Alfredo; Searson, Peter C.; Green, Jordan J.. And the article was published in Nanoscale in 2019. Application In Synthesis of 4-Aminobutan-1-ol The author mentioned the following in the article:

Improved delivery materials are needed to enable siRNA transport across biol. barriers, including the blood-brain barrier (BBB), to treat diseases like brain cancer. We engineered bioreducible nanoparticles for systemic siRNA delivery to patient-derived glioblastoma cells in an orthotopic mouse tumor model. We first utilized a newly developed biomimetic in vitro model to evaluate and optimize the performance of the engineered bioreducible nanoparticles at crossing the brain microvascular endothelium. We performed transmission electron microscopy imaging which indicated that the engineered nanoparticles are able to cross the BBB endothelium via a vesicular mechanism. The nanoparticle formulation engineered to best cross the BBB model in vitro led to safe delivery across the BBB to the brain in vivo. The nanoparticles were internalized by human brain cancer cells, released siRNA to the cytosol via environmentally-triggered degradation, and gene silencing was obtained both in vitro and in vivo. This study opens new frontiers for the in vitro evaluation and engineering of nanomedicines for delivery to the brain, and reports a systemically administered biodegradable nanocarrier for oligonucleotide delivery to treat glioma.4-Aminobutan-1-ol(cas: 13325-10-5Application In Synthesis of 4-Aminobutan-1-ol) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Application In Synthesis of 4-Aminobutan-1-ol

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The author of 《A self-powered triboelectric nanosensor for detecting the corrosion state of magnesium treated by micro-arc oxidation》 were Zhai, Yong-Mei; Li, Wei; Chen, Min-Fang; Li, Yan-Kun; Wang, Qi; Wang, Yan-Song. And the article was published in RSC Advances in 2019. Application In Synthesis of 2-Aminopropane-1,3-diol The author mentioned the following in the article:

Magnesium (Mg) is frequently used as a biocompatible implantable material in the human body, but real-time detection of its corrosion state is not well understood. Fortunately, previous studies of triboelec. nanogenerators (TENG) as self-driven sensors in many fields have proposed solutions for this problem. In this work, Mg-based TENG was prepared as a self-driven sensor to detect the corresponding corrosion state of Mg treated by micro-arc oxidation (MAO-Mg). Mg-based sheets and polydimethylsiloxane (PDMS) film were used as triboelec. materials. The output of TENG was optimal under 350 V-800 Hz micro-arc oxidation (MAO) treatment of Mg, and the Voc, Isc and Qsc were 48.5 V, 35.3μA and 44.2 nC, which were resp. 2.42, 3.42 and 3.27 times that of the untreated devices. Moreover, a linear relationship was found in simulated body fluid (SBF) immersion tests, showing that the rates of decrease in Isc and Voc were resp. 3.48 and 2.74 times the weight reduction rates of MAO-Mg sheets, indicating that our sensors successfully detected the corrosion of MAO-Mg. This work will lay a preliminary foundation for real-time detection of Mg as an implant in the human body (as do other implantable materials), and demonstrates a potential new application for TENG in the biomedical field. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Application In Synthesis of 2-Aminopropane-1,3-diol)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Application In Synthesis of 2-Aminopropane-1,3-diol

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In 2019,Green Chemistry included an article by Hu, Wenkang; Zhang, Yilin; Zhu, Haiyan; Ye, Dongdong; Wang, Dawei. Safety of 3-Aminopropan-1-ol. The article was titled 《Unsymmetrical triazolylnaphthyridinylpyridine bridged highly active copper complexes supported on reduced graphene oxide and their application in water》. The information in the text is summarized as follows:

A novel unsym. triazolylnaphthyridinylpyridine ligand was designed and synthesized, and employed in the synthesis of a heterogeneous copper complex on reduced graphene oxide. The resulting copper composite was characterized by SEM, TEM, XPS and energy dispersive x-ray spectroscopy (EDX). This supported copper catalyst containing unsym. triazolylnaphthyridinylpyridine (only 0.1 mol%) showed excellent catalytic activity in water with good recyclability. Various functionalized quinoline derivatives were successfully synthesized in high yields through the green strategy in water. Other heterocyclic compounds, such as pyridine, 2-(pyridin-2-yl)quinoline, 1,8-naphthyridine, 5,6-dihydronaphtho[1,2-b][1,8]naphthyridine and 2-(pyridin-2-yl)-1,8-naphthyridine derivatives, were achieved in water with >80% yields. Mechanism studies revealed that this transformation occurs via dehydrogenation, condensation, and transfer hydrogenation and dehydrogenation processes which was supported by a deuterium labeling experiment In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6Safety of 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Safety of 3-Aminopropan-1-ol

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Chong, Delano P. published an article in 2021. The article was titled 《Computational study of the electron spectra of vapor-phase indole and four azaindolesã€? and you may find the article in Molecules.Application In Synthesis of Oxetan-3-ol The information in the text is summarized as follows:

After geometry optimization, the electron spectra of indole and four azaindoles are calculated by d. functional theory. Available exptl. photoemission and excitation data for indole and 7-azaindole are used to compare with the theor. values. The results for the other azaindoles are presented as predictions to help the interpretation of exptl. spectra when they become available. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Application In Synthesis of Oxetan-3-ol)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Application In Synthesis of Oxetan-3-ol

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《Organic functionalized graphene oxide behavior in waterã€?was written by Kim, Changwoo; Lee, Junseok; Wang, Will; Fortner, John. Application of 156-87-6 And the article was included in Nanomaterials in 2020. The article conveys some information:

Surface modified graphene oxide (GO) has received broad interest as a potential platform material for sensors, membranes, and sorbents, among other environmental applications. However, compared to parent (unmodified) GO, there is a dearth of information regarding the behavior of subsequently (secondary) modified GO, other than bulk natural organic matter (NOM) coating(s). Here, we systematically explore the critical role of organic functionalization with respect to GO stability in water. Specifically, we synthesized a matrix of GO-based materials considering a carefully chosen range of bound organic mols. (hydrophobic coatings: propylamine, tert-octylamine, and 1-adamantylamine; hydrophilic coatings: 3-amino-1-propanol and 3-amino-1-adamantanol), so that chem. structures and functional groups could be directly compared. GO (without organic functionalization) with varying oxidation extent(s) was also included for comparison. The material matrix was evaluated for aqueous stability by comparing critical coagulation concentration (CCC) as a function of varied ionic strength and type (NaCl, CaCl2, MgCl2, and MgSO4) at pH 7.0. Without surface derivatization (i.e., pristine GO), increased stability was observed with an increase in the GO oxidation state, which is supported by plate-plate Derjaguin, Landau, Verwey and Overbeek (DLVO) energy interaction analyses. For derivatized GO, we observed that hydrophilic additions (phi-GO) are relatively more stable than hydrophobic organic coated GO (pho-GO). We further explored this by altering a single OH group in the adamantane-x structure (3-amino-1-adamantanol vs. 1-adamantylamine). As expected, Ca2+ and monovalent co-ions play an important role in the aggregation of highly oxidized GO(HGO) and phi-GO,while the effects of divalent cations and co-ions were less significant for pho-GO. Taken together, this work provides new insight into the intricate dynamics of GO-based material stability in water as it relates to surface functionalization (surface energies) and ionic conditions including type of co- and counter-ion, valence, and concentration The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Application of 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.Application of 156-87-6

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《Focus on chemistry of the 10-Dioxane-nido-7,8-dicarba-undecahydrido undecaborate Zwitterion; exceptionally easy abstraction of hydrogen bridge and double-action pathways observed in ring cleavage reactions with OH- as Nucleophileã€?was published in Molecules in 2020. These research results belong to Bakardjiev, Mario; El Anwar, Suzan; Bavol, Dmytro; Ruzickova, Zdenka; Gruner, Bohumir. Electric Literature of C3H9NO2 The article mentions the following:

Ring cleavage of cyclic ether substituents attached to a boron cage via an oxonium oxygen atom are amongst the most versatile methods for conjoining boron closo-cages with organic functional groups. Here we focus on much less tackled chem. of the 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11], which is the only known representative of cyclic ether substitution at nido-cages, and explore the scope for the use of this zwitterion 1 in reactions with various types of nucleophiles including bifunctional ones. Most of the nitrogen, oxygen, halogen, and sulfur nucleophiles studied react via nucleophilic substitution at the C1 atom of the dioxane ring, followed by its cleavage that produces six atom chain between the cage and the resp. organic moiety. We also report the differences in reactivity of this nido-cage system with the simplest oxygen nucleophile, i.e., OH-. With 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11], reaction proceeds in two possible directions, either via typical ring cleavage, or by replacement of the whole dioxane ring with -OH at higher temperatures Furthermore, an easy deprotonation of the hydrogen bridge in 11-vertex zwitterionic compound [10-(O-(CH2-CH2)2O)-nido-7,8-C2B9H11] was observed that proceeds even in diluted aqueous KOH. We believe this knowledge can be further applied in the design of functional mols., materials, and drugs. The results came from multiple reactions, including the reaction of 2-Aminopropane-1,3-diol(cas: 534-03-2Electric Literature of C3H9NO2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Electric Literature of C3H9NO2

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Related Products of 534-03-2In 2020 ,《A Quencher-Free Linear Probe from Serinol Nucleic Acid with a Fluorescent Uracil Analogueã€?was published in ChemBioChem. The article was written by Murayama, Keiji; Asanuma, Hiroyuki. The article contains the following contents:

With the goal of developing a quencher-free probe composed of an artificial nucleic acid, the fluorescent nucleobase analog 5-(perylenylethynyl)uracil (PeU), which was incorporated into totally artificial serinol nucleic acid (SNA) as a substitute for thymine, has been synthesized. In the context of a 12-mer duplex with RNA, these fluorophores reduce duplex stability slightly compared with that of an SNA without PeU modification; thus suggesting that structural distortion is not induced by the modification. If two PeUs were incorporated at sep. positions in an SNA, the fluorescent emission at 490 nm was clearly enhanced upon hybridization with complementary RNA. A quencher-free SNA linear probe containing three PeUs, each separated by six nucleobases, has been designed. Detection of target RNA with high sensitivity and discrimination of a single-base mismatch has also been demonstrated. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2Related Products of 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blockingâ€?substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Related Products of 534-03-2

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Safety of 4-Aminobutan-1-olIn 2020 ,《Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymerã€?was published in ACS Nano. The article was written by Blakney, Anna K.; Zhu, Yunqing; McKay, Paul F.; Bouton, Clement R.; Yeow, Jonathan; Tang, Jiaqing; Hu, Kai; Samnuan, Karnyart; Grigsby, Christopher L.; Shattock, Robin J.; Stevens, Molly M.. The article contains the following contents:

Self-amplifying RNA (saRNA) vaccines are highly advantageous, as they result in enhanced protein expression compared to mRNA, thus minimizing the required dose. However, previous delivery strategies were optimized for siRNA or mRNA and do not necessarily deliver saRNA efficiently due to structural differences of these RNAs, thus motivating the development of saRNA delivery platforms. Here, we engineer a bioreducible, linear, cationic polymer called “”pABOL”” for saRNA delivery and show that increasing its mol. weight enhances delivery both in vitro and in vivo. We demonstrate that pABOL enhances protein expression and cellular uptake via both i.m. and intradermal injection compared to com. available polymers in vivo and that i.m. injection confers complete protection against influenza challenge. Due to the scalability of polymer synthesis and ease of formulation preparation, we anticipate that this polymer is highly clin. translatable as a delivery vehicle for saRNA for both vaccines and therapeutics. In the part of experimental materials, we found many familiar compounds, such as 4-Aminobutan-1-ol(cas: 13325-10-5Safety of 4-Aminobutan-1-ol)

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Safety of 4-Aminobutan-1-ol

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《Chemoselective Ring Closure of 4-(3-Methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)butanal Leading to Pandalizine Aã€?was written by Yadav, Mahesh B.; Pandhade, Kailas R.; Argade, Narshinha P.. Computed Properties of C4H11NO And the article was included in ACS Omega in 2020. The article conveys some information:

Starting from methylmaleic anhydride, a facile total synthesis of pandalizine A alkaloid is described via the regioselective reduction of methylmaleimide and acid-catalyzed enolization of 4-(3-methyl-2-oxo-2,5-dihydro-1H-pyrrol-1-yl)butanal followed by chemoselective intramol. dehydrative cyclization as the key steps. It is noteworthy that the analogous model system with an addnl. β-Me group followed an alternative chemoselective intermol. aldol condensation pathway. In addition to this study using 4-Aminobutan-1-ol, there are many other studies that have used 4-Aminobutan-1-ol(cas: 13325-10-5Computed Properties of C4H11NO) was used in this study.

4-Aminobutan-1-ol(cas: 13325-10-5) is used in the synthesis of NSAIDs with anti-inflammatory properties. Also used in the synthesis of polyamine transport ligands with specificity against human cancers allowing easy access to specific cancer cells.Computed Properties of C4H11NO

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《Bio-based thermo-reversible aliphatic polycarbonate networkã€?was published in Molecules in 2020. These research results belong to Durand, Pierre-Luc; Grau, Etienne; Cramail, Henri. Recommanded Product: 534-03-2 The article mentions the following:

Aliphatic polycarbonates represent an important class of materials with notable applications in the biomedical field. In this work, low Tg furan-functionalized bio-based aliphatic polycarbonates were cross-linked thanks to the Diels-Alder (DA) reaction with a bis-maleimide as the crosslinking agent. The thermo-reversible DA reaction allowed for the preparation of reversible cross-linked polycarbonate materials with tuneable properties as a function of the pendent furan content that was grafted on the polycarbonate backbone. The possibility to decrosslink the network around 70°C could be an advantage for biomedical applications, despite the rather poor thermal stability of the furan-functionalized cross-linked polycarbonates. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)â€? RS(O)2â€? and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOORâ€?; the products are amides of the corresponding acids.Recommanded Product: 534-03-2

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