Tag: 0-100

In 2019,ACS Omega included an article by Xie, Jingwei; Ellebracht, Nathan C.; Jones, Christopher W.. Recommanded Product: 3-Aminopropan-1-ol. The article was titled 《Inter- and Intramolecular Cooperativity Effects in Alkanolamine-Based Acid-Base Heterogeneous Organocatalysts》. The information in the text is summarized as follows:

Intramol. cooperativity in heterogeneous organocatalysts is investigated using alkanolamine-functionalized silica acid-base catalysts for the aldol condensation reaction of 4-nitrobenzaldehyde and acetone. Two series of catalysts, one with and one without silanol-capping, are synthesized with varied alkyl linker lengths (two to five) connecting secondary amine and terminal hydroxyl functionalities. The reactivity of these catalysts is assessed to determine the relative potential for intermol. (silane amine-surface silanol) vs. intramol. (amine-hydroxyl within a single silane) cooperativity, the impact of inhibitory surface-silane interactions, and the role of alkyl linker length and flexibility. For the array of catalysts tested, those with longer linker lengths generally give increased catalytic activity, although the turnover frequency (TOF) trends differ between catalysts with and without surface silanol capping. Catalysts with alkyl substituted amines lacking a terminal hydroxyl demonstrate an adverse effect of chain length, where the larger alkyl substituent on the amine provides steric hindrance depressing catalytic activity, while giving addnl. evidence for improved rates afforded by intramol. cooperativity in the alkanolamine materials. The silanol-capped alkanolamine catalyst with the longest alkyl linker is found to be the most active alkanolamine catalyst due to its hydrophobized surface, which removes hypothesized silanol-alkanolamine inhibitory interactions, with the sufficient length and flexibility of its amine-hydroxyl linker allowing for favorable conformations for cooperativity. This study demonstrates the feasibility of and important factors affecting intramol. cooperative activity in acid-base heterogeneous organocatalysis. After reading the article, we found that the author used 3-Aminopropan-1-ol(cas: 156-87-6Recommanded Product: 3-Aminopropan-1-ol)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Amines can be classified according to the nature and number of substituents on nitrogen. Aliphatic amines contain only H and alkyl substituents. Aromatic amines have the nitrogen atom connected to an aromatic ring.Important amines include amino acids, biogenic amines, trimethylamine, and aniline. Inorganic derivatives of ammonia are also called amines, such as monochloramine (NClH2).Recommanded Product: 3-Aminopropan-1-ol

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Category: alcohols-buliding-blocksIn 2022 ,《Synthesis and Characterization of Alkyne-Functionalized Photo-Cross-Linkable Polyesters》 was published in ACS Omega. The article was written by Ma, Warrick; Ding, Xiaochu; Chen, Ying; Wang, Yadong. The article contains the following contents:

An alkyne-functionalized elastomer derived from sebacic acid, 1,3-propanediol, and alkyne-functionalized serinol is synthesized via melt condensation. A low-power UV lamp triggers the crosslinking rapidly via thiol-yne click chem. The crosslinking behavior is studied by photorheol. and NMR spectroscopy. The resultant elastomer possesses mech. properties similar to those of human soft tissues and exhibits in vitro degradability and good cytocompatibility. After reading the article, we found that the author used 2-Aminopropane-1,3-diol(cas: 534-03-2Category: alcohols-buliding-blocks)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Category: alcohols-buliding-blocks

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In 2022,Nguyen, Ngoc The; Bui, Quynh Anh; Nguyen, Hoang Huong Nhu; Nguyen, Tien Thanh; Ly, Khanh Linh; Tran, Ha Le Bao; Doan, Vu Nguyen; Nhi, Tran Thi Yen; Nguyen, Ngoc Hoa; Nguyen, Ngoc Hao; Tran, Ngoc Quyen; Nguyen, Dinh Trung published an article in Gels. The title of the article was 《Curcuminoid Co-Loading Platinum Heparin-Poloxamer P403 Nanogel Increasing Effectiveness in Antitumor Activity》.SDS of cas: 156-87-6 The author mentioned the following in the article:

Nanosized multi-drug delivery systems provide synergistic effects between drugs and bioactive compounds, resulting in increased overall efficiency and restricted side effects compared to conventional single-drug chemotherapy. In this study, we develop an amphiphilic heparin-poloxamer P403 (HP403) nanogel that could effectively co-load curcuminoid (Cur) and cisplatin hydrate (CisOH) (HP403@CisOH@Cur) via two loading mechanisms. The HP403 nanogels and HP403@CisOH@Cur nanogels were closely analyzed with 1H-NMR spectroscopy, FT-IR spectroscopy, TEM, and DLS, exhibiting high stability in spherical forms. In drug release profiles, accelerated behavior of Cur and CisOH at pH 5.5 compared with neutral pH was observed, suggesting effective delivery of the compounds in tumor sites. In vitro studies showed high antitumor activity of HP403@CisOH@Cur nanogels, while in vivo assays showed that the dual-drug platform prolonged the survival time of mice and prevented tail necrosis. In summary, HP403@CisOH@Cur offers an intriguing strategy to achieve the cisplatin and curcumin synergistic effect in a well-designed delivery platform that increases antitumor effectiveness and overcomes undesired consequences caused by cisplatin in breast cancer treatment. In the experiment, the researchers used 3-Aminopropan-1-ol(cas: 156-87-6SDS of cas: 156-87-6)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.SDS of cas: 156-87-6

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Formula: C3H6O2In 2020 ,《Sulfenylation of Arenes with Ethyl Arylsulfinates in Water》 was published in ACS Omega. The article was written by Wei, Yueting; He, Jing; Liu, Yali; Xu, Liang; Vaccaro, Luigi; Liu, Ping; Gu, Yanlong. The article contains the following contents:

A tetrabutylammonium iodide-mediated direct sulfenylation of arenes with Et arylsulfinates in water was developed. Various electron-rich arenes and Et arylsulfinates were investigated in the reaction, and a series of aryl sulfides were obtained in excellent yields. The advantages of this green protocol were simple reaction conditions (metal-free, water as the solvent, and under air), odorless and easily available sulfur reagent, broad substrate scope, and gram-scale synthesis. Moreover, the potential application of aryl sulfides was exemplified by further transformations. In the experiment, the researchers used Oxetan-3-ol(cas: 7748-36-9Formula: C3H6O2)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Formula: C3H6O2

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Formula: C3H9NOIn 2019 ,《Experimental evaluation of highly efficient primary and secondary amines with lower energy by a novel method for post-combustion CO2 capture》 appeared in Applied Energy. The author of the article were Liu, Sen; Gao, Hongxia; He, Chuan; Liang, Zhiwu. The article conveys some information:

In this work, a novel method in terms of reaction energy was proposed to evaluate the potential amine absorbents for post-combustion CO2 capture, including two key parameters, i.e. the molar Gibbs energy change (ΔrGm) of proton combination with amine and the molar reaction enthalpy (ΔrHm) of protonated amine dissociation into amine and proton, which are calculated by the Van’t Hoff equation. Firstly, the equilibrium acid dissociation constant (Ka) of seven primary and secondary amines were exptl. determined at 293-323 K. The calculated ΔrGm and ΔrHm values obtained by the novel method indicated that the 2-(ethylamino)ethanol (EAE) and 2-(methylamino)ethanol (MAE) were the alternative promising absorbents among the seven tested amines, with a relatively low ΔrGm of about -57.0 kJ/mol and ΔrHm of 49.7 kJ/mol. In addition, seven amine solutions with molar concentration of 2.5 M and 5.0 M were investigated by the rate-based fast screening method to validate the reliability and applicability of the novel method. The comprehensive comparison of the absorption rate, desorption rate, CO2 equilibrium solubility and cyclic capacity, also demonstrated the same conclusion that EAE and MAE solutions presented good CO2 capture performances. The 2.5 M and 5.0 M EAE solutions obtain the highest energy efficiency for CO2 capture with the highest cyclic capacity, which is about 52.9% and 32.3% higher than those of Monoethanolamine (MEA) solution, resp. Addnl., the structure-activity anal. of seven amines suggested that the addition of hydroxyl group can obviously decrease the absorption rate and energy consumption of amine solution for CO2 removal, the alkyl group addition on or close to amino group with steric hindrance is favorable for the CO2 capture performance, while the addition of Me group on amine mol. without steric hindrance can reduce the CO2 cyclic capacity. What’s more, four tertiary amines were also investigated by using these two approaches, and the compared results further validated the accuracy and applicability of the proposed novel method. The experimental part of the paper was very detailed, including the reaction process of 3-Aminopropan-1-ol(cas: 156-87-6Formula: C3H9NO)

3-Aminopropan-1-ol(cas: 156-87-6) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C3H9NO

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In 2022,Chen, Mo; Montgomery, John published an article in ACS Catalysis. The title of the article was 《Nickel-Catalyzed Intermolecular Enantioselective Heteroaromatic C-H Alkylation》.SDS of cas: 7748-36-9 The author mentioned the following in the article:

Herein, an approach involving nickel-catalyzed intermol. enantioselective C-H alkylation of heteroarenes, such as benzoxazoles, benzofurans, benzimidazoles, etc., with norbornene is presented. The process can be carried out under mild conditions using nickel(0) catalysts with N-heterocyclic carbene (NHC) ligands in the absence of Lewis acid co-catalysts. A series of NHC nickel complexes stabilized with 1,5-hexadiene was synthesized via an operationally simple approach, resulting in improved functional group tolerance and heteroarene scope. Mechanistic investigations are consistent with a ligand-to-ligand hydrogen transfer (LLHT) pathway where the C-H bond activation precedes a rate-determining reductive elimination step.Oxetan-3-ol(cas: 7748-36-9SDS of cas: 7748-36-9) was used in this study.

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.SDS of cas: 7748-36-9

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Reference of (R)-Oxiran-2-ylmethanolOn October 31, 2020 ,《A Diastereoselective Synthetic Approach towards the Synthesis of Berkeleylactone F and Its 4- epi -Derivative》 appeared in SynOpen. The author of the article were Subba, Srijana; Saha, Sumit; Mandal, Susanta. The article conveys some information:

A diastereoselective approach to the synthesis of berkeleylactone F was presented. The synthetic strategy was initiated with com. available ( R)-glycidol, 1,6-heptadiyne, and ( R)-(+)-Me lactate. The key feature of the approach was directional functionalization at both terminals of 1,6-heptadiyne. The experimental process involved the reaction of (R)-Oxiran-2-ylmethanol(cas: 57044-25-4Reference of (R)-Oxiran-2-ylmethanol)

(R)-Oxiran-2-ylmethanol(cas: 57044-25-4) is a chiral building block used to construct an epoxyvinyl iodide intermediate in a synthesis of a furanocembrane, a marine natural product.Reference of (R)-Oxiran-2-ylmethanol

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《Antitumor activity of new olivacine derivatives》 was published in Molecules in 2020. These research results belong to Piasny, Janusz; Wiatrak, Benita; Dobosz, Agnieszka; Tylinska, Beata; Gebarowski, Tomasz. HPLC of Formula: 534-03-2 The article mentions the following:

Olivacine is an alkaloid-containing pyridocarbazole structure. It is isolated from the bark of the evergreen timber tree, Aspidosperma olivaceum. Its well-documented anticancer activity led to the synthesis of new derivatives, which are semisynthetic and fully synthetic pyridocarbazoles. This study aimed to evaluate the potential antineoplastic activity of four newly synthesized olivacine derivatives Multidrug resistance is a common phenomenon causing failure in the chemotherapy of many tumors. It is mainly related to increased function of P-glycoprotein, an efflux pump removing cytostatic out of the cells. The cell lines used in the study were colorectal carcinoma cell lines: LoVo (doxorubicin-sensitive) and LoVo/DX (doxorubicin-resistant). The NHDF cell line was used to assess cell viability. First, the cells were incubated with olivacine derivatives In the next step, the following assays were performed: DCF-DA assay, MTT assay, rhodamine 123 assay, detection of apoptosis, proliferation inhibition-mitotic index. The tested compounds showed higher antineoplastic potential and lower toxicity than the reference compound ellipticine. The results indicate that the new olivacine derivatives are good candidates for future anticancer drugs. In addition to this study using 2-Aminopropane-1,3-diol, there are many other studies that have used 2-Aminopropane-1,3-diol(cas: 534-03-2HPLC of Formula: 534-03-2) was used in this study.

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 534-03-2

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In 2019,Polyhedron included an article by Abbas, Ghulam; Ibrahim, Masooma; Schmidt, Sebastian F. M.; Moreno-Pineda, Eufemio; Anson, Christopher E.; Powell, Annie K.. Recommanded Product: 534-03-2. The article was titled 《Synthesis of five isostructural tetranuclear Fe2Ln2 (Ln = Gd, Tb, Dy, Ho, Er) complexes with an “”inverse butterfly”” core》. The information in the text is summarized as follows:

A 1-pot synthesis leading to in situ ligand formation enabled the preparation of five isostructural tetranuclear Fe2Ln2 coordination clusters [Fe2Ln2(μ4L)2(mpm)2(piv)2(N3)3.5(Cl)0.5], where H2L is 2-((pyridin-2-ylmethylene)amino)propan-1,3-diol, Hmpm is methoxy(2-pyridinyl)methanol, piv is pivalate and Ln = Gd (1), Tb (2), Dy (3), Ho (4), Er (5). These show an unprecedented core structure. The coordination compounds were fully characterized by IR spectroscopy, elemental anal., powder x-ray diffraction and single crystal X-ray diffraction. Magnetic measurements indicate intramol. antiferromagnetic and ferromagnetic interactions. The finding is important in developing synthetic strategies for the preparation of new mol. based magnetic materials. The experimental part of the paper was very detailed, including the reaction process of 2-Aminopropane-1,3-diol(cas: 534-03-2Recommanded Product: 534-03-2)

2-Aminopropane-1,3-diol(cas: 534-03-2) belongs to anime. The methylamines occur in small amounts in some plants. Many polyfunctional amines (i.e., those having other functional groups in the molecule) occur as alkaloids in plants—for example, mescaline, 2-(3,4,5-trimethoxyphenyl)ethylamine; the cyclic amines nicotine, atropine, morphine, and cocaine; and the quaternary salt choline, N-(2-hydroxyethyl)trimethylammonium chloride, which is present in nerve synapses and in plant and animal cells.Recommanded Product: 534-03-2

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Pan, Yue; Liu, Zhengyi; Zou, Peng; Chen, Yali; Chen, Yiyun published an article in 2022. The article was titled 《Hypervalent Iodine Reagents Enable C(sp2)-H Amidation of (Hetero)arenes with Iminophenylacetic Acids》, and you may find the article in Organic Letters.Product Details of 7748-36-9 The information in the text is summarized as follows:

The sulfonamidyl (hetero)arenes synthesis by the C(sp2)-H amidation from bench-stable amidyl-iminophenylacetic acids was reported. The hypervalent iodine reagents covalently activated iminophenylacetic acids for the facile sulfonamidyl radical generation under mild photocatalytic oxidative conditions. Diversified indoles, pyrroles, imidazopyridines and fused arenes underwent the C(sp2)-H amidation with excellent chemoselectivity and regioselectivity. This reaction performed well under neutral aqueous conditions with potential biol. applications. In the part of experimental materials, we found many familiar compounds, such as Oxetan-3-ol(cas: 7748-36-9Product Details of 7748-36-9)

Oxetan-3-ol(cas: 7748-36-9) is used as a reagent in the synthesis of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. It is also used as a reagent in the synthesis of cyclic sulfone hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors.Product Details of 7748-36-9

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