Tag: 0-100

Synthesis of new pyrrolidine-1,2-dicarboxamides and investigation of their activity for the synthesis of aminonitriles was written by Aydin, Ozge;Yolacan, Cigdem;Aydogan, Feray. And the article was included in American Chemical Science Journal in 2016.Recommanded Product: 5856-63-3 This article mentions the following:

New pyrrolidine-1,2-dicarboxamide derivatives were synthesized by the amidation reactions of some amines, an amino alc. and an amino acid ester with (S)-1-(phenylcarbamoyl)pyrrolidine-2-carboxylic acid, which was obtained by the reaction of L-proline with Ph isocyanate. Activities of these compounds for the synthesis of aminonitriles via Strecker reaction were investigated. The aminonitriles were obtained in good yields; however, no significant asym. induction was observed In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core was written by Wang, Jin-tao;Zheng, Yue-ming;Chen, Yue-ting;Gu, Min;Gao, Zhao-bing;Nan, Fa-jun. And the article was included in Acta Pharmacologica Sinica in 2020.Recommanded Product: 111043-48-2 This article mentions the following:

Nav1.7 channels are mainly distributed in the peripheral nervous system. Blockade of Nav1.7 channels with small-mol. inhibitors in humans might provide pain relief without affecting the central nervous system. Based on the facts that many reported Nav1.7-selective inhibitors contain aryl sulfonamide fragments, as well as a tricyclic antidepressant, maprotiline, has been found to inhibit Nav1.7 channels, we designed and synthesized a series of compounds with ethanoanthracene and aryl sulfonamide moieties. Their inhibitory activity on sodium channels were detected with electrophysiol. techniques. We found that compound 10o potently inhibited Nav1.7 channels stably expressed in HEK293 cells (IC₅₀ = 0.64 ± 0.30 nmol/L) and displayed a high Nav1.7/Nav1.5 selectivity. In mouse small-sized dorsal root ganglion neurons, compound 10o (10, 100 nmol/L) dose-dependently decreased the sodium currents and dramatically suppressed depolarizing current-elicited neuronal discharge. Preliminary in vivo experiments showed that compound 10o possessed good analgesic activity: in a mouse visceral pain model, administration of compound 10o (30-100 mg/kg, i.p.) effectively and dose-dependently suppressed acetic acid-induced writhing. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-1-methylazetidine (cas: 111043-48-2Recommanded Product: 111043-48-2).

3-Hydroxy-1-methylazetidine (cas: 111043-48-2) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 111043-48-2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

3D Printed CO₂-Based Triblock Copolymers and Post-Printing Modification was written by Wei, Peiran;Bhat, Gulzar A.;Cipriani, Ciera E.;Mohammad, Hamza;Schoonover, Krista;Pentzer, Emily B.;Darensbourg, Donald J.. And the article was included in Angewandte Chemie, International Edition in 2022.Synthetic Route of C3H8O2 This article mentions the following:

We report the facile synthesis and 3D printing of a series of triblock copolymers consisting of soft and hard blocks and demonstrate that alkene pendant groups of the hard block can be covalently modified. The polymers are prepared using a salenCo(III)TFA/PPNTFA binary catalyst system and 1,2-propanediol as a chain transfer agent, providing an efficient one-pot, two-step strategy to tailor polymer thermal and mech. properties. Thixotropic inks suitable for direct ink write printing were formulated by dissolving the block copolymers in organic solvent and dispersing NaCl particles. After printing, porous structures were produced by removing solvent and NaCl with water to give printed structures with surfaces that could be modified via UV-initiated thiol-ene click reactions. Alternatively, a tetra-thiol could be incorporated into the ink and used for crosslinking to give objects with high solvent resistance and selective degradability. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Synthetic Route of C3H8O2).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Synthetic Route of C3H8O2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Prediction of infinite-dilution activity coefficients with neural collaborative filtering was written by Tan, Tian;Cheng, Hongye;Chen, Guzhong;Song, Zhen;Qi, Zhiwen. And the article was included in AIChE Journal in 2022.Recommanded Product: 1,2-Propanediol This article mentions the following:

Accurate prediction of infinite dilution activity coefficient (γ^∞) for phase equilibrium and process design is crucial. In this work, an exptl. γ^∞ dataset containing 295 solutes and 407 solvents (21,048 points) is obtained through data integrating, cleaning, and filtering. The dataset is arranged as a sparse matrix with solutes and solvents as columns and rows, resp. Neural collaborative filtering (NCF), a modern matrix completion technique based on deep learning, is proposed to fully fill in the γ^∞ matrix. Ten-fold cross-validation is performed on the collected dataset to test the effectiveness of the proposed NCF, proving that NCF outperforms the state-of-the-art phys. model and previous machine learning model. The completed γ^∞ matrix makes solvent screening and extension of UNIFAC parameters possible. Taking two typical hard-to-sep. systems (benzene/cyclohexane and Me cyclopentane/n-hexane mixtures) as examples, the NCF-developed database provides high-throughput screening for separation systems in terms of solvent selectivity and capacity. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fluorinated solvent-assisted photocatalytic aerobic oxidative amidation of alcohols via visible-light-mediated HKUST-1/Cs-POMoW catalysis was written by Karimi, Meghdad;Sadeghi, Samira;Mohebali, Haleh;Azarkhosh, Zahra;Safarifard, Vahid;Mahjoub, Alireza;Heydari, Akbar. And the article was included in New Journal of Chemistry in 2021.Category: alcohols-buliding-blocks This article mentions the following:

Considering the irreplaceable importance of photocatalytic functionalization reactions and the widespread attention paid to the use of metal-organic frameworks, especially their modified variants, for this purpose in recent years, different types of HKUST-1/POMoW composites were prepared through the immobilization of a series of Keggin-type polyoxometalates (POMs; POW = H₃PW₁₂O₄₀, POMo = H₃PMo₁₂O₄₀, and POMoW = H₃PMo₆W₆O₄₀) on HKUST-1 as a metal-organic framework (HKUST-1; Cu₃(1,3,5-benzenetricarboxilicacid)₂). Then, to produce HKUST-1/Cs-POM, the substitution of H⁺ cations with Cs⁺ ones as counter cations was carried out. The prepared composites were fully characterized with the PXRD (powder X-ray diffraction), FT-IR (Fourier transform IR spectroscopy), BET and BJH (sorption of N₂), TGA (thermo-gravimetric anal.), SEM (SEM), EDX (energy dispersive X-ray), TEM (transmission electron microscopy), UV-vis DRS (diffuse reflectance UV-vis spectroscopy), photoluminescence (PL) spectroscopy and ICP-AES (inductively coupled plasma at. emission spectroscopy) techniques. The great importance of the amide functional group and the attractiveness of photocatalytic oxidative functionalization reactions led us to study the formation of this functional group using the prepared catalytic system in line with our previous research in this field. The HKUST-1/Cs-POMoW composite showed a raised photocatalytic performance compared to the discrete components, HKUST-1 and Cs-POMs, in aerobic oxidative amidation of alcs. under illumination with visible light, owing to the presence of catalytically active Cs-POMs deposited on the MOF particles. Besides, the combination of composite components mitigated the recombination rate of the electron-hole pairs, raising its photocatalytic activity. The attractiveness of fluorine solvents for oxidation reactions has led to the study of their role in the efficiency of oxidative amidation of alcs. and their significant effect on the efficiency of the process has been confirmed. The Cu-MOF/POM catalyst showed excellent stability during the reaction, and no significant decrease in its ability was observed during five consecutive cycles. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Category: alcohols-buliding-blocks).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Category: alcohols-buliding-blocks

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Deep eutectic solvents based biorefining of Value-added chemicals from the diatom Thalassiosira andamanica at room temperature was written by Singh, Kuldeep;Krishna Paidi, Murali;Kulshrestha, Akshay;Bharmoria, Pankaj;Kumar Mandal, Subir;Kumar, Arvind. And the article was included in Separation and Purification Technology in 2022.Reference of 57-55-6 This article mentions the following:

The extraction and biorefining of value-added chems. from bioresources using green solvents are among the key agenda of the circular bioeconomy. Herein we have developed a deep eutectic solvent (DESs) based biorefining approach for clean separation and purification of value-added Fucoxanthin, Chlorophyll, and Biosilica from a diatom microalgae, Thalassiosira andamanica. Several hydrophilic/hydrophobic (DESs) based on quaternary ammonium salt as hydrogen bond acceptor and organic acids and alcs. as hydrogen bond donors were synthesized and tested for microalgae biomass dissolution and biorefining via the phase partitioning method. In an optimized process, ∼30 wt% of fresh weight diatom could be dissolved in hydrophilic DESs at room temperature, followed by a record extraction of 19.93 mg/g of Fucoxanthin via phase partitioning, with a 53% increase in yield and an 81% increase in selectivity over conventional solvents. ¹H NMR, FTIR, LCMS, UV, and HPLC techniques were used to characterize the extracted Fucoxanthin. Subsequently, a hydrophobic DES was added to the remaining hydrophilic DESs and residual biomass and Chlorophyll were extracted into the upper hydrophobic DES layer and Biosilica (80 mg/g) was recovered by simple centrifugation. Extracted Biosilica showed an excellent adsorption capacity of 224.71 mg/g for the removal of methylene blue (MB) dye from water (94.3% up to 88.8% after 4th consecutive steps). Whereas Chlorophyll extracted in the hydrophobic DES phase exhibited excellent photostability (6 folds greater than conventional solvent) indicating the efficacy of DESs as photoprotector for light-sensitive pigments. This is the first report wherein besides an extractant DES also acted as a good photostabilizer. Addnl., we have replaced the acid-based extraction method for Biosilica with non-toxic DESs. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Reference of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral manganese(IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction was written by Li, Zhen;Niu, Meiju;Chang, Guoliang;Zhao, Changqiu. And the article was included in Journal of Photochemistry and Photobiology, B: Biology in 2015.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

Two new pairs of chiral manganese(IV) complexes with Schiff-base ligands, Λ-[Mn(R-L¹)₂]·2(CH₃OH) (Λ–1) and Δ-[Mn(S-L¹)₂]·2(CH₃OH) (Δ–1), Λ-[Mn(R-L²)₂]·(H₂O)₂ (Λ–2) and Δ-[Mn(S-L²)₂]·(H₂O)₂ (Δ–2), {H₂L¹ = (R/S)-(±)-1-[(1-hydroxymethyl-propylimino)methyl]naphthalen-2-ol, H₂L² = (R/S)-(±)-1-[(1-Hydroxymethyl-2-phenylethylimino)methyl]-naphthalen-2-ol} have been synthesized, and fully characterized by elemental analyses, UV-Vis spectrum, CD spectrum, FT-IR spectrum, mass spectrum, and single crystal X-ray diffraction (SXRD). The interaction of the four chiral Mn(IV) complexes with CT-DNA and BSA were also investigated by various spectroscopic techniques (UV-visible, fluorescence spectroscopic). The results show that the Δ-complexes exhibit more efficient CT-DNA interaction with respect to the Λ-complexes. All the complexes could quench the intrinsic fluorescence of BSA by a static quenching process. In addition, the vitro cytotoxicity of these complexes toward four kinds of cancerous cell lines (A549, HeLa, HL-60, and Caco-2) was assayed by the MTT method, which exhibited to be selectively active against certain cell lines. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Quality Control of (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A versatile ternary ion pair complex of 2′-amino-1,1′-binaphthalen-2-ol for sensing enantiomers and assignment of absolute configuration was written by Lakshmipriya, Anamalagundam;Sumana, Gaonkar;Suryaprakash, Nagaraja Rao. And the article was included in Tetrahedron: Asymmetry in 2017.Recommanded Product: (R)-2-Aminobutan-1-ol This article mentions the following:

2′-Amino-1,1′-binaphthalen-2-ol (NOBIN) serves as a versatile chiral solvating agent (CSA) in the presence of trifluoromethanesulfonic acid (TFMS). The formation of a ternary complex was established by NMR, UV-visible, fluorescence and IR studies. The mechanism of interactions among the three components in the ternary complex is proposed and the ternary complex structures of different diastereomers were established by DFT based theor. calculations The present protocol has its ubiquity not only in the anal. of the enantiomeric composition of mols. possessing diverse functionalities, but also in determining the stereospecific assignment of hydroxy acids. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Carbamoyl Pyridone HIV-1 Integrase Inhibitors 3. A Diastereomeric Approach to Chiral Nonracemic Tricyclic Ring Systems and the Discovery of Dolutegravir (S/GSK1349572) and (S/GSK1265744) was written by Johns, Brian A.;Kawasuji, Takashi;Weatherhead, Jason G.;Taishi, Teruhiko;Temelkoff, David P.;Yoshida, Hiroshi;Akiyama, Toshiyuki;Taoda, Yoshiyuki;Murai, Hitoshi;Kiyama, Ryuichi;Fuji, Masahiro;Tanimoto, Norihiko;Jeffrey, Jerry;Foster, Scott A.;Yoshinaga, Tomokazu;Seki, Takahiro;Kobayashi, Masanori;Sato, Akihiko;Johnson, Matthew N.;Garvey, Edward P.;Fujiwara, Tamio. And the article was included in Journal of Medicinal Chemistry in 2013.Recommanded Product: 5856-63-3 This article mentions the following:

We report herein the discovery of the human immunodeficiency virus type-1 (HIV-1) integrase inhibitors dolutegravir (S/GSK1349572) (3, III) and S/GSK1265744 (4, IV). These drugs stem from a series of carbamoyl pyridone analogs designed using a two-metal chelation model of the integrase catalytic active site. Structure-activity studies evolved a tricyclic series of carbamoyl pyridines that demonstrated properties indicative of once-daily dosing and superior potency against resistant viral strains. An inherent hemiaminal ring fusion stereocenter within the tricyclic carbamoyl pyridone scaffold led to a critical substrate controlled diastereoselective synthetic strategy whereby chiral information from small readily available amino alcs. was employed to control relative and absolute stereochem. of the final drug candidates. Modest to extremely high levels of stereochem. control were observed depending on ring size and position of the stereocenter. This approach resulted in the discovery of 3 and 4, which are currently in clin. development. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Impact of glycol-based solvents on indoor air quality-Artificial fog and exposure pathways of formaldehyde and various carbonyls was written by Guo, Xinyang;Ehindero, Toluwatise;Lau, Chester;Zhao, Ran. And the article was included in Indoor Air in 2022.Related Products of 57-55-6 This article mentions the following:

Artificial fog is commonly employed in the entertainment industry and indoor household celebrations. The fog is generated from glycol-based solvents, which can also be found in e-cigarettes and personal care products. Although potential health impacts of glycol inhalation are frequently cited by studies of e-cigarette smoking, the dynamics and the chem. composition of glycol-based aerosols have never been studied systematically. The objective of this work is to investigate the impact of glycol-based aerosol on indoor air quality. Specifically, we targeted artificial fogs generated with common glycols, including propylene glycol (PG) and triethylene glycol (TEG). With the aid of a novel aerosol collecting and monitoring instrument setup, we obtained time-resolved aerosol profiles and their chem. compositions in an exptl. room. Artificial fog has given rise to a significant amount of ultra-fine particulate matter, demonstrating its neg. impact on indoor air quality. Addnl., we found a high concentration (9.75 mM) of formaldehyde and other carbonyls in fog machine fluids stored for months. These compounds are introduced to the indoor air upon artificial fog application. We propose that carbonyls have accumulated from the oxidative decomposition of glycols, initiated by OH radicals and singlet oxygens (¹O₂) and likely sustained by autoxidation Oxidation of glycols by indoor oxidants has never been reported previously. Such chem. processes can represent an unrecognized source of toxic carbonyl compounds which is also applicable to other glycol-based solvents. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts