Tag: 0-100

Selective synthesis of 3-deoxy-5-hydroxy-1-amino-carbasugars as potential α-glucosidase inhibitors was written by Jiang, Chunfeng;Liu, Quan;Liu, Jiaming;Liu, Kaixuan;Tian, Liangliang;Duan, Mingfei;Wang, Ying;Shen, Zhufang;Xu, Youjun. And the article was included in Organic & Biomolecular Chemistry in 2019.Synthetic Route of C4H11NO This article mentions the following:

A convenient synthesis of novel 3-deoxy-5-hydroxy-1-aminocarbasugars was developed here. The benzyl-protected glucose-derived ketone was selectively converted in high yield to enone I via retro-Michael elimination of BnOH. The double bond of I was regio- and stereo-selectively reduced by the induction of C₄-α-OBn to the multi-functionalized II . II contained all the functionalities with similar configurations to carbasugars but with 3-H and 5-OH in the ring, and it would be a very interesting building block for organic synthesis or for bioactive compounds As one application, II was further transformed into 1-amino-carbasugars, e.g. III, by the reductive amination and final deprotection of benzyl groups. The targets were subjected to the in vitro inhibitory activity test against sucrase or maltase. The inhibitory activity of III against sucrase was nearly similar to that of voglibose. In comparison with voglibose, in vivo results similarly showed that III could lower the post-prandial blood glucose level after sucrose loading in healthy male ICR mice, while miglitol or acarbose was less effective. The mol. modeling study of some targets or voglibose with human sucrase could explain the inhibiting action. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Synthetic Route of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Synthetic Route of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Modelling and experimental studies on mass transport of multiple cryoprotective agents in articular cartilage was written by Yu, Xiaoyi;Zhang, Shaozhi;Chen, Guangming. And the article was included in Cryobiology in 2022.Related Products of 57-55-6 This article mentions the following:

Cartilage transplantation is an effective way to repair, reconstruct, and replace damaged articular cartilage (AC) but its use is limited by the inability to preserve AC for long periods of time. Vitrification is an ideal choice for long-term storage of AC, and multiple cryoprotective agents (CPAs) with high concentration are usually used. To obtain high cell viability, chondrocytes at all locations inside AC should be protected properly by the CPAs during cooling and rewarming. Hence, it is important to know the mass transport properties of multiple CPAs as they synergistically infiltrate AC. In this study, a math. model to describe the mass transport behavior of multiple CPAs in AC was developed based on the mixture-averaged diffusion model. In addition, a methodol. for the simultaneous determination of DMSO, glycerol, ethylene glycol, and propylene glycol by carbon-13 NMR was established. The model is applicable for predicting single- and multiple-CPA permeation into AC, and its accuracy was verified by a massive exptl. dataset. Simulation results showed reverse diffusion in the multiple-CPA permeation process, which was not found in the single-CPA permeation process. This curious phenomenon shows the sharp contrast between the diffusion behavior of a binary mixture and a multicomponent mixture In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oxidative amidation of aromatic aldehydes with amine hydrochloride salts catalyzed by silica-coated magnetic carbon nanotubes (MagCNTs@SiO₂)-immobilized imine-Cu(I) was written by Saberi, Dariush;Heydari, Akbar. And the article was included in Applied Organometallic Chemistry in 2014.COA of Formula: C4H11NO This article mentions the following:

Mesoporous silica-coated magnetic carbon nanotubes were prepared; their surface functionalization, followed by reaction with CuI, were carried out to develop a Cu-grafted functionalized mesoporous material. This system is able to catalyze oxidative amidation of aromatic aldehydes with amine hydrochloride salts, generating amide derivatives in moderate to good yields. Magnetic properties of this catalyst led to easy separation as well as providing significant recyclability. Copyright © 2013 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3COA of Formula: C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

CuCo₂O₄ photocatalyst for bifunctional applications: Toxic dye degradation and antimicrobial activity was written by Chen, Mengying;Yang, Xiuying;Wang, Yousheng;Zhang, Xuyuan;Liang, Ning;Zhao, Longshan. And the article was included in Materials Science in Semiconductor Processing in 2022.SDS of cas: 57-55-6 This article mentions the following:

In this paper, an environmentally friendly and facile method for the synthesis of CuCo₂O₄ nanosheets using deep eutectic solvent was reported. The synthesized CuCo₂O₄ nanosheets were characterized by SEM (SEM), XPS, X-ray diffraction (XRD), zeta potential research, Brunauer-Emmett-Teller (BET) surface area anal., Fourier transform IR spectroscopy (FT-IR), diffuse reflectance spectroscopy (DRS) and photoluminescence (PL) techniques. The CuCo₂O₄ nanosheets were successfully applied in degradation of organic dyes based on excellent photocatalytic activity. In the photocatalytic system, with 15 mg catalyst, 99.96% Methyl orange, 99.89% Congo red and 99.90% Amaranth (MO: 300 mg L^-1, CR:300 mg L^-1, AM: 80 mg L^-1) in 200 mL solution were degraded in 120 min, resp. Then, it was proved that removal of dyes was made up of original Langmuir adsorption and first order kinetics. Moreover, the nanomaterial could be reused for six cycles with slight decline of degradation efficiency, proving its high stability. In addition to good photocatalytic activity, the nanomaterial exhibited excellent antimicrobial activity against Escherichia coli and Staphylococcus aureus, achieving a complete bactericidal effect at a concentration of 100μg mL^-1. In conclusion, the as-synthesized nanomaterial had high photocatalytic activity and good antibacterial activity, which was expected to be applied in practical wastewater treatment. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6SDS of cas: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.SDS of cas: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Employing Abraham and Hansen Parameters for Solubility Prediction of Ketoconazole in Binary Solvents at Various Temperatures was written by Karimzadeh, Zahra;Rahimpour, Elaheh;Acree, William E. Jr.;Jouyban, Abolghasem. And the article was included in Journal of Solution Chemistry in 2022.Application of 57-55-6 This article mentions the following:

The Jouyban-Acree model is reported to be the most accurate math. model for predicting drug solubility in the mixed solvents at various temperatures In this study, the solubility of ketoconazole is predicted using the Jouyban-Acree based general models in some previously reported co-solvency systems. For this purpose, parameters of the Hansen solubility and the Abraham solvation parameters are combined with the Jouyban-Acree model and are trained with reported solubility data for ketoconazole to reach predictive co-solvency models. For investigation of the models’ accuracies, the values for mean relative deviations of predicted data from published exptl. values are calculated and discussed. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Application of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evaluation of high flow local extraction for controlling aerosol plumes in operating theaters was written by Sun, Chenlin;Marriott, Logan;Harper, Matthew;Zhou, Tongming. And the article was included in Physics of Fluids in 2022.HPLC of Formula: 57-55-6 This article mentions the following:

SARS-CoV-2 can be transmitted through contact with fomite, respiratory droplets, and aerosolized viruses. Recent evidence suggests that aerosol transmission represents a significant route of infection. In relation to healthcare workers (HCWs), much attention has been focused on personal protective equipment, yet this is the lowest level of the Centers for Disease Control and Prevention hierarchy of controls. Although engineering controls are prominent in the hierarchy, little attention has been given to developing effective interventions. This study aims to evaluate the performance of a simple extraction device in a clin. setting. This was accomplished by using a high flow local extraction (HFLE) that was connected to the existing ventilation system of the hospital on one end and to an intake nozzle near the patient′s airway on the other end. Propylene glycol was aerosolized through a physiol. test apparatus to simulate the breath of a patient. The field of interest was illuminated using a laser sheet in two planes from the model, namely, the sagittal plane and the transverse plane, and the movement of the simulated aerosol was recorded using a video camera to assess the dispersion of the aerosol qual. In the meantime, the concentration of the aerosol particles was measured using a particle meter to evaluate the effectiveness of the extraction quant. It was found that the HFLE device could effectively reduce the dispersion of the exhaled aerosols to undetectable levels when it was positioned within 250 mm from the mouth. This result has significance in the safety of HCWs involved in the management of patients with infectious diseases and may also have potential applications in other clin. areas with high airflow in the ventilation systems. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6HPLC of Formula: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.HPLC of Formula: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In-situ synthesis of Ru-WO_X/biochar catalyst for conversion of cellulose toward ethylene glycol was written by Huang, Haiyun;Chen, Lungang;Gu, Canshuo;Zhang, Xinghua;Liu, Jianguo;Zhang, Qi;Wang, Chenguang;Ma, Longlong;Liao, Yuhe. And the article was included in Cellulose (Dordrecht, Netherlands) in 2022.Related Products of 57-55-6 This article mentions the following:

Efficient utilization of renewable biomass plays a vital role in CO₂ mitigation. Direct conversion of cellulose, the most abundant fraction in lignocellulosic biomass, into ethylene glycol is a promising route. In this work, by using the biowaste pomelo peel as the carbon precursor, the Ru-WO_X/biochar (BC) bifunctional catalyst was prepared via pyrolysis in a nitrogen atm. without further reduction Cellulose could be efficiently converted into ethylene glycol with a yield of 68.8% after 10 h using Ru-WO_X/BC at the temperature of 220 °C and 3 MPa H₂. The effects of reaction temperature, reaction time, H₂ pressure and catalysts obtained from different pyrolysis temperatures on the yield of ethylene glycol were investigated. The characterization and reaction results showed that the gas generated from pyrolysis of pomelo peel could partially reduce ruthenium precursor to metallic form. Metallic Ru can not only promote the reduction of W⁶⁺ to W⁵⁺, but also work on hydrogenation reaction. The catalyst and preparation method have a promising application in cellulose conversion. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Related Products of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design, physico-chemical properties and biological evaluation of some new N-[(phenoxy)alkyl]- and N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols as anticonvulsant agents was written by Waszkielewicz, A. M.;Gunia-Krzyzak, A.;Powroznik, B.;Sloczynska, K.;Pekala, E.;Walczak, M.;Bednarski, M.;Zeslawska, E.;Nitek, W.;Marona, H.. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Recommanded Product: 5856-63-3 This article mentions the following:

A series of thirty N-(phenoxy)alkyl or N-{2-[2-(phenoxy)ethoxy]ethyl}aminoalkanols has been designed, synthesized and evaluated for anticonvulsant activity in MES, 6 Hz test, and pilocarpine-induced status epilepticus. Among the title compounds, the most promising seems to be I with proved absolute configuration with x-ray anal. and enantiomeric purity. The compound is effective in MES test with ED₅₀ = 12.92 mg/kg b.w. and its rotarod TD₅₀ = 33.26 mg/kg b.w. The activity dose is also effective in a neurogenic pain model-the formalin test. Within high throughput profile assay, among eighty one targets, the strongest affinity of the compound is observed towards σ receptors and 5-HT transporter and the compound does not bind to hERG. It also does not exhibit mutagenic properties in the Vibrio harveyi test. Moreover, murine liver microsomal assay and pharmacokinetics profile (mice, iv, p.o., i.p.) indicate that the liver is the primary site of biotransformation of the compound, suggesting that both I and its metabolite(s) are active, compensating probably low bioavailability of the parent mol. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Recommanded Product: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Design of new disubstituted imidazo[1,2-b]pyridazine derivatives as selective Haspin inhibitors. Synthesis, binding mode and anticancer biological evaluation was written by Elie, Jonathan;Feizbakhsh, Omid;Desban, Nathalie;Josselin, Beatrice;Baratte, Blandine;Bescond, Amandine;Duez, Julien;Fant, Xavier;Bach, Stephane;Marie, Dominique;Place, Matthieu;Ben Salah, Sami;Chartier, Agnes;Berteina-Raboin, Sabine;Chaikuad, Apirat;Knapp, Stefan;Carles, Fabrice;Bonnet, Pascal;Buron, Frederic;Routier, Sylvain;Ruchaud, Sandrine. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2020.SDS of cas: 5856-63-3 This article mentions the following:

Haspin is a mitotic protein kinase required for proper cell division by modulating Aurora B kinase localisation and activity as well as histone phosphorylation. Here a series of imidazopyridazines based on the CHR-6494 and Structure Activity Relationship was established. An assessment of the inhibitory activity of the lead structures on human Haspin and several other protein kinases is presented. The lead structure was rapidly optimized using a combination of crystal structures and effective docking models, with the best inhibitors exhibiting potent inhibitory activity on Haspin with IC₅₀ between 6 and 100 nM in vitro. The developed inhibitors displayed anti-proliferative properties against various human cancer cell lines in 2D and spheroid cultures and significantly inhibited the migration ability of osteosarcoma U-2 OS cells. Notably, we show that our lead compounds are powerful Haspin inhibitors in human cells, and did not block G2/M cell cycle transition due to improved selectivity against CDK1/CyclinB. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3SDS of cas: 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.SDS of cas: 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Freezing chicken semen: Influence of base medium osmolality, cryoprotectants, cryoprotectant concentration, and cooling rate on post-thaw sperm survival was written by Woelders, H.;de Wit, A. A. C.;Engel, B.;Hulsegge, B.;Grasseau, I.;Blesbois, E.;Bernal, B.;Santiago-Moreno, J.. And the article was included in Cryobiology in 2022.Recommanded Product: 57-55-6 This article mentions the following:

A classical chicken semen diluent (Lake’s 7.1 diluent) was modified to have lowered osmolalities (ranging from 290 to 410 mOsm/kg). The modified medium with physiol. osmolality of 325 mOsm/kg allowed cold storage of fresh semen for several days with very little loss of membrane integrity and motility, while high osmolalities inhibited motility. This modified medium was then used as base for freezing medium to test effects of the type and concentration of cryoprotective agent (CPA), and the cooling rate (CR). A number of CPAs (methylformamide, methylacetamide, DMF (DMF), dimethylacetamide (DMA), diethylformamide, and propylene glycol) were first compared by freezing semen with 0.6 mol/l of the resp. CPA at a cooling rate of 250°C/min. Post-thaw motility and membrane integrity were highest with DMA and DMF. Finally, in more detailed factorial experiments, semen from individual cocks or pooled semen was frozen using CRs of 4, 50, 250, and 440°C/min and DMA concentrations ([DMA]) of 0.4, 0.6, 1.0, and 1.5 mol/l. Straws from each semen sample x treatment combination were divided for semen assessment at three different research groups for sperm motility, membrane integrity, kinked tails, and DNA fragmentation, using microscopy, computer assisted motility anal., and flow cytometry. There were clear effects of both CR and [DMA] and their interaction. CRs 50 and 250°C/min gave best post-thaw sperm performance. Higher DMA concentrations gave better post-thaw membrane integrity, but concentrations above 1.0 mol/l can decrease sperm velocity or even inhibit sperm motility. Therefore [DMA] may best be 0.6-1.0 mol/l at a CR of 50-250°C/min. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Recommanded Product: 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Recommanded Product: 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts