Tag: 0-100

Enantio sensing property of helicin, the derivative of a natural product: Discrimination of amines and amino alcohols was written by Kumari, Divya;Sachin, S. L.;Suryaprakash, N.. And the article was included in Chemical Physics Letters in 2015.Name: (R)-2-Aminobutan-1-ol This article mentions the following:

The chiral sensing property of helicin (the derivative of natural product obtained by partial oxidation of salicin, extracted from willow tree (Salix helix)) is reported. The use of helicin as a chiral derivatizing agent for the discrimination of amines and amino alcs. is convincingly established using ¹H NMR spectroscopy. The large chem. shift separation achieved between the discriminated peaks facilitated the accurate quantification of enantiomeric composition The consistent trend observed in the shifting of imine proton peak (Δδ) of helicin in all the derivatized mols. might aid the determination of spatial configuration. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Name: (R)-2-Aminobutan-1-ol

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Alcohol – Wikipedia,
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Enantioselective Fluorescent Recognition of β-Amino Alcohols by Stereoselective Cyclization was written by Tian, Jun;Yu, Shanshan;Guo, Hongyu;Zhu, Maoshuai;Lu, Kai;Jiang, Yixuan;Yang, Jiaqiao;Yu, Xiaoqi;Pu, Lin. And the article was included in European Journal of Organic Chemistry in 2022.Quality Control of (R)-2-Aminobutan-1-ol This article mentions the following:

2,2′-Diformyl-1,1′-binaphthyl is found to exhibit highly enantioselective fluorescence enhancement in the presence of various β-amino alcs. and base. It provides a new method to determine the enantiomeric composition of those substrates and has potential for high throughput anal. Based on detailed spectroscopic analyses, it is proposed that a stereoselective cyclization of a β-amino alc. with the probe should occur to form a rigid macrocyclic intermediate, contributing to the greatly enhanced fluorescence. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Quality Control of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of (R)-2-Aminobutan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chitosan/Hydroxyethyl Cellulose Gel Immobilized Polyaniline/CuO/ZnO Adsorptive-Photocatalytic Hybrid Nanocomposite for Congo Red Removal was written by Gelaw, Tadesse Bassie;Sarojini, Balladka Kunhanna;Kodoth, Arun Krishna. And the article was included in Journal of Polymers and the Environment in 2022.Safety of 1,2-Propanediol This article mentions the following:

Advanced photocatalytic degradation based on polymer/metal oxide hybrid composites can convert organic and related pollutants into an environmentally benign product. In this study, chitosan/hydroxyethyl cellulose (CS/HEC) gel immobilized polyaniline (PANI)/CuO/ZnO composite was prepared by in situ oxidative polymerization followed by ex-situ dispersion. The hybrid nanocomposite synthesized was characterized by FESEM, FTIR, EDX, XRD, TGA, and UV-Visible absorption spectroscopy. The degradation study was performed in the optimum time, pH, PANI/CuO/ZnO loading on CS/HEC gel, and catalyst dosage using 100μM Congo red. The correlation coefficients (R2) of pseudo-second-order adsorption kinetics were higher than 0.98 at different temperatures, signifying that the model was well fitted and the chem. interaction between Congo red and the catalyst at the interface. The activation energy of 19.56 kJ/mol showed chemisorption of Congo red at the interface. The neg. values of standard Gibbs free energy demonstrated that the Congo red adsorbed spontaneously to the catalyst surface. According to the Langmuir-Hinshelwood kinetics model, Congo red photocatalytic degradation followed pseudo-first-order kinetics. The decrease in degradation efficiency with the addition of ammonium oxalate and iso-Pr alc. proved that both pos. charged holes and hydroxyl radicals were involved in the catalysis. The catalytic degradation efficiency of the 0.4 g/L catalysts was 99.8 and 93.7% in the 1st and 4th cycle, resp., indicating that it is efficient, stable, and recyclable. The resulting hybrid nanocomposite is a promising photocatalyst for removing anionic dyes. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Safety of 1,2-Propanediol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Extraction of flavonoids from Glycyrrhiza residues using deep eutectic solvents and its molecular mechanism was written by Yu, Qiang;Wang, Fan;Jian, Yating;Chernyshev, Victor M.;Zhang, Yu;Wang, Zhongming;Yuan, Zhenhong;Chen, Xiaoyan. And the article was included in Journal of Molecular Liquids in 2022.Application In Synthesis of 1,2-Propanediol This article mentions the following:

The re-extraction of bioactive compounds from Chinese herb residues is significant for the maximum utilization of biomass resources. However, conventional alc. and aqueous solvents are unsuitable for recovering those compounds In this study, 14 deep eutectic solvents (DESs) were used to improve the efficiency of flavonoid extraction from Glycyrrhiza residues. The maximal total extraction rate (10.68 mg/g) for four flavonoids (liquiritin, isoliquiritin, liquiritigenin, and isoliquiritigenin) was achieved using choline chloride-glycolic acid as the DES under optimal conditions. The extraction rate was 83.03% higher than that by 60% ethanol, a traditional solvent. Anal. of the associated mol. mechanism based on d. functional theory showed that interactions between the solvent and liquiritin were dominated by hydrogen bonds followed by Van der Waals forces, whereas the bonding between the solvent and liquiritigenin only involved Van der Waals forces, thereby verifying the significance of the strength of hydrogen bonding in the DES-flavonoid extraction process. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Application In Synthesis of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Application In Synthesis of 1,2-Propanediol

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Alcohol – Wikipedia,
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Discovery of N²-(4-Amino-cyclohexyl)-9-cyclopentyl-N⁶-(4-morpholin-4-ylmethyl-phenyl)-9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations was written by Gucky, Tomas;Reznickova, Eva;Radosova Muchova, Tereza;Jorda, Radek;Klejova, Zuzana;Malinkova, Veronika;Berka, Karel;Bazgier, Vaclav;Ajani, Haresh;Lepsik, Martin;Divoky, Vladimir;Krystof, Vladimir. And the article was included in Journal of Medicinal Chemistry in 2018.Application In Synthesis of (R)-2-Aminobutan-1-ol This article mentions the following:

FLT3 tyrosine kinase is a potential drug target in acute myeloid leukemia (AML) because patients with FLT3-ITD mutations respond poorly to standard cytotoxic agents and there is a clear link between the disease and the oncogenic properties of FLT3. We present novel 2,6,9-trisubstituted purine derivatives with potent FLT3 inhibitory activity. The lead compound 7d displays nanomolar activity in biochem. assays and selectively blocks proliferation of AML cell lines harboring FLT3-ITD mutations, whereas other transformed and normal human cells are several orders of magnitude less sensitive. The MV4-11 cells treated with 7d suppressed the phosphorylation of FLT3 and its downstream signaling pathways, with subsequent G1 cell cycle arrest and apoptosis. Addnl., a single dose of 7d in mice with s.c. MV4-11 xenografts caused sustained inhibition of FLT3 and STAT5 phosphorylation over 48 h, in contrast to the shorter effect observed after administration of the reference FLT3 inhibitor quizartinib. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Application In Synthesis of (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (R)-2-Aminobutan-1-ol

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

On the interactions of diols and DMPC monolayers was written by Rhys, Natasha H.;Barlow, David J.;Lawrence, M. Jayne;Lorenz, Christian D.. And the article was included in Journal of Molecular Liquids in 2022.Safety of 1,2-Propanediol This article mentions the following:

The interactions of lipid mols. with various solvent mols. is of utmost importance in the formulation of various drug delivery and personal care formulations. In this manuscript, a series of all-atom mol. dynamics simulations were used to investigate how the structural and interfacial properties of a DMPC (1,2-dimyristoyl-sn-glycero-3-phosphocholine) monolayer change when interacting with a range of diols that have varying carbon chain lengths and patterns of hydroxylation. In comparison to water, we find that all of the diols studied result in a more disordered and thinner monolayer. Addnl., we find that the shorter diols with the hydroxyl groups on neighboring carbons (1,2-ethanediol and 1,2-propanediol) are able to penetrate deeper into the head group region of the lipid monolayers and as a result significantly disorder and thin the monolayers. Like water, we find that the diols also form hydrogen-bonded networks that connect the DMPC head groups in neighboring mols. Interestingly, we find that the number of butanediol mols. that form these solvent-mediated interactions between the DMPC head groups is directly affected by the distribution of the hydroxyl groups within the diol mols. The results presented here provide a mechanistic description of how the chem. of diol solvent mols. will affect the structural and interfacial properties of lipid structures in solution In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Safety of 1,2-Propanediol).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of 1,2-Propanediol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chiral Imidazolium-Functionalized Au Nanoparticles: Reversible Aggregation and Molecular Recognition was written by Lomeli-Rosales, Diego Alberto;Rangel-Salas, Irma Idalia;Zamudio-Ojeda, Adalberto;Carbajal-Arizaga, Gregorio Guadalupe;Godoy-Alcantar, Carolina;Manriquez-Gonzalez, Ricardo;Alvarado-Rodriguez, Jose Guadalupe;Martinez-Otero, Diego;Cortes-Llamas, Sara Angelica. And the article was included in ACS Omega in 2016.Name: (R)-2-Aminobutan-1-ol This article mentions the following:

Gold nanoparticles (AuNPs) stabilized by imidazolium salts derived from amino acids [glycine (1), rac-alanine (2), L-phenylalanine (3), and rac-methionine (4)] were prepared The AuNPs were stabilized the most by 4, which kept the particles dispersed in water for months at pH > 5.5. These AuNPs exhibited a well-defined absorption band at 517 nm and had an average particle size of 11.21 ± 0.07 nm. The 4-AuNPs were reversibly aggregated by controlling the pH of the solution Chiral R,R-4-AuNPs and S,S-4-AuNPs were synthesized, and the chiral environment on the nanoparticle surface was confirmed using CD; these nanoparticles exhibited a mol. recognition of chiral substrates. Furthermore, they showed potential for separating racemic mixtures when supported on a layered double hydroxide. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Name: (R)-2-Aminobutan-1-ol).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Name: (R)-2-Aminobutan-1-ol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Discovery of novel 2-(alkylmorpholin-4-yl)-6-(3-fluoropyridin-4-yl)-pyrimidin-4(3H)-ones as orally-active GSK-3β inhibitors for Alzheimer’s disease was written by Fukunaga, Kenji;Sakai, Daiki;Watanabe, Kazutoshi;Nakayama, Kazuki;Kohara, Toshiyuki;Tanaka, Hiroshi;Sunada, Shinji;Nabeno, Mika;Okamoto, Masako;Saito, Ken-Ichi;Eguchi, Jun-ichi;Mori, Akiko;Tanaka, Shinji;Inazawa, Keiko;Horikawa, Takashi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Product Details of 5856-63-3 This article mentions the following:

The authors herein describe the results of further evolution of GSK-3β inhibitors for Alzheimer’s disease from the promising compounds with in vivo tau phosphorylation inhibitory activity by oral administration. Introduction of a low alkyl group instead of the Ph group at the 3-position of the morpholine moiety aiming to improve pharmacokinetic profiles resulted in potent low mol. weight GSK-3β inhibitors with good in vitro pharmacokinetic profiles, which also showed in vivo tau phosphorylation inhibitory activity by oral administration. Effect of the stereochem. of the alkyl moiety is also discussed using docking models. In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Product Details of 5856-63-3).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Product Details of 5856-63-3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In situ approach for testing the enantiopurity of chiral amines and amino alcohols by ¹H NMR was written by Mishra, Sandeep Kumar;Chaudhari, Sachin R.;Suryaprakash, N.. And the article was included in Organic & Biomolecular Chemistry in 2014.Computed Properties of C4H11NO This article mentions the following:

An in situ approach involving a simple mix and shake method for testing the enantiopurity of primary, secondary and tertiary chiral amines and their derivatives, chiral amino alcs., by ¹H-NMR spectroscopy is developed. The protocol involves the in situ formation of chiral ammonium borate salt from a mixture of C₂ sym. chiral BINOL, trialkoxyborane and chiral amines. The proposed concept was demonstrated convincingly on a large number of chiral and pro-chiral amines and amino alcs., and also aids the precise measurement of enantiomeric excess. The protocol can be completed in a couple of minutes directly in the NMR sample tube, without the need for any phys. separation In the experiment, the researchers used many compounds, for example, (R)-2-Aminobutan-1-ol (cas: 5856-63-3Computed Properties of C4H11NO).

(R)-2-Aminobutan-1-ol (cas: 5856-63-3) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Computed Properties of C4H11NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Characterization of a rapid condensate collection apparatus for in vitro assays of electronic nicotine delivery systems was written by Lalonde, Guy;Demir, Kubilay;Yao, Jenny;Wolz, Russell L.;Kosachevsky, Pasha;Gillman, I. Gene;Oldham, Michael J.. And the article was included in Toxicology In Vitro in 2022.Application of 57-55-6 This article mentions the following:

In vitro testing of Electronic Nicotine Delivery System (ENDS) aerosol condensates is important in evaluating their potential toxicity. Collecting sufficient condensate for these tests is a time consuming and costly procedure. The “triple puff (TP)” is a novel system which collects the aerosol from three ENDS devices sequentially into a single filter pad and impinger. The TP substantially reduces condensate collection time relative to the conventional single ENDS, single puff (SP), device system. Both the TP and SP (using two puffing profiles) were used to generate condensates from JUUL ENDS e-liquid Mint 5.0% (nicotine by weight). Aerosols were collected using the filter pad and ethanol-containing impinger method. Condensates produced with the SP and TP were compared for concentrations of primary constituents and carbonyl compounds as well as for their cytotoxicity (OECD 129), mutagenicity (OECD 471) and genotoxicity (OECD 487). Condensates generated with the SP and TP, regardless of puffing regimen, were very similar chem. and equivalent in the biol. assays tested (not cytotoxic, mutagenic, or genotoxic). The TP device significantly reduces production time of ENDS condensates relative to the standard SP method and thus may facilitate further research by reducing the time and effort required to collect ENDS condensates. In the experiment, the researchers used many compounds, for example, 1,2-Propanediol (cas: 57-55-6Application of 57-55-6).

1,2-Propanediol (cas: 57-55-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application of 57-55-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts